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Gastritis

MedGen UID:
4843
Concept ID:
C0017152
Disease or Syndrome
Synonym: Gastritis (disease)
SNOMED CT: Gastritis (4556007); Gastric catarrh (4556007)
 
HPO: HP:0005263
Monarch Initiative: MONDO:0004966

Definition

The presence of inflammation of the gastric mucous membrane. [from HPO]

Conditions with this feature

Immunodeficiency 57
MedGen UID:
1648306
Concept ID:
C4748212
Disease or Syndrome
Inflammatory bowel disease 30
MedGen UID:
1737985
Concept ID:
C5436750
Disease or Syndrome
Inflammatory bowel disease-30 (IBD30) is characterized by abdominal pain and watery or bloody diarrhea, with changes in the intestinal tract consistent with Crohn disease (Mao et al., 2018). For a general description and a discussion of genetic heterogeneity of inflammatory bowel disease, including Crohn disease (CD) and ulcerative colitis (UC), see IBD1 (266600).
Immunodeficiency 82 with systemic inflammation
MedGen UID:
1781752
Concept ID:
C5543581
Disease or Syndrome
Immunodeficiency-82 with systemic inflammation (IMD82) is a complex autosomal dominant immunologic disorder characterized by recurrent infections with various organisms, as well as noninfectious inflammation manifest as lymphocytic organ infiltration with gastritis, colitis, and lung, liver, CNS, or skin disease. One of the more common features is inflammation of the stomach and bowel. Most patients develop symptoms in infancy or early childhood; the severity is variable. There may be accompanying fever, elevated white blood cell count, decreased B cells, hypogammaglobulinemia, increased C-reactive protein (CRP; 123260), and a generalized hyperinflammatory state. Immunologic workup shows variable B- and T-cell abnormalities such as skewed subgroups. Patients have a propensity for the development of lymphoma, usually in adulthood. At the molecular level, the disorder results from a gain-of-function mutation that leads to constitutive and enhanced activation of the intracellular inflammatory signaling pathway. Treatment with SYK inhibitors rescued human cell abnormalities and resulted in clinical improvement in mice (Wang et al., 2021).

Professional guidelines

PubMed

Miwa H, Nagahara A, Asakawa A, Arai M, Oshima T, Kasugai K, Kamada K, Suzuki H, Tanaka F, Tominaga K, Futagami S, Hojo M, Mihara H, Higuchi K, Kusano M, Arisawa T, Kato M, Joh T, Mochida S, Enomoto N, Shimosegawa T, Koike K
J Gastroenterol 2022 Feb;57(2):47-61. Epub 2022 Jan 21 doi: 10.1007/s00535-021-01843-7. PMID: 35061057Free PMC Article
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037

Recent clinical studies

Etiology

Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Bacha D, Walha M, Ben Slama S, Ben Romdhane H, Bouraoui S, Bellil K, Lahmar A
Tunis Med 2018 Jul;96(7):405-410. PMID: 30430483
Sipponen P, Maaroos HI
Scand J Gastroenterol 2015 Jun;50(6):657-67. Epub 2015 Apr 22 doi: 10.3109/00365521.2015.1019918. PMID: 25901896Free PMC Article
Rugge M, Correa P, Di Mario F, El-Omar E, Fiocca R, Geboes K, Genta RM, Graham DY, Hattori T, Malfertheiner P, Nakajima S, Sipponen P, Sung J, Weinstein W, Vieth M
Dig Liver Dis 2008 Aug;40(8):650-8. doi: 10.1016/j.dld.2008.02.030. PMID: 18424244
Dixon MF, Genta RM, Yardley JH, Correa P
Am J Surg Pathol 1996 Oct;20(10):1161-81. doi: 10.1097/00000478-199610000-00001. PMID: 8827022

Diagnosis

Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Annibale B, Esposito G, Lahner E
Expert Rev Gastroenterol Hepatol 2020 Feb;14(2):93-102. Epub 2020 Jan 24 doi: 10.1080/17474124.2020.1718491. PMID: 31951768
Bacha D, Walha M, Ben Slama S, Ben Romdhane H, Bouraoui S, Bellil K, Lahmar A
Tunis Med 2018 Jul;96(7):405-410. PMID: 30430483
Li Y, Xia R, Zhang B, Li C
J Environ Pathol Toxicol Oncol 2018;37(3):241-259. doi: 10.1615/JEnvironPatholToxicolOncol.2018026839. PMID: 30317974
Sipponen P, Maaroos HI
Scand J Gastroenterol 2015 Jun;50(6):657-67. Epub 2015 Apr 22 doi: 10.3109/00365521.2015.1019918. PMID: 25901896Free PMC Article

Therapy

Visaggi P, Ghisa M, Barberio B, Maniero D, Greco E, Savarino V, Black CJ, Ford AC, de Bortoli N, Savarino E
Dig Liver Dis 2023 Feb;55(2):208-222. Epub 2022 May 30 doi: 10.1016/j.dld.2022.05.004. PMID: 35654734
Koga Y
World J Gastroenterol 2022 Dec 21;28(47):6702-6715. doi: 10.3748/wjg.v28.i47.6702. PMID: 36620346Free PMC Article
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
Lucendo AJ, López-Sánchez P
BioDrugs 2020 Aug;34(4):477-493. doi: 10.1007/s40259-020-00427-w. PMID: 32472465
Watari J, Chen N, Amenta PS, Fukui H, Oshima T, Tomita T, Miwa H, Lim KJ, Das KM
World J Gastroenterol 2014 May 14;20(18):5461-73. doi: 10.3748/wjg.v20.i18.5461. PMID: 24833876Free PMC Article

Prognosis

Rugge M, Bricca L, Guzzinati S, Sacchi D, Pizzi M, Savarino E, Farinati F, Zorzi M, Fassan M, Dei Tos AP, Malfertheiner P, Genta RM, Graham DY
Gut 2023 Jan;72(1):30-38. Epub 2022 Jun 30 doi: 10.1136/gutjnl-2022-327827. PMID: 35772926
Yin Y, Liang H, Wei N, Zheng Z
Ann Palliat Med 2022 Dec;11(12):3697-3703. doi: 10.21037/apm-21-1464. PMID: 36635994
Bizzaro N, Antico A
Autoimmun Rev 2014 Apr-May;13(4-5):565-8. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2014.01.042. PMID: 24424200
El-Zimaity H
Curr Opin Gastroenterol 2008 Nov;24(6):682-6. doi: 10.1097/MOG.0b013e328311d1cc. PMID: 19122515
Eagon JC, Miedema BW, Kelly KA
Surg Clin North Am 1992 Apr;72(2):445-65. doi: 10.1016/s0039-6109(16)45689-6. PMID: 1549803

Clinical prediction guides

Greuter T, Katzka D
Immunol Allergy Clin North Am 2024 May;44(2):357-368. Epub 2024 Feb 13 doi: 10.1016/j.iac.2024.01.007. PMID: 38575229
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Toyoshima O, Nishizawa T, Koike K
World J Gastroenterol 2020 Feb 7;26(5):466-477. doi: 10.3748/wjg.v26.i5.466. PMID: 32089624Free PMC Article
Venerito M, Goni E, Malfertheiner P
Expert Rev Gastroenterol Hepatol 2016;10(4):497-503. Epub 2016 Jan 5 doi: 10.1586/17474124.2016.1126507. PMID: 26619972
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article

Recent systematic reviews

Visaggi P, Ghisa M, Barberio B, Maniero D, Greco E, Savarino V, Black CJ, Ford AC, de Bortoli N, Savarino E
Dig Liver Dis 2023 Feb;55(2):208-222. Epub 2022 May 30 doi: 10.1016/j.dld.2022.05.004. PMID: 35654734
Yin Y, Liang H, Wei N, Zheng Z
Ann Palliat Med 2022 Dec;11(12):3697-3703. doi: 10.21037/apm-21-1464. PMID: 36635994
Gisbert JP, Alcedo J, Amador J, Bujanda L, Calvet X, Castro-Fernández M, Fernández-Salazar L, Gené E, Lanas Á, Lucendo AJ, Molina-Infante J, Nyssen OP, Pérez-Aisa A, Puig I
Gastroenterol Hepatol 2022 May;45(5):392-417. Epub 2021 Oct 7 doi: 10.1016/j.gastrohep.2021.07.011. PMID: 34629204
Ashktorab H, Soleimani A, Singh G, Amin A, Tabtabaei S, Latella G, Stein U, Akhondzadeh S, Solanki N, Gondré-Lewis MC, Habtezion A, Brim H
Nutrients 2019 Apr 26;11(5) doi: 10.3390/nu11050943. PMID: 31027364Free PMC Article
Du LJ, Chen BR, Kim JJ, Kim S, Shen JH, Dai N
World J Gastroenterol 2016 Mar 28;22(12):3486-95. doi: 10.3748/wjg.v22.i12.3486. PMID: 27022230Free PMC Article

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