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Rubeosis iridis

MedGen UID:
488789
•Concept ID:
C0154916
•
Disease or Syndrome
Synonyms: Iris neovascularization; Neovascularization of the iris; New blood vessel formation in iris; New vessels in iris; NVI - New vessels iris; rubeosis iridis; Rubeotic iris
SNOMED CT: Iris neovascularization (51995000); New vessels in iris (51995000); NVI - New vessels iris (51995000); Rubeotic iris (51995000); Rubeosis iridis (51995000)
 
HPO: HP:0011497
Monarch Initiative: MONDO:0001855

Definition

Formation of new blood vessels on the iris. The new vessels do not display the typical radially symmertic growth pattern of normal iris blood vessels, but rather appear disorganized. Rubeosis usually starts from the pupillary border with tiny tufts of dilated capillaries or red spots that can only be appreciated with high magnification. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRubeosis iridis

Professional guidelines

PubMed

Current management of diabetic tractional retinal detachments.
Stewart MW, Browning DJ, Landers MB
Indian J Ophthalmol 2018 Dec;66(12):1751-1762. doi: 10.4103/ijo.IJO_1217_18. PMID: 30451175Free PMC Article
Management of traumatic hyphema.
Walton W, Von Hagen S, Grigorian R, Zarbin M
Surv Ophthalmol 2002 Jul-Aug;47(4):297-334. doi: 10.1016/s0039-6257(02)00317-x. PMID: 12161209
Rubeosis iridis and neovascular glaucoma: I. Etiopathogenesis and treatment--the present state of the problem.
Rehák J
Acta Univ Palacki Olomuc Fac Med 1992;134:101-3. PMID: 1364951

Recent clinical studies

Etiology

Radiotherapy in Uveal Melanoma: A Review of Ocular Complications.
Banou L, Tsani Z, Arvanitogiannis K, Pavlaki M, Dastiridou A, Androudi S
Curr Oncol 2023 Jul 3;30(7):6374-6396. doi: 10.3390/curroncol30070470. PMID: 37504330Free PMC Article
The impact of diabetes on visual acuity in Ethiopia, 2021.
Asemu MT, Ahunie MA
PLoS One 2021;16(8):e0256145. Epub 2021 Aug 13 doi: 10.1371/journal.pone.0256145. PMID: 34388219Free PMC Article
Current management of diabetic tractional retinal detachments.
Stewart MW, Browning DJ, Landers MB
Indian J Ophthalmol 2018 Dec;66(12):1751-1762. doi: 10.4103/ijo.IJO_1217_18. PMID: 30451175Free PMC Article
Etiology and Features of Eyes with Rubeosis Iridis among Korean Patients: A Population-Based Single Center Study.
Jeong YC, Hwang YH
PLoS One 2016;11(8):e0160662. Epub 2016 Aug 4 doi: 10.1371/journal.pone.0160662. PMID: 27490797Free PMC Article
Management of traumatic hyphema.
Walton W, Von Hagen S, Grigorian R, Zarbin M
Surv Ophthalmol 2002 Jul-Aug;47(4):297-334. doi: 10.1016/s0039-6257(02)00317-x. PMID: 12161209

Diagnosis

Current management of diabetic tractional retinal detachments.
Stewart MW, Browning DJ, Landers MB
Indian J Ophthalmol 2018 Dec;66(12):1751-1762. doi: 10.4103/ijo.IJO_1217_18. PMID: 30451175Free PMC Article
Green cataract.
Drews RC
Klin Monbl Augenheilkd 1994 Nov;205(5):301-4. doi: 10.1055/s-2008-1045533. PMID: 7844946
The ocular ischemic syndrome.
Dhooge M, de Laey JJ
Bull Soc Belge Ophtalmol 1989;231:1-13. PMID: 2488440
Birdshot retinochoroidopathy.
Fuerst DJ, Tessler HH, Fishman GA, Yokoyama MM, Wyhinny GJ, Vygantas CM
Arch Ophthalmol 1984 Feb;102(2):214-9. doi: 10.1001/archopht.1984.01040030164018. PMID: 6696665
Neovascularization of the iris (rubeosis iridis).
Gartner S, Henkind P
Surv Ophthalmol 1978 Mar-Apr;22(5):291-312. doi: 10.1016/0039-6257(78)90175-3. PMID: 349748

Therapy

Current management of diabetic tractional retinal detachments.
Stewart MW, Browning DJ, Landers MB
Indian J Ophthalmol 2018 Dec;66(12):1751-1762. doi: 10.4103/ijo.IJO_1217_18. PMID: 30451175Free PMC Article
Anterior segment ischemia with rubeosis iridis after a circular buckling operation treated successfully with an intravitreal bevacizumab injection: a case report and review of the literature.
Janssens K, Zeyen T, Van Calster J
Bull Soc Belge Ophtalmol 2012;(319):5-9. PMID: 22550771
Ocular photodynamic therapy--standard applications and new indications (part 1). Review of the literature and personal experience.
Mennel S, Barbazetto I, Meyer CH, Peter S, Stur M
Ophthalmologica 2007;221(4):216-26. doi: 10.1159/000101922. PMID: 17579286
Management of traumatic hyphema.
Walton W, Von Hagen S, Grigorian R, Zarbin M
Surv Ophthalmol 2002 Jul-Aug;47(4):297-334. doi: 10.1016/s0039-6257(02)00317-x. PMID: 12161209
Rubeosis iridis and neovascular glaucoma: II. Our own experiences with the treatment by cryocoagulation.
Rehák J
Acta Univ Palacki Olomuc Fac Med 1992;134:105-8. PMID: 1364952

Prognosis

The impact of diabetes on visual acuity in Ethiopia, 2021.
Asemu MT, Ahunie MA
PLoS One 2021;16(8):e0256145. Epub 2021 Aug 13 doi: 10.1371/journal.pone.0256145. PMID: 34388219Free PMC Article
Management of traumatic hyphema.
Walton W, Von Hagen S, Grigorian R, Zarbin M
Surv Ophthalmol 2002 Jul-Aug;47(4):297-334. doi: 10.1016/s0039-6257(02)00317-x. PMID: 12161209
Rubeosis iridis and neovascular glaucoma: II. Our own experiences with the treatment by cryocoagulation.
Rehák J
Acta Univ Palacki Olomuc Fac Med 1992;134:105-8. PMID: 1364952
Rubeosis iridis and neovascular glaucoma: I. Etiopathogenesis and treatment--the present state of the problem.
Rehák J
Acta Univ Palacki Olomuc Fac Med 1992;134:101-3. PMID: 1364951
The ocular ischemic syndrome.
Dhooge M, de Laey JJ
Bull Soc Belge Ophtalmol 1989;231:1-13. PMID: 2488440

Clinical prediction guides

The impact of diabetes on visual acuity in Ethiopia, 2021.
Asemu MT, Ahunie MA
PLoS One 2021;16(8):e0256145. Epub 2021 Aug 13 doi: 10.1371/journal.pone.0256145. PMID: 34388219Free PMC Article
The uPAR System as a Potential Therapeutic Target in the Diseased Eye.
Cammalleri M, Dal Monte M, Pavone V, De Rosa M, Rusciano D, Bagnoli P
Cells 2019 Aug 18;8(8) doi: 10.3390/cells8080925. PMID: 31426601Free PMC Article
Etiology and Features of Eyes with Rubeosis Iridis among Korean Patients: A Population-Based Single Center Study.
Jeong YC, Hwang YH
PLoS One 2016;11(8):e0160662. Epub 2016 Aug 4 doi: 10.1371/journal.pone.0160662. PMID: 27490797Free PMC Article
Green cataract.
Drews RC
Klin Monbl Augenheilkd 1994 Nov;205(5):301-4. doi: 10.1055/s-2008-1045533. PMID: 7844946
Ocular complications.
Engerman R, Finkelstein D, Aguirre G, Diddie KR, Fox RR, Frank RN, Varma SD
Diabetes 1982;31(Suppl 1 Pt 2):82-8. doi: 10.2337/diab.31.1.s82. PMID: 6819171

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