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Staphylococcal scalded skin syndrome

MedGen UID:
52484
Concept ID:
C0038165
Disease or Syndrome
Synonyms: Disease, Ritter; Disease, Ritter's; Ritter Disease; Ritter's Disease; Ritters Disease; Scalded Skin Syndrome, Staphylococcal; Scalded-Skin Syndrome, Staphylococcal; Scalded-Skin Syndromes, Staphylococcal; Staphylococcal Scalded Skin Syndrome; Staphylococcal Scalded-Skin Syndrome; Staphylococcal Scalded-Skin Syndromes; Syndrome, Staphylococcal Scalded-Skin; Syndromes, Staphylococcal Scalded-Skin
SNOMED CT: Staphylococcal scalded skin syndrome (200946001); Scalded skin syndrome (200946001); SSSS - Staphylococcal scalded skin syndrome (200946001)
 
Monarch Initiative: MONDO:0018181
Orphanet: ORPHA36236

Definition

A rare staphylococcal toxemia caused by epidermolytic toxins of <i>Staphylococcus aureus</i> and characterized by the appearance of widespread erythematous patches, on which large blisters develop. Upon rupture of these blisters, the skin appears reddish and scalded. The lesions typically begin in the face and rapidly expand to other parts of the body. The disease may be complicated by pneumonia and sepsis. It most commonly affects newborns and infants. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStaphylococcal scalded skin syndrome
Follow this link to review classifications for Staphylococcal scalded skin syndrome in Orphanet.

Professional guidelines

PubMed

Gray L, Olson J, Brintz BJ, Cipriano SD
Pediatr Dermatol 2022 Nov;39(6):908-913. Epub 2022 Aug 16 doi: 10.1111/pde.15102. PMID: 36440996
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497

Recent clinical studies

Etiology

Holmes N, Walker JJ, Chapple W
J Fam Pract 2019 Apr;68(3):175-177. PMID: 31039216
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Craiglow BG
Semin Perinatol 2013 Feb;37(1):26-31. doi: 10.1053/j.semperi.2012.11.001. PMID: 23419760Free PMC Article
Callahan EF, Adal KA, Tomecki KJ
Dermatol Clin 2000 Jul;18(3):497-508, x. doi: 10.1016/s0733-8635(05)70197-2. PMID: 10943544

Diagnosis

Moon S, Israeli A, Daze R
Am Fam Physician 2022 Jan 1;105(1):75-76. PMID: 35029947
Brazel M, Desai A, Are A, Motaparthi K
Medicina (Kaunas) 2021 Oct 24;57(11) doi: 10.3390/medicina57111157. PMID: 34833375Free PMC Article
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Maguire CA, Chong H, Ramachandran R, Popoola J, Akhras V, Singh M
Clin Exp Dermatol 2018 Apr;43(3):315-318. Epub 2018 Jan 15 doi: 10.1111/ced.13369. PMID: 29336047
Todd JK
Pediatr Rev 2005 Dec;26(12):444-50. PMID: 16327025

Therapy

Holmes N, Walker JJ, Chapple W
J Fam Pract 2019 Apr;68(3):175-177. PMID: 31039216
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Kress DW
Curr Opin Pediatr 2011 Aug;23(4):403-6. doi: 10.1097/MOP.0b013e3283483efd. PMID: 21670682
Sandhu K, Kanwar AJ
Pediatr Dermatol 2004 Nov-Dec;21(6):667-9. doi: 10.1111/j.1525-1470.2004.21612.x. PMID: 15575854

Prognosis

Sato S, Ragab RF, Guo X, Elfadadny A, Kozono T, Nishikawa A, Nishifuji K, Tonozuka T
Biochem Biophys Res Commun 2024 Nov 12;733:150689. Epub 2024 Sep 11 doi: 10.1016/j.bbrc.2024.150689. PMID: 39276694
Holmes N, Walker JJ, Chapple W
J Fam Pract 2019 Apr;68(3):175-177. PMID: 31039216
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Todd JK
Pediatr Rev 2005 Dec;26(12):444-50. PMID: 16327025

Clinical prediction guides

Sato S, Ragab RF, Guo X, Elfadadny A, Kozono T, Nishikawa A, Nishifuji K, Tonozuka T
Biochem Biophys Res Commun 2024 Nov 12;733:150689. Epub 2024 Sep 11 doi: 10.1016/j.bbrc.2024.150689. PMID: 39276694
Garg VK, Buttar HS, Bhat SA, Ainur N, Priya T, Kashyap D, Tuli HS
Recent Adv Inflamm Allergy Drug Discov 2023;17(2):110-120. doi: 10.2174/2772270817666230821102441. PMID: 37605396
Liy-Wong C, Pope E, Weinstein M, Lara-Corrales I
Pediatr Dermatol 2021 Jan;38(1):149-153. Epub 2020 Dec 1 doi: 10.1111/pde.14470. PMID: 33283348
Prévost G, Couppié P, Monteil H
Curr Opin Infect Dis 2003 Apr;16(2):71-6. doi: 10.1097/00001432-200304000-00002. PMID: 12734438
Revuz J, Penso D, Roujeau JC, Guillaume JC, Payne CR, Wechsler J, Touraine R
Arch Dermatol 1987 Sep;123(9):1160-5. doi: 10.1001/archderm.123.9.1160. PMID: 3632000

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