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Necrotizing granulomatous inflammation

MedGen UID:
507852
•Concept ID:
C0021386
•
Pathologic Function
Synonyms: Caseating granuloma; Caseating granulomatous inflammation; Necrotizing Granuloma; Necrotizing granuloma; Non-healing granuloma
SNOMED CT: Necrotizing granulomatous inflammation (27058005); Caseating granuloma (27058005); Necrotizing granuloma (27058005); Non-healing granuloma (27058005); Caseating granulomatous inflammation (27058005)

Definition

A granuloma that contains areas of necrosis. The majority of cases are of infectious origin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrotizing granulomatous inflammation

Professional guidelines

PubMed

Differential diagnosis of the granulomatous appendicitis: Retrospective analysis of 16 cases.
Akbulut S, Koç C, Sarıcı KB, Şamdancı E, Yakupoğulları Y, Bayındır Y
Ulus Travma Acil Cerrahi Derg 2021 Mar;27(2):214-221. doi: 10.14744/tjtes.2020.98582. PMID: 33630300
Does Every Necrotizing Granulomatous Inflammation Identified by NSCLC Resection Material Require Treatment?
Yakar F, Yakar A, Büyükpınarbaşılı N, Erelel M
Med Sci Monit 2016 Apr 11;22:1218-22. doi: 10.12659/msm.897638. PMID: 27064420Free PMC Article
Wegener's granulomatosis: a review of clinical features and an update in diagnosis and treatment.
Almouhawis HA, Leao JC, Fedele S, Porter SR
J Oral Pathol Med 2013 Aug;42(7):507-16. Epub 2013 Jan 10 doi: 10.1111/jop.12030. PMID: 23301777

Recent clinical studies

Etiology

Ocular and orbital manifestations of granulomatosis with polyangiitis: a systematic review of published cases.
Moin KA, Yeakle MM, Parrill AM, Garofalo VA, Tsiyer AR, Bishev D, Gala D, Fogel J, Hatsis AJ, Wickas TD, Anand P, Morcos M
Rom J Ophthalmol 2023 Jul-Sep;67(3):214-221. doi: 10.22336/rjo.2023.38. PMID: 37876507Free PMC Article
Ocular Manifestations of Granulomatosis with Polyangiitis.
Říhová E, Svozílková P, Brichová M, Klímová A, Kuthan P, Diblík P
Cesk Slov Oftalmol 2019 Spring;74(5):167-174. doi: 10.31348/2018/5/1. PMID: 31234629
Does Every Necrotizing Granulomatous Inflammation Identified by NSCLC Resection Material Require Treatment?
Yakar F, Yakar A, Büyükpınarbaşılı N, Erelel M
Med Sci Monit 2016 Apr 11;22:1218-22. doi: 10.12659/msm.897638. PMID: 27064420Free PMC Article
Complex genetics of Wegener granulomatosis.
Jagiello P, Gross WL, Epplen JT
Autoimmun Rev 2005 Jan;4(1):42-7. doi: 10.1016/j.autrev.2004.06.003. PMID: 15652778
Wegener's granulomatosis.
Lamprecht P, Gross WL
Herz 2004 Feb;29(1):47-56. doi: 10.1007/s00059-004-2525-0. PMID: 14968341

Diagnosis

Diagnosis of Pulmonary Sarcoidosis.
Zhao M, Zhou Y
Clin Chest Med 2024 Mar;45(1):15-24. Epub 2023 Jul 18 doi: 10.1016/j.ccm.2023.06.005. PMID: 38245363
Granulomatous myopathy: Sarcoidosis and beyond.
Chompoopong P, Liewluck T
Muscle Nerve 2023 Mar;67(3):193-203. Epub 2022 Nov 9 doi: 10.1002/mus.27741. PMID: 36352751
Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis.
Sève P, Pacheco Y, Durupt F, Jamilloux Y, Gerfaud-Valentin M, Isaac S, Boussel L, Calender A, Androdias G, Valeyre D, El Jammal T
Cells 2021 Mar 31;10(4) doi: 10.3390/cells10040766. PMID: 33807303Free PMC Article
Lung involvement in ANCA-associated vasculitis.
Sacoto G, Boukhlal S, Specks U, Flores-Suárez LF, Cornec D
Presse Med 2020 Oct;49(3):104039. Epub 2020 Jul 7 doi: 10.1016/j.lpm.2020.104039. PMID: 32650042
Wegener's granulomatosis.
Lamprecht P, Gross WL
Herz 2004 Feb;29(1):47-56. doi: 10.1007/s00059-004-2525-0. PMID: 14968341

Therapy

Persistent Pneumonia in an Infant.
Sekar A, Gupta A, Rawat A, Rudramurthy SM, Kumar R, Bhatia A
Indian Pediatr 2021 Nov 15;58(11):1067-1073. PMID: 34837368
Does Every Necrotizing Granulomatous Inflammation Identified by NSCLC Resection Material Require Treatment?
Yakar F, Yakar A, Büyükpınarbaşılı N, Erelel M
Med Sci Monit 2016 Apr 11;22:1218-22. doi: 10.12659/msm.897638. PMID: 27064420Free PMC Article
Mycobacterium abscessus granulomatous prostatitis.
Chuang AY, Tsou MH, Chang SJ, Yang LY, Shih CC, Tsai MP, Chen YL, Liu TM, Liao CH, Hsueh PR
Am J Surg Pathol 2012 Mar;36(3):418-22. doi: 10.1097/PAS.0b013e31823dafad. PMID: 22261705
Wegener's Granulomatosis vasculitis and granuloma.
Schilder AM
Autoimmun Rev 2010 May;9(7):483-7. Epub 2010 Feb 13 doi: 10.1016/j.autrev.2010.02.006. PMID: 20156603
Wegener's granulomatosis.
Lamprecht P, Gross WL
Herz 2004 Feb;29(1):47-56. doi: 10.1007/s00059-004-2525-0. PMID: 14968341

Prognosis

Persistent Pneumonia in an Infant.
Sekar A, Gupta A, Rawat A, Rudramurthy SM, Kumar R, Bhatia A
Indian Pediatr 2021 Nov 15;58(11):1067-1073. PMID: 34837368
Ocular Manifestations of Granulomatosis with Polyangiitis.
Říhová E, Svozílková P, Brichová M, Klímová A, Kuthan P, Diblík P
Cesk Slov Oftalmol 2019 Spring;74(5):167-174. doi: 10.31348/2018/5/1. PMID: 31234629
Thyroid cancer & sarcoidosis.
Ergin AB, Nasr CE
Sarcoidosis Vasc Diffuse Lung Dis 2014 Oct 20;31(3):239-43. PMID: 25363225
Granuloma in ANCA-associated vasculitides: another reason to distinguish between syndromes?
Mueller A, Holl-Ulrich K, Gross WL
Curr Rheumatol Rep 2013 Nov;15(11):376. doi: 10.1007/s11926-013-0376-5. PMID: 24078103
Wegener's Granulomatosis vasculitis and granuloma.
Schilder AM
Autoimmun Rev 2010 May;9(7):483-7. Epub 2010 Feb 13 doi: 10.1016/j.autrev.2010.02.006. PMID: 20156603

Clinical prediction guides

Diagnosis of Pulmonary Sarcoidosis.
Zhao M, Zhou Y
Clin Chest Med 2024 Mar;45(1):15-24. Epub 2023 Jul 18 doi: 10.1016/j.ccm.2023.06.005. PMID: 38245363
Thyroid cancer & sarcoidosis.
Ergin AB, Nasr CE
Sarcoidosis Vasc Diffuse Lung Dis 2014 Oct 20;31(3):239-43. PMID: 25363225
Granuloma in ANCA-associated vasculitides: another reason to distinguish between syndromes?
Mueller A, Holl-Ulrich K, Gross WL
Curr Rheumatol Rep 2013 Nov;15(11):376. doi: 10.1007/s11926-013-0376-5. PMID: 24078103
Microscopic diversity in oral Kaposi sarcoma.
Bunn BK, Carvalho Mde V, Louw M, Vargas PA, van Heerden WF
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Feb;115(2):241-8. doi: 10.1016/j.oooo.2012.11.009. PMID: 23312917
Wegener's granulomatosis: a review of clinical features and an update in diagnosis and treatment.
Almouhawis HA, Leao JC, Fedele S, Porter SR
J Oral Pathol Med 2013 Aug;42(7):507-16. Epub 2013 Jan 10 doi: 10.1111/jop.12030. PMID: 23301777

Recent systematic reviews

Ocular and orbital manifestations of granulomatosis with polyangiitis: a systematic review of published cases.
Moin KA, Yeakle MM, Parrill AM, Garofalo VA, Tsiyer AR, Bishev D, Gala D, Fogel J, Hatsis AJ, Wickas TD, Anand P, Morcos M
Rom J Ophthalmol 2023 Jul-Sep;67(3):214-221. doi: 10.22336/rjo.2023.38. PMID: 37876507Free PMC Article
Gastric presentation (vasculitis) mimics a gastric cancer as initial symptom in granulomatosis with polyangiitis: a case report and review of the literature.
Zheng Z, Ding J, Li X, Wu Z
Rheumatol Int 2015 Nov;35(11):1925-9. Epub 2015 Aug 7 doi: 10.1007/s00296-015-3334-x. PMID: 26248531

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