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Staphylococcal scalded skin syndrome

MedGen UID:
52484
•Concept ID:
C0038165
•
Disease or Syndrome
Synonyms: Disease, Ritter; Disease, Ritter's; Ritter Disease; Ritter's Disease; Ritters Disease; Scalded Skin Syndrome, Staphylococcal; Scalded-Skin Syndrome, Staphylococcal; Scalded-Skin Syndromes, Staphylococcal; Staphylococcal Scalded Skin Syndrome; Staphylococcal Scalded-Skin Syndrome; Staphylococcal Scalded-Skin Syndromes; Syndrome, Staphylococcal Scalded-Skin; Syndromes, Staphylococcal Scalded-Skin
SNOMED CT: Staphylococcal scalded skin syndrome (200946001); Scalded skin syndrome (200946001); SSSS - Staphylococcal scalded skin syndrome (200946001)
 
Monarch Initiative: MONDO:0018181
Orphanet: ORPHA36236

Definition

A rare staphylococcal toxemia caused by epidermolytic toxins of <i>Staphylococcus aureus</i> and characterized by the appearance of widespread erythematous patches, on which large blisters develop. Upon rupture of these blisters, the skin appears reddish and scalded. The lesions typically begin in the face and rapidly expand to other parts of the body. The disease may be complicated by pneumonia and sepsis. It most commonly affects newborns and infants. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStaphylococcal scalded skin syndrome
Follow this link to review classifications for Staphylococcal scalded skin syndrome in Orphanet.

Professional guidelines

PubMed

Staphylococcal scalded skin syndrome: Clinical features, ancillary testing, and patient management.
Gray L, Olson J, Brintz BJ, Cipriano SD
Pediatr Dermatol 2022 Nov;39(6):908-913. Epub 2022 Aug 16 doi: 10.1111/pde.15102. PMID: 36440996
Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management.
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497

Recent clinical studies

Etiology

Antibiotic Regimens and Associated Outcomes in Children Hospitalized With Staphylococcal Scalded Skin Syndrome.
Neubauer HC, Hall M, Lopez MA, Cruz AT, Queen MA, Foradori DM, Aronson PL, Markham JL, Nead JA, Hester GZ, McCulloh RJ, Wallace SS
J Hosp Med 2021 Mar;16(3):149-155. doi: 10.12788/jhm.3529. PMID: 33617441Free PMC Article
Staphylococcal scalded skin syndrome: An epidemiological and clinical review of 84 cases.
Liy-Wong C, Pope E, Weinstein M, Lara-Corrales I
Pediatr Dermatol 2021 Jan;38(1):149-153. Epub 2020 Dec 1 doi: 10.1111/pde.14470. PMID: 33283348
Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management.
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Pyodermitis.
Empinotti JC, Uyeda H, Ruaro RT, Galhardo AP, Bonatto DC
An Bras Dermatol 2012 Mar-Apr;87(2):277-84. doi: 10.1590/s0365-05962012000200013. PMID: 22570033
Staphylococcal epidermolysins.
Prévost G, Couppié P, Monteil H
Curr Opin Infect Dis 2003 Apr;16(2):71-6. doi: 10.1097/00001432-200304000-00002. PMID: 12734438

Diagnosis

Staphylococcal Scalded Skin Syndrome and Bullous Impetigo.
Brazel M, Desai A, Are A, Motaparthi K
Medicina (Kaunas) 2021 Oct 24;57(11) doi: 10.3390/medicina57111157. PMID: 34833375Free PMC Article
Staphylococcal scalded skin syndrome: An epidemiological and clinical review of 84 cases.
Liy-Wong C, Pope E, Weinstein M, Lara-Corrales I
Pediatr Dermatol 2021 Jan;38(1):149-153. Epub 2020 Dec 1 doi: 10.1111/pde.14470. PMID: 33283348
Impetigo/Staphylococcal Scalded Skin Disease.
Dollani LC, Marathe KS
Pediatr Rev 2020 Apr;41(4):210-212. doi: 10.1542/pir.2018-0206. PMID: 32238552
Neonatal Skin Emergencies.
Siegel M, Lee LW
Pediatr Ann 2019 Jan 1;48(1):e36-e42. doi: 10.3928/19382359-20181210-03. PMID: 30653641
Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management.
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362

Therapy

Staphylococcal scalded skin syndrome: Clinical features, ancillary testing, and patient management.
Gray L, Olson J, Brintz BJ, Cipriano SD
Pediatr Dermatol 2022 Nov;39(6):908-913. Epub 2022 Aug 16 doi: 10.1111/pde.15102. PMID: 36440996
Antibiotic Regimens and Associated Outcomes in Children Hospitalized With Staphylococcal Scalded Skin Syndrome.
Neubauer HC, Hall M, Lopez MA, Cruz AT, Queen MA, Foradori DM, Aronson PL, Markham JL, Nead JA, Hester GZ, McCulloh RJ, Wallace SS
J Hosp Med 2021 Mar;16(3):149-155. doi: 10.12788/jhm.3529. PMID: 33617441Free PMC Article
Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management.
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Pediatric dermatology emergencies.
Kress DW
Curr Opin Pediatr 2011 Aug;23(4):403-6. doi: 10.1097/MOP.0b013e3283483efd. PMID: 21670682

Prognosis

Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management.
Leung AKC, Barankin B, Leong KF
World J Pediatr 2018 Apr;14(2):116-120. Epub 2018 Mar 5 doi: 10.1007/s12519-018-0150-x. PMID: 29508362
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Treatment of bullous impetigo and the staphylococcal scalded skin syndrome in infants.
Johnston GA
Expert Rev Anti Infect Ther 2004 Jun;2(3):439-46. doi: 10.1586/14787210.2.3.439. PMID: 15482208
Staphylococcal scalded skin syndrome: diagnosis and management.
Patel GK, Finlay AY
Am J Clin Dermatol 2003;4(3):165-75. doi: 10.2165/00128071-200304030-00003. PMID: 12627992
Staphylococcal scalded-skin syndrome.
Farrell AM
Lancet 1999 Sep 11;354(9182):880-1. doi: 10.1016/s0140-6736(99)90120-4. PMID: 10489941

Clinical prediction guides

Staphylococcal scalded skin syndrome: An epidemiological and clinical review of 84 cases.
Liy-Wong C, Pope E, Weinstein M, Lara-Corrales I
Pediatr Dermatol 2021 Jan;38(1):149-153. Epub 2020 Dec 1 doi: 10.1111/pde.14470. PMID: 33283348
Increasing Numbers of Staphylococcal Scalded Skin Syndrome Cases Caused by ST121 in Houston, Texas.
Hultén KG, Kok M, King KE, Lamberth LB, Kaplan SL
Pediatr Infect Dis J 2020 Jan;39(1):30-34. doi: 10.1097/INF.0000000000002499. PMID: 31725120
A Unique Pattern of Staphylococcal Scalded Skin Syndrome-Like Erosions in Patients with Atopic Dermatitis: Dermatitis flammeus.
Chan JC, Chiu ML, Yeung CK, Yuen KY, Chan HH
Skinmed 2018;16(5):309-313. Epub 2018 Nov 9 PMID: 30413224
Staphylococcal epidermolysins.
Prévost G, Couppié P, Monteil H
Curr Opin Infect Dis 2003 Apr;16(2):71-6. doi: 10.1097/00001432-200304000-00002. PMID: 12734438
Bacteria and the skin: clinical practice and therapy update.
Thestrup-Pedersen K
Br J Dermatol 1998 Dec;139 Suppl 53:1-3. doi: 10.1046/j.1365-2133.1998.1390s3001.x. PMID: 9990405

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