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Chronic cough

MedGen UID:
507601
Concept ID:
C0010201
Sign or Symptom
Synonyms: Chronic Cough; Chronic Coughs; Cough, Chronic; Cough, Nagging; Cough, Persistent; Nagging Cough; Nagging Coughs; Persistent Cough; Persistent Coughs
SNOMED CT: Chronic cough (68154008)
 
HPO: HP:0034315

Definition

A persistent cough, defined as a cough lasting longer than eight weeks in adults or longer than four weeks in children. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic cough

Conditions with this feature

Primary ciliary dyskinesia 25
MedGen UID:
815971
Concept ID:
C3809641
Disease or Syndrome
Primary ciliary dyskinesia-25 is an autosomal recessive disorder caused by defective ciliary movement. Affected individuals have recurrent upper and lower airway disease, bronchiectasis, and decreased fertility. About half of patients show laterality defects, including situs inversus totalis. Respiratory cilia from patients show defects in the inner and outer dynein arms (summary by Tarkar et al., 2013). For a general phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see 244400.
Immunodeficiency 53
MedGen UID:
1612104
Concept ID:
C4539811
Disease or Syndrome
Ciliary dyskinesia, primary, 49, without situs inversus
MedGen UID:
1824064
Concept ID:
C5774291
Disease or Syndrome
Primary ciliary dyskinesia-49 (CILD49) without situs inversus is an autosomal recessive disorder characterized by the onset of recurrent respiratory infections, chronic cough, and bronchiectasis in early childhood due to defective ciliary clearance. Affected males also show infertility due to defective flagellar morphology and function. Nasal nitric oxide (NO) levels are normal and situs abnormalities are not observed (Sha et al., 2020; Biebach et al., 2022). For a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).
Respiratory infections, recurrent, and failure to thrive with or without diarrhea
MedGen UID:
1824079
Concept ID:
C5774306
Disease or Syndrome
Recurrent respiratory infections and failure to thrive with or without diarrhea (RIFTD) is characterized by neonatal onset of chronic cough, episodic wheezing, recurrent lower respiratory tract infections, chronic diarrhea, and failure to thrive. Despite the resemblance to cystic fibrosis (CF; 219700), these patients have normal sweat chloride and pancreatic elastase tests (Bertoli-Avella et al., 2022).

Professional guidelines

PubMed

Morice AH, Millqvist E, Bieksiene K, Birring SS, Dicpinigaitis P, Domingo Ribas C, Hilton Boon M, Kantar A, Lai K, McGarvey L, Rigau D, Satia I, Smith J, Song WJ, Tonia T, van den Berg JWK, van Manen MJG, Zacharasiewicz A
Eur Respir J 2020 Jan;55(1) Epub 2020 Jan 2 doi: 10.1183/13993003.01136-2019. PMID: 31515408Free PMC Article
Michaudet C, Malaty J
Am Fam Physician 2017 Nov 1;96(9):575-580. PMID: 29094873
Gibson P, Wang G, McGarvey L, Vertigan AE, Altman KW, Birring SS; CHEST Expert Cough Panel
Chest 2016 Jan;149(1):27-44. Epub 2016 Jan 6 doi: 10.1378/chest.15-1496. PMID: 26426314Free PMC Article

Recent clinical studies

Etiology

Chung KF, McGarvey L, Song WJ, Chang AB, Lai K, Canning BJ, Birring SS, Smith JA, Mazzone SB
Nat Rev Dis Primers 2022 Jun 30;8(1):45. doi: 10.1038/s41572-022-00370-w. PMID: 35773287Free PMC Article
Krüger K, Holzinger F, Trauth J, Koch M, Heintze C, Gehrke-Beck S; Collaborators
Dtsch Arztebl Int 2022 Feb 4;119(5):59-65. doi: 10.3238/arztebl.m2021.0396. PMID: 34918623Free PMC Article
Zhang J, Perret JL, Chang AB, Idrose NS, Bui DS, Lowe AJ, Abramson MJ, Walters EH, Lodge CJ, Dharmage SC
Respirology 2022 Jan;27(1):36-47. Epub 2021 Oct 18 doi: 10.1111/resp.14169. PMID: 34658107
Visca D, Beghè B, Fabbri LM, Papi A, Spanevello A
Eur J Intern Med 2020 Nov;81:15-21. Epub 2020 Sep 19 doi: 10.1016/j.ejim.2020.09.008. PMID: 32958373Free PMC Article
Irwin RS, French CL, Chang AB, Altman KW; CHEST Expert Cough Panel*
Chest 2018 Jan;153(1):196-209. Epub 2017 Nov 10 doi: 10.1016/j.chest.2017.10.016. PMID: 29080708Free PMC Article

Diagnosis

Donaldson AM
Otolaryngol Clin North Am 2023 Feb;56(1):147-155. Epub 2022 Oct 22 doi: 10.1016/j.otc.2022.09.011. PMID: 36283869
Chung KF, McGarvey L, Song WJ, Chang AB, Lai K, Canning BJ, Birring SS, Smith JA, Mazzone SB
Nat Rev Dis Primers 2022 Jun 30;8(1):45. doi: 10.1038/s41572-022-00370-w. PMID: 35773287Free PMC Article
Krüger K, Holzinger F, Trauth J, Koch M, Heintze C, Gehrke-Beck S; Collaborators
Dtsch Arztebl Int 2022 Feb 4;119(5):59-65. doi: 10.3238/arztebl.m2021.0396. PMID: 34918623Free PMC Article
Morice A, Dicpinigaitis P, McGarvey L, Birring SS
Eur Respir Rev 2021 Dec 31;30(162) Epub 2021 Nov 30 doi: 10.1183/16000617.0127-2021. PMID: 34853095Free PMC Article
Chung KF, Pavord ID
Lancet 2008 Apr 19;371(9621):1364-74. doi: 10.1016/S0140-6736(08)60595-4. PMID: 18424325

Therapy

Krüger K, Holzinger F, Trauth J, Koch M, Heintze C, Gehrke-Beck S; Collaborators
Dtsch Arztebl Int 2022 Feb 4;119(5):59-65. doi: 10.3238/arztebl.m2021.0396. PMID: 34918623Free PMC Article
Zhang J, Perret JL, Chang AB, Idrose NS, Bui DS, Lowe AJ, Abramson MJ, Walters EH, Lodge CJ, Dharmage SC
Respirology 2022 Jan;27(1):36-47. Epub 2021 Oct 18 doi: 10.1111/resp.14169. PMID: 34658107
Mazzone SB, McGarvey L
Clin Pharmacol Ther 2021 Mar;109(3):619-636. Epub 2020 Aug 28 doi: 10.1002/cpt.2003. PMID: 32748976Free PMC Article
Gibson P, Wang G, McGarvey L, Vertigan AE, Altman KW, Birring SS; CHEST Expert Cough Panel
Chest 2016 Jan;149(1):27-44. Epub 2016 Jan 6 doi: 10.1378/chest.15-1496. PMID: 26426314Free PMC Article
Chung KF, Pavord ID
Lancet 2008 Apr 19;371(9621):1364-74. doi: 10.1016/S0140-6736(08)60595-4. PMID: 18424325

Prognosis

Munchel JK, Shea BS
R I Med J (2013) 2021 Sep 1;104(7):26-29. PMID: 34437662
Diver S, Russell RJ, Brightling CE
J Allergy Clin Immunol Pract 2019 Jul-Aug;7(6):1740-1747. doi: 10.1016/j.jaip.2019.04.048. PMID: 31279462
Irwin RS, French CL, Chang AB, Altman KW; CHEST Expert Cough Panel*
Chest 2018 Jan;153(1):196-209. Epub 2017 Nov 10 doi: 10.1016/j.chest.2017.10.016. PMID: 29080708Free PMC Article
McCallion P, De Soyza A
Pulm Pharmacol Ther 2017 Dec;47:77-83. Epub 2017 Jun 7 doi: 10.1016/j.pupt.2017.04.010. PMID: 28602999
O'Donnell AE
Chest 2008 Oct;134(4):815-823. doi: 10.1378/chest.08-0776. PMID: 18842914

Clinical prediction guides

Lee SP, Lee SM, Lee BJ, Kang SY
J Korean Med Sci 2022 Sep 19;37(36):e275. doi: 10.3346/jkms.2022.37.e275. PMID: 36123964Free PMC Article
McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J, Nguyen AM, Li Q, Tzontcheva A, Iskold B, Green SA, Rosa C, Muccino DR, Smith JA; COUGH-1 and COUGH-2 Investigators
Lancet 2022 Mar 5;399(10328):909-923. doi: 10.1016/S0140-6736(21)02348-5. PMID: 35248186
Zhang J, Perret JL, Chang AB, Idrose NS, Bui DS, Lowe AJ, Abramson MJ, Walters EH, Lodge CJ, Dharmage SC
Respirology 2022 Jan;27(1):36-47. Epub 2021 Oct 18 doi: 10.1111/resp.14169. PMID: 34658107
Irwin RS, French CL, Chang AB, Altman KW; CHEST Expert Cough Panel*
Chest 2018 Jan;153(1):196-209. Epub 2017 Nov 10 doi: 10.1016/j.chest.2017.10.016. PMID: 29080708Free PMC Article
Flament T, Bigot A, Chaigne B, Henique H, Diot E, Marchand-Adam S
Eur Respir Rev 2016 Jun;25(140):110-23. doi: 10.1183/16000617.0011-2016. PMID: 27246587Free PMC Article

Recent systematic reviews

Zhang J, Perret JL, Chang AB, Idrose NS, Bui DS, Lowe AJ, Abramson MJ, Walters EH, Lodge CJ, Dharmage SC
Respirology 2022 Jan;27(1):36-47. Epub 2021 Oct 18 doi: 10.1111/resp.14169. PMID: 34658107
Irwin RS, French CL, Chang AB, Altman KW; CHEST Expert Cough Panel*
Chest 2018 Jan;153(1):196-209. Epub 2017 Nov 10 doi: 10.1016/j.chest.2017.10.016. PMID: 29080708Free PMC Article
Gibson P, Wang G, McGarvey L, Vertigan AE, Altman KW, Birring SS; CHEST Expert Cough Panel
Chest 2016 Jan;149(1):27-44. Epub 2016 Jan 6 doi: 10.1378/chest.15-1496. PMID: 26426314Free PMC Article
Lee AL, Burge AT, Holland AE
Cochrane Database Syst Rev 2015 Nov 23;2015(11):CD008351. doi: 10.1002/14651858.CD008351.pub3. PMID: 26591003Free PMC Article
Magis-Escurra C, Reijers MH
BMJ Clin Evid 2015 Feb 25;2015 PMID: 25715965Free PMC Article

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