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Primary hypersomnia

MedGen UID:
508068
•Concept ID:
C0033138
•
Mental or Behavioral Dysfunction
Synonyms: Idiopathic Hypersomnia; Primary Hypersomnia
SNOMED CT: Primary hypersomnia (36124002)

Definition

A disorder of central nervous system etiology characterized by excessive sleepiness during the daytime. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary hypersomnia

Professional guidelines

PubMed

Idiopathic hypersomnia: clinical features and response to treatment.
Ali M, Auger RR, Slocumb NL, Morgenthaler TI
J Clin Sleep Med 2009 Dec 15;5(6):562-8. PMID: 20465024Free PMC Article
Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications.
Vgontzas AN, Bixler EO, Kales A, Criley C, Vela-Bueno A
Psychosom Med 2000 Mar-Apr;62(2):220-6. doi: 10.1097/00006842-200003000-00013. PMID: 10772401

Recent clinical studies

Etiology

Sleep disorder syndromes of post-acute sequelae of SARS-CoV-2 (PASC) / Long Covid.
Coelho FMS, Czuma R, Ticotsky A, Maley J, Mullington JM, Thomas RJ
Sleep Med 2024 Nov;123:37-41. Epub 2024 Aug 29 doi: 10.1016/j.sleep.2024.08.030. PMID: 39236463
Presentations of primary hypersomnia in Chinese children.
Han F, Lin L, Li J, Aran A, Dong SX, An P, Zhao L, Li M, Li QY, Yan H, Wang JS, Gao HY, Li M, Gao ZC, Strohl KP, Mignot E
Sleep 2011 May 1;34(5):627-32. doi: 10.1093/sleep/34.5.627. PMID: 21532956Free PMC Article
Idiopathic hypersomnia: clinical features and response to treatment.
Ali M, Auger RR, Slocumb NL, Morgenthaler TI
J Clin Sleep Med 2009 Dec 15;5(6):562-8. PMID: 20465024Free PMC Article
Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia.
Ebrahim IO, Sharief MK, de Lacy S, Semra YK, Howard RS, Kopelman MD, Williams AJ
J Neurol Neurosurg Psychiatry 2003 Jan;74(1):127-30. doi: 10.1136/jnnp.74.1.127. PMID: 12486284Free PMC Article
Increased REM density in narcolepsy-cataplexy and the polysymptomatic form of idiopathic hypersomnia.
Vanková J, Nevsímalová S, Sonka K, Spacková N, Svejdová-Blazejová K
Sleep 2001 Sep 15;24(6):707-11. doi: 10.1093/sleep/24.6.707. PMID: 11560185

Diagnosis

Sleep disorder syndromes of post-acute sequelae of SARS-CoV-2 (PASC) / Long Covid.
Coelho FMS, Czuma R, Ticotsky A, Maley J, Mullington JM, Thomas RJ
Sleep Med 2024 Nov;123:37-41. Epub 2024 Aug 29 doi: 10.1016/j.sleep.2024.08.030. PMID: 39236463
Presentations of primary hypersomnia in Chinese children.
Han F, Lin L, Li J, Aran A, Dong SX, An P, Zhao L, Li M, Li QY, Yan H, Wang JS, Gao HY, Li M, Gao ZC, Strohl KP, Mignot E
Sleep 2011 May 1;34(5):627-32. doi: 10.1093/sleep/34.5.627. PMID: 21532956Free PMC Article
Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder.
Oosterloo M, Lammers GJ, Overeem S, de Noord I, Kooij JJ
Psychiatry Res 2006 Aug 30;143(2-3):293-7. Epub 2006 Jul 18 doi: 10.1016/j.psychres.2006.02.009. PMID: 16854470
Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia.
Ebrahim IO, Sharief MK, de Lacy S, Semra YK, Howard RS, Kopelman MD, Williams AJ
J Neurol Neurosurg Psychiatry 2003 Jan;74(1):127-30. doi: 10.1136/jnnp.74.1.127. PMID: 12486284Free PMC Article
Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications.
Vgontzas AN, Bixler EO, Kales A, Criley C, Vela-Bueno A
Psychosom Med 2000 Mar-Apr;62(2):220-6. doi: 10.1097/00006842-200003000-00013. PMID: 10772401

Therapy

Vitamin B(12) Deficiency: A Rare Cause of Excessive Daytime Sleepiness.
Khawaja I, Yingling K, Bukamur H, Abusnina W
J Clin Sleep Med 2019 Sep 15;15(9):1365-1367. doi: 10.5664/jcsm.7936. PMID: 31538608Free PMC Article
Idiopathic hypersomnia: clinical features and response to treatment.
Ali M, Auger RR, Slocumb NL, Morgenthaler TI
J Clin Sleep Med 2009 Dec 15;5(6):562-8. PMID: 20465024Free PMC Article
Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia.
Ebrahim IO, Sharief MK, de Lacy S, Semra YK, Howard RS, Kopelman MD, Williams AJ
J Neurol Neurosurg Psychiatry 2003 Jan;74(1):127-30. doi: 10.1136/jnnp.74.1.127. PMID: 12486284Free PMC Article

Prognosis

Idiopathic hypersomnia: clinical features and response to treatment.
Ali M, Auger RR, Slocumb NL, Morgenthaler TI
J Clin Sleep Med 2009 Dec 15;5(6):562-8. PMID: 20465024Free PMC Article
Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia.
Ebrahim IO, Sharief MK, de Lacy S, Semra YK, Howard RS, Kopelman MD, Williams AJ
J Neurol Neurosurg Psychiatry 2003 Jan;74(1):127-30. doi: 10.1136/jnnp.74.1.127. PMID: 12486284Free PMC Article
Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications.
Vgontzas AN, Bixler EO, Kales A, Criley C, Vela-Bueno A
Psychosom Med 2000 Mar-Apr;62(2):220-6. doi: 10.1097/00006842-200003000-00013. PMID: 10772401

Clinical prediction guides

Sleep disorder syndromes of post-acute sequelae of SARS-CoV-2 (PASC) / Long Covid.
Coelho FMS, Czuma R, Ticotsky A, Maley J, Mullington JM, Thomas RJ
Sleep Med 2024 Nov;123:37-41. Epub 2024 Aug 29 doi: 10.1016/j.sleep.2024.08.030. PMID: 39236463
Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder.
Oosterloo M, Lammers GJ, Overeem S, de Noord I, Kooij JJ
Psychiatry Res 2006 Aug 30;143(2-3):293-7. Epub 2006 Jul 18 doi: 10.1016/j.psychres.2006.02.009. PMID: 16854470
Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia.
Ebrahim IO, Sharief MK, de Lacy S, Semra YK, Howard RS, Kopelman MD, Williams AJ
J Neurol Neurosurg Psychiatry 2003 Jan;74(1):127-30. doi: 10.1136/jnnp.74.1.127. PMID: 12486284Free PMC Article
Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications.
Vgontzas AN, Bixler EO, Kales A, Criley C, Vela-Bueno A
Psychosom Med 2000 Mar-Apr;62(2):220-6. doi: 10.1097/00006842-200003000-00013. PMID: 10772401

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