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Thyrotoxicosis with diffuse goiter

MedGen UID:
488851
•Concept ID:
C0342122
•
Disease or Syndrome
Synonym: Toxic diffuse goiter
SNOMED CT: Toxic diffuse thyroid goiter (267374005); Toxic primary thyroid hyperplasia (267374005); Thyrotoxicosis with diffuse goiter (267374005); Toxic diffuse goiter (267374005); Diffuse toxic goiter (267374005)
 
HPO: HP:0011784
Monarch Initiative: MONDO:0001104

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyrotoxicosis with diffuse goiter

Professional guidelines

PubMed

Current approach to surgical management of hyperthyroidism.
Barczyński M
Q J Nucl Med Mol Imaging 2021 Jun;65(2):124-131. Epub 2021 Jan 26 doi: 10.23736/S1824-4785.21.03330-6. PMID: 33494587
Management of thyrotoxicosis in children and adolescents: 35 years' experience in 304 patients.
Azizi F, Amouzegar A
J Pediatr Endocrinol Metab 2018 Jan 26;31(2):159-165. doi: 10.1515/jpem-2017-0394. PMID: 29306930
Thyroid masses: approach to diagnosis and management in childhood and adolescence.
Hopwood NJ, Kelch RP
Pediatr Rev 1993 Dec;14(12):481-7. PMID: 8115286

Curated

UK NICE Guideline NG145, Thyroid disease: assessment and management, 2023

Recent clinical studies

Etiology

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Current approach to surgical management of hyperthyroidism.
Barczyński M
Q J Nucl Med Mol Imaging 2021 Jun;65(2):124-131. Epub 2021 Jan 26 doi: 10.23736/S1824-4785.21.03330-6. PMID: 33494587
Thyroid cancer in patients with hyperthyroidism.
Pazaitou-Panayiotou K, Michalakis K, Paschke R
Horm Metab Res 2012 Apr;44(4):255-62. Epub 2012 Feb 14 doi: 10.1055/s-0031-1299741. PMID: 22334393
A clinical and therapeutic approach to thyrotoxicosis with thyroid-stimulating hormone suppression only.
Papi G, Pearce EN, Braverman LE, Betterle C, Roti E
Am J Med 2005 Apr;118(4):349-61. doi: 10.1016/j.amjmed.2005.01.004. PMID: 15808130

Diagnosis

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Thyroid functional and molecular imaging.
Giovanella L, Avram AM, Ovčariček PP, Clerc J
Presse Med 2022 Jun;51(2):104116. Epub 2022 Feb 4 doi: 10.1016/j.lpm.2022.104116. PMID: 35124101
Molecular Imaging for Thyrotoxicosis and Thyroid Nodules.
Giovanella L, Avram A, Clerc J
J Nucl Med 2021 Jul;62(Suppl 2):20S-25S. doi: 10.2967/jnumed.120.246017. PMID: 34230069
Diagnosis and classification of Graves' disease.
Menconi F, Marcocci C, Marinò M
Autoimmun Rev 2014 Apr-May;13(4-5):398-402. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.013. PMID: 24424182
Central hyperthyroidism.
McDermott MT, Ridgway EC
Endocrinol Metab Clin North Am 1998 Mar;27(1):187-203. doi: 10.1016/s0889-8529(05)70306-6. PMID: 9534036

Therapy

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Graves' disease after exposure to the SARS-CoV-2 vaccine: a case report and review of the literature.
Takedani K, Notsu M, Ishiai N, Asami Y, Uchida K, Kanasaki K
BMC Endocr Disord 2023 Jun 15;23(1):132. doi: 10.1186/s12902-023-01387-2. PMID: 37316819Free PMC Article
Management of thyrotoxicosis in children and adolescents: 35 years' experience in 304 patients.
Azizi F, Amouzegar A
J Pediatr Endocrinol Metab 2018 Jan 26;31(2):159-165. doi: 10.1515/jpem-2017-0394. PMID: 29306930
The safety and efficacy of antithyroid drugs.
Azizi F
Expert Opin Drug Saf 2006 Jan;5(1):107-16. doi: 10.1517/14740338.5.1.107. PMID: 16370960
Intervention in Graves' disease. Choosing among imperfect but effective treatment options.
Caruso DR, Mazzaferri EL
Postgrad Med 1992 Dec;92(8):117-24, 128-9, 133-4. doi: 10.1080/00325481.1992.11701555. PMID: 1280817

Prognosis

Study and Correlation of Clinical, Laboratory and Radiological Findings in the Diagnosis of Thyroid Disorders.
Upadhyay I, Kukrele P
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443327
Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Diagnosis and classification of Graves' disease.
Menconi F, Marcocci C, Marinò M
Autoimmun Rev 2014 Apr-May;13(4-5):398-402. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.013. PMID: 24424182
Thyroid cancer in patients with hyperthyroidism.
Pazaitou-Panayiotou K, Michalakis K, Paschke R
Horm Metab Res 2012 Apr;44(4):255-62. Epub 2012 Feb 14 doi: 10.1055/s-0031-1299741. PMID: 22334393
The safety and efficacy of antithyroid drugs.
Azizi F
Expert Opin Drug Saf 2006 Jan;5(1):107-16. doi: 10.1517/14740338.5.1.107. PMID: 16370960

Clinical prediction guides

Hyperthyroidism: A Review.
Lee SY, Pearce EN
JAMA 2023 Oct 17;330(15):1472-1483. doi: 10.1001/jama.2023.19052. PMID: 37847271Free PMC Article
Study and Correlation of Clinical, Laboratory and Radiological Findings in the Diagnosis of Thyroid Disorders.
Upadhyay I, Kukrele P
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443327
Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Diagnosis and classification of Graves' disease.
Menconi F, Marcocci C, Marinò M
Autoimmun Rev 2014 Apr-May;13(4-5):398-402. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.013. PMID: 24424182
T4-thyrotoxicosis.
Dorfman SG, Young RL
Arch Intern Med 1978 Jun;138(6):1016-7. PMID: 580554

Recent systematic reviews

A systematic review of the incidence of thyroid carcinoma in patients undergoing thyroidectomy for thyrotoxicosis.
Varadharajan K, Choudhury N
Clin Otolaryngol 2020 Jul;45(4):538-544. Epub 2020 Apr 20 doi: 10.1111/coa.13527. PMID: 32149464

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG145, Thyroid disease: assessment and management, 2023

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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