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Eosinophilic granuloma

MedGen UID:
4979
Concept ID:
C0014461
Neoplastic Process
Synonyms: Eosinophilic Granuloma; Eosinophilic Granulomas; Granuloma, Eosinophilic; Granulomas, Eosinophilic
SNOMED CT: Eosinophilic granuloma (128810002); Eosinophilic granuloma (129000002); Eosinophilic xanthomatous granuloma (129000002)
 
HPO: HP:0032253
Monarch Initiative: MONDO:0020517

Definition

A type of granuloma characterized morphologically by the predominance of Langerhans cells with characteristic grooved, folded, indented nuclei in the appropriate milieu that includes variable numbers of eosinophils and histiocytes including multinucleated forms, often appearing similar to osteoclasts or touton like giant cells, neutrophils and small lymphocytes. The concentration of the eosinophilic infiltrate varies from scattered mature cells to sheet-like masses of cells. Occasionally, areas of bone necrosis may interrupt the cellular infiltrate. The foamy cells may also be amassed in clumps, which are of no clinical significance because these clumps represent phagocytosis of lipid debris. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEosinophilic granuloma
Follow this link to review classifications for Eosinophilic granuloma in Orphanet.

Conditions with this feature

DOCK2 deficiency
MedGen UID:
901370
Concept ID:
C4225328
Disease or Syndrome
Immunodeficiency-40 is an autosomal recessive primary form of combined immunodeficiency mainly affecting T-cell number and function, with other more variable defects in B-cell and NK-cell function. Patients have onset of severe invasive bacterial and viral infections in early childhood and may die without bone marrow transplantation (summary by Dobbs et al., 2015).

Professional guidelines

PubMed

Angelini A, Mavrogenis AF, Rimondi E, Rossi G, Ruggieri P
J Orthop Traumatol 2017 Jun;18(2):83-90. Epub 2016 Oct 21 doi: 10.1007/s10195-016-0434-7. PMID: 27770337Free PMC Article
DiCaprio MR, Roberts TT
J Am Acad Orthop Surg 2014 Oct;22(10):643-52. doi: 10.5435/JAAOS-22-10-643. PMID: 25281259
Azouz EM, Saigal G, Rodriguez MM, Podda A
Pediatr Radiol 2005 Feb;35(2):103-15. Epub 2004 Jul 28 doi: 10.1007/s00247-004-1262-0. PMID: 15289942

Recent clinical studies

Etiology

Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Ann Rheum Dis 2022 Mar;81(3):309-314. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221794. PMID: 35110334
Zhao SS, Yan LF, Feng XL, Du P, Chen BY, Dong WT, Gao Y, He JB, Cui GB, Wang W
J Orthop Surg Res 2019 May 9;14(1):123. doi: 10.1186/s13018-019-1158-1. PMID: 31072377Free PMC Article
Steinfeld J, Bradford ES, Brown J, Mallett S, Yancey SW, Akuthota P, Cid MC, Gleich GJ, Jayne D, Khoury P, Langford CA, Merkel PA, Moosig F, Specks U, Weller PF, Wechsler ME
J Allergy Clin Immunol 2019 Jun;143(6):2170-2177. Epub 2018 Dec 19 doi: 10.1016/j.jaci.2018.11.041. PMID: 30578883Free PMC Article
Angelini A, Mavrogenis AF, Rimondi E, Rossi G, Ruggieri P
J Orthop Traumatol 2017 Jun;18(2):83-90. Epub 2016 Oct 21 doi: 10.1007/s10195-016-0434-7. PMID: 27770337Free PMC Article
Cline MJ
Blood 1994 Nov 1;84(9):2840-53. PMID: 7524755

Diagnosis

Divakaran S, Dellaripa P, Kobzik L, Levy B, Loscalzo J
N Engl J Med 2017 Aug 3;377(5):477-484. doi: 10.1056/NEJMcps1607526. PMID: 28767340
Angelini A, Mavrogenis AF, Rimondi E, Rossi G, Ruggieri P
J Orthop Traumatol 2017 Jun;18(2):83-90. Epub 2016 Oct 21 doi: 10.1007/s10195-016-0434-7. PMID: 27770337Free PMC Article
Duncan WK, Post AC, McCoy BP
Oral Surg Oral Med Oral Pathol 1988 Jun;65(6):736-41. doi: 10.1016/0030-4220(88)90020-5. PMID: 3041337
Oldham RK
South Med J 1971 Aug;64(8):978-82. doi: 10.1097/00007611-197108000-00016. PMID: 5565339
PRYSE-DAVIES J
J Clin Pathol 1964 Jan;17(1):90-4. doi: 10.1136/jcp.17.1.90. PMID: 14100012Free PMC Article

Therapy

Steinfeld J, Bradford ES, Brown J, Mallett S, Yancey SW, Akuthota P, Cid MC, Gleich GJ, Jayne D, Khoury P, Langford CA, Merkel PA, Moosig F, Specks U, Weller PF, Wechsler ME
J Allergy Clin Immunol 2019 Jun;143(6):2170-2177. Epub 2018 Dec 19 doi: 10.1016/j.jaci.2018.11.041. PMID: 30578883Free PMC Article
Divakaran S, Dellaripa P, Kobzik L, Levy B, Loscalzo J
N Engl J Med 2017 Aug 3;377(5):477-484. doi: 10.1056/NEJMcps1607526. PMID: 28767340
Divakaran S, Vaidya A, Kobzik L, Dellaripa P
N Engl J Med 2017 Jul 27;377(4):e6. doi: 10.1056/NEJMimc1613182. PMID: 28745993
Murin S, Bilello KS, Matthay R
Clin Chest Med 2000 Mar;21(1):121-37, ix. doi: 10.1016/s0272-5231(05)70012-5. PMID: 10763094
Oldham RK
South Med J 1971 Aug;64(8):978-82. doi: 10.1097/00007611-197108000-00016. PMID: 5565339

Prognosis

Zhao SS, Yan LF, Feng XL, Du P, Chen BY, Dong WT, Gao Y, He JB, Cui GB, Wang W
J Orthop Surg Res 2019 May 9;14(1):123. doi: 10.1186/s13018-019-1158-1. PMID: 31072377Free PMC Article
Angelini A, Mavrogenis AF, Rimondi E, Rossi G, Ruggieri P
J Orthop Traumatol 2017 Jun;18(2):83-90. Epub 2016 Oct 21 doi: 10.1007/s10195-016-0434-7. PMID: 27770337Free PMC Article
Garnett MR, Puget S, Grill J, Sainte-Rose C
Orphanet J Rare Dis 2007 Apr 10;2:18. doi: 10.1186/1750-1172-2-18. PMID: 17425791Free PMC Article
Cline MJ
Blood 1994 Nov 1;84(9):2840-53. PMID: 7524755
Favara BE, McCarthy RC, Mierau GW
Hum Pathol 1983 Aug;14(8):663-76. doi: 10.1016/s0046-8177(83)80138-5. PMID: 6347865

Clinical prediction guides

Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA; DCVAS Study Group
Ann Rheum Dis 2022 Mar;81(3):309-314. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221794. PMID: 35110334
Zhao SS, Yan LF, Feng XL, Du P, Chen BY, Dong WT, Gao Y, He JB, Cui GB, Wang W
J Orthop Surg Res 2019 May 9;14(1):123. doi: 10.1186/s13018-019-1158-1. PMID: 31072377Free PMC Article
Steinfeld J, Bradford ES, Brown J, Mallett S, Yancey SW, Akuthota P, Cid MC, Gleich GJ, Jayne D, Khoury P, Langford CA, Merkel PA, Moosig F, Specks U, Weller PF, Wechsler ME
J Allergy Clin Immunol 2019 Jun;143(6):2170-2177. Epub 2018 Dec 19 doi: 10.1016/j.jaci.2018.11.041. PMID: 30578883Free PMC Article
Poveda-Roda R, Bagán JV, Sanchis JM, Margaix M
Med Oral Patol Oral Cir Bucal 2013 May 1;18(3):e392-402. doi: 10.4317/medoral.18799. PMID: 23385515Free PMC Article
Thakur NA, Daniels AH, Schiller J, Valdes MA, Czerwein JK, Schiller A, Esmende S, Terek RM
J Am Acad Orthop Surg 2012 Nov;20(11):715-24. doi: 10.5435/JAAOS-20-11-715. PMID: 23118137

Recent systematic reviews

Benato A, Riva G, Raneri F
Childs Nerv Syst 2023 Aug;39(8):2221-2227. Epub 2023 Mar 20 doi: 10.1007/s00381-023-05926-z. PMID: 36939904Free PMC Article
Chen T, Ashman PE, Bojrab DI 2nd, Johnson AP, Benson B, Hong RS, Svider PF
Otolaryngol Head Neck Surg 2022 Jan;166(1):48-59. Epub 2021 May 4 doi: 10.1177/01945998211004590. PMID: 33945752
Tripathi M, Maskara P, Deora H, Bansal D, Mohindra S, Tripathi S, Kaur R, Sheehan JP, Rana R, Kumar N
World Neurosurg 2021 Jun;150:64-70. Epub 2021 Mar 17 doi: 10.1016/j.wneu.2021.03.047. PMID: 33744421
Chugh A, Kaur A, Kumar Patnana A, Kumar P, Chugh VK
Oral Maxillofac Surg 2021 Dec;25(4):429-444. Epub 2021 Feb 16 doi: 10.1007/s10006-021-00949-9. PMID: 33591444

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