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Prodromal Symptoms

MedGen UID:
488311
Concept ID:
C3494358
Sign or Symptom
Synonyms: Characteristic, Prodromal; Characteristics, Prodromal; Prodromal Characteristic; Prodromal Characteristics; Prodromal Sign; Prodromal Signs; Prodromal Symptom; Prodromal Syndrome; Prodromal Syndromes; Sign, Prodromal; Signs, Prodromal; Symptom, Prodromal; Symptoms, Prodromal; Syndrome, Prodromal; Syndromes, Prodromal

Definition

Clinical or physiological indicators that precede the onset of disease. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProdromal Symptoms

Professional guidelines

PubMed

Crump CJ, Good ME, Abuelazm H, El-Mallakh RS
Expert Opin Pharmacother 2023 Jun;24(9):1039-1052. Epub 2023 May 1 doi: 10.1080/14656566.2023.2208269. PMID: 37102321
Weintraub D, Irwin D
Continuum (Minneap Minn) 2022 Oct 1;28(5):1314-1332. doi: 10.1212/CON.0000000000001151. PMID: 36222767
Zdanowicz N, Mees L, Jacques D, Tordeurs D, Reynaert C
Psychiatr Danub 2014 Jun;26(2):115-21. PMID: 24909247

Recent clinical studies

Etiology

Schalkamp AK, Peall KJ, Harrison NA, Sandor C
Nat Med 2023 Aug;29(8):2048-2056. Epub 2023 Jul 3 doi: 10.1038/s41591-023-02440-2. PMID: 37400639
Rajan S, Kaas B
Semin Neurol 2022 Oct;42(5):626-638. Epub 2022 Nov 25 doi: 10.1055/s-0042-1758780. PMID: 36427528
Benasi G, Fava GA, Guidi J
Psychother Psychosom 2021;90(6):365-372. Epub 2021 Jul 20 doi: 10.1159/000517953. PMID: 34350890
Millis MB
J Bone Joint Surg Am 2020 Nov 4;102(Suppl 2):3-7. doi: 10.2106/JBJS.20.01494. PMID: 32947596
Besag FMC, Vasey MJ
Epilepsy Behav 2018 Jun;83:219-233. Epub 2018 Apr 10 doi: 10.1016/j.yebeh.2018.03.019. PMID: 29650466

Diagnosis

Schalkamp AK, Peall KJ, Harrison NA, Sandor C
Nat Med 2023 Aug;29(8):2048-2056. Epub 2023 Jul 3 doi: 10.1038/s41591-023-02440-2. PMID: 37400639
Rajan S, Kaas B
Semin Neurol 2022 Oct;42(5):626-638. Epub 2022 Nov 25 doi: 10.1055/s-0042-1758780. PMID: 36427528
Sampaio Rocha-Filho PA, Gherpelli JLD
Curr Pain Headache Rep 2022 Feb;26(2):151-163. Epub 2022 Jan 22 doi: 10.1007/s11916-022-01015-z. PMID: 35064917
Jackson AC
Rev Sci Tech 2018 Aug;37(2):569-580. doi: 10.20506/rst.37.2.2825. PMID: 30747124
Besag FMC, Vasey MJ
Epilepsy Behav 2018 Jun;83:219-233. Epub 2018 Apr 10 doi: 10.1016/j.yebeh.2018.03.019. PMID: 29650466

Therapy

Bloem BR, Okun MS, Klein C
Lancet 2021 Jun 12;397(10291):2284-2303. Epub 2021 Apr 10 doi: 10.1016/S0140-6736(21)00218-X. PMID: 33848468
McCutcheon RA, Reis Marques T, Howes OD
JAMA Psychiatry 2020 Feb 1;77(2):201-210. doi: 10.1001/jamapsychiatry.2019.3360. PMID: 31664453
Shah RA, Limmer AL, Nwannunu CE, Patel RR, Mui UN, Tyring SK
Skin Therapy Lett 2019 Jul;24(4):5-7. PMID: 31339679
Vermunt L, Sikkes SAM, van den Hout A, Handels R, Bos I, van der Flier WM, Kern S, Ousset PJ, Maruff P, Skoog I, Verhey FRJ, Freund-Levi Y, Tsolaki M, Wallin ÅK, Olde Rikkert M, Soininen H, Spiru L, Zetterberg H, Blennow K, Scheltens P, Muniz-Terrera G, Visser PJ; Alzheimer Disease Neuroimaging Initiative; AIBL Research Group; ICTUS/DSA study groups
Alzheimers Dement 2019 Jul;15(7):888-898. Epub 2019 Jun 1 doi: 10.1016/j.jalz.2019.04.001. PMID: 31164314Free PMC Article
Dodick DW
Headache 2018 May;58 Suppl 1:4-16. doi: 10.1111/head.13300. PMID: 29697154

Prognosis

Schalkamp AK, Peall KJ, Harrison NA, Sandor C
Nat Med 2023 Aug;29(8):2048-2056. Epub 2023 Jul 3 doi: 10.1038/s41591-023-02440-2. PMID: 37400639
Schaeffer E, Toedt I, Köhler S, Rogge A, Berg D
Mov Disord 2021 Dec;36(12):2833-2839. Epub 2021 Aug 5 doi: 10.1002/mds.28723. PMID: 34351002
Benasi G, Fava GA, Guidi J
Psychother Psychosom 2021;90(6):365-372. Epub 2021 Jul 20 doi: 10.1159/000517953. PMID: 34350890
Besag FMC, Vasey MJ
Epilepsy Behav 2018 Jun;83:219-233. Epub 2018 Apr 10 doi: 10.1016/j.yebeh.2018.03.019. PMID: 29650466
Fusar-Poli P, Borgwardt S, Bechdolf A, Addington J, Riecher-Rössler A, Schultze-Lutter F, Keshavan M, Wood S, Ruhrmann S, Seidman LJ, Valmaggia L, Cannon T, Velthorst E, De Haan L, Cornblatt B, Bonoldi I, Birchwood M, McGlashan T, Carpenter W, McGorry P, Klosterkötter J, McGuire P, Yung A
JAMA Psychiatry 2013 Jan;70(1):107-20. doi: 10.1001/jamapsychiatry.2013.269. PMID: 23165428Free PMC Article

Clinical prediction guides

Schalkamp AK, Peall KJ, Harrison NA, Sandor C
Nat Med 2023 Aug;29(8):2048-2056. Epub 2023 Jul 3 doi: 10.1038/s41591-023-02440-2. PMID: 37400639
Matheson SL, Laurie M, Laurens KR
Psychol Med 2023 Jan;53(2):305-319. Epub 2022 Nov 15 doi: 10.1017/S0033291722003440. PMID: 36377500Free PMC Article
Schaeffer E, Toedt I, Köhler S, Rogge A, Berg D
Mov Disord 2021 Dec;36(12):2833-2839. Epub 2021 Aug 5 doi: 10.1002/mds.28723. PMID: 34351002
Heinzel S, Berg D, Gasser T, Chen H, Yao C, Postuma RB; MDS Task Force on the Definition of Parkinson's Disease
Mov Disord 2019 Oct;34(10):1464-1470. Epub 2019 Aug 14 doi: 10.1002/mds.27802. PMID: 31412427
Besag FMC, Vasey MJ
Epilepsy Behav 2018 Jun;83:219-233. Epub 2018 Apr 10 doi: 10.1016/j.yebeh.2018.03.019. PMID: 29650466

Recent systematic reviews

Jemimah S, Chabib CMM, Hadjileontiadis L, AlShehhi A
PLoS One 2023;18(5):e0285346. Epub 2023 May 24 doi: 10.1371/journal.pone.0285346. PMID: 37224131Free PMC Article
Matheson SL, Laurie M, Laurens KR
Psychol Med 2023 Jan;53(2):305-319. Epub 2022 Nov 15 doi: 10.1017/S0033291722003440. PMID: 36377500Free PMC Article
Thompson BS, Philcox S, Devereaux B, Metz AJ, Croagh D, Gray A, Hamarneh Z, Windsor JA, Neale RE
J Clin Gastroenterol 2022 Jan 1;56(1):e1-e10. doi: 10.1097/MCG.0000000000001544. PMID: 34049375
Benasi G, Fava GA, Guidi J
Psychother Psychosom 2021;90(6):365-372. Epub 2021 Jul 20 doi: 10.1159/000517953. PMID: 34350890
Parnetti L, Chipi E, Salvadori N, D'Andrea K, Eusebi P
Alzheimers Res Ther 2019 Jan 15;11(1):7. doi: 10.1186/s13195-018-0459-7. PMID: 30646955Free PMC Article

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