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Trachoma

MedGen UID:
52801
•Concept ID:
C0040592
•
Disease or Syndrome
Synonyms: Egyptian Ophthalmia; Ophthalmia, Egyptian; Trachomas
SNOMED CT: Trachoma (2576002)
 
Monarch Initiative: MONDO:0001249

Definition

A chronic infection of the conjunctiva and cornea caused by chlamydia trachomatis. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrachoma

Professional guidelines

PubMed

Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Natural products for the treatment of trachoma and Chlamydia trachomatis.
Potroz MG, Cho NJ
Molecules 2015 Mar 5;20(3):4180-203. doi: 10.3390/molecules20034180. PMID: 25751782Free PMC Article
Trachoma: an update on prevention, diagnosis, and treatment.
Bhosai SJ, Bailey RL, Gaynor BD, Lietman TM
Curr Opin Ophthalmol 2012 Jul;23(4):288-95. doi: 10.1097/ICU.0b013e32835438fc. PMID: 22569465Free PMC Article

Recent clinical studies

Etiology

Trachoma elimination, approaching 2020.
Diab MM, Allen RC, Gawdat TI, Saif AS
Curr Opin Ophthalmol 2018 Sep;29(5):451-457. doi: 10.1097/ICU.0000000000000504. PMID: 29965850
Trachoma.
Lansingh VC
BMJ Clin Evid 2016 Feb 9;2016 PMID: 26860629Free PMC Article
Antibiotics for trachoma.
Evans JR, Solomon AW
Cochrane Database Syst Rev 2011 Mar 16;(3):CD001860. doi: 10.1002/14651858.CD001860.pub3. PMID: 21412875
Trachoma survey methods: a literature review.
Ngondi J, Reacher M, Matthews F, Brayne C, Emerson P
Bull World Health Organ 2009 Feb;87(2):143-51. doi: 10.2471/blt.07.046326. PMID: 19274367Free PMC Article
Antibiotics for trachoma.
Mabey D, Fraser-Hurt N, Powell C
Cochrane Database Syst Rev 2005 Apr 18;(2):CD001860. doi: 10.1002/14651858.CD001860.pub2. PMID: 15846624

Diagnosis

Trachoma.
Nat Rev Dis Primers 2022 May 26;8(1):33. doi: 10.1038/s41572-022-00369-3. PMID: 35618865
Trachoma.
Taylor HR, Burton MJ, Haddad D, West S, Wright H
Lancet 2014 Dec 13;384(9960):2142-52. Epub 2014 Jul 17 doi: 10.1016/S0140-6736(13)62182-0. PMID: 25043452
Trichiasis.
Ferreira IS, Bernardes TF, Bonfioli AA
Semin Ophthalmol 2010 May;25(3):66-71. doi: 10.3109/08820538.2010.488580. PMID: 20590415
Trachoma.
Wright HR, Turner A, Taylor HR
Lancet 2008 Jun 7;371(9628):1945-54. doi: 10.1016/S0140-6736(08)60836-3. PMID: 18539226
Madarosis.
Khong JJ, Casson RJ, Huilgol SC, Selva D
Surv Ophthalmol 2006 Nov-Dec;51(6):550-60. doi: 10.1016/j.survophthal.2006.08.004. PMID: 17134645

Therapy

Trachoma.
Lansingh VC
BMJ Clin Evid 2016 Feb 9;2016 PMID: 26860629Free PMC Article
Antibiotics for trachoma.
Evans JR, Solomon AW
Cochrane Database Syst Rev 2011 Mar 16;(3):CD001860. doi: 10.1002/14651858.CD001860.pub3. PMID: 21412875
Trachoma survey methods: a literature review.
Ngondi J, Reacher M, Matthews F, Brayne C, Emerson P
Bull World Health Organ 2009 Feb;87(2):143-51. doi: 10.2471/blt.07.046326. PMID: 19274367Free PMC Article
Trachoma.
Wright HR, Turner A, Taylor HR
Lancet 2008 Jun 7;371(9628):1945-54. doi: 10.1016/S0140-6736(08)60836-3. PMID: 18539226
Antibiotics for trachoma.
Mabey D, Fraser-Hurt N, Powell C
Cochrane Database Syst Rev 2005 Apr 18;(2):CD001860. doi: 10.1002/14651858.CD001860.pub2. PMID: 15846624

Prognosis

History through the eyes of a pandemic.
Graversen VK, Hamichi SE, Gold A, Murray TG
Curr Opin Ophthalmol 2020 Nov;31(6):538-548. doi: 10.1097/ICU.0000000000000711. PMID: 33009087
A Review of the Literature on the Global Epidemiology of Corneal Blindness.
Porth JM, Deiotte E, Dunn M, Bashshur R
Cornea 2019 Dec;38(12):1602-1609. doi: 10.1097/ICO.0000000000002122. PMID: 31433359
Trachoma elimination, approaching 2020.
Diab MM, Allen RC, Gawdat TI, Saif AS
Curr Opin Ophthalmol 2018 Sep;29(5):451-457. doi: 10.1097/ICU.0000000000000504. PMID: 29965850
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Azithromycin in periodontal treatment: more than an antibiotic.
Hirsch R, Deng H, Laohachai MN
J Periodontal Res 2012 Apr;47(2):137-48. Epub 2011 Nov 4 doi: 10.1111/j.1600-0765.2011.01418.x. PMID: 22050485

Clinical prediction guides

Monitoring transmission intensity of trachoma with serology.
Tedijanto C, Solomon AW, Martin DL, Nash SD, Keenan JD, Lietman TM, Lammie PJ, Aiemjoy K, Amza A, Aragie S, Arzika AM, Callahan EK, Carolan S, Dawed AA, Goodhew EB, Gwyn S, Hammou J, Kadri B, Kalua K, Maliki R, Nassirou B, Seife F, Tadesse Z, West SK, Wittberg DM, Zeru Tadege T, Arnold BF
Nat Commun 2023 Jun 5;14(1):3269. doi: 10.1038/s41467-023-38940-5. PMID: 37277341Free PMC Article
Effect of water, sanitation, and hygiene on the prevention of trachoma: a systematic review and meta-analysis.
Stocks ME, Ogden S, Haddad D, Addiss DG, McGuire C, Freeman MC
PLoS Med 2014 Feb;11(2):e1001605. Epub 2014 Feb 25 doi: 10.1371/journal.pmed.1001605. PMID: 24586120Free PMC Article
Modelling trachoma for control programmes.
Gambhir M, Basáñez MG, Blake IM, Grassly NC
Adv Exp Med Biol 2010;673:141-56. doi: 10.1007/978-1-4419-6064-1_10. PMID: 20632535
Trachoma.
Solomon A, Mabey D
BMJ Clin Evid 2007 Nov 7;2007 PMID: 19450349Free PMC Article
Trachoma: transmission, infection, and control.
Gambhir M, Basáñez MG, Turner F, Kumaresan J, Grassly NC
Lancet Infect Dis 2007 Jun;7(6):420-7. doi: 10.1016/S1473-3099(07)70137-8. PMID: 17521595

Recent systematic reviews

TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface.
Alves M, Asbell P, Dogru M, Giannaccare G, Grau A, Gregory D, Kim DH, Marini MC, Ngo W, Nowinska A, Saldanha IJ, Villani E, Wakamatsu TH, Yu M, Stapleton F
Ocul Surf 2023 Jul;29:1-52. Epub 2023 Apr 14 doi: 10.1016/j.jtos.2023.04.007. PMID: 37062427
Antibiotics for trachoma.
Evans JR, Solomon AW, Kumar R, Perez Á, Singh BP, Srivastava RM, Harding-Esch E
Cochrane Database Syst Rev 2019 Sep 26;9(9):CD001860. doi: 10.1002/14651858.CD001860.pub4. PMID: 31554017Free PMC Article
Trachoma.
Lansingh VC
BMJ Clin Evid 2016 Feb 9;2016 PMID: 26860629Free PMC Article
Antibiotics for trachoma.
Evans JR, Solomon AW
Cochrane Database Syst Rev 2011 Mar 16;(3):CD001860. doi: 10.1002/14651858.CD001860.pub3. PMID: 21412875
Antibiotics for trachoma.
Mabey D, Fraser-Hurt N, Powell C
Cochrane Database Syst Rev 2005 Apr 18;(2):CD001860. doi: 10.1002/14651858.CD001860.pub2. PMID: 15846624

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