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Cystic acne

MedGen UID:
507614
Concept ID:
C0010666
Disease or Syndrome
Synonyms: Acne cystica; Cystic acne vulgaris
SNOMED CT: Cystic acne (13277001); Acne cystica (13277001); Cystic acne vulgaris (13277001)
 
HPO: HP:0033188

Definition

A severe type of acne characterized by the formation of cysts enclosing a mixture of keratin and sebum. [from HPO]

Conditions with this feature

Acute febrile neutrophilic dermatosis
MedGen UID:
43097
Concept ID:
C0085077
Disease or Syndrome
Acute febrile neutrophilic dermatosis (AFND) is an autosomal dominant autoinflammatory disorder characterized by onset of recurrent fever and dermatologic abnormalities in childhood. Laboratory studies show elevated acute-phase reactants and activation of the inflammatory response, particularly IL1B (147720). Additional more variable features may include myalgia and arthralgia (summary by Masters et al., 2016).
Pyogenic arthritis-pyoderma gangrenosum-acne syndrome
MedGen UID:
346801
Concept ID:
C1858361
Disease or Syndrome
A rare pleiotropic auto-inflammatory disorder of childhood, primarily affecting the joints and skin. The first affected family contained ten affected members from three generations and manifested variable expression of a pauciarticular, nonaxial, arthritis that began in childhood; pyoderma gangrenosum; and severe cystic acne in adolescence and beyond. Recurrent sterile arthritis usually occurs after minor trauma, but can also occur spontaneously. PAPA syndrome is a self-limiting disease, but it can lead to severe joint destruction. The gene responsible for the syndrome is the proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1).

Professional guidelines

PubMed

Patel N, McKenzie SA, Harview CL, Truong AK, Shi VY, Chen L, Grogan TR, Bennett RG, Hsiao JL
J Dermatolog Treat 2021 Jun;32(4):473-475. Epub 2019 Sep 26 doi: 10.1080/09546634.2019.1670779. PMID: 31535587
López-Estebaranz JL, Herranz-Pinto P, Dréno B; el grupo de dermatólogos expertos en acné
Actas Dermosifiliogr 2017 Mar;108(2):120-131. Epub 2016 Nov 3 doi: 10.1016/j.ad.2016.10.001. PMID: 27816123
Chien AL, Qi J, Rainer B, Sachs DL, Helfrich YR
J Am Board Fam Med 2016 Mar-Apr;29(2):254-62. doi: 10.3122/jabfm.2016.02.150165. PMID: 26957383

Recent clinical studies

Etiology

Patel N, McKenzie SA, Harview CL, Truong AK, Shi VY, Chen L, Grogan TR, Bennett RG, Hsiao JL
J Dermatolog Treat 2021 Jun;32(4):473-475. Epub 2019 Sep 26 doi: 10.1080/09546634.2019.1670779. PMID: 31535587
López-Estebaranz JL, Herranz-Pinto P, Dréno B; el grupo de dermatólogos expertos en acné
Actas Dermosifiliogr 2017 Mar;108(2):120-131. Epub 2016 Nov 3 doi: 10.1016/j.ad.2016.10.001. PMID: 27816123
Chien AL, Qi J, Rainer B, Sachs DL, Helfrich YR
J Am Board Fam Med 2016 Mar-Apr;29(2):254-62. doi: 10.3122/jabfm.2016.02.150165. PMID: 26957383
New MI
J Clin Endocrinol Metab 2006 Nov;91(11):4205-14. Epub 2006 Aug 15 doi: 10.1210/jc.2006-1645. PMID: 16912124
Bremner JD
Psychopharmacol Bull 2003 Winter;37(1):64-78. PMID: 14561949

Diagnosis

Esquivel-Zuniga MR, Kirschner CK, McCartney CR, Burt Solorzano CM
Semin Reprod Med 2022 Mar;40(1-02):42-52. Epub 2022 Jan 20 doi: 10.1055/s-0041-1742259. PMID: 35052005
Cheng SK, Michael A, Rizzuti AE
Cornea 2022 Jan 1;41(1):113-115. doi: 10.1097/ICO.0000000000002700. PMID: 33758137
New MI
J Clin Endocrinol Metab 2006 Nov;91(11):4205-14. Epub 2006 Aug 15 doi: 10.1210/jc.2006-1645. PMID: 16912124
Price VH
J Investig Dermatol Symp Proc 2003 Jun;8(1):24-7. doi: 10.1046/j.1523-1747.2003.12168.x. PMID: 12894991
Wilson BB
Prim Care 1989 Sep;16(3):695-712. PMID: 2529576

Therapy

López-Estebaranz JL, Herranz-Pinto P, Dréno B; el grupo de dermatólogos expertos en acné
Actas Dermosifiliogr 2017 Mar;108(2):120-131. Epub 2016 Nov 3 doi: 10.1016/j.ad.2016.10.001. PMID: 27816123
Chien AL, Qi J, Rainer B, Sachs DL, Helfrich YR
J Am Board Fam Med 2016 Mar-Apr;29(2):254-62. doi: 10.3122/jabfm.2016.02.150165. PMID: 26957383
On SC, Zeichner J
Dermatol Ther 2013 Sep-Oct;26(5):377-89. doi: 10.1111/dth.12084. PMID: 24099068
Chan A, Hanna M, Abbott M, Keane RJ
Med J Aust 1996 Aug 5;165(3):164-7. doi: 10.5694/j.1326-5377.1996.tb124895.x. PMID: 8709884
Martin P, Manley PN, Depew WT, Blakeman JM
Gastroenterology 1987 Sep;93(3):606-9. doi: 10.1016/0016-5085(87)90925-5. PMID: 3475230

Prognosis

Patel N, McKenzie SA, Harview CL, Truong AK, Shi VY, Chen L, Grogan TR, Bennett RG, Hsiao JL
J Dermatolog Treat 2021 Jun;32(4):473-475. Epub 2019 Sep 26 doi: 10.1080/09546634.2019.1670779. PMID: 31535587
Meister H, Shihab N, Lebwohl M, Silverberg NB
Pediatr Dermatol 2020 Nov;37(6):1055-1056. Epub 2020 Sep 19 doi: 10.1111/pde.14344. PMID: 32951249
Chien AL, Qi J, Rainer B, Sachs DL, Helfrich YR
J Am Board Fam Med 2016 Mar-Apr;29(2):254-62. doi: 10.3122/jabfm.2016.02.150165. PMID: 26957383
On SC, Zeichner J
Dermatol Ther 2013 Sep-Oct;26(5):377-89. doi: 10.1111/dth.12084. PMID: 24099068
Wilson BB
Prim Care 1989 Sep;16(3):695-712. PMID: 2529576

Clinical prediction guides

Patel N, McKenzie SA, Harview CL, Truong AK, Shi VY, Chen L, Grogan TR, Bennett RG, Hsiao JL
J Dermatolog Treat 2021 Jun;32(4):473-475. Epub 2019 Sep 26 doi: 10.1080/09546634.2019.1670779. PMID: 31535587
On SC, Zeichner J
Dermatol Ther 2013 Sep-Oct;26(5):377-89. doi: 10.1111/dth.12084. PMID: 24099068
Lowe NJ
J Am Acad Dermatol 1986 Oct;15(4 Pt 2):766-72. doi: 10.1016/s0190-9622(86)70232-6. PMID: 2945843
Lucek RW, Colburn WA
Clin Pharmacokinet 1985 Jan-Feb;10(1):38-62. doi: 10.2165/00003088-198510010-00002. PMID: 3882304
Conner CS
Drug Intell Clin Pharm 1984 Apr;18(4):308-9. doi: 10.1177/106002808401800406. PMID: 6232121

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