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Solar lentigo

MedGen UID:
48619
•Concept ID:
C0036651
•
Disease or Syndrome
Synonyms: Actinic lentigo; Lentigo Senilis; Liver spot; Senile lentigo; Solar Lentigo
SNOMED CT: Senile lentigo (72100002); Solar lentigo (72100002); Liver spot (72100002); Actinic lentigo (72100002); Solar lentigo (1295259008)

Definition

Benign, pigmented spots on the skin that are associated with aging and exposure to ultraviolet radiation from the sun. The spots are found on areas of the body that are most often exposed to the sun; including the hands, face, shoulders, arms, forehead, and scalp. In some cases, this condition may mimic melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSolar lentigo

Professional guidelines

PubMed

The role of reflectance confocal microscopy in the diagnosis and management of pigmentary disorders: A review.
Farabi B, Khan S, Jamgochian M, Atak MF, Jain M, Rao BK
J Cosmet Dermatol 2023 Dec;22(12):3213-3222. Epub 2023 Sep 27 doi: 10.1111/jocd.15827. PMID: 37759421
A risk-scoring model for the differential diagnosis of lentigo maligna and other atypical pigmented facial lesions of the face: The facial iDScore.
Tognetti L, Cartocci A, Żychowska M, Savarese I, Cinotti E, Pizzichetta MA, Moscarella E, Longo C, Farnetani F, Guida S, Paoli J, Lallas A, Tiodorovic D, Stanganelli I, Magi S, Dika E, Zalaudek I, Suppa M, Argenziano G, Pellacani G, Perrot JL, Miracapillo C, Rubegni G, Cevenini G, Rubegni P
J Eur Acad Dermatol Venereol 2023 Nov;37(11):2301-2310. Epub 2023 Jul 26 doi: 10.1111/jdv.19360. PMID: 37467376
Algorithmic approach to the treatment of solar lentigines with picosecond lasers.
Murray T, Wu D, Boen M
Lasers Surg Med 2023 Oct;55(8):712-714. Epub 2023 Jul 9 doi: 10.1002/lsm.23701. PMID: 37422883

Recent clinical studies

Etiology

Can we predict postinflammatory hyperpigmentation after laser treatment based on dermoscopic findings of solar lentigo?
Park JH, Lee JH, Chung BY, Kim JE, Shin JH, Oh SH, Choi M, Lee SH, Kim YC, Ryu HJ
Lasers Med Sci 2023 May 29;38(1):130. doi: 10.1007/s10103-023-03790-6. PMID: 37247095
The detectability of intraepidermal melanocytes-A narrative review of immunohistochemical studies.
Kuźbicki Ł, Brożyna AA
J Cutan Pathol 2022 Dec;49(12):1074-1089. Epub 2022 Sep 20 doi: 10.1111/cup.14295. PMID: 35851493
Predictors of subsequent primary melanoma: a case-control study.
Bellinato F, Rosina P, Tonin B, Gisondi P, Girolomoni G
Arch Dermatol Res 2022 Nov;314(9):881-885. Epub 2021 Nov 26 doi: 10.1007/s00403-021-02309-9. PMID: 34825952
Change of the diagnostic distribution in applicants to dermatology after COVID-19 pandemic: What it whispers to us?
Turan Ç, Metin N, Utlu Z, Öner Ü, Kotan ÖS
Dermatol Ther 2020 Jul;33(4):e13804. Epub 2020 Jul 9 doi: 10.1111/dth.13804. PMID: 32530503Free PMC Article
Laser therapy for solar lentigines: review of the literature and case report.
Bukvić Mokos Z, Lipozencić J, Pasić A, Fattorini I
Acta Dermatovenerol Croat 2006;14(2):81-5. PMID: 16859612

Diagnosis

The detectability of intraepidermal melanocytes-A narrative review of immunohistochemical studies.
Kuźbicki Ł, Brożyna AA
J Cutan Pathol 2022 Dec;49(12):1074-1089. Epub 2022 Sep 20 doi: 10.1111/cup.14295. PMID: 35851493
Predictors of subsequent primary melanoma: a case-control study.
Bellinato F, Rosina P, Tonin B, Gisondi P, Girolomoni G
Arch Dermatol Res 2022 Nov;314(9):881-885. Epub 2021 Nov 26 doi: 10.1007/s00403-021-02309-9. PMID: 34825952
Melanocyte Activation Mechanisms and Rational Therapeutic Treatments of Solar Lentigos.
Imokawa G
Int J Mol Sci 2019 Jul 26;20(15) doi: 10.3390/ijms20153666. PMID: 31357457Free PMC Article
Biological processes in solar lentigo: insights brought by experimental models.
Goorochurn R, Viennet C, Granger C, Fanian F, Varin-Blank N, Roy CL, Humbert P
Exp Dermatol 2016 Mar;25(3):174-7. doi: 10.1111/exd.12937. PMID: 26739821
Pigmented Bowen's disease.
Mota AN, Piñeiro-Maceira J, Alves Mde F, Tarazona MJ
An Bras Dermatol 2014 Sep-Oct;89(5):825-7. doi: 10.1590/abd1806-4841.20142725. PMID: 25184929Free PMC Article

Therapy

Melanocyte Activation Mechanisms and Rational Therapeutic Treatments of Solar Lentigos.
Imokawa G
Int J Mol Sci 2019 Jul 26;20(15) doi: 10.3390/ijms20153666. PMID: 31357457Free PMC Article
Biological processes in solar lentigo: insights brought by experimental models.
Goorochurn R, Viennet C, Granger C, Fanian F, Varin-Blank N, Roy CL, Humbert P
Exp Dermatol 2016 Mar;25(3):174-7. doi: 10.1111/exd.12937. PMID: 26739821
Mechanisms underlying post-inflammatory hyperpigmentation: lessons from solar lentigo.
Cardinali G, Kovacs D, Picardo M
Ann Dermatol Venereol 2012 Dec;139 Suppl 4:S148-52. doi: 10.1016/S0151-9638(12)70127-8. PMID: 23522630
The melanogenesis and mechanisms of skin-lightening agents--existing and new approaches.
Gillbro JM, Olsson MJ
Int J Cosmet Sci 2011 Jun;33(3):210-21. Epub 2011 Jan 25 doi: 10.1111/j.1468-2494.2010.00616.x. PMID: 21265866
Large-cell acanthoma. A distinctive keratosis.
Rabinowitz AD, Inghirami G
Am J Dermatopathol 1992 Apr;14(2):136-8; discussion 139. PMID: 1348913

Prognosis

Can we predict postinflammatory hyperpigmentation after laser treatment based on dermoscopic findings of solar lentigo?
Park JH, Lee JH, Chung BY, Kim JE, Shin JH, Oh SH, Choi M, Lee SH, Kim YC, Ryu HJ
Lasers Med Sci 2023 May 29;38(1):130. doi: 10.1007/s10103-023-03790-6. PMID: 37247095
Predictors of subsequent primary melanoma: a case-control study.
Bellinato F, Rosina P, Tonin B, Gisondi P, Girolomoni G
Arch Dermatol Res 2022 Nov;314(9):881-885. Epub 2021 Nov 26 doi: 10.1007/s00403-021-02309-9. PMID: 34825952
Skin lesions of face and scalp - Classification by a market-approved convolutional neural network in comparison with 64 dermatologists.
Haenssle HA, Winkler JK, Fink C, Toberer F, Enk A, Stolz W, Deinlein T, Hofmann-Wellenhof R, Kittler H, Tschandl P, Rosendahl C, Lallas A, Blum A, Abassi MS, Thomas L, Tromme I, Rosenberger A; Reader study level-I and level-II Groups Christina Alt
Eur J Cancer 2021 Feb;144:192-199. Epub 2020 Dec 25 doi: 10.1016/j.ejca.2020.11.034. PMID: 33370644
Lentigo maligna of the face: A quantitative simple method to identify individual patient risk probability on dermoscopy.
Carbone A, Ferrari A, Paolino G, Buccini P, De Simone P, Eibenschutz L, Piemonte P, Silipo V, Sperduti I, Catricalà C, Frascione P
Australas J Dermatol 2017 Nov;58(4):286-291. Epub 2017 Jun 7 doi: 10.1111/ajd.12595. PMID: 28589538
Nonmelanocytic lesions defying the two-step dermoscopy algorithm.
Scope A, Benvenuto-Andrade C, Agero AL, Marghoob AA
Dermatol Surg 2006 Nov;32(11):1398-406. doi: 10.1111/j.1524-4725.2006.32312.x. PMID: 17083595

Clinical prediction guides

Melanin accumulation in dermal stem cells deteriorates their exosome-mediated skin basement membrane construction in solar lentigo.
Miyachi K, Yamada T, Sanada A, Inoue Y, Hasebe Y, Arima M, Iwata Y, Hasegawa S, Sugiura K, Akamatsu H
Exp Dermatol 2022 Dec;31(12):1881-1890. Epub 2022 Sep 1 doi: 10.1111/exd.14667. PMID: 36048560
A Machine Vision Approach for Classification of Skin Cancer Using Hybrid Texture Features.
Zareen SS, Guangmin S, Li Y, Kundi M, Qadri S, Qadri SF, Ahmad M, Khan AH
Comput Intell Neurosci 2022;2022:4942637. Epub 2022 Jul 18 doi: 10.1155/2022/4942637. PMID: 35898782Free PMC Article
Predictors of subsequent primary melanoma: a case-control study.
Bellinato F, Rosina P, Tonin B, Gisondi P, Girolomoni G
Arch Dermatol Res 2022 Nov;314(9):881-885. Epub 2021 Nov 26 doi: 10.1007/s00403-021-02309-9. PMID: 34825952
Mechanisms underlying post-inflammatory hyperpigmentation: lessons from solar lentigo.
Cardinali G, Kovacs D, Picardo M
Ann Dermatol Venereol 2012 Dec;139 Suppl 4:S148-52. doi: 10.1016/S0151-9638(12)70127-8. PMID: 23522630
Nonmelanocytic lesions defying the two-step dermoscopy algorithm.
Scope A, Benvenuto-Andrade C, Agero AL, Marghoob AA
Dermatol Surg 2006 Nov;32(11):1398-406. doi: 10.1111/j.1524-4725.2006.32312.x. PMID: 17083595

Recent systematic reviews

Reflectance confocal microscopy terminology glossary for nonmelanocytic skin lesions: A systematic review.
Navarrete-Dechent C, DeRosa AP, Longo C, Liopyris K, Oliviero M, Rabinovitz H, Marghoob AA, Halpern AC, Pellacani G, Scope A, Jain M
J Am Acad Dermatol 2019 May;80(5):1414-1427.e3. Epub 2018 Dec 8 doi: 10.1016/j.jaad.2018.12.007. PMID: 30529706Free PMC Article

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