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Myalgic encephalomeyelitis/chronic fatigue syndrome

MedGen UID:
5130
Concept ID:
C0015674
Disease or Syndrome
Synonyms: Chronic Fatigue and Immune Dysfunction Syndrome; Chronic Fatigue Disorder; Chronic Fatigue Disorders; Chronic Fatigue Fibromyalgia Syndrome; Chronic Fatigue Syndrome; Chronic Fatigue Syndromes; Chronic Fatigue-Fibromyalgia Syndrome; Chronic Fatigue-Fibromyalgia Syndromes; Encephalomyelitis, Myalgic; Fatigue Disorder, Chronic; Fatigue Syndrome, Chronic; Fatigue Syndrome, Postviral; Fatigue Syndromes, Chronic; Fatigue-Fibromyalgia Syndrome, Chronic; Fatigue-Fibromyalgia Syndromes, Chronic; Infectious Mononucleosis Like Syndrome, Chronic; Infectious Mononucleosis-Like Syndrome, Chronic; Myalgic Encephalomyelitis; Postviral Fatigue Syndrome; Postviral Fatigue Syndromes; Royal Free Disease; Syndrome, Postviral Fatigue; Systemic Exertion Intolerance Disease
SNOMED CT: Myalgic encephalomyelitis syndrome (52702003); ME - Myalgic encephalomyelitis (52702003); Myalgic encephalomyelitis (52702003); CFS - Chronic fatigue syndrome (52702003); Postviral fatigue syndrome (51771007); Iceland disease (52702003); Benign myalgic encephalomyelitis (52702003); Chronic fatigue syndrome (52702003)
 
Monarch Initiative: MONDO:0005404
Orphanet: ORPHA1983

Definition

A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months'' duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyalgic encephalomeyelitis/chronic fatigue syndrome

Professional guidelines

PubMed

Grach SL, Seltzer J, Chon TY, Ganesh R
Mayo Clin Proc 2023 Oct;98(10):1544-1551. doi: 10.1016/j.mayocp.2023.07.032. PMID: 37793728
Bateman L, Bested AC, Bonilla HF, Chheda BV, Chu L, Curtin JM, Dempsey TT, Dimmock ME, Dowell TG, Felsenstein D, Kaufman DL, Klimas NG, Komaroff AL, Lapp CW, Levine SM, Montoya JG, Natelson BH, Peterson DL, Podell RN, Rey IR, Ruhoy IS, Vera-Nunez MA, Yellman BP
Mayo Clin Proc 2021 Nov;96(11):2861-2878. Epub 2021 Aug 25 doi: 10.1016/j.mayocp.2021.07.004. PMID: 34454716
Dukes JC, Chakan M, Mills A, Marcaurd M
Med Clin North Am 2021 Jan;105(1):137-148. doi: 10.1016/j.mcna.2020.09.007. PMID: 33246515

Curated

UK NICE Guideline NG206, Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management, 2021

Recent clinical studies

Etiology

Davis HE, McCorkell L, Vogel JM, Topol EJ
Nat Rev Microbiol 2023 Mar;21(3):133-146. Epub 2023 Jan 13 doi: 10.1038/s41579-022-00846-2. PMID: 36639608Free PMC Article
Astin R, Banerjee A, Baker MR, Dani M, Ford E, Hull JH, Lim PB, McNarry M, Morten K, O'Sullivan O, Pretorius E, Raman B, Soteropoulos DS, Taquet M, Hall CN
Exp Physiol 2023 Jan;108(1):12-27. Epub 2022 Nov 22 doi: 10.1113/EP090802. PMID: 36412084Free PMC Article
Choutka J, Jansari V, Hornig M, Iwasaki A
Nat Med 2022 May;28(5):911-923. Epub 2022 May 18 doi: 10.1038/s41591-022-01810-6. PMID: 35585196
Yong SJ
Infect Dis (Lond) 2021 Oct;53(10):737-754. Epub 2021 May 22 doi: 10.1080/23744235.2021.1924397. PMID: 34024217Free PMC Article
Sotzny F, Blanco J, Capelli E, Castro-Marrero J, Steiner S, Murovska M, Scheibenbogen C; European Network on ME/CFS (EUROMENE)
Autoimmun Rev 2018 Jun;17(6):601-609. Epub 2018 Apr 7 doi: 10.1016/j.autrev.2018.01.009. PMID: 29635081

Diagnosis

Grach SL, Seltzer J, Chon TY, Ganesh R
Mayo Clin Proc 2023 Oct;98(10):1544-1551. doi: 10.1016/j.mayocp.2023.07.032. PMID: 37793728
Choutka J, Jansari V, Hornig M, Iwasaki A
Nat Med 2022 May;28(5):911-923. Epub 2022 May 18 doi: 10.1038/s41591-022-01810-6. PMID: 35585196
Bateman L, Bested AC, Bonilla HF, Chheda BV, Chu L, Curtin JM, Dempsey TT, Dimmock ME, Dowell TG, Felsenstein D, Kaufman DL, Klimas NG, Komaroff AL, Lapp CW, Levine SM, Montoya JG, Natelson BH, Peterson DL, Podell RN, Rey IR, Ruhoy IS, Vera-Nunez MA, Yellman BP
Mayo Clin Proc 2021 Nov;96(11):2861-2878. Epub 2021 Aug 25 doi: 10.1016/j.mayocp.2021.07.004. PMID: 34454716
Dukes JC, Chakan M, Mills A, Marcaurd M
Med Clin North Am 2021 Jan;105(1):137-148. doi: 10.1016/j.mcna.2020.09.007. PMID: 33246515
Bested AC, Marshall LM
Rev Environ Health 2015;30(4):223-49. doi: 10.1515/reveh-2015-0026. PMID: 26613325

Therapy

Cohen Tervaert JW, Martinez-Lavin M, Jara LJ, Halpert G, Watad A, Amital H, Shoenfeld Y
Autoimmun Rev 2023 May;22(5):103287. Epub 2023 Feb 3 doi: 10.1016/j.autrev.2023.103287. PMID: 36738954
Cohen Tervaert JW, Mohazab N, Redmond D, van Eeden C, Osman M
Expert Rev Clin Immunol 2022 Jan;18(1):15-29. Epub 2022 Jan 5 doi: 10.1080/1744666X.2022.2010546. PMID: 34882509
Toogood PL, Clauw DJ, Phadke S, Hoffman D
Pharmacol Res 2021 Mar;165:105465. Epub 2021 Jan 30 doi: 10.1016/j.phrs.2021.105465. PMID: 33529750
Kerr JR
J Clin Pathol 2019 Oct;72(10):651-658. Epub 2019 Jul 17 doi: 10.1136/jclinpath-2019-205822. PMID: 31315893
Sotzny F, Blanco J, Capelli E, Castro-Marrero J, Steiner S, Murovska M, Scheibenbogen C; European Network on ME/CFS (EUROMENE)
Autoimmun Rev 2018 Jun;17(6):601-609. Epub 2018 Apr 7 doi: 10.1016/j.autrev.2018.01.009. PMID: 29635081

Prognosis

Latimer KM, Gunther A, Kopec M
Am Fam Physician 2023 Jul;108(1):58-69. PMID: 37440739
Lv Y, Zhang T, Cai J, Huang C, Zhan S, Liu J
Front Immunol 2022;13:952987. Epub 2022 Sep 16 doi: 10.3389/fimmu.2022.952987. PMID: 36189286Free PMC Article
Gregorowski A, Simpson J, Segal TY
Curr Opin Pediatr 2019 Aug;31(4):462-468. doi: 10.1097/MOP.0000000000000777. PMID: 31045885
Sharif K, Watad A, Bragazzi NL, Lichtbroun M, Martini M, Perricone C, Amital H, Shoenfeld Y
Clin Rheumatol 2018 May;37(5):1161-1170. Epub 2018 Feb 7 doi: 10.1007/s10067-018-4009-2. PMID: 29417255
Bested AC, Marshall LM
Rev Environ Health 2015;30(4):223-49. doi: 10.1515/reveh-2015-0026. PMID: 26613325

Clinical prediction guides

Thorlacius GE, Björk A, Wahren-Herlenius M
Nat Rev Rheumatol 2023 May;19(5):288-306. Epub 2023 Mar 13 doi: 10.1038/s41584-023-00932-6. PMID: 36914790Free PMC Article
Barletta MA, Marino G, Spagnolo B, Bianchi FP, Falappone PCF, Spagnolo L, Gatti P
Clin Exp Med 2023 Jul;23(3):667-678. Epub 2022 Aug 22 doi: 10.1007/s10238-022-00871-8. PMID: 35994177Free PMC Article
Sukocheva OA, Maksoud R, Beeraka NM, Madhunapantula SV, Sinelnikov M, Nikolenko VN, Neganova ME, Klochkov SG, Amjad Kamal M, Staines DR, Marshall-Gradisnik S
J Adv Res 2022 Sep;40:179-196. Epub 2021 Nov 26 doi: 10.1016/j.jare.2021.11.013. PMID: 36100326Free PMC Article
Twomey R, DeMars J, Franklin K, Culos-Reed SN, Weatherald J, Wrightson JG
Phys Ther 2022 Apr 1;102(4) doi: 10.1093/ptj/pzac005. PMID: 35079817Free PMC Article
Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, Alegre-Martin J
Nutrients 2021 Jul 30;13(8) doi: 10.3390/nu13082658. PMID: 34444817Free PMC Article

Recent systematic reviews

Maksoud R, Magawa C, Eaton-Fitch N, Thapaliya K, Marshall-Gradisnik S
BMC Med 2023 May 24;21(1):189. doi: 10.1186/s12916-023-02893-9. PMID: 37226227Free PMC Article
Tziastoudi M, Cholevas C, Stefanidis I, Theoharides TC
Ann Clin Transl Neurol 2022 Nov;9(11):1838-1857. Epub 2022 Oct 6 doi: 10.1002/acn3.51631. PMID: 36204816Free PMC Article
Wong TL, Weitzer DJ
Medicina (Kaunas) 2021 Apr 26;57(5) doi: 10.3390/medicina57050418. PMID: 33925784Free PMC Article
Kim DY, Lee JS, Park SY, Kim SJ, Son CG
J Transl Med 2020 Jan 6;18(1):7. doi: 10.1186/s12967-019-02196-9. PMID: 31906979Free PMC Article
Blundell S, Ray KK, Buckland M, White PD
Brain Behav Immun 2015 Nov;50:186-195. Epub 2015 Jul 3 doi: 10.1016/j.bbi.2015.07.004. PMID: 26148446

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG206, Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management, 2021

    Consumer resources

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