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Balkan nephropathy(BEN)

MedGen UID:
495
Concept ID:
C0004698
Disease or Syndrome
Synonyms: Aristolochic acid nephropathy; Balkan endemic nephropathy; Danubian endemic familial nephropathy; Nephropathia epidemica
SNOMED CT: Balkan nephropathy (26121002)
 
Monarch Initiative: MONDO:0007416
OMIM®: 124100

Definition

A chronic tubulointerstitial nephropathy that affects people in certain rural areas along the Danube river in the Balkans. It leads to end-stage renal disease. [from MONDO]

Clinical features

From HPO
Kidney disorder
MedGen UID:
9635
Concept ID:
C0022658
Disease or Syndrome
A nonspecific term referring to disease or damage of the kidneys.

Professional guidelines

PubMed

Jelaković B, Nikolić J, Radovanović Z, Nortier J, Cosyns JP, Grollman AP, Bašić-Jukić N, Belicza M, Bukvić D, Čavaljuga S, Čvorišćec D, Cvitković A, Dika Ž, Dimitrov P, Đukanović L, Edwards K, Ferluga D, Fuštar-Preradović L, Gluhovschi G, Imamović G, Jakovina T, Kes P, Leko N, Medverec Z, Mesić E, Miletić-Medved M, Miller F, Pavlović N, Pasini J, Pleština S, Polenaković M, Stefanović V, Tomić K, Trnačević S, Vuković Lela I, Štern-Padovan R
Nephrol Dial Transplant 2014 Nov;29(11):2020-7. Epub 2013 Oct 28 doi: 10.1093/ndt/gft384. PMID: 24166461Free PMC Article
Ozsahin M, Ugurluer G, Zouhair A
Swiss Med Wkly 2009 Jun 27;139(25-26):353-6. doi: 10.4414/smw.2009.12676. PMID: 19562529
Ikonomov V, Melzer H, Nenov V, Stoicheva A, Stiller S, Mann H
Artif Organs 1999 Jan;23(1):75-80. doi: 10.1046/j.1525-1594.1999.06281.x. PMID: 9950183

Recent clinical studies

Etiology

Malir F, Ostry V, Pfohl-Leszkowicz A, Malir J, Toman J
Toxins (Basel) 2016 Jul 4;8(7) doi: 10.3390/toxins8070191. PMID: 27384585Free PMC Article
Stefanovic V, Toncheva D, Polenakovic M
Clin Nephrol 2015;83(7 Suppl 1):64-9. doi: 10.5414/cnp83s064. PMID: 25725245
Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY, Yang CW
Lancet 2013 Jul 20;382(9888):260-72. Epub 2013 May 31 doi: 10.1016/S0140-6736(13)60687-X. PMID: 23727169
Gökmen MR, Lord GM
BMJ 2012 Jun 15;344:e4000. doi: 10.1136/bmj.e4000. PMID: 22705815
Barceloux DG
J Toxicol Clin Toxicol 1999;37(2):145-72. doi: 10.1081/clt-100102417. PMID: 10382553

Diagnosis

Jelaković B, Dika Ž, Arlt VM, Stiborova M, Pavlović NM, Nikolić J, Colet JM, Vanherweghem JL, Nortier JL
Semin Nephrol 2019 May;39(3):284-296. doi: 10.1016/j.semnephrol.2019.02.007. PMID: 31054628
Wernerson A, Wijkström J, Elinder CG
Curr Opin Nephrol Hypertens 2014 May;23(3):232-8. doi: 10.1097/01.mnh.0000444911.32794.e7. PMID: 24717833
Jelaković B, Nikolić J, Radovanović Z, Nortier J, Cosyns JP, Grollman AP, Bašić-Jukić N, Belicza M, Bukvić D, Čavaljuga S, Čvorišćec D, Cvitković A, Dika Ž, Dimitrov P, Đukanović L, Edwards K, Ferluga D, Fuštar-Preradović L, Gluhovschi G, Imamović G, Jakovina T, Kes P, Leko N, Medverec Z, Mesić E, Miletić-Medved M, Miller F, Pavlović N, Pasini J, Pleština S, Polenaković M, Stefanović V, Tomić K, Trnačević S, Vuković Lela I, Štern-Padovan R
Nephrol Dial Transplant 2014 Nov;29(11):2020-7. Epub 2013 Oct 28 doi: 10.1093/ndt/gft384. PMID: 24166461Free PMC Article
Ghahramani N
Int J Occup Environ Med 2010 Jul;1(3):108-115. PMID: 23022796
Papper S
Contrib Nephrol 1980;23:204-19. doi: 10.1159/000390008. PMID: 7002450

Therapy

Jelaković B, Dika Ž, Arlt VM, Stiborova M, Pavlović NM, Nikolić J, Colet JM, Vanherweghem JL, Nortier JL
Semin Nephrol 2019 May;39(3):284-296. doi: 10.1016/j.semnephrol.2019.02.007. PMID: 31054628
Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY, Yang CW
Lancet 2013 Jul 20;382(9888):260-72. Epub 2013 May 31 doi: 10.1016/S0140-6736(13)60687-X. PMID: 23727169
Ghahramani N
Int J Occup Environ Med 2010 Jul;1(3):108-115. PMID: 23022796
IARC Monogr Eval Carcinog Risks Hum 1993;56:489-521. PMID: 8411629Free PMC Article
Austwick PK
Proc R Soc Med 1975 Apr;68(4):219-21. PMID: 1197312Free PMC Article

Prognosis

Stefanovic V, Toncheva D, Polenakovic M
Clin Nephrol 2015;83(7 Suppl 1):64-9. doi: 10.5414/cnp83s064. PMID: 25725245
Wernerson A, Wijkström J, Elinder CG
Curr Opin Nephrol Hypertens 2014 May;23(3):232-8. doi: 10.1097/01.mnh.0000444911.32794.e7. PMID: 24717833
Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY, Yang CW
Lancet 2013 Jul 20;382(9888):260-72. Epub 2013 May 31 doi: 10.1016/S0140-6736(13)60687-X. PMID: 23727169
Debelle FD, Vanherweghem JL, Nortier JL
Kidney Int 2008 Jul;74(2):158-69. Epub 2008 Apr 16 doi: 10.1038/ki.2008.129. PMID: 18418355
Wibell L
Ups J Med Sci 1985;90(1):5-14. doi: 10.3109/03009738509178632. PMID: 3890321

Clinical prediction guides

Martynova E, Stott-Marshall RJ, Shakirova V, Saubanova A, Bulatova A, Davidyuk YN, Kabwe E, Markelova M, Khaertynova I, Foster TL, Khaiboullina S
Int J Mol Sci 2023 Apr 10;24(8) doi: 10.3390/ijms24087016. PMID: 37108178Free PMC Article
Dittrich D, Maskalan M, Kastelan Z, Palenkic H, Grubic Z
Gene 2021 Jan 30;767:145179. Epub 2020 Sep 28 doi: 10.1016/j.gene.2020.145179. PMID: 33002571
Stefanović V, Pešić I, Cukuranović R, Müller G, Dihazi H
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2014;35(1):35-42. PMID: 24798594
Debelle FD, Vanherweghem JL, Nortier JL
Kidney Int 2008 Jul;74(2):158-69. Epub 2008 Apr 16 doi: 10.1038/ki.2008.129. PMID: 18418355
Stefanovic V, Radovanovic Z
Nat Clin Pract Urol 2008 Feb;5(2):105-12. doi: 10.1038/ncpuro1019. PMID: 18259188

Recent systematic reviews

Bui-Klimke TR, Wu F
Crit Rev Food Sci Nutr 2015;55(13):1860-9. doi: 10.1080/10408398.2012.724480. PMID: 24874522Free PMC Article

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