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Restless legs

MedGen UID:
48427
Concept ID:
C0035258
Disease or Syndrome
Synonym: Restless legs syndrome
SNOMED CT: Willis-Ekbom disease (32914008); Restless legs (32914008); Restless legs syndrome (32914008)
 
HPO: HP:0012452
Monarch Initiative: MONDO:0005391

Definition

Restless Leg Syndrome (RLS) is a condition characterized by an uncomfortable and restless sensation in the legs that occurs after going to bed, often leading to insomnia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRestless legs

Conditions with this feature

Restless legs syndrome, susceptibility to, 1
MedGen UID:
360293
Concept ID:
C1876177
Finding
Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation (Bonati et al., 2003). Genetic Heterogeneity of Restless Legs Syndrome RLS1 has been mapped to chromosome 12q. Other susceptibility loci for RLS include RLS2 (608831) on chromosome 14q13-q31; RLS3 (610438) on chromosome 9p24-p22; RLS4 (610439) on chromosome 2q33; RLS5 (611242) on chromosome 20p13; RLS6 (611185) on chromosome 6p21; RLS7 (612853) on chromosome 2p14; and RLS8 (615197) on chromosome 5q31.
L-ferritin deficiency
MedGen UID:
816420
Concept ID:
C3810090
Disease or Syndrome
A rare genetic haematologic disease characterised by decreased or undetectable serum L-ferritin with otherwise normal laboratory parameters. Clinical signs and symptoms include generalised seizures, atypical restless leg syndrome, mild neuropsychologic impairment and progressive hair loss. Asymptomatic cases have also been reported.
Parkinson disease 22, autosomal dominant
MedGen UID:
907886
Concept ID:
C4225238
Disease or Syndrome
Any Parkinson disease in which the cause of the disease is a mutation in the CHCHD2 gene.

Professional guidelines

PubMed

Silber MH, Buchfuhrer MJ, Earley CJ, Koo BB, Manconi M, Winkelman JW; Scientific and Medical Advisory Board of the Restless Legs Syndrome Foundation
Mayo Clin Proc 2021 Jul;96(7):1921-1937. doi: 10.1016/j.mayocp.2020.12.026. PMID: 34218864
Gossard TR, Trotti LM, Videnovic A, St Louis EK
Neurotherapeutics 2021 Jan;18(1):140-155. Epub 2021 Apr 20 doi: 10.1007/s13311-021-01019-4. PMID: 33880737Free PMC Article
Maness DL, Khan M
Am Fam Physician 2015 Dec 15;92(12):1058-64. PMID: 26760592

Recent clinical studies

Etiology

Jadidi A, Rezaei Ashtiani A, Khanmohamadi Hezaveh A, Aghaepour SM
BMC Complement Med Ther 2022 Dec 31;23(1):1. doi: 10.1186/s12906-022-03814-8. PMID: 36587225Free PMC Article
Gossard TR, Trotti LM, Videnovic A, St Louis EK
Neurotherapeutics 2021 Jan;18(1):140-155. Epub 2021 Apr 20 doi: 10.1007/s13311-021-01019-4. PMID: 33880737Free PMC Article
Kolla BP, Mansukhani MP, Bostwick JM
Sleep Med Rev 2018 Apr;38:131-140. Epub 2017 Jun 15 doi: 10.1016/j.smrv.2017.06.002. PMID: 28822709
Allen RP
Sleep Med Clin 2015 Sep;10(3):207-14, xi. Epub 2015 Jul 15 doi: 10.1016/j.jsmc.2015.05.022. PMID: 26329430Free PMC Article
Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB; International Restless Legs Syndrome Study Group
Sleep Med 2014 Aug;15(8):860-73. Epub 2014 May 17 doi: 10.1016/j.sleep.2014.03.025. PMID: 25023924

Diagnosis

Silber MH, Buchfuhrer MJ, Earley CJ, Koo BB, Manconi M, Winkelman JW; Scientific and Medical Advisory Board of the Restless Legs Syndrome Foundation
Mayo Clin Proc 2021 Jul;96(7):1921-1937. doi: 10.1016/j.mayocp.2020.12.026. PMID: 34218864
Gossard TR, Trotti LM, Videnovic A, St Louis EK
Neurotherapeutics 2021 Jan;18(1):140-155. Epub 2021 Apr 20 doi: 10.1007/s13311-021-01019-4. PMID: 33880737Free PMC Article
Trenkwalder C, Allen R, Högl B, Clemens S, Patton S, Schormair B, Winkelmann J
Lancet Neurol 2018 Nov;17(11):994-1005. Epub 2018 Sep 21 doi: 10.1016/S1474-4422(18)30311-9. PMID: 30244828
Tipton PW, Wszołek ZK
Pol Arch Intern Med 2017 Dec 22;127(12):865-872. Epub 2017 Nov 9 doi: 10.20452/pamw.4148. PMID: 29120993
Klingelhoefer L, Bhattacharya K, Reichmann H
Clin Med (Lond) 2016 Aug;16(4):379-82. doi: 10.7861/clinmedicine.16-4-379. PMID: 27481386Free PMC Article

Therapy

Jadidi A, Rezaei Ashtiani A, Khanmohamadi Hezaveh A, Aghaepour SM
BMC Complement Med Ther 2022 Dec 31;23(1):1. doi: 10.1186/s12906-022-03814-8. PMID: 36587225Free PMC Article
Abboud M
Nutrients 2022 Mar 3;14(5) doi: 10.3390/nu14051076. PMID: 35268051Free PMC Article
Hargrove N, El Tobgy N, Zhou O, Pinder M, Plant B, Askin N, Bieber L, Collister D, Whitlock R, Tangri N, Bohm C
Clin J Am Soc Nephrol 2021 Apr 7;16(4):560-574. Epub 2021 Mar 25 doi: 10.2215/CJN.15080920. PMID: 33766925Free PMC Article
Harrison EG, Keating JL, Morgan PE
Disabil Rehabil 2019 Aug;41(17):2006-2014. Epub 2018 Mar 21 doi: 10.1080/09638288.2018.1453875. PMID: 29561180
Klingelhoefer L, Bhattacharya K, Reichmann H
Clin Med (Lond) 2016 Aug;16(4):379-82. doi: 10.7861/clinmedicine.16-4-379. PMID: 27481386Free PMC Article

Prognosis

Rumble ME, Okoyeh P, Benca RM
Psychiatr Clin North Am 2023 Sep;46(3):527-537. Epub 2023 May 27 doi: 10.1016/j.psc.2023.04.008. PMID: 37500248
Miller MA, Mehta N, Clark-Bilodeau C, Bourjeily G
Chest 2020 Jan;157(1):184-197. Epub 2019 Oct 14 doi: 10.1016/j.chest.2019.09.026. PMID: 31622589Free PMC Article
Pengo MF, Won CH, Bourjeily G
Chest 2018 Jul;154(1):196-206. Epub 2018 Apr 19 doi: 10.1016/j.chest.2018.04.005. PMID: 29679598Free PMC Article
Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB; International Restless Legs Syndrome Study Group
Sleep Med 2014 Aug;15(8):860-73. Epub 2014 May 17 doi: 10.1016/j.sleep.2014.03.025. PMID: 25023924
Carter KA, Hathaway NE, Lettieri CF
Am Fam Physician 2014 Mar 1;89(5):368-77. PMID: 24695508

Clinical prediction guides

Harrer P, Mirza-Schreiber N, Mandel V, Roeber S, Stefani A, Naher S, Wagner M, Gieger C, Waldenberger M, Peters A, Högl B, Herms J, Schormair B, Zhao C, Winkelmann J, Oexle K
Mov Disord 2023 Aug;38(8):1410-1418. Epub 2023 May 22 doi: 10.1002/mds.29440. PMID: 37212434
Wang S, Zheng X, Huang J, Lin J, Yang T, Xiao Y, Jiang Q, Li C, Shang H
J Neurol 2023 Mar;270(3):1361-1370. Epub 2022 Dec 6 doi: 10.1007/s00415-022-11484-2. PMID: 36472687
Halioua B, Chelli C, Misery L, Taieb J, Taieb C
Acta Derm Venereol 2022 Apr 27;102:adv00699. doi: 10.2340/actadv.v102.1991. PMID: 35191513Free PMC Article
Winkelmann J, Allen RP, Högl B, Inoue Y, Oertel W, Salminen AV, Winkelman JW, Trenkwalder C, Sampaio C
Mov Disord 2018 Jul;33(7):1077-1091. Epub 2018 May 14 doi: 10.1002/mds.27260. PMID: 29756335
Johns MW
Sleep 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540. PMID: 1798888

Recent systematic reviews

Safarpour Y, Vaziri ND, Jabbari B
Tremor Other Hyperkinet Mov (N Y) 2023;13:10. Epub 2023 Mar 29 doi: 10.5334/tohm.752. PMID: 37008995Free PMC Article
Kuang B, Li D, Lobbezoo F, de Vries R, Hilgevoord A, de Vries N, Huynh N, Lavigne G, Aarab G
Sleep Med 2022 Jan;89:31-47. Epub 2021 Nov 19 doi: 10.1016/j.sleep.2021.11.008. PMID: 34879286
Büttner-Teleagă A, Kim YT, Osel T, Richter K
Int J Environ Res Public Health 2021 Nov 7;18(21) doi: 10.3390/ijerph182111696. PMID: 34770209Free PMC Article
DelRosso LM, Picchietti DL, Spruyt K, Bruni O, Garcia-Borreguero D, Kotagal S, Owens JA, Simakajornboon N, Ferri R; International Restless Legs Syndrome Study Group (IRLSSG)
Sleep Med Rev 2021 Apr;56:101406. Epub 2020 Dec 1 doi: 10.1016/j.smrv.2020.101406. PMID: 33341437
Kolla BP, Mansukhani MP, Bostwick JM
Sleep Med Rev 2018 Apr;38:131-140. Epub 2017 Jun 15 doi: 10.1016/j.smrv.2017.06.002. PMID: 28822709

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