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myoclonic epilepsy

MedGen UID:
4988
Concept ID:
C0014550
Disease or Syndrome
Synonyms: Epilepsies, Myoclonic; Epilepsy, Myoclonic; Epilepsy, Myoclonus; Myoclonic Epilepsies; Myoclonic Epilepsy; Myoclonic Seizure Disorder; Myoclonic Seizure Disorders; Myoclonus Epilepsies; Myoclonus Epilepsy; Seizure Disorder, Myoclonic; Seizure Disorders, Myoclonic

Definition

A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • myoclonic epilepsy

Professional guidelines

PubMed

Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Moshé SL, Tinuper P, Wirrell EC
Epilepsia 2022 Jun;63(6):1475-1499. Epub 2022 May 3 doi: 10.1111/epi.17236. PMID: 35503716
Bayat A, Bayat M, Rubboli G, Møller RS
Genes (Basel) 2021 Jul 8;12(7) doi: 10.3390/genes12071051. PMID: 34356067Free PMC Article
Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386

Recent clinical studies

Etiology

Liu J, Tai YJ, Wang LN
Cochrane Database Syst Rev 2021 Nov 24;11(11):CD010008. doi: 10.1002/14651858.CD010008.pub5. PMID: 34817852Free PMC Article
Pietrafusa N, La Neve A, de Palma L, Boero G, Luisi C, Vigevano F, Specchio N
Brain Dev 2021 Jun;43(6):688-697. Epub 2021 Mar 27 doi: 10.1016/j.braindev.2021.02.005. PMID: 33781581
Park JT, Shahid AM, Jammoul A
Pediatr Ann 2015 Feb;44(2):e30-5. doi: 10.3928/00904481-20150203-09. PMID: 25658216
Fejerman N
Indian J Pediatr 1997 Sep-Oct;64(5):583-602. doi: 10.1007/BF02726110. PMID: 10771893
Doose H
Epilepsy Res Suppl 1992;6:163-8. PMID: 1418479

Diagnosis

Ghossein J, Pohl D
Epileptic Disord 2019 Dec 1;21(6):585-589. doi: 10.1684/epd.2019.1116. PMID: 31843733
Xu L, Guo D, Liu YY, Qiao DD, Ye JY, Xue R
Epilepsy Behav 2018 Mar;80:326-330. Epub 2018 Jan 19 doi: 10.1016/j.yebeh.2017.11.008. PMID: 29358100
Baykan B, Wolf P
Seizure 2017 Jul;49:36-41. Epub 2017 May 18 doi: 10.1016/j.seizure.2017.05.011. PMID: 28544889
Caraballo RH, Dalla Bernardina B
Handb Clin Neurol 2013;111:579-89. doi: 10.1016/B978-0-444-52891-9.00060-9. PMID: 23622205
Satishchandra P, Sinha S
Neurol India 2010 Jul-Aug;58(4):514-22. doi: 10.4103/0028-3886.68660. PMID: 20739785

Therapy

Xu L, Guo D, Liu YY, Qiao DD, Ye JY, Xue R
Epilepsy Behav 2018 Mar;80:326-330. Epub 2018 Jan 19 doi: 10.1016/j.yebeh.2017.11.008. PMID: 29358100
Poleon S, Szaflarski JP
Epilepsy Behav 2017 Mar;68:225-233. Epub 2017 Feb 16 doi: 10.1016/j.yebeh.2016.10.040. PMID: 28215998
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927
Aneja S, Sharma S
Indian Pediatr 2013 Nov 8;50(11):1033-40. doi: 10.1007/s13312-013-0284-9. PMID: 24382900
Ng YT, Collins SD
Neurotherapeutics 2007 Jan;4(1):138-44. doi: 10.1016/j.nurt.2006.11.002. PMID: 17199029Free PMC Article

Prognosis

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Moshé SL, Tinuper P, Wirrell EC
Epilepsia 2022 Jun;63(6):1475-1499. Epub 2022 May 3 doi: 10.1111/epi.17236. PMID: 35503716
Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386
Thakran S, Guin D, Singh P, Singh P, Kukal S, Rawat C, Yadav S, Kushwaha SS, Srivastava AK, Hasija Y, Saso L, Ramachandran S, Kukreti R
Int J Mol Sci 2020 Oct 21;21(20) doi: 10.3390/ijms21207784. PMID: 33096746Free PMC Article
Baykan B, Wolf P
Seizure 2017 Jul;49:36-41. Epub 2017 May 18 doi: 10.1016/j.seizure.2017.05.011. PMID: 28544889

Clinical prediction guides

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432Free PMC Article
Van Bogaert P
Epileptic Disord 2016 Sep 1;18(S2):115-119. doi: 10.1684/epd.2016.0856. PMID: 27629772
Franceschetti S, Canafoglia L
Epileptic Disord 2016 Sep 1;18(S2):89-93. doi: 10.1684/epd.2016.0845. PMID: 27621198
Schmitt B
Neuropediatrics 2015 Jun;46(3):171-80. Epub 2015 May 12 doi: 10.1055/s-0035-1551574. PMID: 25965811
Dravet C
Dev Med Child Neurol 2011 Apr;53 Suppl 2:1-6. doi: 10.1111/j.1469-8749.2011.03964.x. PMID: 21504424

Recent systematic reviews

Sanjari Moghaddam H, Sanjari Moghaddam A, Hasanzadeh A, Sanatian Z, Mafi A, Aarabi MH, Samimi M, Aghamollaii V, Gholipour T, Tafakhori A
Brain Imaging Behav 2022 Jun;16(3):1465-1494. Epub 2021 Nov 17 doi: 10.1007/s11682-021-00595-5. PMID: 34786666
Liu J, Tai YJ, Wang LN
Cochrane Database Syst Rev 2021 Nov 24;11(11):CD010008. doi: 10.1002/14651858.CD010008.pub5. PMID: 34817852Free PMC Article
Giuliano L, Mainieri G, Aguglia U, Bilo L, Durante V, Ermio C, Galimberti CA, La Neve A, Monti G, Ranzato F, Zambrelli E, Mostacci B
Seizure 2021 Mar;86:41-48. Epub 2021 Jan 23 doi: 10.1016/j.seizure.2021.01.005. PMID: 33524768
Liu J, Wang LN, Wang YP
Cochrane Database Syst Rev 2017 Apr 23;4(4):CD010008. doi: 10.1002/14651858.CD010008.pub3. PMID: 28434203Free PMC Article
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927

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