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Neoplasm of the skeletal system

MedGen UID:: 488993
•Concept ID:: C2732838
•: Neoplastic Process

Synonym:	Bone neoplasm
SNOMED CT:	Neoplasm of skeletal system (442868003)

HPO:	HP:0010622
Monarch Initiative:	MONDO:0019060
Orphanet:	ORPHA68411

Definition

A tumor (abnormal growth of tissue) of the skeleton. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeoplasm of the skeletal system

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the skeletal system
    - Abnormal skeletal morphology
      - Neoplasm of the skeletal system
        Adamantinoma
        Tibial adamantinoma
        Aneurysmal bone cyst
        Bone cyst
        Cystic angiomatosis of bone
        Multiple bony cystic lesions
        Unicameral bone cyst
        Chondroblastoma
        Maxillofacial Chondroblastoma
        Chondromyxoid fibroma
        Maxillofacial Chondromyxoid Fibroma
        Sternal Chondromyxoid Fibroma
        Chordoma
        Conventional Chordoma
        Chondroid chordoma
        Dedifferentiated Chordoma
        Recurrent Dedifferentiated Chordoma
        Refractory Dedifferentiated Chordoma
        Sellar Dedifferentiated Chordoma
        Metastatic Chordoma
        Advanced Chordoma
        Locally Advanced Chordoma
        Poorly differentiated chordoma
        Recurrent Chordoma
        Refractory Chordoma
        Skull base chordoma
        Clivus chordoma
        Sellar Chordoma
        Spinal chordoma
        Sacral Chordoma
        Thoracic Chordoma
        Unresectable Chordoma
        Diaphyseal medullary stenosis-bone malignancy syndrome
        Enchondroma
        Enchondromatosis
        Exostoses
        Exostoses of hand bones
        Exostoses of the forearm bones
        Exostoses of the radius
        Exostosis of external ear canal
        Heberden node
        Heel spur
        Multiple congenital exostosis
        Exostoses, multiple, type 2
        Exostoses, multiple, type III
        Multiple digital exostoses
        Multiple long-bone exostoses
        Osteophyte of bone
        Pelvic bone exostoses
        Rib exostoses
        Scapular exostoses
        Giant cell tumor of bone
        Gigantiform cementoma
        Maffucci syndrome
        OSLAM syndrome
        Osteoblastoma
        Cementoma
        Maxillofacial Osteoblastoma
        Osteochondroma
        Multiple Osteochondromas
        Solitary Osteochondroma
        Osteochondromyxoma
        Osteoma
        Enostosis
        Ivory Exostosis
        Osteoid osteoma
        Maxillofacial Osteoid Osteoma
        Skull Osteoma
        Maxillofacial Osteoma

Professional guidelines

PubMed

Diagnosis and Management of Multiple Myeloma: A Review.

Cowan AJ, Green DJ, Kwok M, Lee S, Coffey DG, Holmberg LA, Tuazon S, Gopal AK, Libby EN
JAMA 2022 Feb 1;327(5):464-477. doi: 10.1001/jama.2022.0003. PMID: 35103762

Epidemiology, Staging, and Management of Multiple Myeloma.

Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH
Med Sci (Basel) 2021 Jan 20;9(1) doi: 10.3390/medsci9010003. PMID: 33498356 Free PMC Article

Bone Pain in Cancer Patients: Mechanisms and Current Treatment.

Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267 Free PMC Article

Recent clinical studies

Diagnosis

Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses.

Liang WS, Dardis C, Helland A, Sekar S, Adkins J, Cuyugan L, Enriquez D, Byron S, Little AS
Cold Spring Harb Mol Case Stud 2018 Dec;4(6) Epub 2018 Dec 17 doi: 10.1101/mcs.a003418. PMID: 30322893 Free PMC Article

Therapy

Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses.

Liang WS, Dardis C, Helland A, Sekar S, Adkins J, Cuyugan L, Enriquez D, Byron S, Little AS
Cold Spring Harb Mol Case Stud 2018 Dec;4(6) Epub 2018 Dec 17 doi: 10.1101/mcs.a003418. PMID: 30322893 Free PMC Article

Prognosis

Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses.

Liang WS, Dardis C, Helland A, Sekar S, Adkins J, Cuyugan L, Enriquez D, Byron S, Little AS
Cold Spring Harb Mol Case Stud 2018 Dec;4(6) Epub 2018 Dec 17 doi: 10.1101/mcs.a003418. PMID: 30322893 Free PMC Article

Clinical prediction guides

Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses.

Liang WS, Dardis C, Helland A, Sekar S, Adkins J, Cuyugan L, Enriquez D, Byron S, Little AS
Cold Spring Harb Mol Case Stud 2018 Dec;4(6) Epub 2018 Dec 17 doi: 10.1101/mcs.a003418. PMID: 30322893 Free PMC Article

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

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Consumer resources

MedlinePlus

Reviews

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