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Childhood-onset schizophrenia

MedGen UID:
48576
•Concept ID:
C0036346
•
Mental or Behavioral Dysfunction
Synonym: Childhood schizophrenia
 
Monarch Initiative: MONDO:0957430

Definition

Schizophrenia occurring in childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Clozapine for Management of Childhood and Adolescent-Onset Schizophrenia: A Systematic Review and Meta-Analysis.
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
An overview of medical risk factors for childhood psychosis: Implications for research and treatment.
Giannitelli M, Consoli A, Raffin M, Jardri R, Levinson DF, Cohen D, Laurent-Levinson C
Schizophr Res 2018 Feb;192:39-49. Epub 2017 May 16 doi: 10.1016/j.schres.2017.05.011. PMID: 28526280
New developments in diagnosis and treatment update: Schizophrenia/first episode psychosis in children and adolescents.
Lachman A
J Child Adolesc Ment Health 2014;26(2):109-24. doi: 10.2989/17280583.2014.924416. PMID: 25391710

Recent clinical studies

Etiology

Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update.
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Genetics of Childhood-onset Schizophrenia 2019 Update.
Forsyth JK, Asarnow RF
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):157-170. Epub 2019 Oct 17 doi: 10.1016/j.chc.2019.08.007. PMID: 31708045Free PMC Article
Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.
Ordóñez AE, Luscher ZI, Gogtay N
Schizophr Res 2016 Jun;173(3):124-131. Epub 2015 Mar 26 doi: 10.1016/j.schres.2015.03.003. PMID: 25819937Free PMC Article
Early-onset schizophrenia.
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279

Diagnosis

Sleep neurophysiology in childhood onset schizophrenia.
Markovic A, Buckley A, Driver DI, Dillard-Broadnax D, Gochman PA, Hoedlmoser K, Rapoport JL, Tarokh L
J Sleep Res 2021 Apr;30(2):e13039. Epub 2020 Apr 30 doi: 10.1111/jsr.13039. PMID: 32350968
Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update.
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
Genetics of childhood-onset schizophrenia.
Asarnow RF, Forsyth JK
Child Adolesc Psychiatr Clin N Am 2013 Oct;22(4):675-87. Epub 2013 Jul 23 doi: 10.1016/j.chc.2013.06.004. PMID: 24012080Free PMC Article
Early-onset schizophrenia.
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279

Therapy

Clozapine for Management of Childhood and Adolescent-Onset Schizophrenia: A Systematic Review and Meta-Analysis.
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update.
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Early-onset schizophrenia.
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279
Antipsychotic medication for childhood-onset schizophrenia.
Kennedy E, Kumar A, Datta SS
Cochrane Database Syst Rev 2007 Jul 18;2007(3):CD004027. doi: 10.1002/14651858.CD004027.pub2. PMID: 17636744Free PMC Article
Childhood-onset schizophrenia.
Gordon CT
New Dir Ment Health Serv 1992 Summer;(54):71-5. doi: 10.1002/yd.23319925414. PMID: 1352624

Prognosis

Alternating hemiplegia of childhood: a distinct clinical entity and ATP1A3-related disorders: A narrative review.
Pavone P, Pappalardo XG, Ruggieri M, Falsaperla R, Parano E
Medicine (Baltimore) 2022 Aug 5;101(31):e29413. doi: 10.1097/MD.0000000000029413. PMID: 35945798Free PMC Article
Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update.
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
Functional and clinical insights from neuroimaging studies in childhood-onset schizophrenia.
Ordóñez AE, Sastry NV, Gogtay N
CNS Spectr 2015 Aug;20(4):442-50. doi: 10.1017/S1092852915000437. PMID: 26234702
Early-onset schizophrenia.
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279

Clinical prediction guides

Genetic insights into childhood-onset schizophrenia: The yield of clinical exome sequencing.
Alkelai A, Greenbaum L, Shohat S, Povysil G, Malakar A, Ren Z, Motelow JE, Schechter T, Draiman B, Chitrit-Raveh E, Hughes D, Jobanputra V, Shifman S, Goldstein DB, Kohn Y
Schizophr Res 2023 Feb;252:138-145. Epub 2023 Jan 14 doi: 10.1016/j.schres.2022.12.033. PMID: 36645932
Clozapine for Management of Childhood and Adolescent-Onset Schizophrenia: A Systematic Review and Meta-Analysis.
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Symptom dimensions and subgroups in childhood-onset schizophrenia.
Craddock KES, Zhou X, Liu S, Gochman P, Dickinson D, Rapoport JL
Schizophr Res 2018 Jul;197:71-77. Epub 2017 Nov 13 doi: 10.1016/j.schres.2017.10.045. PMID: 29146021Free PMC Article
Research update: childhood-onset schizophrenia: implications of clinical and neurobiological research.
Jacobsen LK, Rapoport JL
J Child Psychol Psychiatry 1998 Jan;39(1):101-13. PMID: 9534088
The clinical presentation of childhood-onset schizophrenia.
Russell AT
Schizophr Bull 1994;20(4):631-46. doi: 10.1093/schbul/20.4.631. PMID: 7701273

Recent systematic reviews

Clozapine for Management of Childhood and Adolescent-Onset Schizophrenia: A Systematic Review and Meta-Analysis.
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Antipsychotic medication for childhood-onset schizophrenia.
Kennedy E, Kumar A, Datta SS
Cochrane Database Syst Rev 2007 Jul 18;2007(3):CD004027. doi: 10.1002/14651858.CD004027.pub2. PMID: 17636744Free PMC Article

Supplemental Content

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    Clinical resources

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    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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