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Tractional retinal detachment

MedGen UID:
509678
Concept ID:
C0154828
Pathologic Function
Synonym: Retinal detachment, tractional
SNOMED CT: Traction retinal detachment (34711008); TRD - Traction retinal detachment (34711008); Traction detachment of retina (34711008)
 
HPO: HP:0007917

Definition

A type of retinal detachment arising due to a combination of contracting retinal membranes, abnormal vitreoretinal adhesions, and vitreous changes. It is usually seen in the context of diseases that induce a fibrovascular response, e.g. diabetes. [from HPO]

Term Hierarchy

Conditions with this feature

Exudative vitreoretinopathy 4
MedGen UID:
356171
Concept ID:
C1866176
Disease or Syndrome
Familial exudative vitreoretinopathy (FEVR) is an inherited disorder characterized by the incomplete development of the retinal vasculature. Its clinical appearance varies considerably, even within families, with severely affected patients often registered as blind during infancy, whereas mildly affected patients with few or no visual problems may have such a small area of avascularity in their peripheral retina that it is visible only by fluorescein angiography. It is believed that this peripheral avascularity is the primary anomaly in FEVR and results from defective retinal angiogenesis. The sight-threatening features of the FEVR phenotype are considered secondary to retinal avascularity and develop because of the resulting retinal ischemia; they include the development of hyperpermeable blood vessels, neovascularization, vitreoretinal traction, retinal folds, and retinal detachments (summary by Poulter et al., 2010). For a discussion of genetic heterogeneity of familial exudative vitreoretinopathy, see EVR1 (133780).
Exudative vitreoretinopathy 5
MedGen UID:
412872
Concept ID:
C2750079
Disease or Syndrome
Familial exudative vitreoretinopathy is an inherited blinding disorder caused by defects in the development of retinal vasculature. There is extensive variation in disease severity among patients, even between members of the same family. Severely affected individuals often are registered as blind during infancy and can present with a phenotype resembling retinal dysplasia. Conversely, mildly affected individuals frequently have few or no visual problems and may have just a small area of avascularity in their peripheral retina, detectable only by fluorescein angiography (summary by Poulter et al., 2012). For a discussion of genetic heterogeneity of familial exudative vitreoretinopathy (FEVR), see EVR1 (133780).
Exudative vitreoretinopathy 6
MedGen UID:
902559
Concept ID:
C4225316
Disease or Syndrome
Familial exudative vitreoretinopathy is a hereditary disorder that can cause vision loss that worsens over time. This condition affects the retina, the specialized light-sensitive tissue that lines the back of the eye. In people with this disorder, blood vessels do not fully develop at the outer edges (periphery) of the retina, which reduces the blood supply to this tissue. This prolonged reduction in blood supply (chronic ischemia) causes continued damage to the retina and can lead to worsening of the condition. \n\nThe signs and symptoms of familial exudative vitreoretinopathy vary widely, even within the same family. In many affected individuals, the retinal abnormalities never cause any vision problems. Other people with this condition develop abnormal vessels that leak. This  causes chronic inflammation which, over time, can lead to fluid under the retina (exudate). A reduction in the retina's blood supply causes the retina to fold, tear, or separate from the back of the eye (retinal detachment). The resulting retinal damage can lead to vision loss and blindness. Other eye abnormalities are also possible, including eyes that do not look in the same direction (strabismus) and a visible whiteness (leukocoria) in the normally black pupil.\n\nSome people with familial exudative vitreoretinopathy also have a condition known as osteoporosis-pseudoglioma syndrome, which is characterized by reduced bone density. People with this condition have weakened bones and an increased risk of fractures.

Professional guidelines

PubMed

Iyer SSR, Regan KA, Burnham JM, Chen CJ
Surv Ophthalmol 2019 Nov-Dec;64(6):780-809. Epub 2019 May 9 doi: 10.1016/j.survophthal.2019.04.008. PMID: 31077688
El Rami H, Barham R, Sun JK, Silva PS
Semin Ophthalmol 2017;32(1):67-74. Epub 2016 Oct 4 doi: 10.1080/08820538.2016.1228397. PMID: 27700224
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Recent clinical studies

Etiology

Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Iyer SSR, Regan KA, Burnham JM, Chen CJ
Surv Ophthalmol 2019 Nov-Dec;64(6):780-809. Epub 2019 May 9 doi: 10.1016/j.survophthal.2019.04.008. PMID: 31077688
Fierson WM; AMERICAN ACADEMY OF PEDIATRICS Section on Ophthalmology; AMERICAN ACADEMY OF OPHTHALMOLOGY; AMERICAN ASSOCIATION FOR PEDIATRIC OPHTHALMOLOGY AND STRABISMUS; AMERICAN ASSOCIATION OF CERTIFIED ORTHOPTISTS
Pediatrics 2018 Dec;142(6) doi: 10.1542/peds.2018-3061. PMID: 30478242
Savoie BT, Ferrone PJ
Retin Cases Brief Rep 2017 Winter;11 Suppl 1:S202-S210. doi: 10.1097/ICB.0000000000000444. PMID: 27680778
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Diagnosis

Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
van Dijk EHC, Boon CJF
Prog Retin Eye Res 2021 Sep;84:100955. Epub 2021 Mar 11 doi: 10.1016/j.preteyeres.2021.100955. PMID: 33716160
Fierson WM; AMERICAN ACADEMY OF PEDIATRICS Section on Ophthalmology; AMERICAN ACADEMY OF OPHTHALMOLOGY; AMERICAN ASSOCIATION FOR PEDIATRIC OPHTHALMOLOGY AND STRABISMUS; AMERICAN ASSOCIATION OF CERTIFIED ORTHOPTISTS
Pediatrics 2018 Dec;142(6) doi: 10.1542/peds.2018-3061. PMID: 30478242
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article
Bonfioli AA, Damico FM, Curi AL, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):147-54. doi: 10.1080/08820530500232035. PMID: 16282148

Therapy

Dervenis P, Dervenis N, Smith JM, Steel DH
Cochrane Database Syst Rev 2023 May 31;5(5):CD008214. doi: 10.1002/14651858.CD008214.pub4. PMID: 37260074Free PMC Article
Rittiphairoj T, Roberti G, Michelessi M
Cochrane Database Syst Rev 2023 Apr 3;4(4):CD007920. doi: 10.1002/14651858.CD007920.pub4. PMID: 37010901Free PMC Article
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Iyer SSR, Regan KA, Burnham JM, Chen CJ
Surv Ophthalmol 2019 Nov-Dec;64(6):780-809. Epub 2019 May 9 doi: 10.1016/j.survophthal.2019.04.008. PMID: 31077688
Stewart MW, Browning DJ, Landers MB
Indian J Ophthalmol 2018 Dec;66(12):1751-1762. doi: 10.4103/ijo.IJO_1217_18. PMID: 30451175Free PMC Article

Prognosis

Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
van Dijk EHC, Boon CJF
Prog Retin Eye Res 2021 Sep;84:100955. Epub 2021 Mar 11 doi: 10.1016/j.preteyeres.2021.100955. PMID: 33716160
Iyer SSR, Regan KA, Burnham JM, Chen CJ
Surv Ophthalmol 2019 Nov-Dec;64(6):780-809. Epub 2019 May 9 doi: 10.1016/j.survophthal.2019.04.008. PMID: 31077688
Fierson WM; AMERICAN ACADEMY OF PEDIATRICS Section on Ophthalmology; AMERICAN ACADEMY OF OPHTHALMOLOGY; AMERICAN ASSOCIATION FOR PEDIATRIC OPHTHALMOLOGY AND STRABISMUS; AMERICAN ASSOCIATION OF CERTIFIED ORTHOPTISTS
Pediatrics 2018 Dec;142(6) doi: 10.1542/peds.2018-3061. PMID: 30478242
Bonfioli AA, Damico FM, Curi AL, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):147-54. doi: 10.1080/08820530500232035. PMID: 16282148

Clinical prediction guides

Guo H, Wang Z, Nie Z, Zhang X, Wang K, Duan N, Bai S, Li W, Li X, Hu B
Front Endocrinol (Lausanne) 2023;14:1196335. Epub 2023 Aug 25 doi: 10.3389/fendo.2023.1196335. PMID: 37693349Free PMC Article
Joo CW, An Y, Kim YK, Kim YD, Park SP, Kim KL
Korean J Ophthalmol 2023 Jun;37(3):207-215. Epub 2023 Apr 17 doi: 10.3341/kjo.2022.0161. PMID: 37068834Free PMC Article
Rittiphairoj T, Roberti G, Michelessi M
Cochrane Database Syst Rev 2023 Apr 3;4(4):CD007920. doi: 10.1002/14651858.CD007920.pub4. PMID: 37010901Free PMC Article
Sun J, Chen L, Chen R, Lou Q, Wang H
Discov Med 2021 Jul-Aug;32(165):13-22. PMID: 35219352
Eibenberger K, Sacu S, Rezar-Dreindl S, Schmidt-Erfurth U, Stifter E, Georgopoulos M
Eur J Ophthalmol 2021 May;31(3):1367-1374. Epub 2020 Mar 19 doi: 10.1177/1120672120913030. PMID: 32192354

Recent systematic reviews

Dervenis P, Dervenis N, Smith JM, Steel DH
Cochrane Database Syst Rev 2023 May 31;5(5):CD008214. doi: 10.1002/14651858.CD008214.pub4. PMID: 37260074Free PMC Article
Rittiphairoj T, Roberti G, Michelessi M
Cochrane Database Syst Rev 2023 Apr 3;4(4):CD007920. doi: 10.1002/14651858.CD007920.pub4. PMID: 37010901Free PMC Article
Pei M, Zhao X, Wan G
Ophthalmic Res 2023;66(1):777-790. Epub 2023 Mar 27 doi: 10.1159/000530231. PMID: 36972566
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
McCullough P, Mohite A, Virgili G, Lois N
JAMA Ophthalmol 2023 Feb 1;141(2):186-195. doi: 10.1001/jamaophthalmol.2022.5817. PMID: 36633878Free PMC Article

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