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Decreased number of epithelia cells

MedGen UID:
478781
•Concept ID:
C3277151
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased number of epithelia cells

Professional guidelines

PubMed

Correlating genotype with phenotype using CFTR-mediated whole-cell Cl(-) currents in human nasal epithelial cells.
Noel S, Servel N, Hatton A, Golec A, Rodrat M, Ng DRS, Li H, Pranke I, Hinzpeter A, Edelman A, Sheppard DN, Sermet-Gaudelus I
J Physiol 2022 Mar;600(6):1515-1531. Epub 2021 Dec 8 doi: 10.1113/JP282143. PMID: 34761808
An adenosine derivative (IFC-305) reduced the risk of radiation-induced intestinal toxicity in the treatment of colon cancer by suppressing the methylation of PPAR-r promoter.
Lian B, Ren Y, Zhang H, Lin T, Wang Y
Biomed Pharmacother 2019 Oct;118:109202. Epub 2019 Aug 19 doi: 10.1016/j.biopha.2019.109202. PMID: 31545232
An experimental study of amniotic lacrimal duct stents in the treatment of perimenopausal female rabbits with dry eye.
Ma M, Yuan Q, Ye L, Liu K, Ye L, Min YL, Jiang N, Li Q, Shi W, Xu X, Zhu P, Shao Y
Mol Med Rep 2019 Feb;19(2):1056-1064. Epub 2018 Dec 10 doi: 10.3892/mmr.2018.9731. PMID: 30569093Free PMC Article

Recent clinical studies

Etiology

Comparison of the regenerative effects of bone marrow/adipose-derived stem cells in the Asherman model following local or systemic administration.
Monsef F, Artimani T, Alizadeh Z, Ramazani M, Solgi G, Yavangi M, Asl SS
J Assist Reprod Genet 2020 Aug;37(8):1861-1868. Epub 2020 Jun 14 doi: 10.1007/s10815-020-01856-w. PMID: 32535814Free PMC Article
Gene Delivery to Human Limbal Stem Cells Using Viral Vectors.
Song L, Song Z, Fry NJ, Conatser L, Llanga T, Mei H, Kafri T, Hirsch ML
Hum Gene Ther 2019 Nov;30(11):1336-1348. Epub 2019 Sep 25 doi: 10.1089/hum.2019.071. PMID: 31392914Free PMC Article
Suppression of Stromal Interferon Signaling by Human Papillomavirus 16.
Raikhy G, Woodby BL, Scott ML, Shin G, Myers JE, Scott RS, Bodily JM
J Virol 2019 Oct 1;93(19) Epub 2019 Sep 12 doi: 10.1128/JVI.00458-19. PMID: 31292244Free PMC Article
IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma.
Blair AB, Kleponis J, Thomas DL 2nd, Muth ST, Murphy AG, Kim V, Zheng L
J Clin Invest 2019 Apr 1;129(4):1742-1755. Epub 2019 Mar 18 doi: 10.1172/JCI124077. PMID: 30747725Free PMC Article
Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells.
Fleyshman D, Prendergast L, Safina A, Paszkiewicz G, Commane M, Morgan K, Attwood K, Gurova K
Oncotarget 2017 Mar 28;8(13):20525-20542. doi: 10.18632/oncotarget.15656. PMID: 28423528Free PMC Article

Diagnosis

Probing the Ubiquitination-Mediated Function of Epithelial Sodium Channel in A549 Cells.
Shabbir W, Susan Yang KH, Dogar AM, Isaev D, Oz M
Curr Mol Pharmacol 2023;16(3):411-418. doi: 10.2174/1874467215666220726112002. PMID: 35894469
Roles of pulmonary telocytes in airway epithelia to benefit experimental acute lung injury through production of telocyte-driven mediators and exosomes.
Tang L, Song D, Qi R, Zhu B, Wang X
Cell Biol Toxicol 2023 Apr;39(2):451-465. Epub 2022 Jan 3 doi: 10.1007/s10565-021-09670-5. PMID: 34978009Free PMC Article
Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomes.
Capocelli KE, Fernando SD, Menard-Katcher C, Furuta GT, Masterson JC, Wartchow EP
J Clin Pathol 2015 Jan;68(1):51-6. Epub 2014 Oct 30 doi: 10.1136/jclinpath-2014-202586. PMID: 25359789Free PMC Article
Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation.
Bian Y, Hall B, Sun ZJ, Molinolo A, Chen W, Gutkind JS, Waes CV, Kulkarni AB
Oncogene 2012 Jul 12;31(28):3322-32. Epub 2011 Oct 31 doi: 10.1038/onc.2011.494. PMID: 22037217Free PMC Article
Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium.
Harris JF, Fischer MJ, Hotchkiss JR, Monia BP, Randell SH, Harkema JR, Tesfaigzi Y
Am J Respir Crit Care Med 2005 Apr 1;171(7):764-72. Epub 2004 Dec 23 doi: 10.1164/rccm.200408-1108OC. PMID: 15618464

Therapy

MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains.
Van Doren SR
Biochem Soc Trans 2022 Apr 29;50(2):839-851. doi: 10.1042/BST20210640. PMID: 35343563Free PMC Article
GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia.
Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Kurokawa K, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K
Gastroenterology 2020 May;158(6):1650-1666.e15. Epub 2020 Feb 4 doi: 10.1053/j.gastro.2020.01.046. PMID: 32032583Free PMC Article
Gene Delivery to Human Limbal Stem Cells Using Viral Vectors.
Song L, Song Z, Fry NJ, Conatser L, Llanga T, Mei H, Kafri T, Hirsch ML
Hum Gene Ther 2019 Nov;30(11):1336-1348. Epub 2019 Sep 25 doi: 10.1089/hum.2019.071. PMID: 31392914Free PMC Article
Patterns and possible roles of LINE-1 methylation changes in smoke-exposed epithelia.
Wangsri S, Subbalekha K, Kitkumthorn N, Mutirangura A
PLoS One 2012;7(9):e45292. Epub 2012 Sep 18 doi: 10.1371/journal.pone.0045292. PMID: 23028911Free PMC Article
Cutaneous graft-versus-host disease: a guide for the dermatologist.
Häusermann P, Walter RB, Halter J, Biedermann BC, Tichelli A, Itin P, Gratwohl A
Dermatology 2008;216(4):287-304. Epub 2008 Jan 29 doi: 10.1159/000113941. PMID: 18230976

Prognosis

MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains.
Van Doren SR
Biochem Soc Trans 2022 Apr 29;50(2):839-851. doi: 10.1042/BST20210640. PMID: 35343563Free PMC Article
The epithelial sodium channel has a role in breast cancer cell proliferation.
Ware AW, Harris JJ, Slatter TL, Cunliffe HE, McDonald FJ
Breast Cancer Res Treat 2021 May;187(1):31-43. Epub 2021 Feb 25 doi: 10.1007/s10549-021-06133-7. PMID: 33630195
Upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome.
Yang Y, Wu Q, Li N, Che S, Jin T, Nan Y, Lin Z, Chen L
Hum Pathol 2018 May;75:179-188. Epub 2018 Feb 13 doi: 10.1016/j.humpath.2018.02.006. PMID: 29452216
Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells.
Fleyshman D, Prendergast L, Safina A, Paszkiewicz G, Commane M, Morgan K, Attwood K, Gurova K
Oncotarget 2017 Mar 28;8(13):20525-20542. doi: 10.18632/oncotarget.15656. PMID: 28423528Free PMC Article
Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression.
Pagliuca A, Valvo C, Fabrizi E, di Martino S, Biffoni M, Runci D, Forte S, De Maria R, Ricci-Vitiani L
Oncogene 2013 Oct;32(40):4806-13. Epub 2012 Nov 5 doi: 10.1038/onc.2012.495. PMID: 23128394

Clinical prediction guides

Aβ monomers protect lens epithelial cells against oxidative stress by upregulating CDC25B.
Xu J, Li D, Lu Y, Zheng TY
Free Radic Biol Med 2021 Nov 1;175:161-170. Epub 2021 Aug 31 doi: 10.1016/j.freeradbiomed.2021.08.242. PMID: 34478836
Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture.
Yamazaki D, Hashizume O, Taniguchi S, Funato Y, Miki H
Sci Rep 2021 Feb 17;11(1):3980. doi: 10.1038/s41598-021-83590-6. PMID: 33597597Free PMC Article
Mechanical force-induced morphology changes in a human fungal pathogen.
Puerner C, Kukhaleishvili N, Thomson D, Schaub S, Noblin X, Seminara A, Bassilana M, Arkowitz RA
BMC Biol 2020 Sep 11;18(1):122. doi: 10.1186/s12915-020-00833-0. PMID: 32912212Free PMC Article
Gene Delivery to Human Limbal Stem Cells Using Viral Vectors.
Song L, Song Z, Fry NJ, Conatser L, Llanga T, Mei H, Kafri T, Hirsch ML
Hum Gene Ther 2019 Nov;30(11):1336-1348. Epub 2019 Sep 25 doi: 10.1089/hum.2019.071. PMID: 31392914Free PMC Article
Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells.
Fleyshman D, Prendergast L, Safina A, Paszkiewicz G, Commane M, Morgan K, Attwood K, Gurova K
Oncotarget 2017 Mar 28;8(13):20525-20542. doi: 10.18632/oncotarget.15656. PMID: 28423528Free PMC Article

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