U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neoplasm of the eye

MedGen UID:
5095
•Concept ID:
C0015414
•
Neoplastic Process
Synonym: Eye neoplasm
SNOMED CT: Neoplasm of eye proper (371486001); Tumor of eye (371486001); Neoplasm of eye (371486001)
 
HPO: HP:0100012
Monarch Initiative: MONDO:0021220

Definition

A tumor (abnormal growth of tissue) of the eye. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of the eye

Professional guidelines

PubMed

Advances in the clinical management of uveal melanoma.
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
Nat Rev Clin Oncol 2023 Feb;20(2):99-115. Epub 2023 Jan 4 doi: 10.1038/s41571-022-00714-1. PMID: 36600005
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities.
Korshunov A, Jakobiec FA, Eberhart CG, Hovestadt V, Capper D, Jones DT, Sturm D, Stagner AM, Edward DP, Eagle RC, Proia AD, Koch A, Ryzhova M, Ektova A, Schüller U, Zheludkova O, Lichter P, von Deimling A, Pfister SM, Kool M
Neuropathology 2015 Dec;35(6):538-44. Epub 2015 Jul 16 doi: 10.1111/neup.12227. PMID: 26183384
Applicability of ultrasound in ocular tumors in children and adolescents.
Orawiec B, Grałek M, Stefańczyk L, Niwald A
Klin Oczna 2005;107(7-9):437-41. PMID: 16416991
Congenital malignant teratoid neoplasm of the eye and orbit: a case report and review of the literature.
Steinkuller PG, Font RL
Ophthalmology 1997 Jan;104(1):38-42. doi: 10.1016/s0161-6420(97)30364-9. PMID: 9022102

Diagnosis

Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.
Chahal M, Pleasance E, Grewal J, Zhao E, Ng T, Chapman E, Jones MR, Shen Y, Mungall KL, Bonakdar M, Taylor GA, Ma Y, Mungall AJ, Moore RA, Lim H, Renouf D, Yip S, Jones SJM, Marra MA, Laskin J
Cold Spring Harb Mol Case Stud 2018 Apr;4(2) Epub 2018 Apr 2 doi: 10.1101/mcs.a002626. PMID: 29610392Free PMC Article
Retinoblastoma.
Rodriguez-Galindo C, Orbach DB, VanderVeen D
Pediatr Clin North Am 2015 Feb;62(1):201-23. doi: 10.1016/j.pcl.2014.09.014. PMID: 25435120
Preserving vision in retinoblastoma through early detection and intervention.
Epelman S
Curr Oncol Rep 2012 Apr;14(2):213-9. doi: 10.1007/s11912-012-0226-z. PMID: 22350438
Applicability of ultrasound in ocular tumors in children and adolescents.
Orawiec B, Grałek M, Stefańczyk L, Niwald A
Klin Oczna 2005;107(7-9):437-41. PMID: 16416991
Congenital malignant teratoid neoplasm of the eye and orbit: a case report and review of the literature.
Steinkuller PG, Font RL
Ophthalmology 1997 Jan;104(1):38-42. doi: 10.1016/s0161-6420(97)30364-9. PMID: 9022102

Therapy

A phase II study of bendamustine chemotherapy as second-line treatment in metastatic uveal melanoma.
Schmidt-Hieber M, Schmittel A, Thiel E, Keilholz U
Melanoma Res 2004 Dec;14(6):439-42. doi: 10.1097/00008390-200412000-00001. PMID: 15577312

Prognosis

Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.
Chahal M, Pleasance E, Grewal J, Zhao E, Ng T, Chapman E, Jones MR, Shen Y, Mungall KL, Bonakdar M, Taylor GA, Ma Y, Mungall AJ, Moore RA, Lim H, Renouf D, Yip S, Jones SJM, Marra MA, Laskin J
Cold Spring Harb Mol Case Stud 2018 Apr;4(2) Epub 2018 Apr 2 doi: 10.1101/mcs.a002626. PMID: 29610392Free PMC Article
Applicability of ultrasound in ocular tumors in children and adolescents.
Orawiec B, Grałek M, Stefańczyk L, Niwald A
Klin Oczna 2005;107(7-9):437-41. PMID: 16416991
A phase II study of bendamustine chemotherapy as second-line treatment in metastatic uveal melanoma.
Schmidt-Hieber M, Schmittel A, Thiel E, Keilholz U
Melanoma Res 2004 Dec;14(6):439-42. doi: 10.1097/00008390-200412000-00001. PMID: 15577312
Congenital malignant teratoid neoplasm of the eye and orbit: a case report and review of the literature.
Steinkuller PG, Font RL
Ophthalmology 1997 Jan;104(1):38-42. doi: 10.1016/s0161-6420(97)30364-9. PMID: 9022102

Clinical prediction guides

Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.
Chahal M, Pleasance E, Grewal J, Zhao E, Ng T, Chapman E, Jones MR, Shen Y, Mungall KL, Bonakdar M, Taylor GA, Ma Y, Mungall AJ, Moore RA, Lim H, Renouf D, Yip S, Jones SJM, Marra MA, Laskin J
Cold Spring Harb Mol Case Stud 2018 Apr;4(2) Epub 2018 Apr 2 doi: 10.1101/mcs.a002626. PMID: 29610392Free PMC Article
A phase II study of bendamustine chemotherapy as second-line treatment in metastatic uveal melanoma.
Schmidt-Hieber M, Schmittel A, Thiel E, Keilholz U
Melanoma Res 2004 Dec;14(6):439-42. doi: 10.1097/00008390-200412000-00001. PMID: 15577312

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...