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Isolated Hypogonadotropic Hypogonadism

MedGen UID:
483350
Concept ID:
C3489396
Disease or Syndrome
Synonym: Hypogonadism, Isolated Hypogonadotropic
 
OMIM®: 146110

Definition

Hypogonadotropic hypogonadism not associated with a deficiency of other pituitary hormones. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIsolated Hypogonadotropic Hypogonadism

Professional guidelines

PubMed

Giovanelli L, Quinton R
J Clin Endocrinol Metab 2023 Mar 10;108(4):e50-e51. doi: 10.1210/clinem/dgac727. PMID: 36520986
Dwyer AA, Stamou MI, Anghel E, Hornstein S, Chen D, Salnikov KB, McDonald IR, Plummer L, Seminara SB, Balasubramanian R
J Clin Endocrinol Metab 2023 Mar 10;108(4):897-908. doi: 10.1210/clinem/dgac615. PMID: 36268624Free PMC Article
Nair S, Jadhav S, Lila A, Jagtap V, Bukan A, Pandit R, Ekbote A, Dharmalingam M, Kumar P, Kalra P, Gandhi P, Walia R, Sankhe S, Raghavan V, Shivane V, Menon P, Bandgar T, Shah N
Clin Endocrinol (Oxf) 2016 Jul;85(1):100-9. Epub 2016 Feb 12 doi: 10.1111/cen.13009. PMID: 26708526

Recent clinical studies

Etiology

Xu W, Li R, Qiao J
BMC Pregnancy Childbirth 2023 Apr 14;23(1):255. doi: 10.1186/s12884-023-05579-5. PMID: 37059970Free PMC Article
Dwyer AA, Stamou MI, Anghel E, Hornstein S, Chen D, Salnikov KB, McDonald IR, Plummer L, Seminara SB, Balasubramanian R
J Clin Endocrinol Metab 2023 Mar 10;108(4):897-908. doi: 10.1210/clinem/dgac615. PMID: 36268624Free PMC Article
Cho CY, Tsai WY, Lee CT, Liu SY, Huang SY, Chien YH, Hwu WL, Lee NC, Tung YC
J Formos Med Assoc 2022 Jan;121(1 Pt 1):218-226. Epub 2021 Mar 26 doi: 10.1016/j.jfma.2021.03.010. PMID: 33775534
Zhou C, Niu Y, Xu H, Li Z, Wang T, Yang W, Wang S, Wang DW, Liu J
Fertil Steril 2018 Aug;110(3):486-495.e5. doi: 10.1016/j.fertnstert.2018.04.010. PMID: 30098700
Villanueva C, Argente J
Horm Res Paediatr 2014;82(4):213-21. Epub 2014 Jul 7 doi: 10.1159/000362600. PMID: 25011467

Diagnosis

Cho CY, Tsai WY, Lee CT, Liu SY, Huang SY, Chien YH, Hwu WL, Lee NC, Tung YC
J Formos Med Assoc 2022 Jan;121(1 Pt 1):218-226. Epub 2021 Mar 26 doi: 10.1016/j.jfma.2021.03.010. PMID: 33775534
Muñoz-Calvo MT, Argente J
Endocr Dev 2016;29:153-73. Epub 2015 Dec 17 doi: 10.1159/000438884. PMID: 26680577
McCabe MJ, Bancalari RE, Dattani MT
Pediatr Endocrinol Rev 2014 Feb;11 Suppl 2:214-29. PMID: 24683946
Fraietta R, Zylberstejn DS, Esteves SC
Clinics (Sao Paulo) 2013;68 Suppl 1(Suppl 1):81-8. doi: 10.6061/clinics/2013(sup01)09. PMID: 23503957Free PMC Article
Fenichel P
Endocr Dev 2012;22:138-159. Epub 2012 Jul 25 doi: 10.1159/000326686. PMID: 22846526

Therapy

Xu W, Li R, Qiao J
BMC Pregnancy Childbirth 2023 Apr 14;23(1):255. doi: 10.1186/s12884-023-05579-5. PMID: 37059970Free PMC Article
Chen YW, Niu YH, Xu H, Wang DQ, Jiang HY, Pokhrel G, Wang T, Wang SG, Liu JH
Asian J Androl 2019 Jul-Aug;21(4):413-418. doi: 10.4103/aja.aja_107_18. PMID: 30604694Free PMC Article
Trabado S, Lamothe S, Maione L, Bouvattier C, Sarfati J, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2014 May;75(2):79-87. Epub 2014 May 9 doi: 10.1016/j.ando.2014.04.011. PMID: 24815726
Vizeneux A, Hilfiger A, Bouligand J, Pouillot M, Brailly-Tabard S, Bashamboo A, McElreavey K, Brauner R
PLoS One 2013;8(10):e77827. Epub 2013 Oct 24 doi: 10.1371/journal.pone.0077827. PMID: 24204987Free PMC Article
Guo CY, Jones TH, Eastell R
J Clin Endocrinol Metab 1997 Feb;82(2):658-65. doi: 10.1210/jcem.82.2.3758. PMID: 9024272

Prognosis

Xu W, Li R, Qiao J
BMC Pregnancy Childbirth 2023 Apr 14;23(1):255. doi: 10.1186/s12884-023-05579-5. PMID: 37059970Free PMC Article
Dwyer AA, Stamou MI, Anghel E, Hornstein S, Chen D, Salnikov KB, McDonald IR, Plummer L, Seminara SB, Balasubramanian R
J Clin Endocrinol Metab 2023 Mar 10;108(4):897-908. doi: 10.1210/clinem/dgac615. PMID: 36268624Free PMC Article
Stamou MI, Brand H, Wang M, Wong I, Lippincott MF, Plummer L, Crowley WF, Talkowski M, Seminara S, Balasubramanian R
J Clin Endocrinol Metab 2022 Jul 14;107(8):2228-2242. doi: 10.1210/clinem/dgac300. PMID: 35574646Free PMC Article
Cangiano B, Swee DS, Quinton R, Bonomi M
Hum Genet 2021 Jan;140(1):77-111. Epub 2020 Mar 21 doi: 10.1007/s00439-020-02147-1. PMID: 32200437
Fenichel P
Endocr Dev 2012;22:138-159. Epub 2012 Jul 25 doi: 10.1159/000326686. PMID: 22846526

Clinical prediction guides

Dwyer AA, Stamou MI, Anghel E, Hornstein S, Chen D, Salnikov KB, McDonald IR, Plummer L, Seminara SB, Balasubramanian R
J Clin Endocrinol Metab 2023 Mar 10;108(4):897-908. doi: 10.1210/clinem/dgac615. PMID: 36268624Free PMC Article
Stamou MI, Brand H, Wang M, Wong I, Lippincott MF, Plummer L, Crowley WF, Talkowski M, Seminara S, Balasubramanian R
J Clin Endocrinol Metab 2022 Jul 14;107(8):2228-2242. doi: 10.1210/clinem/dgac300. PMID: 35574646Free PMC Article
Cangiano B, Swee DS, Quinton R, Bonomi M
Hum Genet 2021 Jan;140(1):77-111. Epub 2020 Mar 21 doi: 10.1007/s00439-020-02147-1. PMID: 32200437
Ilovayskaya I, Zektser V, Lazebnik L
Climacteric 2017 Aug;20(4):356-361. Epub 2017 Apr 24 doi: 10.1080/13697137.2017.1315086. PMID: 28438051
Muñoz-Calvo MT, Argente J
Endocr Dev 2016;29:153-73. Epub 2015 Dec 17 doi: 10.1159/000438884. PMID: 26680577

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