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Tumor lysis syndrome

MedGen UID:
52890
•Concept ID:
C0041364
•
Disease or Syndrome
Synonyms: Syndrome, Tumor Lysis; Syndrome, Tumour Lysis; Syndromes, Tumor Lysis; Syndromes, Tumour Lysis; Tumor Lysis Syndrome; Tumor Lysis Syndromes; Tumour Lysis Syndrome; Tumour Lysis Syndromes
SNOMED CT: Tumor lysis syndrome (277605001)
 
Monarch Initiative: MONDO:0043875

Definition

A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor lysis syndrome

Professional guidelines

PubMed

Diagnosis and Management of Oncologic Emergencies.
Klemencic S, Perkins J
West J Emerg Med 2019 Mar;20(2):316-322. Epub 2019 Feb 14 doi: 10.5811/westjem.2018.12.37335. PMID: 30881552Free PMC Article
Hyperleukocytosis and leukostasis: management of a medical emergency.
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252
Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review.
Coiffier B, Altman A, Pui CH, Younes A, Cairo MS
J Clin Oncol 2008 Jun 1;26(16):2767-78. doi: 10.1200/JCO.2007.15.0177. PMID: 18509186

Recent clinical studies

Etiology

Tumor Lysis Syndrome.
Durfee EM
Crit Care Nurse 2022 Jun 1;42(3):19-25. doi: 10.4037/ccn2022795. PMID: 35640898
Emergencies in haematology: tumour lysis syndrome.
Durani U, Hogan WJ
Br J Haematol 2020 Feb;188(4):494-500. Epub 2019 Nov 27 doi: 10.1111/bjh.16278. PMID: 31774551
Tumour lysis syndrome.
Calvo Villas JM
Med Clin (Barc) 2019 May 17;152(10):397-404. Epub 2019 Jan 3 doi: 10.1016/j.medcli.2018.10.029. PMID: 30612747
The tumor lysis syndrome.
Howard SC, Jones DP, Pui CH
N Engl J Med 2011 May 12;364(19):1844-54. doi: 10.1056/NEJMra0904569. PMID: 21561350Free PMC Article
Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review.
Coiffier B, Altman A, Pui CH, Younes A, Cairo MS
J Clin Oncol 2008 Jun 1;26(16):2767-78. doi: 10.1200/JCO.2007.15.0177. PMID: 18509186

Diagnosis

Tumor Lysis Syndrome.
Durfee EM
Crit Care Nurse 2022 Jun 1;42(3):19-25. doi: 10.4037/ccn2022795. PMID: 35640898
Tumor Lysis Syndrome.
Barbar T, Jaffer Sathick I
Adv Chronic Kidney Dis 2021 Sep;28(5):438-446.e1. doi: 10.1053/j.ackd.2021.09.007. PMID: 35190110
Diagnosis and Management of Oncologic Emergencies.
Klemencic S, Perkins J
West J Emerg Med 2019 Mar;20(2):316-322. Epub 2019 Feb 14 doi: 10.5811/westjem.2018.12.37335. PMID: 30881552Free PMC Article
Tumour lysis syndrome.
Calvo Villas JM
Med Clin (Barc) 2019 May 17;152(10):397-404. Epub 2019 Jan 3 doi: 10.1016/j.medcli.2018.10.029. PMID: 30612747
Hyperleukocytosis and leukostasis: management of a medical emergency.
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252

Therapy

Tumor Lysis Syndrome.
Barbar T, Jaffer Sathick I
Adv Chronic Kidney Dis 2021 Sep;28(5):438-446.e1. doi: 10.1053/j.ackd.2021.09.007. PMID: 35190110
Emergencies in haematology: tumour lysis syndrome.
Durani U, Hogan WJ
Br J Haematol 2020 Feb;188(4):494-500. Epub 2019 Nov 27 doi: 10.1111/bjh.16278. PMID: 31774551
Tumour lysis syndrome.
Calvo Villas JM
Med Clin (Barc) 2019 May 17;152(10):397-404. Epub 2019 Jan 3 doi: 10.1016/j.medcli.2018.10.029. PMID: 30612747
Venetoclax-Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia.
Seymour JF, Kipps TJ, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Gerecitano J, Robak T, De la Serna J, Jaeger U, Cartron G, Montillo M, Humerickhouse R, Punnoose EA, Li Y, Boyer M, Humphrey K, Mobasher M, Kater AP
N Engl J Med 2018 Mar 22;378(12):1107-1120. doi: 10.1056/NEJMoa1713976. PMID: 29562156
Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review.
Coiffier B, Altman A, Pui CH, Younes A, Cairo MS
J Clin Oncol 2008 Jun 1;26(16):2767-78. doi: 10.1200/JCO.2007.15.0177. PMID: 18509186

Prognosis

Pediatric Hematologic and Oncologic Emergencies.
Stephanos K, Dubbs SB
Emerg Med Clin North Am 2021 Aug;39(3):555-571. Epub 2021 Jun 9 doi: 10.1016/j.emc.2021.04.007. PMID: 34215402
Prevention and Treatment of Tumor Lysis Syndrome in the Era of Onco-Nephrology Progress.
Matuszkiewicz-Rowinska J, Malyszko J
Kidney Blood Press Res 2020;45(5):645-660. Epub 2020 Sep 30 doi: 10.1159/000509934. PMID: 32998135
Emergencies in haematology: tumour lysis syndrome.
Durani U, Hogan WJ
Br J Haematol 2020 Feb;188(4):494-500. Epub 2019 Nov 27 doi: 10.1111/bjh.16278. PMID: 31774551
Tumour lysis syndrome.
Calvo Villas JM
Med Clin (Barc) 2019 May 17;152(10):397-404. Epub 2019 Jan 3 doi: 10.1016/j.medcli.2018.10.029. PMID: 30612747
Hyperleukocytosis and leukostasis: management of a medical emergency.
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252

Clinical prediction guides

Recognizing, defining, and managing CAR-T hematologic toxicities.
Rejeski K, Subklewe M, Locke FL
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):198-208. doi: 10.1182/hematology.2023000472. PMID: 38066881Free PMC Article
Electrolyte and Acid-Base Disorders Associated with Cancer Immunotherapy.
Uppal NN, Workeneh BT, Rondon-Berrios H, Jhaveri KD
Clin J Am Soc Nephrol 2022 Jun;17(6):922-933. Epub 2022 Jan 21 doi: 10.2215/CJN.14671121. PMID: 35063968Free PMC Article
Prevention and Treatment of Tumor Lysis Syndrome in the Era of Onco-Nephrology Progress.
Matuszkiewicz-Rowinska J, Malyszko J
Kidney Blood Press Res 2020;45(5):645-660. Epub 2020 Sep 30 doi: 10.1159/000509934. PMID: 32998135
Emergencies in haematology: tumour lysis syndrome.
Durani U, Hogan WJ
Br J Haematol 2020 Feb;188(4):494-500. Epub 2019 Nov 27 doi: 10.1111/bjh.16278. PMID: 31774551
Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia.
DiNardo CD, Pratz K, Pullarkat V, Jonas BA, Arellano M, Becker PS, Frankfurt O, Konopleva M, Wei AH, Kantarjian HM, Xu T, Hong WJ, Chyla B, Potluri J, Pollyea DA, Letai A
Blood 2019 Jan 3;133(1):7-17. Epub 2018 Oct 25 doi: 10.1182/blood-2018-08-868752. PMID: 30361262Free PMC Article

Recent systematic reviews

Tyrosine kinase inhibitors and tumor lysis syndrome in hematologic malignancies: A systemic review.
Salter B, Burns I, Fuller K, Eshaghpour A, Lionel AC, Crowther M
Eur J Haematol 2022 Aug;109(2):166-181. Epub 2022 May 24 doi: 10.1111/ejh.13786. PMID: 35531791
Tumor lysis syndrome in the era of novel and targeted agents in patients with hematologic malignancies: a systematic review.
Howard SC, Trifilio S, Gregory TK, Baxter N, McBride A
Ann Hematol 2016 Mar;95(4):563-73. Epub 2016 Jan 12 doi: 10.1007/s00277-015-2585-7. PMID: 26758269
Rasburicase in tumor lysis syndrome of the adult: a systematic review and meta-analysis.
Lopez-Olivo MA, Pratt G, Palla SL, Salahudeen A
Am J Kidney Dis 2013 Sep;62(3):481-92. Epub 2013 May 14 doi: 10.1053/j.ajkd.2013.02.378. PMID: 23684124
Tumor lysis syndrome: a systematic review of case series and case reports.
Firwana BM, Hasan R, Hasan N, Alahdab F, Alnahhas I, Hasan S, Varon J
Postgrad Med 2012 Mar;124(2):92-101. doi: 10.3810/pgm.2012.03.2540. PMID: 22437219
Urate oxidase for the prevention and treatment of tumor lysis syndrome in children with cancer.
Cheuk DK, Chiang AK, Chan GC, Ha SY
Cochrane Database Syst Rev 2010 Jun 16;(6):CD006945. doi: 10.1002/14651858.CD006945.pub2. PMID: 20556770

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