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Foreign body reaction

MedGen UID:
4769
•Concept ID:
C0016549
•
Pathologic Function
Synonyms: Foreign Body Reaction; Foreign-Body Reaction; Reaction, Foreign-Body
SNOMED CT: Foreign body reaction (37058002)

Definition

A granulomatous inflammatory reaction evoked by the presence of an exogenous material in the tissues, a characteristic feature of which is the formation of foreign body giant cells. [from NCI]

Professional guidelines

PubMed

Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies.
Alshaikh RA, Waeber C, Ryan KB
Adv Drug Deliv Rev 2022 Aug;187:114342. Epub 2022 May 13 doi: 10.1016/j.addr.2022.114342. PMID: 35569559
Management of granulomatous foreign body reaction to fillers with methotrexate.
Broly M, Marie J, Picard C, Demoures A, Raimbault C, Beylot-Barry M, Cogrel O
J Eur Acad Dermatol Venereol 2020 Apr;34(4):817-820. Epub 2019 Nov 28 doi: 10.1111/jdv.16027. PMID: 31650637
Diagnostics and new developments in the treatment of ocular allergies.
Kari O, Saari KM
Curr Allergy Asthma Rep 2012 Jun;12(3):232-9. doi: 10.1007/s11882-012-0252-9. PMID: 22382607

Recent clinical studies

Etiology

Modulating the foreign body response of implants for diabetes treatment.
Kharbikar BN, Chendke GS, Desai TA
Adv Drug Deliv Rev 2021 Jul;174:87-113. Epub 2021 Jan 21 doi: 10.1016/j.addr.2021.01.011. PMID: 33484736Free PMC Article
Mesotherapy: Safety profile and management of complications.
Plachouri KM, Georgiou S
J Cosmet Dermatol 2019 Dec;18(6):1601-1605. Epub 2019 Aug 24 doi: 10.1111/jocd.13115. PMID: 31444843
Homologous Tissue for Dorsal Augmentation.
Kim CH, Park SC
Facial Plast Surg Clin North Am 2018 Aug;26(3):311-321. Epub 2018 Jun 7 doi: 10.1016/j.fsc.2018.03.005. PMID: 30005787
Wear particles.
Jacobs JJ, Hallab NJ, Urban RM, Wimmer MA
J Bone Joint Surg Am 2006 Apr;88 Suppl 2:99-102. doi: 10.2106/JBJS.F.00102. PMID: 16595453
Reoperative tracheal surgery.
Donahue DM
Chest Surg Clin N Am 2003 May;13(2):375-83. doi: 10.1016/s1052-3359(03)00028-0. PMID: 12755322

Diagnosis

Non-infectious Granulomatous Lesions of the Orofacial Region.
Müller S
Head Neck Pathol 2019 Sep;13(3):449-456. Epub 2019 Jan 9 doi: 10.1007/s12105-018-00997-w. PMID: 30627963Free PMC Article
Foreign body reaction from anti-adhesion material during follow-up of gynaecological malignancies: Mimicking local recurrence.
Kwon YS, Gwack JY, Im KS, Choi DI
Aust N Z J Obstet Gynaecol 2016 Aug;56(4):403-7. Epub 2016 Jun 14 doi: 10.1111/ajo.12469. PMID: 27297456
Foreign body reaction to acellular dermal matrix allograft in biologic glenoid resurfacing.
Namdari S, Melnic C, Huffman GR
Clin Orthop Relat Res 2013 Aug;471(8):2455-8. Epub 2013 Mar 12 doi: 10.1007/s11999-013-2904-z. PMID: 23479235Free PMC Article
Tattoo-associated complications.
Juhas E, English JC 3rd
J Pediatr Adolesc Gynecol 2013 Apr;26(2):125-9. Epub 2012 Dec 31 doi: 10.1016/j.jpag.2012.08.005. PMID: 23287600
Soft tissue foreign bodies.
Lammers RL
Ann Emerg Med 1988 Dec;17(12):1336-47. doi: 10.1016/s0196-0644(88)80361-5. PMID: 3057951

Therapy

The role of foreign body response in peri-implantitis: What is the evidence?
Ivanovski S, Bartold PM, Huang YS
Periodontol 2000 2022 Oct;90(1):176-185. Epub 2022 Aug 2 doi: 10.1111/prd.12456. PMID: 35916872Free PMC Article
Modulation of foreign body reaction and macrophage phenotypes concerning microenvironment.
Chu C, Liu L, Rung S, Wang Y, Ma Y, Hu C, Zhao X, Man Y, Qu Y
J Biomed Mater Res A 2020 Jan;108(1):127-135. Epub 2019 Oct 6 doi: 10.1002/jbm.a.36798. PMID: 31515867
The pathology of the foreign body reaction against biomaterials.
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Foreign Body Reaction to Subcutaneous Implants.
Kastellorizios M, Tipnis N, Burgess DJ
Adv Exp Med Biol 2015;865:93-108. doi: 10.1007/978-3-319-18603-0_6. PMID: 26306445
Foreign body reaction to biomaterials.
Anderson JM, Rodriguez A, Chang DT
Semin Immunol 2008 Apr;20(2):86-100. Epub 2007 Dec 26 doi: 10.1016/j.smim.2007.11.004. PMID: 18162407Free PMC Article

Prognosis

Interactions between the foreign body reaction and Staphylococcus aureus biomaterial-associated infection. Winning strategies in the derby on biomaterial implant surfaces.
Rosman CWK, van Dijl JM, Sjollema J
Crit Rev Microbiol 2022 Sep;48(5):624-640. Epub 2021 Dec 8 doi: 10.1080/1040841X.2021.2011132. PMID: 34879216
Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions.
Buser D, Sennerby L, De Bruyn H
Periodontol 2000 2017 Feb;73(1):7-21. doi: 10.1111/prd.12185. PMID: 28000280
The pathology of the foreign body reaction against biomaterials.
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Foreign body reactions may not influence the keloid recurrence.
Park TH, Lee B, Park JH, Rah DK
J Cosmet Dermatol 2016 Mar;15(1):78-81. Epub 2015 Aug 25 doi: 10.1111/jocd.12177. PMID: 26302719
Lipoid pneumonia: an overview.
Hadda V, Khilnani GC
Expert Rev Respir Med 2010 Dec;4(6):799-807. doi: 10.1586/ers.10.74. PMID: 21128754

Clinical prediction guides

Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration.
Crawford L, Wyatt M, Bryers J, Ratner B
Adv Healthc Mater 2021 Jun;10(11):e2002153. Epub 2021 Apr 7 doi: 10.1002/adhm.202002153. PMID: 33829678Free PMC Article
The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering.
Yang D, Xiao J, Wang B, Li L, Kong X, Liao J
Mater Sci Eng C Mater Biol Appl 2019 Nov;104:109927. Epub 2019 Jun 28 doi: 10.1016/j.msec.2019.109927. PMID: 31500038
The pathology of the foreign body reaction against biomaterials.
Klopfleisch R, Jung F
J Biomed Mater Res A 2017 Mar;105(3):927-940. Epub 2016 Nov 25 doi: 10.1002/jbm.a.35958. PMID: 27813288
Dermal fillers: pathophysiology, prevention and treatment of complications.
Chiang YZ, Pierone G, Al-Niaimi F
J Eur Acad Dermatol Venereol 2017 Mar;31(3):405-413. Epub 2016 Oct 28 doi: 10.1111/jdv.13977. PMID: 27662522
Foreign Body Reaction to Biomaterials: On Mechanisms for Buildup and Breakdown of Osseointegration.
Trindade R, Albrektsson T, Tengvall P, Wennerberg A
Clin Implant Dent Relat Res 2016 Feb;18(1):192-203. Epub 2014 Sep 25 doi: 10.1111/cid.12274. PMID: 25257971

Recent systematic reviews

Autoimmunity and hernia mesh: fact or fiction?
Jisova B, Wolesky J, Strizova Z, de Beaux A, East B
Hernia 2023 Aug;27(4):741-749. Epub 2023 Feb 4 doi: 10.1007/s10029-023-02749-4. PMID: 36739352Free PMC Article
A systematic analysis of controlled clinical trials using the NiTi CAR™ compression ring in colorectal anastomoses.
Tabola R, Cirocchi R, Fingerhut A, Arezzo A, Randolph J, Grassi V, Binda GA, D'Andrea V, Abraha I, Popivanov G, Di Saverio S, Zbar A
Tech Coloproctol 2017 Mar;21(3):177-184. Epub 2017 Jan 28 doi: 10.1007/s10151-017-1583-2. PMID: 28132113
Teflon granulomas mimicking cerebellopontine angle tumors following microvascular decompression.
Deep NL, Graffeo CS, Copeland WR 3rd, Link MJ, Atkinson JL, Neff BA, Raghunathan A, Carlson ML
Laryngoscope 2017 Mar;127(3):715-719. Epub 2016 Jun 19 doi: 10.1002/lary.26126. PMID: 27320780
Do retrieval analysis and blood metal measurements contribute to our understanding of adverse local tissue reactions?
Campbell PA, Kung MS, Hsu AR, Jacobs JJ
Clin Orthop Relat Res 2014 Dec;472(12):3718-27. doi: 10.1007/s11999-014-3893-2. PMID: 25160942Free PMC Article
What are the advantages and disadvantages of imaging modalities to diagnose wear-related corrosion problems?
Nam D, Barrack RL, Potter HG
Clin Orthop Relat Res 2014 Dec;472(12):3665-73. Epub 2014 Mar 25 doi: 10.1007/s11999-014-3579-9. PMID: 24664197Free PMC Article

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