U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Foreign body reaction

MedGen UID:
4769
Concept ID:
C0016549
Pathologic Function
Synonyms: Foreign Body Reaction; Foreign-Body Reaction; Reaction, Foreign-Body
SNOMED CT: Foreign body reaction (37058002)

Definition

A granulomatous inflammatory reaction evoked by the presence of an exogenous material in the tissues, a characteristic feature of which is the formation of foreign body giant cells. [from NCI]

Professional guidelines

PubMed

Alshaikh RA, Waeber C, Ryan KB
Adv Drug Deliv Rev 2022 Aug;187:114342. Epub 2022 May 13 doi: 10.1016/j.addr.2022.114342. PMID: 35569559
Broly M, Marie J, Picard C, Demoures A, Raimbault C, Beylot-Barry M, Cogrel O
J Eur Acad Dermatol Venereol 2020 Apr;34(4):817-820. Epub 2019 Nov 28 doi: 10.1111/jdv.16027. PMID: 31650637
Kari O, Saari KM
Curr Allergy Asthma Rep 2012 Jun;12(3):232-9. doi: 10.1007/s11882-012-0252-9. PMID: 22382607

Recent clinical studies

Etiology

Gupta AK, Venkataraman M, Quinlan EM
J Dermatolog Treat 2022 May;33(3):1312-1318. Epub 2021 Feb 21 doi: 10.1080/09546634.2021.1887442. PMID: 33565339
Plachouri KM, Georgiou S
J Cosmet Dermatol 2019 Dec;18(6):1601-1605. Epub 2019 Aug 24 doi: 10.1111/jocd.13115. PMID: 31444843
Willekens P, Verstraete K, Hollevoet N
Hand Surg Rehabil 2016 Feb;35(1):27-33. Epub 2016 Feb 16 doi: 10.1016/j.hansur.2015.11.001. PMID: 27117021
Juhas E, English JC 3rd
J Pediatr Adolesc Gynecol 2013 Apr;26(2):125-9. Epub 2012 Dec 31 doi: 10.1016/j.jpag.2012.08.005. PMID: 23287600
Jacobs JJ, Hallab NJ, Urban RM, Wimmer MA
J Bone Joint Surg Am 2006 Apr;88 Suppl 2:99-102. doi: 10.2106/JBJS.F.00102. PMID: 16595453

Diagnosis

Cimenoglu B, Dogruyol T, Ozdemir A, Buz M, Ece D, Comert SS, Demirhan R
Thorac Cardiovasc Surg 2024 Apr;72(3):235-241. Epub 2023 Aug 28 doi: 10.1055/a-2161-0690. PMID: 37640061
Mohammed K, Iqbal J, Arshad M, Abu-Dayeh AS, Albozom I, Alyafei A, Ben Zabih T, Belkhair S
World Neurosurg 2023 Apr;172:e585-e592. Epub 2023 Feb 7 doi: 10.1016/j.wneu.2023.01.089. PMID: 36754353
Juhas E, English JC 3rd
J Pediatr Adolesc Gynecol 2013 Apr;26(2):125-9. Epub 2012 Dec 31 doi: 10.1016/j.jpag.2012.08.005. PMID: 23287600
Baskar S, Mann JS, Thomas AP, Newton P
J Clin Rheumatol 2006 Jun;12(3):137-8. doi: 10.1097/01.rhu.0000221997.57886.a6. PMID: 16755243
Pereira TC, Prichard JW, Khalid M, Medich DS, Silverman JF
Arch Pathol Lab Med 2001 Jun;125(6):822-3. doi: 10.5858/2001-125-0822-RPG. PMID: 11371241

Therapy

Dumanian GA, Moradian S
Adv Surg 2020 Sep;54:215-229. Epub 2020 Jun 17 doi: 10.1016/j.yasu.2020.05.007. PMID: 32713432
Chu C, Liu L, Rung S, Wang Y, Ma Y, Hu C, Zhao X, Man Y, Qu Y
J Biomed Mater Res A 2020 Jan;108(1):127-135. Epub 2019 Oct 6 doi: 10.1002/jbm.a.36798. PMID: 31515867
Rahmati M, Mozafari M
J Cell Physiol 2019 Apr;234(4):3321-3335. Epub 2018 Sep 6 doi: 10.1002/jcp.27292. PMID: 30187477
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Willekens P, Verstraete K, Hollevoet N
Hand Surg Rehabil 2016 Feb;35(1):27-33. Epub 2016 Feb 16 doi: 10.1016/j.hansur.2015.11.001. PMID: 27117021

Prognosis

Rosman CWK, van Dijl JM, Sjollema J
Crit Rev Microbiol 2022 Sep;48(5):624-640. Epub 2021 Dec 8 doi: 10.1080/1040841X.2021.2011132. PMID: 34879216
Buser D, Sennerby L, De Bruyn H
Periodontol 2000 2017 Feb;73(1):7-21. doi: 10.1111/prd.12185. PMID: 28000280
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Hadda V, Khilnani GC
Expert Rev Respir Med 2010 Dec;4(6):799-807. doi: 10.1586/ers.10.74. PMID: 21128754
Simamora P, Chern W
J Drugs Dermatol 2006 May;5(5):436-40. PMID: 16703779

Clinical prediction guides

Crawford L, Wyatt M, Bryers J, Ratner B
Adv Healthc Mater 2021 Jun;10(11):e2002153. Epub 2021 Apr 7 doi: 10.1002/adhm.202002153. PMID: 33829678Free PMC Article
Schmitt A, Volz A
J Dtsch Dermatol Ges 2019 May;17(5):518-533. doi: 10.1111/ddg.13848. PMID: 31115996
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Trindade R, Albrektsson T, Tengvall P, Wennerberg A
Clin Implant Dent Relat Res 2016 Feb;18(1):192-203. Epub 2014 Sep 25 doi: 10.1111/cid.12274. PMID: 25257971
Hadda V, Khilnani GC
Expert Rev Respir Med 2010 Dec;4(6):799-807. doi: 10.1586/ers.10.74. PMID: 21128754

Recent systematic reviews

Matthews BG, Thomson CE, Harding MP, McKinley JC, Ware RS
Cochrane Database Syst Rev 2024 Feb 9;2(2):CD014687. doi: 10.1002/14651858.CD014687.pub2. PMID: 38334217Free PMC Article
Jisova B, Wolesky J, Strizova Z, de Beaux A, East B
Hernia 2023 Aug;27(4):741-749. Epub 2023 Feb 4 doi: 10.1007/s10029-023-02749-4. PMID: 36739352Free PMC Article
Deep NL, Graffeo CS, Copeland WR 3rd, Link MJ, Atkinson JL, Neff BA, Raghunathan A, Carlson ML
Laryngoscope 2017 Mar;127(3):715-719. Epub 2016 Jun 19 doi: 10.1002/lary.26126. PMID: 27320780
Campbell PA, Kung MS, Hsu AR, Jacobs JJ
Clin Orthop Relat Res 2014 Dec;472(12):3718-27. doi: 10.1007/s11999-014-3893-2. PMID: 25160942Free PMC Article
Nam D, Barrack RL, Potter HG
Clin Orthop Relat Res 2014 Dec;472(12):3665-73. Epub 2014 Mar 25 doi: 10.1007/s11999-014-3579-9. PMID: 24664197Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...