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Toxic optic neuropathy

MedGen UID:
509903
•Concept ID:
C0155303
•
Disease or Syndrome
Synonyms: Neuropathy, Toxic Optic; Optic Neuropathy, Toxic; Toxic Optic Neuropathies; Toxic Optic Neuropathy
SNOMED CT: Toxic optic neuropathy (26125006)
 
Monarch Initiative: MONDO:0001688

Definition

Damage to the eye or its function (e.g., VISUAL IMPAIRMENT) due to OPTIC NERVE damage secondary to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic optic neuropathy

Professional guidelines

PubMed

Baseline demographics, clinical features, and treatment protocols of 240 patients with optic neuropathy: experiences from a neuro-ophthalmological clinic in the Aegean region of Turkey.
Karti O, Karti DT, Kilic İH, Gokcay F, Celebisoy N
Int Ophthalmol 2019 Jan;39(1):155-166. Epub 2017 Dec 19 doi: 10.1007/s10792-017-0799-5. PMID: 29260500

Recent clinical studies

Etiology

Ocular involvement in allergic drug reactions.
Fernandez E, Phillips E, Saeed HN
Curr Opin Allergy Clin Immunol 2023 Oct 1;23(5):397-408. Epub 2023 Jul 26 doi: 10.1097/ACI.0000000000000932. PMID: 37493235
FDA Approval Summary: Mirvetuximab Soravtansine-Gynx for FRα-Positive, Platinum-Resistant Ovarian Cancer.
Dilawari A, Shah M, Ison G, Gittleman H, Fiero MH, Shah A, Hamed SS, Qiu J, Yu J, Manheng W, Ricks TK, Pragani R, Arudchandran A, Patel P, Zaman S, Roy A, Kalavar S, Ghosh S, Pierce WF, Rahman NA, Tang S, Mixter BD, Kluetz PG, Pazdur R, Amiri-Kordestani L
Clin Cancer Res 2023 Oct 2;29(19):3835-3840. doi: 10.1158/1078-0432.CCR-23-0991. PMID: 37212825Free PMC Article
Toxic and Nutritional Optic Neuropathies-An Updated Mini-Review.
Baj J, Forma A, Kobak J, Tyczyńska M, Dudek I, Maani A, Teresiński G, Buszewicz G, Januszewski J, Flieger J
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053092. PMID: 35270784Free PMC Article
Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
Drug-induced optic neuropathies.
Lloyd MJ, Fraunfelder FW
Drugs Today (Barc) 2007 Nov;43(11):827-36. doi: 10.1358/dot.2007.43.11.1157621. PMID: 18174968

Diagnosis

FDA Approval Summary: Mirvetuximab Soravtansine-Gynx for FRα-Positive, Platinum-Resistant Ovarian Cancer.
Dilawari A, Shah M, Ison G, Gittleman H, Fiero MH, Shah A, Hamed SS, Qiu J, Yu J, Manheng W, Ricks TK, Pragani R, Arudchandran A, Patel P, Zaman S, Roy A, Kalavar S, Ghosh S, Pierce WF, Rahman NA, Tang S, Mixter BD, Kluetz PG, Pazdur R, Amiri-Kordestani L
Clin Cancer Res 2023 Oct 2;29(19):3835-3840. doi: 10.1158/1078-0432.CCR-23-0991. PMID: 37212825Free PMC Article
Toxic and Nutritional Optic Neuropathies-An Updated Mini-Review.
Baj J, Forma A, Kobak J, Tyczyńska M, Dudek I, Maani A, Teresiński G, Buszewicz G, Januszewski J, Flieger J
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053092. PMID: 35270784Free PMC Article
Toxic optic neuropathies: an updated review.
Grzybowski A, Zülsdorff M, Wilhelm H, Tonagel F
Acta Ophthalmol 2015 Aug;93(5):402-410. Epub 2014 Aug 27 doi: 10.1111/aos.12515. PMID: 25159832
Toxic optic neuropathies.
Altiparmak UE
Curr Opin Ophthalmol 2013 Nov;24(6):534-9. doi: 10.1097/ICU.0000000000000001. PMID: 24100370
Toxic optic neuropathy.
Kesler A, Pianka P
Curr Neurol Neurosci Rep 2003 Sep;3(5):410-4. doi: 10.1007/s11910-003-0024-y. PMID: 12914684

Therapy

FDA Approval Summary: Mirvetuximab Soravtansine-Gynx for FRα-Positive, Platinum-Resistant Ovarian Cancer.
Dilawari A, Shah M, Ison G, Gittleman H, Fiero MH, Shah A, Hamed SS, Qiu J, Yu J, Manheng W, Ricks TK, Pragani R, Arudchandran A, Patel P, Zaman S, Roy A, Kalavar S, Ghosh S, Pierce WF, Rahman NA, Tang S, Mixter BD, Kluetz PG, Pazdur R, Amiri-Kordestani L
Clin Cancer Res 2023 Oct 2;29(19):3835-3840. doi: 10.1158/1078-0432.CCR-23-0991. PMID: 37212825Free PMC Article
Tacrolimus Optic Neuropathy.
Rasool N, Boudreault K, Lessell S, Prasad S, Cestari DM
J Neuroophthalmol 2018 Jun;38(2):160-166. doi: 10.1097/WNO.0000000000000635. PMID: 29420328
Toxic optic neuropathy.
Sharma P, Sharma R
Indian J Ophthalmol 2011 Mar-Apr;59(2):137-41. doi: 10.4103/0301-4738.77035. PMID: 21350283Free PMC Article
Drug-induced optic neuropathies.
Lloyd MJ, Fraunfelder FW
Drugs Today (Barc) 2007 Nov;43(11):827-36. doi: 10.1358/dot.2007.43.11.1157621. PMID: 18174968
Toxic optic neuropathy.
Kesler A, Pianka P
Curr Neurol Neurosci Rep 2003 Sep;3(5):410-4. doi: 10.1007/s11910-003-0024-y. PMID: 12914684

Prognosis

Visual outcomes of toxic optic neuropathy secondary to Ethambutol: A retrospective observational study from India, an endemic country.
Ambika S, Lakshmi KP, Gopal M, Noronha OV
Indian J Ophthalmol 2022 Sep;70(9):3388-3392. doi: 10.4103/ijo.IJO_2996_21. PMID: 36018127Free PMC Article
Neuro-ophthalmic manifestations of tuberculosis.
Dhiman R, Lakra S, Panda PK, Hemachandran N, Sharma S, Saxena R
Eye (Lond) 2022 Jan;36(1):15-28. Epub 2021 Jun 14 doi: 10.1038/s41433-021-01619-6. PMID: 34127839Free PMC Article
Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
Predicting visual function after an ocular bee sting.
Ahmed M, Lee CS, McMillan B, Jain P, Wiley L, Odom JV, Leys M
Int Ophthalmol 2019 Jul;39(7):1621-1626. Epub 2018 Aug 13 doi: 10.1007/s10792-018-0978-z. PMID: 30105490
Incidence of toxic optic neuropathy with low-dose ethambutol.
Yang HK, Park MJ, Lee JH, Lee CT, Park JS, Hwang JM
Int J Tuberc Lung Dis 2016 Feb;20(2):261-4. doi: 10.5588/ijtld.15.0275. PMID: 26792482

Clinical prediction guides

Ocular involvement in allergic drug reactions.
Fernandez E, Phillips E, Saeed HN
Curr Opin Allergy Clin Immunol 2023 Oct 1;23(5):397-408. Epub 2023 Jul 26 doi: 10.1097/ACI.0000000000000932. PMID: 37493235
Ethambutol induced toxic optic neuropathy - A retrospective study in a tertiary eye care centre in Southern India.
Shanmugam MK, Sajja S, Kowsalya A, Balakrishnan HK, Jayasri KN
Nepal J Ophthalmol 2022 Jul;14(28):108-115. doi: 10.3126/nepjoph.v14i2.42780. PMID: 37609972
Visual outcomes of toxic optic neuropathy secondary to Ethambutol: A retrospective observational study from India, an endemic country.
Ambika S, Lakshmi KP, Gopal M, Noronha OV
Indian J Ophthalmol 2022 Sep;70(9):3388-3392. doi: 10.4103/ijo.IJO_2996_21. PMID: 36018127Free PMC Article
Neuro-ophthalmic manifestations of tuberculosis.
Dhiman R, Lakra S, Panda PK, Hemachandran N, Sharma S, Saxena R
Eye (Lond) 2022 Jan;36(1):15-28. Epub 2021 Jun 14 doi: 10.1038/s41433-021-01619-6. PMID: 34127839Free PMC Article
Case Report: Nutritional and Toxic Optic Neuropathy: A Diagnostic Dilemma.
Monferrer-Adsuara C, García-Villanueva C, Mata-Moret L, Ortiz-Salvador M, Remolí-Sargues L, Cervera-Taulet E
Optom Vis Sci 2020 Jul;97(7):477-481. doi: 10.1097/OPX.0000000000001531. PMID: 32697552

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