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Upper gastrointestinal bleeding

MedGen UID:
52926
Concept ID:
C0041909
Pathologic Function
Synonym: Upper gastrointestinal hemorrhage
SNOMED CT: Upper GI - gastrointestinal hemorrhage (37372002); Upper gastrointestinal hemorrhage (37372002); Upper gastrointestinal bleeding (37372002); Upper GI hemorrhage (37372002); Upper GI bleeding (37372002)

Definition

Bleeding originating from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach). [from NCI]

Professional guidelines

PubMed

Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI
Am J Gastroenterol 2021 May 1;116(5):899-917. doi: 10.14309/ajg.0000000000001245. PMID: 33929377
Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M
Ann Intern Med 2019 Dec 3;171(11):805-822. Epub 2019 Oct 22 doi: 10.7326/M19-1795. PMID: 31634917Free PMC Article
Kamboj AK, Hoversten P, Leggett CL
Mayo Clin Proc 2019 Apr;94(4):697-703. doi: 10.1016/j.mayocp.2019.01.022. PMID: 30947833

Recent clinical studies

Etiology

Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip HC, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY
N Engl J Med 2020 Apr 2;382(14):1299-1308. doi: 10.1056/NEJMoa1912484. PMID: 32242355
Kamboj AK, Hoversten P, Leggett CL
Mayo Clin Proc 2019 Apr;94(4):697-703. doi: 10.1016/j.mayocp.2019.01.022. PMID: 30947833
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Tielleman T, Bujanda D, Cryer B
Gastrointest Endosc Clin N Am 2015 Jul;25(3):415-28. doi: 10.1016/j.giec.2015.02.010. PMID: 26142028
Khamaysi I, Gralnek IM
Best Pract Res Clin Gastroenterol 2013 Oct;27(5):633-8. Epub 2013 Sep 25 doi: 10.1016/j.bpg.2013.09.002. PMID: 24160923

Diagnosis

Novak I, Bass LM
Gastrointest Endosc Clin N Am 2023 Apr;33(2):401-421. doi: 10.1016/j.giec.2022.11.003. PMID: 36948753
Lau LHS, Sung JJY
Dig Endosc 2021 Jan;33(1):83-94. Epub 2020 May 20 doi: 10.1111/den.13674. PMID: 32216134
Kamboj AK, Hoversten P, Leggett CL
Mayo Clin Proc 2019 Apr;94(4):697-703. doi: 10.1016/j.mayocp.2019.01.022. PMID: 30947833
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Khamaysi I, Gralnek IM
Best Pract Res Clin Gastroenterol 2013 Oct;27(5):633-8. Epub 2013 Sep 25 doi: 10.1016/j.bpg.2013.09.002. PMID: 24160923

Therapy

Novak I, Bass LM
Gastrointest Endosc Clin N Am 2023 Apr;33(2):401-421. doi: 10.1016/j.giec.2022.11.003. PMID: 36948753
Targownik LE, Fisher DA, Saini SD
Gastroenterology 2022 Apr;162(4):1334-1342. Epub 2022 Feb 17 doi: 10.1053/j.gastro.2021.12.247. PMID: 35183361
Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip HC, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY
N Engl J Med 2020 Apr 2;382(14):1299-1308. doi: 10.1056/NEJMoa1912484. PMID: 32242355
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Villanueva C, Colomo A, Bosch A, Concepción M, Hernandez-Gea V, Aracil C, Graupera I, Poca M, Alvarez-Urturi C, Gordillo J, Guarner-Argente C, Santaló M, Muñiz E, Guarner C
N Engl J Med 2013 Jan 3;368(1):11-21. doi: 10.1056/NEJMoa1211801. PMID: 23281973

Prognosis

PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM
JAMA 2020 Feb 18;323(7):616-626. doi: 10.1001/jama.2019.22190. PMID: 31950977Free PMC Article
Oakland K
Best Pract Res Clin Gastroenterol 2019 Oct-Dec;42-43:101610. Epub 2019 Apr 17 doi: 10.1016/j.bpg.2019.04.003. PMID: 31785737
Cook D, Guyatt G
N Engl J Med 2018 Jun 28;378(26):2506-2516. doi: 10.1056/NEJMra1605507. PMID: 29949497
Tielleman T, Bujanda D, Cryer B
Gastrointest Endosc Clin N Am 2015 Jul;25(3):415-28. doi: 10.1016/j.giec.2015.02.010. PMID: 26142028
Arora NK, Ganguly S, Mathur P, Ahuja A, Patwari A
Indian J Pediatr 2002 Feb;69(2):155-68. doi: 10.1007/BF02859378. PMID: 11929033

Clinical prediction guides

Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI
Am J Gastroenterol 2021 May 1;116(5):899-917. doi: 10.14309/ajg.0000000000001245. PMID: 33929377
Lau LHS, Sung JJY
Dig Endosc 2021 Jan;33(1):83-94. Epub 2020 May 20 doi: 10.1111/den.13674. PMID: 32216134
Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip HC, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY
N Engl J Med 2020 Apr 2;382(14):1299-1308. doi: 10.1056/NEJMoa1912484. PMID: 32242355
Sung JJ, Chiu PW, Chan FKL, Lau JY, Goh KL, Ho LH, Jung HY, Sollano JD, Gotoda T, Reddy N, Singh R, Sugano K, Wu KC, Wu CY, Bjorkman DJ, Jensen DM, Kuipers EJ, Lanas A
Gut 2018 Oct;67(10):1757-1768. Epub 2018 Apr 24 doi: 10.1136/gutjnl-2018-316276. PMID: 29691276Free PMC Article
Blatchford O, Murray WR, Blatchford M
Lancet 2000 Oct 14;356(9238):1318-21. doi: 10.1016/S0140-6736(00)02816-6. PMID: 11073021

Recent systematic reviews

Kurlander JE, Barnes GD, Fisher A, Gonzalez JJ, Helminski D, Saini SD, Sengupta N, Yang YX, Scheiman J, Laine L
Am J Med 2022 Oct;135(10):1231-1243.e8. Epub 2022 Jun 7 doi: 10.1016/j.amjmed.2022.05.031. PMID: 35679879Free PMC Article
Kanno T, Yuan Y, Tse F, Howden CW, Moayyedi P, Leontiadis GI
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD005415. doi: 10.1002/14651858.CD005415.pub4. PMID: 34995368Free PMC Article
Lee PL, Yang KS, Tsai HW, Hou SK, Kang YN, Chang CC
Am J Emerg Med 2021 Jul;45:269-279. Epub 2020 Aug 29 doi: 10.1016/j.ajem.2020.08.062. PMID: 33041136
Stanley AJ, Laine L
BMJ 2019 Mar 25;364:l536. doi: 10.1136/bmj.l536. PMID: 30910853
Odutayo A, Desborough MJ, Trivella M, Stanley AJ, Dorée C, Collins GS, Hopewell S, Brunskill SJ, Kahan BC, Logan RF, Barkun AN, Murphy MF, Jairath V
Lancet Gastroenterol Hepatol 2017 May;2(5):354-360. Epub 2017 Mar 23 doi: 10.1016/S2468-1253(17)30054-7. PMID: 28397699

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