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Glomus tumor

MedGen UID:
4903
Concept ID:
C0017653
Neoplastic Process
Synonyms: Glomus Tumor; Glomus Tumors; Tumor, Glomus; Tumors, Glomus
SNOMED CT: Glomus tumor (403969002); Glomus tumor (10438002)
 
Monarch Initiative: MONDO:0018327
Orphanet: ORPHA391651

Definition

A rare soft tissue tumor characterized by a nodular lesion composed of cells closely resembling the modified smooth muscle cells of the normal glomus body. The tumors most often arise in the skin or soft tissues of the distal extremities, in particular the subungual region, but have been reported in almost any location. They occur as typical glomus tumors, glomangiomatosis (multiple nodules of solid glomus tumor investing the vascular walls), symplastic (showing striking nuclear atypia without mitotic activity or necrosis) or malignant glomus tumors, and glomus tumors of uncertain malignant potential. [from ORDO]

Professional guidelines

PubMed

Starace M, Rubin AI, Di Chiacchio NG, Pampaloni F, Alessandrini A, Piraccini BM, Iorizzo M
J Dtsch Dermatol Ges 2023 Feb;21(2):116-129. doi: 10.1111/ddg.14942. PMID: 36808456
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Wanna GB, Sweeney AD, Haynes DS, Carlson ML
Otolaryngol Clin North Am 2015 Apr;48(2):331-41. doi: 10.1016/j.otc.2014.12.007. PMID: 25769354

Recent clinical studies

Etiology

Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Xing JJ, Huang WP, Wang F, Chai YR, Gao JB
BMC Gastroenterol 2022 Apr 9;22(1):174. doi: 10.1186/s12876-022-02241-w. PMID: 35397495Free PMC Article
Valero C, Ganly I
J Oral Pathol Med 2022 Nov;51(10):897-903. Epub 2022 Feb 23 doi: 10.1111/jop.13286. PMID: 35178777
Spina A, Boari N, Gagliardi F, Bailo M, Del Vecchio A, Bolognesi A, Mortini P
Head Neck 2018 Dec;40(12):2677-2684. Epub 2018 Nov 20 doi: 10.1002/hed.25517. PMID: 30456888
Mravic M, LaChaud G, Nguyen A, Scott MA, Dry SM, James AW
Int J Surg Pathol 2015 May;23(3):181-8. Epub 2015 Jan 22 doi: 10.1177/1066896914567330. PMID: 25614464Free PMC Article

Diagnosis

Huang JS, Wang D
J Pediatr Gastroenterol Nutr 2023 Apr 1;76(4):e81. Epub 2022 Dec 27 doi: 10.1097/MPG.0000000000003691. PMID: 36728817
Sethu C, Sethu AU
Ann R Coll Surg Engl 2016 Jan;98(1):e1-2. doi: 10.1308/rcsann.2016.0005. PMID: 26688416Free PMC Article
Mravic M, LaChaud G, Nguyen A, Scott MA, Dry SM, James AW
Int J Surg Pathol 2015 May;23(3):181-8. Epub 2015 Jan 22 doi: 10.1177/1066896914567330. PMID: 25614464Free PMC Article
Gombos Z, Zhang PJ
Arch Pathol Lab Med 2008 Sep;132(9):1448-52. doi: 10.5858/2008-132-1448-GT. PMID: 18788860
McDermott EM, Weiss AP
J Hand Surg Am 2006 Oct;31(8):1397-400. doi: 10.1016/j.jhsa.2006.05.018. PMID: 17027805

Therapy

Wang J, Liu C, Ao W, An Y, Zhang W, Niu Z, Jia Y
J Int Med Res 2020 Aug;48(8):300060520936194. doi: 10.1177/0300060520936194. PMID: 32779507Free PMC Article
Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY
World J Gastroenterol 2017 Apr 14;23(14):2493-2504. doi: 10.3748/wjg.v23.i14.2493. PMID: 28465633Free PMC Article
Ashour R, Aziz-Sultan A
Neurosurg Clin N Am 2014 Jul;25(3):607-17. Epub 2014 May 20 doi: 10.1016/j.nec.2014.04.015. PMID: 24994094
Harrison B, Moore AM, Calfee R, Sammer DM
J Hand Surg Am 2013 Aug;38(8):1571-4. Epub 2013 Jul 9 doi: 10.1016/j.jhsa.2013.05.025. PMID: 23849732
Dalfior D, Parisi A, Cannizzaro C, Bontempini L, Di Pace C, Menestrina F, Dalla Palma P, Barbareschi M
Int J Surg Pathol 2008 Jan;16(1):81-4. doi: 10.1177/1066896907304520. PMID: 18203793

Prognosis

Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Spina A, Boari N, Gagliardi F, Bailo M, Del Vecchio A, Bolognesi A, Mortini P
Head Neck 2018 Dec;40(12):2677-2684. Epub 2018 Nov 20 doi: 10.1002/hed.25517. PMID: 30456888
Park ES, Kim J, Jun SY
Head Neck 2017 Sep;39(9):1897-1909. Epub 2017 May 12 doi: 10.1002/hed.24818. PMID: 28497509
Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY
World J Gastroenterol 2017 Apr 14;23(14):2493-2504. doi: 10.3748/wjg.v23.i14.2493. PMID: 28465633Free PMC Article

Clinical prediction guides

Xing JJ, Huang WP, Wang F, Chai YR, Gao JB
BMC Gastroenterol 2022 Apr 9;22(1):174. doi: 10.1186/s12876-022-02241-w. PMID: 35397495Free PMC Article
Valero C, Ganly I
J Oral Pathol Med 2022 Nov;51(10):897-903. Epub 2022 Feb 23 doi: 10.1111/jop.13286. PMID: 35178777
Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY
World J Gastroenterol 2017 Apr 14;23(14):2493-2504. doi: 10.3748/wjg.v23.i14.2493. PMID: 28465633Free PMC Article
Smith KJ, Skelton HG, Barrett TL, Lupton GP, Graham JH
Mod Pathol 1989 Nov;2(6):603-9. PMID: 2587567

Recent systematic reviews

Pansa A, Samà L, Ruspi L, Sicoli F, Cananzi FCM, Quagliuolo V
Dig Dis 2023;41(1):17-33. Epub 2022 Jun 26 doi: 10.1159/000525513. PMID: 35753305
Yuhan BT, Trang A, Hutz MJ, Leonetti JP
Otolaryngol Head Neck Surg 2020 Apr;162(4):458-468. Epub 2020 Feb 25 doi: 10.1177/0194599820907303. PMID: 32093508
Oliver JD, Boczar D, Huayllani MT, Restrepo DJ, Sisti A, Manrique OJ, Broer PN, Forte AJ
Ann Plast Surg 2019 Dec;83(6):e77-e84. doi: 10.1097/SAP.0000000000002004. PMID: 31599787
Park ES, Kim J, Jun SY
Head Neck 2017 Sep;39(9):1897-1909. Epub 2017 May 12 doi: 10.1002/hed.24818. PMID: 28497509

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