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Mesocardia

MedGen UID:
488817
Concept ID:
C0265865
Congenital Abnormality; Finding
Synonyms: Heart in central chest; mesocardia; mesocardia (disease); Midline heart
SNOMED CT: Midline heart (16567006); Mesocardia (16567006); Heart in central chest (16567006)
 
HPO: HP:0011599
Monarch Initiative: MONDO:0019807
Orphanet: ORPHA95443

Definition

Mesocardia is an abnormal location of the heart in which the heart is in a midline position and the longitudinal axis of the heart lies in the mid-sagittal plane. [from HPO]

Conditions with this feature

Floating-Harbor syndrome
MedGen UID:
152667
Concept ID:
C0729582
Disease or Syndrome
Floating-Harbor syndrome (FHS) is characterized by typical craniofacial features; low birth weight, normal head circumference, and short stature; bone age delay that normalizes between ages six and 12 years; skeletal anomalies (brachydactyly, clubbing, clinodactyly, short thumbs, prominent joints, clavicular abnormalities); severe receptive and expressive language impairment; hypernasality and high-pitched voice; and intellectual disability that is typically mild to moderate. Difficulties with temperament and behavior that are present in many children tend to improve in adulthood. Other features can include hyperopia and/or strabismus, conductive hearing loss, seizures, gastroesophageal reflux, renal anomalies (e.g., hydronephrosis / renal pelviectasis, cysts, and/or agenesis), and genital anomalies (e.g., hypospadias and/or undescended testes).
Heterotaxy, visceral, 2, autosomal
MedGen UID:
237904
Concept ID:
C1415817
Disease or Syndrome
The more common form of transposition of the great arteries, dextro-looped TGA, consists of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. (In the less common type of TGA, levo-looped TGA, the ventricles are inverted instead) (Goldmuntz et al., 2002). This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. Patients with TGA often have atrial and/or ventricular septal defects or other types of shunting that allow some mixing between the circulations in order to support life minimally, but surgical intervention is always required. For a discussion of genetic heterogeneity of dextro-looped transposition of the great arteries, see 608808.
Cardiac-urogenital syndrome
MedGen UID:
1648333
Concept ID:
C4748946
Disease or Syndrome
Cardiac-urogenital syndrome is characterized by partial anomalous pulmonary venous return in association with tracheal anomalies, pulmonary hypoplasia, congenital diaphragmatic hernia, thyroid fibrosis, thymic involution, cleft spleen, penoscrotal hypospadias, and cryptorchidism (Pinz et al., 2018).

Professional guidelines

PubMed

Vorisek CN, Enzensberger C, Willomeit S, Kurkevych A, Stessig R, Ritgen J, Degenhardt J, Mielke G, Bosselmann S, Krapp M, Slodki M, Respondek-Liberska M, Wolter A, Kawecki A, Goette M, Axt-Fliedner R
Ultraschall Med 2021 Jun;42(3):291-296. Epub 2020 Jan 29 doi: 10.1055/a-1069-7698. PMID: 31995816

Recent clinical studies

Etiology

Dalldorf K, Parness I, Ezon D
Pediatr Cardiol 2022 Jun;43(5):1094-1103. Epub 2022 Feb 2 doi: 10.1007/s00246-022-02829-9. PMID: 35107630
Liu X, Chen W, Li W, Priest JR, Fu Y, Pang K, Ma B, Han B, Liu X, Hu S, Zhou Z
Circ Res 2020 Mar 27;126(7):811-821. Epub 2020 Feb 11 doi: 10.1161/CIRCRESAHA.119.315821. PMID: 32078439
Bhatnagar P, Bhatnagar S
Ann Thorac Surg 2018 Jul;106(1):e3-e5. Epub 2018 Mar 13 doi: 10.1016/j.athoracsur.2018.02.023. PMID: 29549008
Ali MA, Tazmin T, Latif T, Haque SA, Hossain MA, Islam MN, Khan RH, Hoque MA
Mymensingh Med J 2016 Jan;25(1):153-7. PMID: 26931266
Falkensammer CB, Ayres NA, Altman CA, Ge S, Bezold LI, Eidem BW, Kovalchin JP
Am J Perinatol 2008 May;25(5):277-81. Epub 2008 Apr 9 doi: 10.1055/s-2008-1066874. PMID: 18401841

Diagnosis

Kumar S, Nandyal SR, Kaushik S, Ibrahim S
BMJ Case Rep 2022 Apr 25;15(4) doi: 10.1136/bcr-2022-249263. PMID: 35470165Free PMC Article
Dalldorf K, Parness I, Ezon D
Pediatr Cardiol 2022 Jun;43(5):1094-1103. Epub 2022 Feb 2 doi: 10.1007/s00246-022-02829-9. PMID: 35107630
Vorisek CN, Enzensberger C, Willomeit S, Kurkevych A, Stessig R, Ritgen J, Degenhardt J, Mielke G, Bosselmann S, Krapp M, Slodki M, Respondek-Liberska M, Wolter A, Kawecki A, Goette M, Axt-Fliedner R
Ultraschall Med 2021 Jun;42(3):291-296. Epub 2020 Jan 29 doi: 10.1055/a-1069-7698. PMID: 31995816
Kantzis M, Happel CM, Haas NA
Cardiol Young 2018 Feb;28(2):229-233. Epub 2017 Oct 4 doi: 10.1017/S1047951117001743. PMID: 28974283
Ali MA, Tazmin T, Latif T, Haque SA, Hossain MA, Islam MN, Khan RH, Hoque MA
Mymensingh Med J 2016 Jan;25(1):153-7. PMID: 26931266

Therapy

Ozkan H, Cetinkaya M, Köksal N, Yapici S
J Matern Fetal Neonatal Med 2011 Mar;24(3):521-4. doi: 10.3109/14767058.2010.501120. PMID: 21291342
Clarke CJ, Jayakumar KA, Hoyer AW
Pediatr Cardiol 2010 May;31(4):562-3. Epub 2010 Jan 5 doi: 10.1007/s00246-009-9618-8. PMID: 20049427

Prognosis

Bhatnagar P, Bhatnagar S
Ann Thorac Surg 2018 Jul;106(1):e3-e5. Epub 2018 Mar 13 doi: 10.1016/j.athoracsur.2018.02.023. PMID: 29549008
Abdullah NL, Quek SC, Seto KY, Teo LL
Singapore Med J 2015 Apr;56(4):198-201; quiz 202. doi: 10.11622/smedj.2015059. PMID: 25917470Free PMC Article
Secchi F, Resta EC, Di Leo G, Petrini M, Messina C, Carminati M, Sardanelli F
Int J Cardiovasc Imaging 2014 Aug;30(6):1117-24. Epub 2014 May 7 doi: 10.1007/s10554-014-0438-4. PMID: 24801178
Ozkan H, Cetinkaya M, Köksal N, Yapici S
J Matern Fetal Neonatal Med 2011 Mar;24(3):521-4. doi: 10.3109/14767058.2010.501120. PMID: 21291342
Russo P, Danielson GK, Driscoll DJ
Circulation 1987 Sep;76(3 Pt 2):III88-92. PMID: 3621545

Clinical prediction guides

Vorisek CN, Enzensberger C, Willomeit S, Kurkevych A, Stessig R, Ritgen J, Degenhardt J, Mielke G, Bosselmann S, Krapp M, Slodki M, Respondek-Liberska M, Wolter A, Kawecki A, Goette M, Axt-Fliedner R
Ultraschall Med 2021 Jun;42(3):291-296. Epub 2020 Jan 29 doi: 10.1055/a-1069-7698. PMID: 31995816
Liu X, Chen W, Li W, Priest JR, Fu Y, Pang K, Ma B, Han B, Liu X, Hu S, Zhou Z
Circ Res 2020 Mar 27;126(7):811-821. Epub 2020 Feb 11 doi: 10.1161/CIRCRESAHA.119.315821. PMID: 32078439
Secchi F, Resta EC, Di Leo G, Petrini M, Messina C, Carminati M, Sardanelli F
Int J Cardiovasc Imaging 2014 Aug;30(6):1117-24. Epub 2014 May 7 doi: 10.1007/s10554-014-0438-4. PMID: 24801178
Paladini D, Volpe P, Marasini M, Russo MG, Vassallo M, Gentile M, Calabrò R
Ultrasound Obstet Gynecol 2006 Mar;27(3):281-5. doi: 10.1002/uog.2715. PMID: 16485324
DaCosta H, Pathak A, Noronha O, Dalal S, Shah K, Merchant S
Eur J Nucl Med 1981;6(6):265-7. doi: 10.1007/BF00251350. PMID: 7238544

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