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Skin-picking

MedGen UID:
488979
Concept ID:
C1696701
Mental or Behavioral Dysfunction
Synonyms: Behavior, Skin Picking; Dermatillomania; Dermatillomanias; Disorder, Excoriation; Disorder, Skin Picking; Excoriation Disorder; Excoriation Disorders; Pathologic Skin Picking; Pathologic Skin Picking Disorder; Pathological Skin Picking Disorder; Picking Behavior, Skin; Picking Disorder, Skin; Picking, Skin; Skin Picking; Skin Picking Behavior; Skin Picking Behaviors; Skin Picking Disorder; Skin Picking Disorders; Skin Picking, Pathologic
 
HPO: HP:0012166

Definition

Repetitive and compulsive picking of skin which results in tissue damage. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin-picking

Conditions with this feature

Obsessive-compulsive disorder
MedGen UID:
14445
Concept ID:
C0028768
Mental or Behavioral Dysfunction
Obsessive-compulsive disorder (OCD) is characterized by recurring obsessions and/or compulsions and has been estimated to affect nearly 5 million people in the United States (Karno et al., 1988). Evidence for a strong genetic component in OCD comes from twin studies, family genetics studies, and segregation analyses, as reviewed by Alsobrook et al. (2002). Zhang et al. (2002) suggested that hoarding is likely to be an evolutionarily conserved trait that, in times of adversity, was associated with increased survival and reproductive fitness. However, extreme forms of this trait are associated with marked disability and poor response to treatment (Black et al., 1998; Mataix-Cols et al., 1999).
Chromosome 2q37 deletion syndrome
MedGen UID:
419169
Concept ID:
C2931817
Disease or Syndrome
Patients with chromosome 2q37 deletion syndrome show highly variable clinical manifestations likely resulting from different deletion sizes and deletions of different genes. Variable clinical features included brachydactyly type E (BDE), affecting the metacarpals and metatarsals (in about 50% of patients), short stature, mild to moderate intellectual disability, behavioral abnormalities, and dysmorphic facial features. However, many individuals with deletions do not show cognitive deficits (summary by Villavicencio-Lorini et al., 2013, Wheeler et al., 2014, Jean-Marcais et al., 2015).
O'Donnell-Luria-Rodan syndrome
MedGen UID:
1677602
Concept ID:
C5193138
Disease or Syndrome
O'Donnell-Luria-Rodan syndrome (ODLURO) is a neurodevelopmental disorder characterized by global developmental delay, speech delay, variably delayed intellectual development, and subtle dysmorphic features. Some patients may have autism, seizures, hypotonia, and/or feeding difficulties (summary by O'Donnell-Luria et al., 2019).
Schaaf-Yang syndrome
MedGen UID:
1807366
Concept ID:
C5575066
Disease or Syndrome
Schaaf-Yang syndrome (SYS) is a rare neurodevelopmental disorder that shares multiple clinical features with the genetically related Prader-Willi syndrome. It usually manifests at birth with muscular hypotonia in all and distal joint contractures in a majority of affected individuals. Gastrointestinal/feeding problems are particularly pronounced in infancy and childhood, but can transition to hyperphagia and obesity in adulthood. Respiratory distress is present in many individuals at birth, with approximately half requiring intubation and mechanical ventilation, and approximately 20% requiring tracheostomy. Skeletal manifestations such as joint contractures, scoliosis, and decreased bone mineral density are frequently observed. All affected individuals show developmental delay, resulting in intellectual disability of variable degree, from low-normal intelligence to severe intellectual disability. Other findings may include short stature, seizures, eye anomalies, and hypogonadism.
Parenti-mignot neurodevelopmental syndrome
MedGen UID:
1808333
Concept ID:
C5676984
Disease or Syndrome
Parenti-Mignot neurodevelopmental syndrome (PMNDS) is an autosomal dominant neurodevelopmental disorder frequently characterized by impaired intellectual development, speech delay, motor delay, behavioral problems, and epilepsy (Parenti et al., 2021).

Professional guidelines

PubMed

Butler MG, Miller JL, Forster JL
Curr Pediatr Rev 2019;15(4):207-244. doi: 10.2174/1573396315666190716120925. PMID: 31333129Free PMC Article
Sani G, Gualtieri I, Paolini M, Bonanni L, Spinazzola E, Maggiora M, Pinzone V, Brugnoli R, Angeletti G, Girardi P, Rapinesi C, Kotzalidis GD
Curr Neuropharmacol 2019;17(8):775-786. doi: 10.2174/1570159X17666190320164223. PMID: 30892151Free PMC Article
Dreno B, Bagatin E, Blume-Peytavi U, Rocha M, Gollnick H
J Dtsch Dermatol Ges 2018 Oct;16(10):1185-1194. Epub 2018 Sep 24 doi: 10.1111/ddg.13664. PMID: 30248242

Recent clinical studies

Etiology

Grant JE, Chesivoir E, Valle S, Ehsan D, Chamberlain SR
Am J Psychiatry 2023 May 1;180(5):348-356. Epub 2023 Feb 22 doi: 10.1176/appi.ajp.20220737. PMID: 36856701
Lee DK, Lipner SR
Int J Environ Res Public Health 2022 May 24;19(11) doi: 10.3390/ijerph19116370. PMID: 35681955Free PMC Article
Mattina GF, Slyepchenko A, Steiner M
Handb Clin Neurol 2020;175:369-386. doi: 10.1016/B978-0-444-64123-6.00025-4. PMID: 33008538
Dreno B, Bagatin E, Blume-Peytavi U, Rocha M, Gollnick H
J Dtsch Dermatol Ges 2018 Oct;16(10):1185-1194. Epub 2018 Sep 24 doi: 10.1111/ddg.13664. PMID: 30248242
Grant JE, Chamberlain SR, Redden SA, Leppink EW, Odlaug BL, Kim SW
JAMA Psychiatry 2016 May 1;73(5):490-6. doi: 10.1001/jamapsychiatry.2016.0060. PMID: 27007062

Diagnosis

Grant JE, Chesivoir E, Valle S, Ehsan D, Chamberlain SR
Am J Psychiatry 2023 May 1;180(5):348-356. Epub 2023 Feb 22 doi: 10.1176/appi.ajp.20220737. PMID: 36856701
Nwankwo CO, Jafferany M
Dermatol Ther 2019 Sep;32(5):e13073. Epub 2019 Sep 4 doi: 10.1111/dth.13073. PMID: 31444827
Butler MG, Miller JL, Forster JL
Curr Pediatr Rev 2019;15(4):207-244. doi: 10.2174/1573396315666190716120925. PMID: 31333129Free PMC Article
Dreno B, Bagatin E, Blume-Peytavi U, Rocha M, Gollnick H
J Dtsch Dermatol Ges 2018 Oct;16(10):1185-1194. Epub 2018 Sep 24 doi: 10.1111/ddg.13664. PMID: 30248242
Grant JE, Chamberlain SR, Redden SA, Leppink EW, Odlaug BL, Kim SW
JAMA Psychiatry 2016 May 1;73(5):490-6. doi: 10.1001/jamapsychiatry.2016.0060. PMID: 27007062

Therapy

Grant JE, Chesivoir E, Valle S, Ehsan D, Chamberlain SR
Am J Psychiatry 2023 May 1;180(5):348-356. Epub 2023 Feb 22 doi: 10.1176/appi.ajp.20220737. PMID: 36856701
Sani G, Gualtieri I, Paolini M, Bonanni L, Spinazzola E, Maggiora M, Pinzone V, Brugnoli R, Angeletti G, Girardi P, Rapinesi C, Kotzalidis GD
Curr Neuropharmacol 2019;17(8):775-786. doi: 10.2174/1570159X17666190320164223. PMID: 30892151Free PMC Article
Adil M, Amin SS, Mohtashim M
Indian J Dermatol Venereol Leprol 2018 Nov-Dec;84(6):652-659. doi: 10.4103/ijdvl.IJDVL_33_18. PMID: 30246706
Grant JE, Chamberlain SR, Redden SA, Leppink EW, Odlaug BL, Kim SW
JAMA Psychiatry 2016 May 1;73(5):490-6. doi: 10.1001/jamapsychiatry.2016.0060. PMID: 27007062
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927

Prognosis

Grant JE, Collins M, Chamberlain SR
Ann Clin Psychiatry 2023 Nov;35(4):228-233. doi: 10.12788/acp.0120. PMID: 37850990
Kłosowska J, Prochwicz K, Sznajder D, Antosz-Rekucka R, Tuleja A, Dembińska A, Snorrason I
Int J Environ Res Public Health 2022 Feb 23;19(5) doi: 10.3390/ijerph19052578. PMID: 35270270Free PMC Article
Valle S, Chesivoir E, Grant JE
Psychiatr Q 2022 Jun;93(2):409-418. Epub 2021 Oct 6 doi: 10.1007/s11126-021-09961-4. PMID: 34613556
Mattina GF, Slyepchenko A, Steiner M
Handb Clin Neurol 2020;175:369-386. doi: 10.1016/B978-0-444-64123-6.00025-4. PMID: 33008538
Nwankwo CO, Jafferany M
Dermatol Ther 2019 Sep;32(5):e13073. Epub 2019 Sep 4 doi: 10.1111/dth.13073. PMID: 31444827

Clinical prediction guides

Grant JE, Valle S, Aslan I, Chesivoir EK, Chamberlain SR
Ann Clin Psychiatry 2023 May;35(2):87-92. doi: 10.12788/acp.0096. PMID: 37074974Free PMC Article
Grant JE, Chesivoir E, Valle S, Ehsan D, Chamberlain SR
Am J Psychiatry 2023 May 1;180(5):348-356. Epub 2023 Feb 22 doi: 10.1176/appi.ajp.20220737. PMID: 36856701
Grant JE, Chamberlain SR
BMC Psychiatry 2021 Apr 21;21(1):203. doi: 10.1186/s12888-021-03209-y. PMID: 33882867Free PMC Article
Bull LE, Oliver C, Woodcock KA
J Autism Dev Disord 2021 Jan;51(1):286-297. doi: 10.1007/s10803-020-04504-5. PMID: 32495267
Grant JE, Chamberlain SR, Redden SA, Leppink EW, Odlaug BL, Kim SW
JAMA Psychiatry 2016 May 1;73(5):490-6. doi: 10.1001/jamapsychiatry.2016.0060. PMID: 27007062

Recent systematic reviews

Sani G, Gualtieri I, Paolini M, Bonanni L, Spinazzola E, Maggiora M, Pinzone V, Brugnoli R, Angeletti G, Girardi P, Rapinesi C, Kotzalidis GD
Curr Neuropharmacol 2019;17(8):775-786. doi: 10.2174/1570159X17666190320164223. PMID: 30892151Free PMC Article
Selles RR, McGuire JF, Small BJ, Storch EA
Gen Hosp Psychiatry 2016 Jul-Aug;41:29-37. Epub 2016 Apr 13 doi: 10.1016/j.genhosppsych.2016.04.001. PMID: 27143352
Schumer MC, Bartley CA, Bloch MH
J Clin Psychopharmacol 2016 Apr;36(2):147-52. doi: 10.1097/JCP.0000000000000462. PMID: 26872117Free PMC Article
Bonnot O, Cohen D, Thuilleaux D, Consoli A, Cabal S, Tauber M
Eur J Pediatr 2016 Jan;175(1):9-18. Epub 2015 Nov 19 doi: 10.1007/s00431-015-2670-x. PMID: 26584571
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927

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