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Metastatic Carcinoma in the Liver

MedGen UID:
482989
Concept ID:
C3282903
Neoplastic Process
Synonyms: Metastatic carcinoma of liver; Metastatic carcinoma to liver; Metastatic Carcinoma to the Liver; Secondary carcinoma of liver
SNOMED CT: Secondary carcinoma of liver (1251486007); Metastatic carcinoma to liver (1251486007); Metastatic carcinoma of liver (1251486007)

Definition

A carcinoma that has spread to the liver from another primary anatomic site. Representative examples include metastatic carcinomas from the colon, breast, and lung. [from NCI]

Professional guidelines

PubMed

Park JH, Kim JH
Clin Mol Hepatol 2019 Mar;25(1):12-20. Epub 2018 Oct 5 doi: 10.3350/cmh.2018.0067. PMID: 30300991Free PMC Article

Recent clinical studies

Etiology

Quaresima S, Melandro F, Giovanardi F, Shah K, De Peppo V, Mennini G, Ghinolfi D, Limkemann A, Pawlik TM, Lai Q
Medicina (Kaunas) 2023 Mar 14;59(3) doi: 10.3390/medicina59030568. PMID: 36984569Free PMC Article
Rio E, Mornex F, Maingon P, Peiffert D, Parent L
Cancer Radiother 2022 Feb-Apr;26(1-2):266-271. Epub 2021 Dec 23 doi: 10.1016/j.canrad.2021.08.013. PMID: 34953707
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
Strathearn LS, Stepanov AI, Font-Burgada J
Nutrients 2020 Mar 27;12(4) doi: 10.3390/nu12040933. PMID: 32230953Free PMC Article
O'Neill EK, Cogley JR, Miller FH
Clin Liver Dis 2015 Feb;19(1):99-121. Epub 2014 Oct 29 doi: 10.1016/j.cld.2014.09.006. PMID: 25454299

Diagnosis

Kutlu R, Karatoprak S
J Gastrointest Cancer 2020 Dec;51(4):1157-1164. doi: 10.1007/s12029-020-00492-y. PMID: 32880041
Kim MJ, Lee S, An C
Eur Radiol 2019 Sep;29(9):5101-5110. Epub 2019 Feb 20 doi: 10.1007/s00330-019-06030-0. PMID: 30788586
Park JH, Kim JH
Clin Mol Hepatol 2019 Mar;25(1):12-20. Epub 2018 Oct 5 doi: 10.3350/cmh.2018.0067. PMID: 30300991Free PMC Article
Pittman ME, Yantiss RK
Surg Pathol Clin 2018 Jun;11(2):453-466. Epub 2018 Mar 26 doi: 10.1016/j.path.2018.02.012. PMID: 29751885
Vyas M, Jain D
Indian J Pathol Microbiol 2018 Jan-Mar;61(1):2-17. doi: 10.4103/IJPM.IJPM_578_17. PMID: 29567877

Therapy

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Shi GM, Huang XY, Wu D, Sun HC, Liang F, Ji Y, Chen Y, Yang GH, Lu JC, Meng XL, Wang XY, Sun L, Ge NL, Huang XW, Qiu SJ, Yang XR, Gao Q, He YF, Xu Y, Sun J, Ren ZG, Fan J, Zhou J
Signal Transduct Target Ther 2023 Mar 17;8(1):106. doi: 10.1038/s41392-023-01317-7. PMID: 36928584Free PMC Article
Al-Rajabi R, Sun W
Curr Opin Gastroenterol 2021 Mar 1;37(2):105-111. doi: 10.1097/MOG.0000000000000715. PMID: 33507028
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
Munoz-Schuffenegger P, Ng S, Dawson LA
Semin Radiat Oncol 2017 Oct;27(4):350-357. doi: 10.1016/j.semradonc.2017.04.002. PMID: 28865518

Prognosis

Huang L, Feng Y, Xie T, Zhu H, Tang L, Shi Y
BMC Cancer 2023 Apr 5;23(1):312. doi: 10.1186/s12885-023-10797-3. PMID: 37020179Free PMC Article
Sarici B, Isik B, Yilmaz S
J Gastrointest Cancer 2020 Dec;51(4):1197-1199. doi: 10.1007/s12029-020-00498-6. PMID: 32839944
Zhou K, Wang A, Ao S, Chen J, Ji K, He Q, Ji X, Wu X, Zhang J, Li Z, Bu Z, Ji J
BMC Cancer 2020 Jul 17;20(1):671. doi: 10.1186/s12885-020-07031-9. PMID: 32680468Free PMC Article
Cazauran JB, Pâris L, Rousset P, Mercier F, Kepenekian V, Viste A, Passot G
J Gastrointest Surg 2018 Oct;22(10):1819-1831. Epub 2018 Jun 18 doi: 10.1007/s11605-018-3831-9. PMID: 29916108
Meza-Junco J, Montano-Loza AJ, Ma M, Wong W, Sawyer MB, Bain VG
Can J Gastroenterol 2010 Jan;24(1):52-7. doi: 10.1155/2010/704759. PMID: 20186357Free PMC Article

Clinical prediction guides

Quaresima S, Melandro F, Giovanardi F, Shah K, De Peppo V, Mennini G, Ghinolfi D, Limkemann A, Pawlik TM, Lai Q
Medicina (Kaunas) 2023 Mar 14;59(3) doi: 10.3390/medicina59030568. PMID: 36984569Free PMC Article
Rio E, Mornex F, Maingon P, Peiffert D, Parent L
Cancer Radiother 2022 Feb-Apr;26(1-2):266-271. Epub 2021 Dec 23 doi: 10.1016/j.canrad.2021.08.013. PMID: 34953707
Machado MAC, Surjan RC, Makdissi F
Ann Surg Oncol 2020 Apr;27(4):1174-1179. Epub 2019 Nov 4 doi: 10.1245/s10434-019-08027-x. PMID: 31686346
Sugarbaker PH
Eur J Surg Oncol 2018 Jul;44(7):1083-1086. Epub 2018 Apr 11 doi: 10.1016/j.ejso.2018.03.031. PMID: 29699839
Munoz-Schuffenegger P, Ng S, Dawson LA
Semin Radiat Oncol 2017 Oct;27(4):350-357. doi: 10.1016/j.semradonc.2017.04.002. PMID: 28865518

Recent systematic reviews

Nichetti F, Rota S, Ambrosini P, Pircher C, Gusmaroli E, Droz Dit Busset M, Pusceddu S, Sposito C, Coppa J, Morano F, Pietrantonio F, Di Bartolomeo M, Mariani L, Mazzaferro V, de Braud F, Niger M
JAMA Netw Open 2024 Jan 2;7(1):e2350756. doi: 10.1001/jamanetworkopen.2023.50756. PMID: 38190183Free PMC Article
Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR
Hepatology 2020 Jul;72(1):315-329. doi: 10.1002/hep.31227. PMID: 32167613
Dafni U, Tsourti Z, Vervita K, Peters S
Lung Cancer 2019 Aug;134:127-140. Epub 2019 May 30 doi: 10.1016/j.lungcan.2019.05.029. PMID: 31319971

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