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Congenital toxoplasmosis

MedGen UID:
52799
•Concept ID:
C0040560
•
Disease or Syndrome
Synonyms: Congenital Infection, Toxoplasma gondii; Congenital Toxoplasma gondii Infection; Congenital Toxoplasma Infection; Congenital Toxoplasma Infections; Congenital Toxoplasmoses; Congenital Toxoplasmosis; Infection, Congenital Toxoplasma; Infections, Congenital Toxoplasma; Toxoplasma Infection, Congenital; Toxoplasma Infections, Congenital; Toxoplasmoses, Congenital; Toxoplasmosis, Congenital
SNOMED CT: Congenital toxoplasmosis (73893000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005715
Orphanet: ORPHA858

Definition

A rare fetopathy characterized by ocular, visceral or intracranial lesions secondary to maternal primary infection by <i>Toxoplasma gondii</i> (Tg). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital toxoplasmosis
Follow this link to review classifications for Congenital toxoplasmosis in Orphanet.

Professional guidelines

PubMed

Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.
Dunay IR, Gajurel K, Dhakal R, Liesenfeld O, Montoya JG
Clin Microbiol Rev 2018 Oct;31(4) Epub 2018 Sep 12 doi: 10.1128/CMR.00057-17. PMID: 30209035Free PMC Article
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.
Maldonado YA, Read JS; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-3860. PMID: 28138010
Toxoplasmosis in pregnancy: prevention, screening, and treatment.
Paquet C, Yudin MH; Society of Obstetricians and Gynaecologists of Canada
J Obstet Gynaecol Can 2013 Jan;35(1):78-81. doi: 10.1016/s1701-2163(15)31053-7. PMID: 23343802

Recent clinical studies

Etiology

Toxoplasmosis in pregnancy.
Ahmed M, Sood A, Gupta J
Eur J Obstet Gynecol Reprod Biol 2020 Dec;255:44-50. Epub 2020 Oct 8 doi: 10.1016/j.ejogrb.2020.10.003. PMID: 33075679
General Features and Laboratory Diagnosis of Toxoplasma gondii Infection.
Beder D, Esenkaya Taşbent F
Turkiye Parazitol Derg 2020 Jun 2;44(2):94-101. doi: 10.4274/tpd.galenos.2020.6634. PMID: 32482042
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.
Maldonado YA, Read JS; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-3860. PMID: 28138010
Congenital toxoplasmosis.
Kieffer F, Wallon M
Handb Clin Neurol 2013;112:1099-101. doi: 10.1016/B978-0-444-52910-7.00028-3. PMID: 23622316
Toxoplasmosis in pregnancy: prevention, screening, and treatment.
Paquet C, Yudin MH; Society of Obstetricians and Gynaecologists of Canada
J Obstet Gynaecol Can 2013 Jan;35(1):78-81. doi: 10.1016/s1701-2163(15)31053-7. PMID: 23343802

Diagnosis

Toxoplasmosis in pregnancy.
Ahmed M, Sood A, Gupta J
Eur J Obstet Gynecol Reprod Biol 2020 Dec;255:44-50. Epub 2020 Oct 8 doi: 10.1016/j.ejogrb.2020.10.003. PMID: 33075679
General Features and Laboratory Diagnosis of Toxoplasma gondii Infection.
Beder D, Esenkaya Taşbent F
Turkiye Parazitol Derg 2020 Jun 2;44(2):94-101. doi: 10.4274/tpd.galenos.2020.6634. PMID: 32482042
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.
Maldonado YA, Read JS; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-3860. PMID: 28138010
Congenital Toxoplasmosis: A Review.
Hampton MM
Neonatal Netw 2015;34(5):274-8. doi: 10.1891/0730-0832.34.5.274. PMID: 26802827
Congenital toxoplasmosis.
Kieffer F, Wallon M
Handb Clin Neurol 2013;112:1099-101. doi: 10.1016/B978-0-444-52910-7.00028-3. PMID: 23622316

Therapy

Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.
Dunay IR, Gajurel K, Dhakal R, Liesenfeld O, Montoya JG
Clin Microbiol Rev 2018 Oct;31(4) Epub 2018 Sep 12 doi: 10.1128/CMR.00057-17. PMID: 30209035Free PMC Article
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.
Maldonado YA, Read JS; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-3860. PMID: 28138010
TORCH infections.
Neu N, Duchon J, Zachariah P
Clin Perinatol 2015 Mar;42(1):77-103, viii. Epub 2014 Dec 20 doi: 10.1016/j.clp.2014.11.001. PMID: 25677998
Management of Toxoplasma gondii infection during pregnancy.
Montoya JG, Remington JS
Clin Infect Dis 2008 Aug 15;47(4):554-66. doi: 10.1086/590149. PMID: 18624630
Toxoplasma gondii: transmission, diagnosis and prevention.
Hill D, Dubey JP
Clin Microbiol Infect 2002 Oct;8(10):634-40. doi: 10.1046/j.1469-0691.2002.00485.x. PMID: 12390281

Prognosis

Toxoplasmosis in Germany.
Pleyer U, Gross U, Schlüter D, Wilking H, Seeber F
Dtsch Arztebl Int 2019 Jun 21;116(25):435-444. doi: 10.3238/arztebl.2019.0435. PMID: 31423982Free PMC Article
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.
Maldonado YA, Read JS; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-3860. PMID: 28138010
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418689Free PMC Article
Congenital toxoplasmosis.
Martin S
Neonatal Netw 2001 Jun;20(4):23-30. doi: 10.1891/0730-0832.20.4.23. PMID: 12143899
Toxoplasmosis.
Beazley DM, Egerman RS
Semin Perinatol 1998 Aug;22(4):332-8. doi: 10.1016/s0146-0005(98)80022-0. PMID: 9738998

Clinical prediction guides

Congenital Toxoplasmosis and Long-term Outcomes.
Gundeslioglu OO, Haytoglu Z, Esen E, Alabaz D, Cay U, Ozlu F, Kibar F, Cetiner S
Turkiye Parazitol Derg 2024 Mar 5;48(1):8-14. doi: 10.4274/tpd.galenos.2024.74046. PMID: 38449361
Toxoplasmosis in Germany.
Pleyer U, Gross U, Schlüter D, Wilking H, Seeber F
Dtsch Arztebl Int 2019 Jun 21;116(25):435-444. doi: 10.3238/arztebl.2019.0435. PMID: 31423982Free PMC Article
Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis.
El Bissati K, Levigne P, Lykins J, Adlaoui EB, Barkat A, Berraho A, Laboudi M, El Mansouri B, Ibrahimi A, Rhajaoui M, Quinn F, Murugesan M, Seghrouchni F, Gómez-Marín JE, Peyron F, McLeod R
Emerg Microbes Infect 2018 Sep 27;7(1):165. doi: 10.1038/s41426-018-0164-4. PMID: 30262847Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2013 Aug 29;2013 PMID: 23987732Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418689Free PMC Article

Recent systematic reviews

A systematic review of maternal TORCH serology as a screen for suspected fetal infection.
Fitzpatrick D, Holmes NE, Hui L
Prenat Diagn 2022 Jan;42(1):87-96. Epub 2021 Dec 11 doi: 10.1002/pd.6073. PMID: 34893980
Prophylaxis of human toxoplasmosis: a systematic review.
Rajapakse S, Weeratunga P, Rodrigo C, de Silva NL, Fernando SD
Pathog Glob Health 2017 Oct;111(7):333-342. Epub 2017 Sep 26 doi: 10.1080/20477724.2017.1370528. PMID: 28948861Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2013 Aug 29;2013 PMID: 23987732Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418689Free PMC Article
Congenital toxoplasmosis.
Kravetz J
BMJ Clin Evid 2008 Mar 27;2008 PMID: 19450322Free PMC Article

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