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Polymorphic light eruption

MedGen UID:
508043
Concept ID:
C0031736
Disease or Syndrome
Synonyms: PLE - Polymorphic light eruption; polymorphic light eruption; Polymorphic photodermatitis; polymorphic photodermatitis; Polymorphous light eruption; Polymorphous Light Eruption; polymorphous light eruption; Pruritus estivalis; Sun allergy
SNOMED CT: Polymorphic light eruption (238525001); Polymorphous light eruption (238525001); PLE - Polymorphic light eruption (238525001); Polymorphic photodermatitis (238525001); Pruritus estivalis (238525001)
 
HPO: HP:0032379
Monarch Initiative: MONDO:0041182

Definition

The cardinal symptom is severely pruritic skin lesions. Macular, papular, papulovesicular, urticarial, multiforme- and plaque-like variants are differentiated morphologically, hence the name polymorphous. Usually one morphology dominates in a single individual (monomorphous). The skin lesions develop a few hours to several days after sun exposure. Initially, patchy erythema develops, accompanied by pruritus. Distinct lesions then develop. The upper chest, upper arms, backs of the hands, thighs, and the sides of the face are the primary localizations. The skin lesions resolve spontaneously within several days of ceasing sun exposure and do not leave behind any traces. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolymorphic light eruption

Professional guidelines

PubMed

Kadurina M, Kazandjieva J, Bocheva G
Dermatol Ther 2021 Nov;34(6):e15167. Epub 2021 Oct 27 doi: 10.1111/dth.15167. PMID: 34676645
Lehmann P, Schwarz T
Dtsch Arztebl Int 2011 Mar;108(9):135-41. Epub 2011 Mar 4 doi: 10.3238/arztebl.2011.0135. PMID: 21442060Free PMC Article
Ling TC, Gibbs NK, Rhodes LE
Photodermatol Photoimmunol Photomed 2003 Oct;19(5):217-27. doi: 10.1034/j.1600-0781.2003.00048.x. PMID: 14535892

Recent clinical studies

Etiology

Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Gambichler T, Al-Muhammadi R, Boms S
Am J Clin Dermatol 2009;10(3):169-80. doi: 10.2165/00128071-200910030-00003. PMID: 19354331
van de Kerkhof PC, Murphy GM, Austad J, Ljungberg A, Cambazard F, Duvold LB
J Dermatolog Treat 2007;18(6):351-60. doi: 10.1080/09546630701341949. PMID: 17907013
Millard TP, Hawk JL
Am J Clin Dermatol 2002;3(4):239-46. doi: 10.2165/00128071-200203040-00002. PMID: 12010069
Millard TP, Kondeatis E, Vaughan RW, Lewis CM, Khamashta MA, Hughes GR, Hawk JL, McGregor JM
Lupus 2001;10(7):473-9. doi: 10.1191/096120301678416024. PMID: 11480844

Diagnosis

Snyder M, Turrentine JE, Cruz PD Jr
Clin Rev Allergy Immunol 2019 Feb;56(1):32-40. doi: 10.1007/s12016-018-8696-x. PMID: 29951786
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
ten Berge O, Sigurdsson V, Bruijnzeel-Koomen CA, van Weelden H, Pasmans SG
J Am Acad Dermatol 2010 Dec;63(6):1019-25. doi: 10.1016/j.jaad.2009.12.032. PMID: 20889233
van de Kerkhof PC, Murphy GM, Austad J, Ljungberg A, Cambazard F, Duvold LB
J Dermatolog Treat 2007;18(6):351-60. doi: 10.1080/09546630701341949. PMID: 17907013
Scheen SR 3rd, Connolly SM, Dicken CH
J Am Acad Dermatol 1981 Aug;5(2):183-90. doi: 10.1016/s0190-9622(81)70086-0. PMID: 7263963

Therapy

Snyder M, Turrentine JE, Cruz PD Jr
Clin Rev Allergy Immunol 2019 Feb;56(1):32-40. doi: 10.1007/s12016-018-8696-x. PMID: 29951786
Berman B, Ellis C, Elmets C
J Drugs Dermatol 2016 Feb;15(2):224-8. PMID: 26885792Free PMC Article
Dawe RS
Br J Dermatol 2003 Apr;148(4):626-37. doi: 10.1046/j.1365-2133.2003.05261.x. PMID: 12752118
Hawk JL
Br J Dermatol 1990 Apr;122 Suppl 35:29-36. doi: 10.1111/j.1365-2133.1990.tb16122.x. PMID: 2186782
Scheen SR 3rd, Connolly SM, Dicken CH
J Am Acad Dermatol 1981 Aug;5(2):183-90. doi: 10.1016/s0190-9622(81)70086-0. PMID: 7263963

Prognosis

Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
van de Kerkhof PC, Murphy GM, Austad J, Ljungberg A, Cambazard F, Duvold LB
J Dermatolog Treat 2007;18(6):351-60. doi: 10.1080/09546630701341949. PMID: 17907013
Millard TP, Hawk JL
Am J Clin Dermatol 2002;3(4):239-46. doi: 10.2165/00128071-200203040-00002. PMID: 12010069
Simon JC, Pfieger D, Schöpf E
Eur J Dermatol 2000 Dec;10(8):642-5. PMID: 11125334
Scheen SR 3rd, Connolly SM, Dicken CH
J Am Acad Dermatol 1981 Aug;5(2):183-90. doi: 10.1016/s0190-9622(81)70086-0. PMID: 7263963

Clinical prediction guides

Juzeniene A, Grigalavicius M, Juraleviciute M, Grant WB
Clin Dermatol 2016 Sep-Oct;34(5):548-55. Epub 2016 May 20 doi: 10.1016/j.clindermatol.2016.05.004. PMID: 27638432
Rizwan M, Reddick CL, Bundy C, Unsworth R, Richards HL, Rhodes LE
Photochem Photobiol Sci 2013 Jan;12(1):182-9. doi: 10.1039/c2pp25177a. PMID: 22961505
Gambichler T, Breuckmann F, Boms S, Altmeyer P, Kreuter A
J Am Acad Dermatol 2005 Apr;52(4):660-70. doi: 10.1016/j.jaad.2004.08.047. PMID: 15793518
Millard TP, Kondeatis E, Vaughan RW, Lewis CM, Khamashta MA, Hughes GR, Hawk JL, McGregor JM
Lupus 2001;10(7):473-9. doi: 10.1191/096120301678416024. PMID: 11480844
Scheen SR 3rd, Connolly SM, Dicken CH
J Am Acad Dermatol 1981 Aug;5(2):183-90. doi: 10.1016/s0190-9622(81)70086-0. PMID: 7263963

Recent systematic reviews

Burfield L, Rutter KJ, Thompson B, Marjanovic EJ, Neale RE, Rhodes LE
J Eur Acad Dermatol Venereol 2023 Mar;37(3):511-520. Epub 2022 Dec 3 doi: 10.1111/jdv.18772. PMID: 36433668
Lava SA, Simonetti GD, Ragazzi M, Guarino Gubler S, Bianchetti MG
Br J Dermatol 2013 May;168(5):1066-72. doi: 10.1111/bjd.12197. PMID: 23374016

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