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Leukemia, acute myeloid, susceptibility to

MedGen UID:
477590
•Concept ID:
C3275959
•
Finding
Synonym: LEUKEMIA, ACUTE MYELOID, SUSCEPTIBILITY TO
 
Monarch Initiative: MONDO:0100173
OMIM®: 137295; 187270; 601626

Definition

An inherited susceptibility or predisposition to developing leukemia, acute myeloid. [from MONDO]

Professional guidelines

PubMed

Effects of GST null genotypes on individual susceptibility to leukemia: A meta-analysis.
Wang J, Wu D, Sun A
Exp Mol Pathol 2019 Jun;108:137-142. Epub 2019 Jan 17 doi: 10.1016/j.yexmp.2019.01.004. PMID: 30659796
High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia.
Rollinson S, Allan JM, Law GR, Roddam PL, Smith MT, Skibola C, Smith AG, Forrest MS, Sibley K, Higuchi R, Germer S, Morgan GJ
Cancer Epidemiol Biomarkers Prev 2004 May;13(5):795-800. PMID: 15159312
An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents.
Worrillow LJ, Travis LB, Smith AG, Rollinson S, Smith AJ, Wild CP, Holowaty EJ, Kohler BA, Wiklund T, Pukkala E, Roman E, Morgan GJ, Allan JM
Clin Cancer Res 2003 Aug 1;9(8):3012-20. PMID: 12912950

Recent clinical studies

Etiology

Advances in acute myeloid leukemia.
Newell LF, Cook RJ
BMJ 2021 Oct 6;375:n2026. doi: 10.1136/bmj.n2026. PMID: 34615640
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767
Molecular biomarkers in acute myeloid leukemia.
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Leukemia.
Juliusson G, Hough R
Prog Tumor Res 2016;43:87-100. Epub 2016 Sep 5 doi: 10.1159/000447076. PMID: 27595359

Diagnosis

Advances in acute myeloid leukemia.
Newell LF, Cook RJ
BMJ 2021 Oct 6;375:n2026. doi: 10.1136/bmj.n2026. PMID: 34615640
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767
Molecular biomarkers in acute myeloid leukemia.
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Leukemia.
Juliusson G, Hough R
Prog Tumor Res 2016;43:87-100. Epub 2016 Sep 5 doi: 10.1159/000447076. PMID: 27595359

Therapy

The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.
Issa GC, Aldoss I, DiPersio J, Cuglievan B, Stone R, Arellano M, Thirman MJ, Patel MR, Dickens DS, Shenoy S, Shukla N, Kantarjian H, Armstrong SA, Perner F, Perry JA, Rosen G, Bagley RG, Meyers ML, Ordentlich P, Gu Y, Kumar V, Smith S, McGeehan GM, Stein EM
Nature 2023 Mar;615(7954):920-924. Epub 2023 Mar 15 doi: 10.1038/s41586-023-05812-3. PMID: 36922593Free PMC Article
Leukemic stem cells and therapy resistance in acute myeloid leukemia.
Stelmach P, Trumpp A
Haematologica 2023 Feb 1;108(2):353-366. doi: 10.3324/haematol.2022.280800. PMID: 36722405Free PMC Article
Advances in acute myeloid leukemia.
Newell LF, Cook RJ
BMJ 2021 Oct 6;375:n2026. doi: 10.1136/bmj.n2026. PMID: 34615640
Treatment of Relapsed Acute Myeloid Leukemia.
Thol F, Ganser A
Curr Treat Options Oncol 2020 Jun 29;21(8):66. doi: 10.1007/s11864-020-00765-5. PMID: 32601974Free PMC Article
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Prognosis

NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Treatment of Relapsed Acute Myeloid Leukemia.
Thol F, Ganser A
Curr Treat Options Oncol 2020 Jun 29;21(8):66. doi: 10.1007/s11864-020-00765-5. PMID: 32601974Free PMC Article
DNMT3A in Leukemia.
Brunetti L, Gundry MC, Goodell MA
Cold Spring Harb Perspect Med 2017 Feb 1;7(2) doi: 10.1101/cshperspect.a030320. PMID: 28003281Free PMC Article
Molecular biomarkers in acute myeloid leukemia.
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Leukemia.
Juliusson G, Hough R
Prog Tumor Res 2016;43:87-100. Epub 2016 Sep 5 doi: 10.1159/000447076. PMID: 27595359

Clinical prediction guides

Updates on targeted therapies for acute myeloid leukaemia.
Kayser S, Levis MJ
Br J Haematol 2022 Jan;196(2):316-328. Epub 2021 Aug 4 doi: 10.1111/bjh.17746. PMID: 34350585
The Genetics of Myelodysplastic Syndromes: Clinical Relevance.
Chiereghin C, Travaglino E, Zampini M, Saba E, Saitta C, Riva E, Bersanelli M, Della Porta MG
Genes (Basel) 2021 Jul 27;12(8) doi: 10.3390/genes12081144. PMID: 34440317Free PMC Article
Therapeutic implications of menin inhibition in acute leukemias.
Issa GC, Ravandi F, DiNardo CD, Jabbour E, Kantarjian HM, Andreeff M
Leukemia 2021 Sep;35(9):2482-2495. Epub 2021 Jun 15 doi: 10.1038/s41375-021-01309-y. PMID: 34131281
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Molecular biomarkers in acute myeloid leukemia.
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498

Recent systematic reviews

Ile105Val polymorphism in the GSTP1 gene is associated with susceptibility to acute myeloid leukemia: an updated systematic review and meta-analysis.
Tiongco RE, Cayanan ND, Catacata M, Dominguez MJ
Biomarkers 2024 May;29(3):134-142. Epub 2024 Mar 13 doi: 10.1080/1354750X.2024.2326538. PMID: 38428950
Anthracyclines and the risk of arrhythmias: A systematic review and meta-analysis.
Dean YE, Dahshan H, Motawea KR, Khalifa Z, Tanas Y, Rakha I, Hasan W, Kishk M, Mahmoud A, Elsayed A, Abdelkader O, Tokunaga A, Khalifa A, Helmy A, Elhalag RH, Farghaly RM, Abdelkader OKS, Shah J, Hakim D, Aiash H
Medicine (Baltimore) 2023 Nov 17;102(46):e35770. doi: 10.1097/MD.0000000000035770. PMID: 37986405Free PMC Article
The impact of antifungal prophylaxis in patients diagnosed with acute leukemias undergoing induction chemotherapy: a systematic review and meta-analysis.
Soldi LR, Coelho YNB, Paranhos LR, Silva MJB
Clin Exp Med 2023 Nov;23(7):3231-3249. Epub 2023 Apr 14 doi: 10.1007/s10238-023-01062-9. PMID: 37058186
The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.
Jiang D, Hong Q, Shen Y, Xu Y, Zhu H, Li Y, Xu C, Ouyang G, Duan S
PLoS One 2014;9(5):e96822. Epub 2014 May 8 doi: 10.1371/journal.pone.0096822. PMID: 24810788Free PMC Article
The effect of XPD/ERCC2 Lys751Gln polymorphism on acute leukemia risk: a systematic review and meta-analysis.
Liu D, Wu D, Li H, Dong M
Gene 2014 Apr 1;538(2):209-16. Epub 2014 Jan 28 doi: 10.1016/j.gene.2014.01.049. PMID: 24486506

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