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Foreign body reaction

MedGen UID:
4769
•Concept ID:
C0016549
•
Pathologic Function
Synonyms: Foreign Body Reaction; Foreign-Body Reaction; Reaction, Foreign-Body
SNOMED CT: Foreign body reaction (37058002)

Definition

A granulomatous inflammatory reaction evoked by the presence of an exogenous material in the tissues, a characteristic feature of which is the formation of foreign body giant cells. [from NCI]

Professional guidelines

PubMed

Novel management of granuloma formation secondary to dermal filler: A multi-modality approach.
Bowles A, Ghalili S, Ojong OB, Vasile GF, Li YM, Aguilera SB
J Cosmet Dermatol 2023 Apr;22(4):1233-1237. Epub 2022 Dec 25 doi: 10.1111/jocd.15579. PMID: 36566488
Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies.
Alshaikh RA, Waeber C, Ryan KB
Adv Drug Deliv Rev 2022 Aug;187:114342. Epub 2022 May 13 doi: 10.1016/j.addr.2022.114342. PMID: 35569559
Management of granulomatous foreign body reaction to fillers with methotrexate.
Broly M, Marie J, Picard C, Demoures A, Raimbault C, Beylot-Barry M, Cogrel O
J Eur Acad Dermatol Venereol 2020 Apr;34(4):817-820. Epub 2019 Nov 28 doi: 10.1111/jdv.16027. PMID: 31650637

Recent clinical studies

Etiology

Artificial hair implantation for hair restoration.
Gupta AK, Venkataraman M, Quinlan EM
J Dermatolog Treat 2022 May;33(3):1312-1318. Epub 2021 Feb 21 doi: 10.1080/09546634.2021.1887442. PMID: 33565339
Modulating the foreign body response of implants for diabetes treatment.
Kharbikar BN, Chendke GS, Desai TA
Adv Drug Deliv Rev 2021 Jul;174:87-113. Epub 2021 Jan 21 doi: 10.1016/j.addr.2021.01.011. PMID: 33484736Free PMC Article
Mesotherapy: Safety profile and management of complications.
Plachouri KM, Georgiou S
J Cosmet Dermatol 2019 Dec;18(6):1601-1605. Epub 2019 Aug 24 doi: 10.1111/jocd.13115. PMID: 31444843
Foreign body reaction after trapeziectomy and Dacron interposition.
Willekens P, Verstraete K, Hollevoet N
Hand Surg Rehabil 2016 Feb;35(1):27-33. Epub 2016 Feb 16 doi: 10.1016/j.hansur.2015.11.001. PMID: 27117021
Wear particles.
Jacobs JJ, Hallab NJ, Urban RM, Wimmer MA
J Bone Joint Surg Am 2006 Apr;88 Suppl 2:99-102. doi: 10.2106/JBJS.F.00102. PMID: 16595453

Diagnosis

Foreign Body Reaction Mimicking Lymph Node Metastasis is Not Rare After Lung Cancer Resection.
Cimenoglu B, Dogruyol T, Ozdemir A, Buz M, Ece D, Comert SS, Demirhan R
Thorac Cardiovasc Surg 2024 Apr;72(3):235-241. Epub 2023 Aug 28 doi: 10.1055/a-2161-0690. PMID: 37640061
Extensive Foreign Body Reaction to Synthetic Dural Replacement After Decompressive Craniectomy with Radiological and Histopathology Evidence: Observational Case Series.
Mohammed K, Iqbal J, Arshad M, Abu-Dayeh AS, Albozom I, Alyafei A, Ben Zabih T, Belkhair S
World Neurosurg 2023 Apr;172:e585-e592. Epub 2023 Feb 7 doi: 10.1016/j.wneu.2023.01.089. PMID: 36754353
Foreign body reaction mimicking local recurrence from polyactide adhesion barrier film after laparoscopic colorectal cancer surgery: A retrospective cohort study.
Hsieh TC, Hsu CW
Medicine (Baltimore) 2022 Feb 4;101(5):e28692. doi: 10.1097/MD.0000000000028692. PMID: 35119013Free PMC Article
Circular Rectal Lesion.
Wilhelmi M, Loetscher S, Netzer P
Gastroenterology 2018 Oct;155(4):979-980. Epub 2018 Mar 13 doi: 10.1053/j.gastro.2018.03.023. PMID: 29549043
Foreign body reactions may not influence the keloid recurrence.
Park TH, Lee B, Park JH, Rah DK
J Cosmet Dermatol 2016 Mar;15(1):78-81. Epub 2015 Aug 25 doi: 10.1111/jocd.12177. PMID: 26302719

Therapy

Fascial Closure: New Surgery Paradigms.
Dumanian GA, Moradian S
Adv Surg 2020 Sep;54:215-229. Epub 2020 Jun 17 doi: 10.1016/j.yasu.2020.05.007. PMID: 32713432
Modulation of foreign body reaction and macrophage phenotypes concerning microenvironment.
Chu C, Liu L, Rung S, Wang Y, Ma Y, Hu C, Zhao X, Man Y, Qu Y
J Biomed Mater Res A 2020 Jan;108(1):127-135. Epub 2019 Oct 6 doi: 10.1002/jbm.a.36798. PMID: 31515867
Biocompatibility of alumina-based biomaterials-A review.
Rahmati M, Mozafari M
J Cell Physiol 2019 Apr;234(4):3321-3335. Epub 2018 Sep 6 doi: 10.1002/jcp.27292. PMID: 30187477
The pathology of the foreign body reaction against biomaterials.
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Foreign body reaction after trapeziectomy and Dacron interposition.
Willekens P, Verstraete K, Hollevoet N
Hand Surg Rehabil 2016 Feb;35(1):27-33. Epub 2016 Feb 16 doi: 10.1016/j.hansur.2015.11.001. PMID: 27117021

Prognosis

Interactions between the foreign body reaction and Staphylococcus aureus biomaterial-associated infection. Winning strategies in the derby on biomaterial implant surfaces.
Rosman CWK, van Dijl JM, Sjollema J
Crit Rev Microbiol 2022 Sep;48(5):624-640. Epub 2021 Dec 8 doi: 10.1080/1040841X.2021.2011132. PMID: 34879216
Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions.
Buser D, Sennerby L, De Bruyn H
Periodontol 2000 2017 Feb;73(1):7-21. doi: 10.1111/prd.12185. PMID: 28000280
The pathology of the foreign body reaction against biomaterials.
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Teflon granulomas mimicking cerebellopontine angle tumors following microvascular decompression.
Deep NL, Graffeo CS, Copeland WR 3rd, Link MJ, Atkinson JL, Neff BA, Raghunathan A, Carlson ML
Laryngoscope 2017 Mar;127(3):715-719. Epub 2016 Jun 19 doi: 10.1002/lary.26126. PMID: 27320780
Lipoid pneumonia: an overview.
Hadda V, Khilnani GC
Expert Rev Respir Med 2010 Dec;4(6):799-807. doi: 10.1586/ers.10.74. PMID: 21128754

Clinical prediction guides

Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration.
Crawford L, Wyatt M, Bryers J, Ratner B
Adv Healthc Mater 2021 Jun;10(11):e2002153. Epub 2021 Apr 7 doi: 10.1002/adhm.202002153. PMID: 33829678Free PMC Article
Non-infectious granulomatous dermatoses.
Schmitt A, Volz A
J Dtsch Dermatol Ges 2019 May;17(5):518-533. doi: 10.1111/ddg.13848. PMID: 31115996
The pathology of the foreign body reaction against biomaterials.
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Foreign body reaction after trapeziectomy and Dacron interposition.
Willekens P, Verstraete K, Hollevoet N
Hand Surg Rehabil 2016 Feb;35(1):27-33. Epub 2016 Feb 16 doi: 10.1016/j.hansur.2015.11.001. PMID: 27117021
Foreign Body Reaction to Biomaterials: On Mechanisms for Buildup and Breakdown of Osseointegration.
Trindade R, Albrektsson T, Tengvall P, Wennerberg A
Clin Implant Dent Relat Res 2016 Feb;18(1):192-203. Epub 2014 Sep 25 doi: 10.1111/cid.12274. PMID: 25257971

Recent systematic reviews

Treatments for Morton's neuroma.
Matthews BG, Thomson CE, Harding MP, McKinley JC, Ware RS
Cochrane Database Syst Rev 2024 Feb 9;2(2):CD014687. doi: 10.1002/14651858.CD014687.pub2. PMID: 38334217Free PMC Article
Autoimmunity and hernia mesh: fact or fiction?
Jisova B, Wolesky J, Strizova Z, de Beaux A, East B
Hernia 2023 Aug;27(4):741-749. Epub 2023 Feb 4 doi: 10.1007/s10029-023-02749-4. PMID: 36739352Free PMC Article
A systematic analysis of controlled clinical trials using the NiTi CAR™ compression ring in colorectal anastomoses.
Tabola R, Cirocchi R, Fingerhut A, Arezzo A, Randolph J, Grassi V, Binda GA, D'Andrea V, Abraha I, Popivanov G, Di Saverio S, Zbar A
Tech Coloproctol 2017 Mar;21(3):177-184. Epub 2017 Jan 28 doi: 10.1007/s10151-017-1583-2. PMID: 28132113
Teflon granulomas mimicking cerebellopontine angle tumors following microvascular decompression.
Deep NL, Graffeo CS, Copeland WR 3rd, Link MJ, Atkinson JL, Neff BA, Raghunathan A, Carlson ML
Laryngoscope 2017 Mar;127(3):715-719. Epub 2016 Jun 19 doi: 10.1002/lary.26126. PMID: 27320780
Do retrieval analysis and blood metal measurements contribute to our understanding of adverse local tissue reactions?
Campbell PA, Kung MS, Hsu AR, Jacobs JJ
Clin Orthop Relat Res 2014 Dec;472(12):3718-27. doi: 10.1007/s11999-014-3893-2. PMID: 25160942Free PMC Article

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