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Congenital toxoplasmosis

MedGen UID:
52799
•Concept ID:
C0040560
•
Disease or Syndrome
Synonyms: Congenital Infection, Toxoplasma gondii; Congenital Toxoplasma gondii Infection; Congenital Toxoplasma Infection; Congenital Toxoplasma Infections; Congenital Toxoplasmoses; Congenital Toxoplasmosis; Infection, Congenital Toxoplasma; Infections, Congenital Toxoplasma; Toxoplasma Infection, Congenital; Toxoplasma Infections, Congenital; Toxoplasmoses, Congenital; Toxoplasmosis, Congenital
SNOMED CT: Congenital toxoplasmosis (73893000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005715
Orphanet: ORPHA858

Definition

A rare fetopathy characterized by ocular, visceral or intracranial lesions secondary to maternal primary infection by <i>Toxoplasma gondii</i> (Tg). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital toxoplasmosis
Follow this link to review classifications for Congenital toxoplasmosis in Orphanet.

Professional guidelines

PubMed

Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.
Dunay IR, Gajurel K, Dhakal R, Liesenfeld O, Montoya JG
Clin Microbiol Rev 2018 Oct;31(4) Epub 2018 Sep 12 doi: 10.1128/CMR.00057-17. PMID: 30209035Free PMC Article
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.
Maldonado YA, Read JS; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-3860. PMID: 28138010
Toxoplasmosis in pregnancy: prevention, screening, and treatment.
Paquet C, Yudin MH; Society of Obstetricians and Gynaecologists of Canada
J Obstet Gynaecol Can 2013 Jan;35(1):78-81. doi: 10.1016/s1701-2163(15)31053-7. PMID: 23343802

Recent clinical studies

Etiology

Toxoplasmosis in pregnancy.
Ahmed M, Sood A, Gupta J
Eur J Obstet Gynecol Reprod Biol 2020 Dec;255:44-50. Epub 2020 Oct 8 doi: 10.1016/j.ejogrb.2020.10.003. PMID: 33075679
General Features and Laboratory Diagnosis of Toxoplasma gondii Infection.
Beder D, Esenkaya Taşbent F
Turkiye Parazitol Derg 2020 Jun 2;44(2):94-101. doi: 10.4274/tpd.galenos.2020.6634. PMID: 32482042
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.
Maldonado YA, Read JS; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-3860. PMID: 28138010
Congenital toxoplasmosis.
Kieffer F, Wallon M
Handb Clin Neurol 2013;112:1099-101. doi: 10.1016/B978-0-444-52910-7.00028-3. PMID: 23622316
Toxoplasmosis in pregnancy: prevention, screening, and treatment.
Paquet C, Yudin MH; Society of Obstetricians and Gynaecologists of Canada
J Obstet Gynaecol Can 2013 Jan;35(1):78-81. doi: 10.1016/s1701-2163(15)31053-7. PMID: 23343802

Diagnosis

Toxoplasmosis in pregnancy.
Ahmed M, Sood A, Gupta J
Eur J Obstet Gynecol Reprod Biol 2020 Dec;255:44-50. Epub 2020 Oct 8 doi: 10.1016/j.ejogrb.2020.10.003. PMID: 33075679
General Features and Laboratory Diagnosis of Toxoplasma gondii Infection.
Beder D, Esenkaya Taşbent F
Turkiye Parazitol Derg 2020 Jun 2;44(2):94-101. doi: 10.4274/tpd.galenos.2020.6634. PMID: 32482042
Congenital toxoplasmosis: An overview of the neurological and ocular manifestations.
Khan K, Khan W
Parasitol Int 2018 Dec;67(6):715-721. Epub 2018 Jul 21 doi: 10.1016/j.parint.2018.07.004. PMID: 30041005
Congenital Toxoplasmosis: A Review.
Hampton MM
Neonatal Netw 2015;34(5):274-8. doi: 10.1891/0730-0832.34.5.274. PMID: 26802827
Congenital toxoplasmosis.
Kieffer F, Wallon M
Handb Clin Neurol 2013;112:1099-101. doi: 10.1016/B978-0-444-52910-7.00028-3. PMID: 23622316

Therapy

Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.
Dunay IR, Gajurel K, Dhakal R, Liesenfeld O, Montoya JG
Clin Microbiol Rev 2018 Oct;31(4) Epub 2018 Sep 12 doi: 10.1128/CMR.00057-17. PMID: 30209035Free PMC Article
Congenital toxoplasmosis: An overview of the neurological and ocular manifestations.
Khan K, Khan W
Parasitol Int 2018 Dec;67(6):715-721. Epub 2018 Jul 21 doi: 10.1016/j.parint.2018.07.004. PMID: 30041005
TORCH infections.
Neu N, Duchon J, Zachariah P
Clin Perinatol 2015 Mar;42(1):77-103, viii. Epub 2014 Dec 20 doi: 10.1016/j.clp.2014.11.001. PMID: 25677998
Management of Toxoplasma gondii infection during pregnancy.
Montoya JG, Remington JS
Clin Infect Dis 2008 Aug 15;47(4):554-66. doi: 10.1086/590149. PMID: 18624630
Toxoplasma gondii: transmission, diagnosis and prevention.
Hill D, Dubey JP
Clin Microbiol Infect 2002 Oct;8(10):634-40. doi: 10.1046/j.1469-0691.2002.00485.x. PMID: 12390281

Prognosis

Is the incidence of congenital toxoplasmosis declining?
Milne GC, Webster JP, Walker M
Trends Parasitol 2023 Jan;39(1):26-37. Epub 2022 Nov 15 doi: 10.1016/j.pt.2022.10.003. PMID: 36400672
Toxoplasmosis in Germany.
Pleyer U, Gross U, Schlüter D, Wilking H, Seeber F
Dtsch Arztebl Int 2019 Jun 21;116(25):435-444. doi: 10.3238/arztebl.2019.0435. PMID: 31423982Free PMC Article
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.
Maldonado YA, Read JS; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-3860. PMID: 28138010
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418689Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2008 Mar 27;2008 PMID: 19450322Free PMC Article

Clinical prediction guides

Toxoplasmosis in Germany.
Pleyer U, Gross U, Schlüter D, Wilking H, Seeber F
Dtsch Arztebl Int 2019 Jun 21;116(25):435-444. doi: 10.3238/arztebl.2019.0435. PMID: 31423982Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2013 Aug 29;2013 PMID: 23987732Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418689Free PMC Article
Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis.
Pappas G, Roussos N, Falagas ME
Int J Parasitol 2009 Oct;39(12):1385-94. Epub 2009 May 9 doi: 10.1016/j.ijpara.2009.04.003. PMID: 19433092
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2008 Mar 27;2008 PMID: 19450322Free PMC Article

Recent systematic reviews

A systematic review of maternal TORCH serology as a screen for suspected fetal infection.
Fitzpatrick D, Holmes NE, Hui L
Prenat Diagn 2022 Jan;42(1):87-96. Epub 2021 Dec 11 doi: 10.1002/pd.6073. PMID: 34893980
Prophylaxis of human toxoplasmosis: a systematic review.
Rajapakse S, Weeratunga P, Rodrigo C, de Silva NL, Fernando SD
Pathog Glob Health 2017 Oct;111(7):333-342. Epub 2017 Sep 26 doi: 10.1080/20477724.2017.1370528. PMID: 28948861Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2013 Aug 29;2013 PMID: 23987732Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418689Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2008 Mar 27;2008 PMID: 19450322Free PMC Article

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