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Neovascular glaucoma

MedGen UID:
4898
•Concept ID:
C0017609
•
Disease or Syndrome
Synonyms: Glaucoma, Neovascular; Glaucomas, Neovascular; Neovascular Glaucoma; Neovascular Glaucomas
SNOMED CT: Secondary angle closure glaucoma with rubeosis (232086000); Rubeotic glaucoma (232086000); Neovascular glaucoma (232086000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019783
Orphanet: ORPHA94058

Definition

Neovascular glaucoma is the most common type of secondary glaucoma, usually caused by diabetic retinopathy, central retinal vein occlusion and carotid artery obstruction but sometimes by trauma, uvietis or ocular tumors, and characterized by severe eye pain, synechial angle glaucoma, high intraocular pressure and leading to loss of vision. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeovascular glaucoma
Follow this link to review classifications for Neovascular glaucoma in Orphanet.

Professional guidelines

PubMed

A Review of Neovascular Glaucoma: Etiology, Pathogenesis, Diagnosis, and Treatment.
Urbonavičiūtė D, Buteikienė D, Janulevičienė I
Medicina (Kaunas) 2022 Dec 18;58(12) doi: 10.3390/medicina58121870. PMID: 36557072Free PMC Article
A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Retinal vein thrombosis: pathogenesis and management.
Rehak M, Wiedemann P
J Thromb Haemost 2010 Sep;8(9):1886-94. doi: 10.1111/j.1538-7836.2010.03909.x. PMID: 20492457

Recent clinical studies

Etiology

Infections and glaucoma.
Aldaas K, Challa P, Weber DJ, Fleischman D
Surv Ophthalmol 2022 May-Jun;67(3):637-658. Epub 2021 Sep 4 doi: 10.1016/j.survophthal.2021.08.009. PMID: 34487741
A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Photocoagulation for retinal vein occlusion.
Hayreh SS
Prog Retin Eye Res 2021 Nov;85:100964. Epub 2021 Mar 11 doi: 10.1016/j.preteyeres.2021.100964. PMID: 33713810
Neovascular Glaucoma.
Havens SJ, Gulati V
Dev Ophthalmol 2016;55:196-204. Epub 2015 Oct 26 doi: 10.1159/000431196. PMID: 26501989Free PMC Article
Endoscopic cyclophotocoagulation.
Lin S
Br J Ophthalmol 2002 Dec;86(12):1434-8. doi: 10.1136/bjo.86.12.1434. PMID: 12446381Free PMC Article

Diagnosis

The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy.
Tang Y, Shi Y, Fan Z
Front Endocrinol (Lausanne) 2023;14:1102361. Epub 2023 Jan 23 doi: 10.3389/fendo.2023.1102361. PMID: 36755912Free PMC Article
A Review of Neovascular Glaucoma: Etiology, Pathogenesis, Diagnosis, and Treatment.
Urbonavičiūtė D, Buteikienė D, Janulevičienė I
Medicina (Kaunas) 2022 Dec 18;58(12) doi: 10.3390/medicina58121870. PMID: 36557072Free PMC Article
A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Neovascular glaucoma - A review.
Senthil S, Dada T, Das T, Kaushik S, Puthuran GV, Philip R, Rani PK, Rao H, Singla S, Vijaya L
Indian J Ophthalmol 2021 Mar;69(3):525-534. doi: 10.4103/ijo.IJO_1591_20. PMID: 33595466Free PMC Article
Retinal vein thrombosis: pathogenesis and management.
Rehak M, Wiedemann P
J Thromb Haemost 2010 Sep;8(9):1886-94. doi: 10.1111/j.1538-7836.2010.03909.x. PMID: 20492457

Therapy

A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Photocoagulation for retinal vein occlusion.
Hayreh SS
Prog Retin Eye Res 2021 Nov;85:100964. Epub 2021 Mar 11 doi: 10.1016/j.preteyeres.2021.100964. PMID: 33713810
Neovascular Glaucoma.
Havens SJ, Gulati V
Dev Ophthalmol 2016;55:196-204. Epub 2015 Oct 26 doi: 10.1159/000431196. PMID: 26501989Free PMC Article
Retinal vein thrombosis: pathogenesis and management.
Rehak M, Wiedemann P
J Thromb Haemost 2010 Sep;8(9):1886-94. doi: 10.1111/j.1538-7836.2010.03909.x. PMID: 20492457
Endoscopic cyclophotocoagulation.
Lin S
Br J Ophthalmol 2002 Dec;86(12):1434-8. doi: 10.1136/bjo.86.12.1434. PMID: 12446381Free PMC Article

Prognosis

Neovascular Glaucoma: An Update.
Kalogeropoulos D, Moussa G, Sung VC, Pappa C, Kalogeropoulos C
Klin Monbl Augenheilkd 2023 Mar;240(3):305-315. Epub 2022 Nov 27 doi: 10.1055/a-1956-9348. PMID: 36436509
A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Surgical Management and Techniques.
Codenotti M, Iuliano L, Maestranzi G
Dev Ophthalmol 2017;60:143-159. Epub 2017 Apr 20 doi: 10.1159/000459702. PMID: 28427073
NEOVASCULAR SECONDARY GLAUCOMA, ETIOLOGY AND PATHOGENESIS.
Barac IR, Pop MD, Gheorghe AI, Taban C
Rom J Ophthalmol 2015 Jan-Mar;59(1):24-8. PMID: 27373111Free PMC Article
Endoscopic cyclophotocoagulation.
Lin S
Br J Ophthalmol 2002 Dec;86(12):1434-8. doi: 10.1136/bjo.86.12.1434. PMID: 12446381Free PMC Article

Clinical prediction guides

The role of Anti-VEGF agents in treatment of neovascular glaucoma.
Palfi Salavat MC, Șeclăman EP, Barac R, Ungureanu E, Iorgu G, Artamonov A, Leuștean L, Borugă MV
Rom J Ophthalmol 2022 Jul-Sep;66(3):209-213. doi: 10.22336/rjo.2022.41. PMID: 36349171Free PMC Article
Outcomes of Ahmed glaucoma valve and transscleral cyclophotocoagulation in neovascular glaucoma.
Shalaby WS, Ganjei AY, Wogu B, Myers JS, Moster MR, Razeghinejad R, Lee D, Kolomeyer NN, Eid TE, Katz LJ, Shukla AG
Indian J Ophthalmol 2022 Apr;70(4):1253-1259. doi: 10.4103/ijo.IJO_2107_21. PMID: 35326027Free PMC Article
Outcomes of Valved and Nonvalved Tube Shunts in Neovascular Glaucoma.
Shalaby WS, Myers JS, Razeghinejad R, Katz LJ, Pro M, Dale E, Fudemberg SJ, Mantravadi AV, Shukla AG
Ophthalmol Glaucoma 2021 Mar-Apr;4(2):182-192. Epub 2020 Sep 18 doi: 10.1016/j.ogla.2020.09.010. PMID: 32956898
Management and Systemic Implications of Diabetic Neovascular Glaucoma.
Sánchez-Tabernero S, Juberías JR, Artells N, Crespo-Millas S, Meneses C, Muñoz-Moreno MF, Manzanas L, López Gálvez MI
Ophthalmic Res 2019;62(2):111-115. Epub 2019 Jun 5 doi: 10.1159/000500607. PMID: 31167215
Endoscopic cyclophotocoagulation.
Lin S
Br J Ophthalmol 2002 Dec;86(12):1434-8. doi: 10.1136/bjo.86.12.1434. PMID: 12446381Free PMC Article

Recent systematic reviews

Short-Term Outcomes of Trabeculectomy With or Without Anti-VEGF in Patients With Neovascular Glaucoma: A Systematic Review and Meta-Analysis.
Zhou X, Chen J, Luo W, Du Y
Transl Vis Sci Technol 2023 Sep 1;12(9):12. doi: 10.1167/tvst.12.9.12. PMID: 37728893Free PMC Article
The incidence and risk factors of neovascular glaucoma secondary to proliferative diabetic retinopathy after vitrectomy.
Sun D, Lin Y, Zeng R, Yang Z, Deng X, Lan Y
Eur J Ophthalmol 2021 Nov;31(6):3057-3067. Epub 2020 Dec 18 doi: 10.1177/1120672120980686. PMID: 33334171
Surgical treatment of neovascular glaucoma: a systematic review and meta-analysis.
Shchomak Z, Cordeiro Sousa D, Leal I, Abegão Pinto L
Graefes Arch Clin Exp Ophthalmol 2019 Jun;257(6):1079-1089. Epub 2019 Feb 6 doi: 10.1007/s00417-019-04256-8. PMID: 30726529
Ocular ischemic syndrome - a systematic review.
Terelak-Borys B, Skonieczna K, Grabska-Liberek I
Med Sci Monit 2012 Aug;18(8):RA138-144. doi: 10.12659/msm.883260. PMID: 22847215Free PMC Article
Glaucoma drainage devices: a systematic literature review and current controversies.
Hong CH, Arosemena A, Zurakowski D, Ayyala RS
Surv Ophthalmol 2005 Jan-Feb;50(1):48-60. doi: 10.1016/j.survophthal.2004.10.006. PMID: 15621077

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