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Crystal arthropathy

MedGen UID:
508879
•Concept ID:
C0152087
•
Disease or Syndrome
Synonyms: Arthritides, Crystal; Arthritides, Crystalline; Arthritis, Crystal; Arthritis, Crystalline; Arthropathies, Crystal; Arthropathies, Crystalline; Arthropathy, Crystal; Arthropathy, Crystalline; Crystal Arthritides; Crystal Arthritis; Crystal Arthropathies; Crystal Arthropathy; Crystalline Arthritides; Crystalline Arthritis; Crystalline Arthropathies; Crystalline Arthropathy
SNOMED CT: Crystal-related arthropathy and periarthropathy (18834007); Crystal arthropathy (18834007); Crystal-induced arthritis AND/OR synovitis (18834007); Crystalline arthritis (18834007)
 
Monarch Initiative: MONDO:0022208

Definition

Joint disorders that are characterized by accumulation of microcrystals in and around the joint including in the SYNOVIAL FLUID. They are classified according to the chemical nature of the crystals such as CALCIUM PYROPHOSPHATE; basic CALCIUM PHOSPHATES; and monosodium urate (see URIC ACID). [from MeSH]

Professional guidelines

PubMed

Subgroups of patients with osteoarthritis and medial meniscus tear or crystal arthropathy benefit from arthroscopic treatment.
Karpinski K, Müller-Rath R, Niemeyer P, Angele P, Petersen W
Knee Surg Sports Traumatol Arthrosc 2019 Mar;27(3):782-796. Epub 2018 Aug 20 doi: 10.1007/s00167-018-5086-0. PMID: 30128683
Current and future therapeutic options for the management of gout.
Whelton A
Am J Ther 2010 Jul-Aug;17(4):402-17. doi: 10.1097/MJT.0b013e3181df8ad2. PMID: 20562597
Treatment of crystal arthropathy--history and advances.
Nuki G
Rheum Dis Clin North Am 2006 May;32(2):333-57, vi. doi: 10.1016/j.rdc.2006.03.003. PMID: 16716883

Recent clinical studies

Etiology

Imaging of Crystal Disorders:: Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Calcium Hydroxyapatite Crystal Deposition Disease and Gout Pathophysiology, Imaging, and Diagnosis.
Reijnierse M, Schwabl C, Klauser A
Radiol Clin North Am 2022 Jul;60(4):641-656. doi: 10.1016/j.rcl.2022.03.007. PMID: 35672096
Prevalence and incidence of non-gout crystal arthropathy in southern Sweden.
Hameed M, Turkiewicz A, Englund M, Jacobsson L, Kapetanovic MC
Arthritis Res Ther 2019 Dec 17;21(1):291. doi: 10.1186/s13075-019-2077-6. PMID: 31847885Free PMC Article
Can drugs trigger CPPD acute attacks?
Huang YJ, Kuo CF
Joint Bone Spine 2019 Mar;86(2):131-134. Epub 2018 Jun 6 doi: 10.1016/j.jbspin.2018.05.010. PMID: 29885550
Epidemiology of calcium pyrophosphate crystal arthritis and basic calcium phosphate crystal arthropathy.
Abhishek A, Doherty M
Rheum Dis Clin North Am 2014 May;40(2):177-91. Epub 2014 Feb 20 doi: 10.1016/j.rdc.2014.01.002. PMID: 24703342
Approach to septic arthritis.
Horowitz DL, Katzap E, Horowitz S, Barilla-LaBarca ML
Am Fam Physician 2011 Sep 15;84(6):653-60. PMID: 21916390

Diagnosis

Imaging of Crystal Disorders:: Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Calcium Hydroxyapatite Crystal Deposition Disease and Gout Pathophysiology, Imaging, and Diagnosis.
Reijnierse M, Schwabl C, Klauser A
Radiol Clin North Am 2022 Jul;60(4):641-656. doi: 10.1016/j.rcl.2022.03.007. PMID: 35672096
Imaging of gout: findings and pitfalls. A pictorial review.
Sudoł-Szopińska I, Afonso PD, Jacobson JA, Teh J
Acta Reumatol Port 2020 Jan-Mar;45(1):20-25. PMID: 32572014
Inflammatory arthritis and crystal arthropathy: Current concepts of skin and systemic manifestations.
Fazel M, Merola JF, Kurtzman DJB
Clin Dermatol 2018 Jul-Aug;36(4):533-550. Epub 2018 Apr 10 doi: 10.1016/j.clindermatol.2018.04.010. PMID: 30047436
Imaging in Gout and Other Crystal-Related Arthropathies.
Omoumi P, Zufferey P, Malghem J, So A
Rheum Dis Clin North Am 2016 Nov;42(4):621-644. Epub 2016 Sep 9 doi: 10.1016/j.rdc.2016.07.005. PMID: 27742018
Approach to septic arthritis.
Horowitz DL, Katzap E, Horowitz S, Barilla-LaBarca ML
Am Fam Physician 2011 Sep 15;84(6):653-60. PMID: 21916390

Therapy

Acute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for Recurrence.
Yates KA, Yoshida K, Xu C, Lyu H, Norvang V, Solomon DH, Tedeschi SK
J Rheumatol 2020 Aug 1;47(8):1261-1266. Epub 2019 Nov 1 doi: 10.3899/jrheum.190778. PMID: 31676701Free PMC Article
Can drugs trigger CPPD acute attacks?
Huang YJ, Kuo CF
Joint Bone Spine 2019 Mar;86(2):131-134. Epub 2018 Jun 6 doi: 10.1016/j.jbspin.2018.05.010. PMID: 29885550
Approach to septic arthritis.
Horowitz DL, Katzap E, Horowitz S, Barilla-LaBarca ML
Am Fam Physician 2011 Sep 15;84(6):653-60. PMID: 21916390
Current and future therapeutic options for the management of gout.
Whelton A
Am J Ther 2010 Jul-Aug;17(4):402-17. doi: 10.1097/MJT.0b013e3181df8ad2. PMID: 20562597
Clinical trials in crystal arthropathy.
Joseph-Ridge N, Cazzetta S, MacDonald P
Rheum Dis Clin North Am 2006 May;32(2):359-82, vii. doi: 10.1016/j.rdc.2006.02.002. PMID: 16716884

Prognosis

Gout and incidence of 12 cardiovascular diseases: a case-control study including 152 663 individuals with gout and 709 981 matched controls.
Ferguson LD, Molenberghs G, Verbeke G, Rahimi K, Rao S, McInnes IB, McMurray JJV, Sattar N, Conrad N
Lancet Rheumatol 2024 Mar;6(3):e156-e167. doi: 10.1016/S2665-9913(23)00338-7. PMID: 38383089
Extra-pulmonary applications of procalcitonin: an updated literature review.
Atallah CJ, Panossian VS, Atallah NJ, Roberts MB, Mansour MK
Expert Rev Mol Diagn 2022 May;22(5):537-544. Epub 2022 Jul 13 doi: 10.1080/14737159.2022.2094705. PMID: 35757858
Acute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for Recurrence.
Yates KA, Yoshida K, Xu C, Lyu H, Norvang V, Solomon DH, Tedeschi SK
J Rheumatol 2020 Aug 1;47(8):1261-1266. Epub 2019 Nov 1 doi: 10.3899/jrheum.190778. PMID: 31676701Free PMC Article
Prevalence and incidence of non-gout crystal arthropathy in southern Sweden.
Hameed M, Turkiewicz A, Englund M, Jacobsson L, Kapetanovic MC
Arthritis Res Ther 2019 Dec 17;21(1):291. doi: 10.1186/s13075-019-2077-6. PMID: 31847885Free PMC Article
Inflammatory arthritis and crystal arthropathy: Current concepts of skin and systemic manifestations.
Fazel M, Merola JF, Kurtzman DJB
Clin Dermatol 2018 Jul-Aug;36(4):533-550. Epub 2018 Apr 10 doi: 10.1016/j.clindermatol.2018.04.010. PMID: 30047436

Clinical prediction guides

Gout and incidence of 12 cardiovascular diseases: a case-control study including 152 663 individuals with gout and 709 981 matched controls.
Ferguson LD, Molenberghs G, Verbeke G, Rahimi K, Rao S, McInnes IB, McMurray JJV, Sattar N, Conrad N
Lancet Rheumatol 2024 Mar;6(3):e156-e167. doi: 10.1016/S2665-9913(23)00338-7. PMID: 38383089
Acute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for Recurrence.
Yates KA, Yoshida K, Xu C, Lyu H, Norvang V, Solomon DH, Tedeschi SK
J Rheumatol 2020 Aug 1;47(8):1261-1266. Epub 2019 Nov 1 doi: 10.3899/jrheum.190778. PMID: 31676701Free PMC Article
Subclinical crystal arthropathy: a silent contributor to inflammation and functional disability in knees with osteoarthritis-an ultrasound study.
Mohammed RHA, Kotb H, Amir M, Di Matteo A
J Med Ultrason (2001) 2019 Jan;46(1):137-146. Epub 2018 Oct 16 doi: 10.1007/s10396-018-0912-z. PMID: 30327988
M1/M2 Macrophages in Diabetic Nephropathy: Nrf2/HO-1 as Therapeutic Targets.
Landis RC, Quimby KR, Greenidge AR
Curr Pharm Des 2018;24(20):2241-2249. doi: 10.2174/1381612824666180716163845. PMID: 30014796
Clinical trials in crystal arthropathy.
Joseph-Ridge N, Cazzetta S, MacDonald P
Rheum Dis Clin North Am 2006 May;32(2):359-82, vii. doi: 10.1016/j.rdc.2006.02.002. PMID: 16716884

Recent systematic reviews

The diagnostic value of conventional radiography and musculoskeletal ultrasonography in calcium pyrophosphate deposition disease: a systematic literature review and meta-analysis.
Cipolletta E, Filippou G, Scirè CA, Di Matteo A, Di Battista J, Salaffi F, Grassi W, Filippucci E
Osteoarthritis Cartilage 2021 May;29(5):619-632. Epub 2021 Feb 10 doi: 10.1016/j.joca.2021.01.007. PMID: 33577959
Subgroups of patients with osteoarthritis and medial meniscus tear or crystal arthropathy benefit from arthroscopic treatment.
Karpinski K, Müller-Rath R, Niemeyer P, Angele P, Petersen W
Knee Surg Sports Traumatol Arthrosc 2019 Mar;27(3):782-796. Epub 2018 Aug 20 doi: 10.1007/s00167-018-5086-0. PMID: 30128683

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