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Anemia due to chronic disorder

MedGen UID:
507442
•Concept ID:
C0002873
•
Disease or Syndrome
Synonyms: anaemia due to Chronic Disorder; anaemia of chronic disease; anaemia of chronic disorder; anaemia of chronic illness; anaemia of chronic inflammation; anaemia of systemic disease; Anemia due to Chronic Disorder; anemia due to chronic disorder; anemia due to Chronic Disorder; Anemia of chronic disease; anemia of chronic disease; Anemia of chronic disorder; anemia of chronic disorder; anemia of chronic illness; anemia of chronic inflammation; Anemia of systemic disease; anemia of systemic disease; Secondary anaemia; Secondary anemia
SNOMED CT: Anemia of chronic disease (234347009); Anemia of chronic disorder (234347009); Anemia of systemic disease (234347009); Secondary anemia (234347009)
 
Monarch Initiative: MONDO:0020725

Definition

Anemia due to a disorder that is persistent or long-standing in nature. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnemia due to chronic disorder

Professional guidelines

PubMed

Advances in the diagnosis and treatment of sickle cell disease.
Brandow AM, Liem RI
J Hematol Oncol 2022 Mar 3;15(1):20. doi: 10.1186/s13045-022-01237-z. PMID: 35241123Free PMC Article
Iron deficiency anaemia: pathophysiology, assessment, practical management.
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article

Recent clinical studies

Etiology

Effect of Roxadustat on Thyroid Function in Patients With Renal Anemia.
Haraguchi T, Hamamoto Y, Kuwata H, Yamazaki Y, Nakatani S, Hyo T, Yamada Y, Yabe D, Seino Y
J Clin Endocrinol Metab 2023 Dec 21;109(1):e69-e75. doi: 10.1210/clinem/dgad483. PMID: 37597171
Future perspectives of anemia management in chronic kidney disease using hypoxia-inducible factor-prolyl hydroxylase inhibitors.
Sugahara M, Tanaka T, Nangaku M
Pharmacol Ther 2022 Nov;239:108272. Epub 2022 Aug 27 doi: 10.1016/j.pharmthera.2022.108272. PMID: 36031160
Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries.
Chaparro CM, Suchdev PS
Ann N Y Acad Sci 2019 Aug;1450(1):15-31. Epub 2019 Apr 22 doi: 10.1111/nyas.14092. PMID: 31008520Free PMC Article
Sickle cell disease.
Ware RE, de Montalembert M, Tshilolo L, Abboud MR
Lancet 2017 Jul 15;390(10091):311-323. Epub 2017 Feb 1 doi: 10.1016/S0140-6736(17)30193-9. PMID: 28159390
Evaluation of anemia in children.
Janus J, Moerschel SK
Am Fam Physician 2010 Jun 15;81(12):1462-71. PMID: 20540485

Diagnosis

Novel anemia therapies in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Ku E, Del Vecchio L, Eckardt KU, Haase VH, Johansen KL, Nangaku M, Tangri N, Waikar SS, Więcek A, Cheung M, Jadoul M, Winkelmayer WC, Wheeler DC; for Conference Participants
Kidney Int 2023 Oct;104(4):655-680. Epub 2023 May 24 doi: 10.1016/j.kint.2023.05.009. PMID: 37236424
Iron deficiency anaemia: pathophysiology, assessment, practical management.
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
Anaemia of chronic diseases: Pathophysiology, diagnosis and treatment.
de Las Cuevas Allende R, Díaz de Entresotos L, Conde Díez S
Med Clin (Barc) 2021 Mar 12;156(5):235-242. Epub 2020 Dec 24 doi: 10.1016/j.medcli.2020.07.035. PMID: 33358297
Anaemia: A disease or symptom.
Newhall DA, Oliver R, Lugthart S
Neth J Med 2020 Apr;78(3):104-110. PMID: 32332184
Sickle cell disease.
Ware RE, de Montalembert M, Tshilolo L, Abboud MR
Lancet 2017 Jul 15;390(10091):311-323. Epub 2017 Feb 1 doi: 10.1016/S0140-6736(17)30193-9. PMID: 28159390

Therapy

Anaemia in CKD-treatment standard.
Macdougall IC
Nephrol Dial Transplant 2024 Apr 26;39(5):770-777. doi: 10.1093/ndt/gfad250. PMID: 38012124
Novel anemia therapies in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Ku E, Del Vecchio L, Eckardt KU, Haase VH, Johansen KL, Nangaku M, Tangri N, Waikar SS, Więcek A, Cheung M, Jadoul M, Winkelmayer WC, Wheeler DC; for Conference Participants
Kidney Int 2023 Oct;104(4):655-680. Epub 2023 May 24 doi: 10.1016/j.kint.2023.05.009. PMID: 37236424
Roxadustat Versus Epoetin Alfa for Treating Anemia in Patients with Chronic Kidney Disease on Dialysis: Results from the Randomized Phase 3 ROCKIES Study.
Fishbane S, Pollock CA, El-Shahawy M, Escudero ET, Rastogi A, Van BP, Frison L, Houser M, Pola M, Little DJ, Guzman N, Pergola PE
J Am Soc Nephrol 2022 Apr;33(4):850-866. doi: 10.1681/ASN.2020111638. PMID: 35361724Free PMC Article
Iron deficiency anaemia: pathophysiology, assessment, practical management.
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.
Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB; Conference Participants
Kidney Int 2021 Jun;99(6):1280-1295. Epub 2021 Apr 8 doi: 10.1016/j.kint.2021.03.020. PMID: 33839163

Prognosis

Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease.
Natale P, Palmer SC, Jaure A, Hodson EM, Ruospo M, Cooper TE, Hahn D, Saglimbene VM, Craig JC, Strippoli GF
Cochrane Database Syst Rev 2022 Aug 25;8(8):CD013751. doi: 10.1002/14651858.CD013751.pub2. PMID: 36005278Free PMC Article
The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation.
Marques O, Weiss G, Muckenthaler MU
Blood 2022 Nov 10;140(19):2011-2023. doi: 10.1182/blood.2021013472. PMID: 35994752
Iron deficiency anaemia: pathophysiology, assessment, practical management.
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018.
Fishbane S, Spinowitz B
Am J Kidney Dis 2018 Mar;71(3):423-435. Epub 2018 Jan 11 doi: 10.1053/j.ajkd.2017.09.026. PMID: 29336855
Meta-analysis of the association between preoperative anaemia and mortality after surgery.
Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM
Br J Surg 2015 Oct;102(11):1314-24. doi: 10.1002/bjs.9861. PMID: 26349842

Clinical prediction guides

Effect of Roxadustat on Thyroid Function in Patients With Renal Anemia.
Haraguchi T, Hamamoto Y, Kuwata H, Yamazaki Y, Nakatani S, Hyo T, Yamada Y, Yabe D, Seino Y
J Clin Endocrinol Metab 2023 Dec 21;109(1):e69-e75. doi: 10.1210/clinem/dgad483. PMID: 37597171
Burden of Anemia in Chronic Kidney Disease: Beyond Erythropoietin.
Hanna RM, Streja E, Kalantar-Zadeh K
Adv Ther 2021 Jan;38(1):52-75. Epub 2020 Oct 29 doi: 10.1007/s12325-020-01524-6. PMID: 33123967Free PMC Article
The Influence of Inflammation on Anemia in CKD Patients.
Gluba-Brzózka A, Franczyk B, Olszewski R, Rysz J
Int J Mol Sci 2020 Jan 22;21(3) doi: 10.3390/ijms21030725. PMID: 31979104Free PMC Article
Anaemia of Chronic Disease: An In-Depth Review.
Madu AJ, Ughasoro MD
Med Princ Pract 2017;26(1):1-9. Epub 2016 Sep 28 doi: 10.1159/000452104. PMID: 27756061Free PMC Article
Cardio-renal anemia syndrome.
von Haehling S, Anker SD
Contrib Nephrol 2011;171:266-273. Epub 2011 May 23 doi: 10.1159/000327342. PMID: 21625123

Recent systematic reviews

Hydroxyurea (hydroxycarbamide) for sickle cell disease.
Rankine-Mullings AE, Nevitt SJ
Cochrane Database Syst Rev 2022 Sep 1;9(9):CD002202. doi: 10.1002/14651858.CD002202.pub3. PMID: 36047926Free PMC Article
Osteoporosis in COPD patients: Risk factors and pulmonary rehabilitation.
Li Y, Gao H, Zhao L, Wang J
Clin Respir J 2022 Jul;16(7):487-496. Epub 2022 Jun 10 doi: 10.1111/crj.13514. PMID: 35688435Free PMC Article
Transfusion thresholds for guiding red blood cell transfusion.
Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Dorée C, Hébert PC
Cochrane Database Syst Rev 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5. PMID: 34932836Free PMC Article
Psychological therapies for the management of chronic and recurrent pain in children and adolescents.
Fisher E, Law E, Dudeney J, Palermo TM, Stewart G, Eccleston C
Cochrane Database Syst Rev 2018 Sep 29;9(9):CD003968. doi: 10.1002/14651858.CD003968.pub5. PMID: 30270423Free PMC Article
Insulin resistance in chronic kidney disease: a systematic review.
Spoto B, Pisano A, Zoccali C
Am J Physiol Renal Physiol 2016 Dec 1;311(6):F1087-F1108. Epub 2016 Oct 5 doi: 10.1152/ajprenal.00340.2016. PMID: 27707707

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