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Froelich syndrome

MedGen UID:
4795
•Concept ID:
C0016724
•
Disease or Syndrome
Synonyms: Adiposodysgenesis; Adiposogenital dystrophy; Babinski-Froelich syndrome; Froehlich syndrome; Froelich's adiposity; Froelich's syndrome
SNOMED CT: Adiposogenital dystrophy (62999006); Frohlich's syndrome (62999006); Launois-Cleret syndrome (62999006); Adiposogenital syndrome (62999006); Hypothalamic infantilism with obesity syndrome (62999006); Froehlich syndrome (62999006)
 
Monarch Initiative: MONDO:0003962

Definition

A rare acquired endocrine disorder more commonly affecting males. It is caused by lesions in the hypothalamus. Clinical signs include obesity, short stature, pubertal delay, hypogonadism, visual impairment, polydipsia and polyuria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFroelich syndrome

Professional guidelines

PubMed

High-dose proton therapy and tomotherapy for the treatment of sacral chordoma: a retrospective monocentric study.
Beddok A, Saint-Martin C, Mammar H, Feuvret L, Helfre S, Bolle S, Froelich S, Goudjil F, Zefkili S, Amessis M, Peurien D, Cornet S, Dendale R, Alapetite C, Calugaru V
Acta Oncol 2021 Feb;60(2):245-251. Epub 2020 Oct 23 doi: 10.1080/0284186X.2020.1834140. PMID: 33095672
Pharmacological treatment of dementia.
Schwarz S, Froelich L, Burns A
Curr Opin Psychiatry 2012 Nov;25(6):542-50. doi: 10.1097/YCO.0b013e328358e4f2. PMID: 22992546

Recent clinical studies

Etiology

A systematic literature review of clinical trials and therapeutic applications of ibogaine.
Köck P, Froelich K, Walter M, Lang U, Dürsteler KM
J Subst Abuse Treat 2022 Jul;138:108717. Epub 2021 Dec 30 doi: 10.1016/j.jsat.2021.108717. PMID: 35012793
Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease.
Halbgebauer S, Oeckl P, Steinacker P, Yilmazer-Hanke D, Anderl-Straub S, von Arnim C, Froelich L, Gomes LA, Hausner L, Huss A, Jahn H, Weishaupt J, Ludolph AC, Thal DR, Otto M
J Neurol Neurosurg Psychiatry 2021 Apr;92(4):349-356. Epub 2020 Dec 30 doi: 10.1136/jnnp-2020-324306. PMID: 33380492
Chiasmapexy for secondary empty sella syndrome: diagnostic and therapeutic considerations.
Graillon T, Passeri T, Boucekine M, Meyer M, Abritti R, Bernat AL, Labidi M, Dufour H, Froelich S
Pituitary 2021 Apr;24(2):292-301. Epub 2020 Nov 2 doi: 10.1007/s11102-020-01104-5. PMID: 33136230
High-dose proton therapy and tomotherapy for the treatment of sacral chordoma: a retrospective monocentric study.
Beddok A, Saint-Martin C, Mammar H, Feuvret L, Helfre S, Bolle S, Froelich S, Goudjil F, Zefkili S, Amessis M, Peurien D, Cornet S, Dendale R, Alapetite C, Calugaru V
Acta Oncol 2021 Feb;60(2):245-251. Epub 2020 Oct 23 doi: 10.1080/0284186X.2020.1834140. PMID: 33095672
Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia.
Frölich L, Peters O, Lewczuk P, Gruber O, Teipel SJ, Gertz HJ, Jahn H, Jessen F, Kurz A, Luckhaus C, Hüll M, Pantel J, Reischies FM, Schröder J, Wagner M, Rienhoff O, Wolf S, Bauer C, Schuchhardt J, Heuser I, Rüther E, Henn F, Maier W, Wiltfang J, Kornhuber J
Alzheimers Res Ther 2017 Oct 10;9(1):84. doi: 10.1186/s13195-017-0301-7. PMID: 29017593Free PMC Article

Diagnosis

Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease.
Halbgebauer S, Oeckl P, Steinacker P, Yilmazer-Hanke D, Anderl-Straub S, von Arnim C, Froelich L, Gomes LA, Hausner L, Huss A, Jahn H, Weishaupt J, Ludolph AC, Thal DR, Otto M
J Neurol Neurosurg Psychiatry 2021 Apr;92(4):349-356. Epub 2020 Dec 30 doi: 10.1136/jnnp-2020-324306. PMID: 33380492
Chiasmapexy for secondary empty sella syndrome: diagnostic and therapeutic considerations.
Graillon T, Passeri T, Boucekine M, Meyer M, Abritti R, Bernat AL, Labidi M, Dufour H, Froelich S
Pituitary 2021 Apr;24(2):292-301. Epub 2020 Nov 2 doi: 10.1007/s11102-020-01104-5. PMID: 33136230
Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia.
Frölich L, Peters O, Lewczuk P, Gruber O, Teipel SJ, Gertz HJ, Jahn H, Jessen F, Kurz A, Luckhaus C, Hüll M, Pantel J, Reischies FM, Schröder J, Wagner M, Rienhoff O, Wolf S, Bauer C, Schuchhardt J, Heuser I, Rüther E, Henn F, Maier W, Wiltfang J, Kornhuber J
Alzheimers Res Ther 2017 Oct 10;9(1):84. doi: 10.1186/s13195-017-0301-7. PMID: 29017593Free PMC Article
Bilateral gluteal compartment syndrome following robotic-assisted prostatectomy.
Keene R, Froelich JM, Milbrandt JC, Idusuyi OB
Orthopedics 2010 Nov 2;33(11):852. doi: 10.3928/01477447-20100924-25. PMID: 21053878
Targets of antidementive therapy: drugs with a specific pharmacological mechanism of action.
Frölich L, Fox J, Padberg F, Maurer K, Möller HJ, Hampel H
Curr Pharm Des 2004;10(3):223-9. doi: 10.2174/1381612043386527. PMID: 14754383

Therapy

Vitamin D and the Ability to Produce 1,25(OH)(2)D Are Critical for Protection from Viral Infection of the Lungs.
Arora J, Patel DR, Nicol MJ, Field CJ, Restori KH, Wang J, Froelich NE, Katkere B, Terwilliger JA, Weaver V, Luley E, Kelly K, Kirimanjeswara GS, Sutton TC, Cantorna MT
Nutrients 2022 Jul 26;14(15) doi: 10.3390/nu14153061. PMID: 35893921Free PMC Article
A systematic literature review of clinical trials and therapeutic applications of ibogaine.
Köck P, Froelich K, Walter M, Lang U, Dürsteler KM
J Subst Abuse Treat 2022 Jul;138:108717. Epub 2021 Dec 30 doi: 10.1016/j.jsat.2021.108717. PMID: 35012793
High-dose proton therapy and tomotherapy for the treatment of sacral chordoma: a retrospective monocentric study.
Beddok A, Saint-Martin C, Mammar H, Feuvret L, Helfre S, Bolle S, Froelich S, Goudjil F, Zefkili S, Amessis M, Peurien D, Cornet S, Dendale R, Alapetite C, Calugaru V
Acta Oncol 2021 Feb;60(2):245-251. Epub 2020 Oct 23 doi: 10.1080/0284186X.2020.1834140. PMID: 33095672
Pharmacological treatment of dementia.
Schwarz S, Froelich L, Burns A
Curr Opin Psychiatry 2012 Nov;25(6):542-50. doi: 10.1097/YCO.0b013e328358e4f2. PMID: 22992546
Targets of antidementive therapy: drugs with a specific pharmacological mechanism of action.
Frölich L, Fox J, Padberg F, Maurer K, Möller HJ, Hampel H
Curr Pharm Des 2004;10(3):223-9. doi: 10.2174/1381612043386527. PMID: 14754383

Prognosis

Humoral SARS-CoV-2 Immune Response in COVID-19 Recovered Vaccinated and Unvaccinated Individuals Related to Post-COVID-Syndrome.
Gerhards C, Kittel M, Ast V, Bugert P, Froelich MF, Hetjens M, Haselmann V, Neumaier M, Thiaucourt M
Viruses 2023 Feb 6;15(2) doi: 10.3390/v15020454. PMID: 36851668Free PMC Article
Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease.
Halbgebauer S, Oeckl P, Steinacker P, Yilmazer-Hanke D, Anderl-Straub S, von Arnim C, Froelich L, Gomes LA, Hausner L, Huss A, Jahn H, Weishaupt J, Ludolph AC, Thal DR, Otto M
J Neurol Neurosurg Psychiatry 2021 Apr;92(4):349-356. Epub 2020 Dec 30 doi: 10.1136/jnnp-2020-324306. PMID: 33380492
Chiasmapexy for secondary empty sella syndrome: diagnostic and therapeutic considerations.
Graillon T, Passeri T, Boucekine M, Meyer M, Abritti R, Bernat AL, Labidi M, Dufour H, Froelich S
Pituitary 2021 Apr;24(2):292-301. Epub 2020 Nov 2 doi: 10.1007/s11102-020-01104-5. PMID: 33136230
Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia.
Frölich L, Peters O, Lewczuk P, Gruber O, Teipel SJ, Gertz HJ, Jahn H, Jessen F, Kurz A, Luckhaus C, Hüll M, Pantel J, Reischies FM, Schröder J, Wagner M, Rienhoff O, Wolf S, Bauer C, Schuchhardt J, Heuser I, Rüther E, Henn F, Maier W, Wiltfang J, Kornhuber J
Alzheimers Res Ther 2017 Oct 10;9(1):84. doi: 10.1186/s13195-017-0301-7. PMID: 29017593Free PMC Article
Successful and unsuccessful approaches to imaging carcinoids: comparison of a radiolabelled tryptophan hydroxylase inhibitor with a tracer of biogenic amine uptake and storage, and a somatostatin analogue.
Macfarlane D, Gonin J, Wieland D, Mangner T, Froelich J, Beierwaltes W, Shapiro B
Eur J Nucl Med 1996 Feb;23(2):131-40. doi: 10.1007/BF01731835. PMID: 8925846

Clinical prediction guides

Humoral SARS-CoV-2 Immune Response in COVID-19 Recovered Vaccinated and Unvaccinated Individuals Related to Post-COVID-Syndrome.
Gerhards C, Kittel M, Ast V, Bugert P, Froelich MF, Hetjens M, Haselmann V, Neumaier M, Thiaucourt M
Viruses 2023 Feb 6;15(2) doi: 10.3390/v15020454. PMID: 36851668Free PMC Article
Vitamin D and the Ability to Produce 1,25(OH)(2)D Are Critical for Protection from Viral Infection of the Lungs.
Arora J, Patel DR, Nicol MJ, Field CJ, Restori KH, Wang J, Froelich NE, Katkere B, Terwilliger JA, Weaver V, Luley E, Kelly K, Kirimanjeswara GS, Sutton TC, Cantorna MT
Nutrients 2022 Jul 26;14(15) doi: 10.3390/nu14153061. PMID: 35893921Free PMC Article
A systematic literature review of clinical trials and therapeutic applications of ibogaine.
Köck P, Froelich K, Walter M, Lang U, Dürsteler KM
J Subst Abuse Treat 2022 Jul;138:108717. Epub 2021 Dec 30 doi: 10.1016/j.jsat.2021.108717. PMID: 35012793
Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease.
Halbgebauer S, Oeckl P, Steinacker P, Yilmazer-Hanke D, Anderl-Straub S, von Arnim C, Froelich L, Gomes LA, Hausner L, Huss A, Jahn H, Weishaupt J, Ludolph AC, Thal DR, Otto M
J Neurol Neurosurg Psychiatry 2021 Apr;92(4):349-356. Epub 2020 Dec 30 doi: 10.1136/jnnp-2020-324306. PMID: 33380492
High-dose proton therapy and tomotherapy for the treatment of sacral chordoma: a retrospective monocentric study.
Beddok A, Saint-Martin C, Mammar H, Feuvret L, Helfre S, Bolle S, Froelich S, Goudjil F, Zefkili S, Amessis M, Peurien D, Cornet S, Dendale R, Alapetite C, Calugaru V
Acta Oncol 2021 Feb;60(2):245-251. Epub 2020 Oct 23 doi: 10.1080/0284186X.2020.1834140. PMID: 33095672

Recent systematic reviews

A systematic literature review of clinical trials and therapeutic applications of ibogaine.
Köck P, Froelich K, Walter M, Lang U, Dürsteler KM
J Subst Abuse Treat 2022 Jul;138:108717. Epub 2021 Dec 30 doi: 10.1016/j.jsat.2021.108717. PMID: 35012793
Mental disorder prevalence among populations impacted by coronavirus pandemics: A multilevel meta-analytic study of COVID-19, MERS & SARS.
Boden M, Cohen N, Froelich JM, Hoggatt KJ, Abdel Magid HS, Mushiana SS
Gen Hosp Psychiatry 2021 May-Jun;70:124-133. Epub 2021 Mar 12 doi: 10.1016/j.genhosppsych.2021.03.006. PMID: 33894561Free PMC Article

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