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Upper gastrointestinal bleeding

MedGen UID:
52926
Concept ID:
C0041909
Pathologic Function
Synonym: Upper gastrointestinal hemorrhage
SNOMED CT: Upper GI - gastrointestinal hemorrhage (37372002); Upper gastrointestinal hemorrhage (37372002); Upper gastrointestinal bleeding (37372002); Upper GI hemorrhage (37372002); Upper GI bleeding (37372002)

Definition

Bleeding originating from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach). [from NCI]

Professional guidelines

PubMed

Wilkins T, Wheeler B, Carpenter M
Am Fam Physician 2020 Mar 1;101(5):294-300. PMID: 32109037
Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M
Ann Intern Med 2019 Dec 3;171(11):805-822. Epub 2019 Oct 22 doi: 10.7326/M19-1795. PMID: 31634917Free PMC Article
Kamboj AK, Hoversten P, Leggett CL
Mayo Clin Proc 2019 Apr;94(4):697-703. doi: 10.1016/j.mayocp.2019.01.022. PMID: 30947833

Recent clinical studies

Etiology

Lau LHS, Sung JJY
Dig Endosc 2021 Jan;33(1):83-94. Epub 2020 May 20 doi: 10.1111/den.13674. PMID: 32216134
Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip HC, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY
N Engl J Med 2020 Apr 2;382(14):1299-1308. doi: 10.1056/NEJMoa1912484. PMID: 32242355
Kamboj AK, Hoversten P, Leggett CL
Mayo Clin Proc 2019 Apr;94(4):697-703. doi: 10.1016/j.mayocp.2019.01.022. PMID: 30947833
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Khamaysi I, Gralnek IM
Best Pract Res Clin Gastroenterol 2013 Oct;27(5):633-8. Epub 2013 Sep 25 doi: 10.1016/j.bpg.2013.09.002. PMID: 24160923

Diagnosis

Lau LHS, Sung JJY
Dig Endosc 2021 Jan;33(1):83-94. Epub 2020 May 20 doi: 10.1111/den.13674. PMID: 32216134
Kamboj AK, Hoversten P, Leggett CL
Mayo Clin Proc 2019 Apr;94(4):697-703. doi: 10.1016/j.mayocp.2019.01.022. PMID: 30947833
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Owensby S, Taylor K, Wilkins T
J Am Board Fam Med 2015 Jan-Feb;28(1):134-45. doi: 10.3122/jabfm.2015.01.140153. PMID: 25567834
Khamaysi I, Gralnek IM
Best Pract Res Clin Gastroenterol 2013 Oct;27(5):633-8. Epub 2013 Sep 25 doi: 10.1016/j.bpg.2013.09.002. PMID: 24160923

Therapy

Targownik LE, Fisher DA, Saini SD
Gastroenterology 2022 Apr;162(4):1334-1342. Epub 2022 Feb 17 doi: 10.1053/j.gastro.2021.12.247. PMID: 35183361
Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip HC, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY
N Engl J Med 2020 Apr 2;382(14):1299-1308. doi: 10.1056/NEJMoa1912484. PMID: 32242355
Kherad O, Restellini S, Martel M, Barkun A
Best Pract Res Clin Gastroenterol 2019 Oct-Dec;42-43:101609. Epub 2019 Apr 17 doi: 10.1016/j.bpg.2019.04.002. PMID: 31785730
Samuel R, Bilal M, Tayyem O, Guturu P
Dis Mon 2018 Jul;64(7):333-343. Epub 2018 Mar 7 doi: 10.1016/j.disamonth.2018.02.003. PMID: 29525375
Villanueva C, Colomo A, Bosch A, Concepción M, Hernandez-Gea V, Aracil C, Graupera I, Poca M, Alvarez-Urturi C, Gordillo J, Guarner-Argente C, Santaló M, Muñiz E, Guarner C
N Engl J Med 2013 Jan 3;368(1):11-21. doi: 10.1056/NEJMoa1211801. PMID: 23281973

Prognosis

Mauro A, De Grazia F, Lenti MV, Penagini R, Frego R, Ardizzone S, Savarino E, Radaelli F, Bosani M, Orlando S, Amato A, Dinelli M, Ferretti F, Filippi E, Vecchi M, Stradella D, Bardone M, Pozzi L, Rovedatti L, Strada E, Di Sabatino A
Clin Res Hepatol Gastroenterol 2021 May;45(3):101521. Epub 2020 Aug 14 doi: 10.1016/j.clinre.2020.07.025. PMID: 32888875Free PMC Article
PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM
JAMA 2020 Feb 18;323(7):616-626. doi: 10.1001/jama.2019.22190. PMID: 31950977Free PMC Article
Oakland K
Best Pract Res Clin Gastroenterol 2019 Oct-Dec;42-43:101610. Epub 2019 Apr 17 doi: 10.1016/j.bpg.2019.04.003. PMID: 31785737
Cook D, Guyatt G
N Engl J Med 2018 Jun 28;378(26):2506-2516. doi: 10.1056/NEJMra1605507. PMID: 29949497
Tielleman T, Bujanda D, Cryer B
Gastrointest Endosc Clin N Am 2015 Jul;25(3):415-28. doi: 10.1016/j.giec.2015.02.010. PMID: 26142028

Clinical prediction guides

Lau JYW
Dig Endosc 2022 Jan;34(2):260-264. Epub 2021 Oct 11 doi: 10.1111/den.14144. PMID: 34551156
Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI
Am J Gastroenterol 2021 May 1;116(5):899-917. doi: 10.14309/ajg.0000000000001245. PMID: 33929377
Lau LHS, Sung JJY
Dig Endosc 2021 Jan;33(1):83-94. Epub 2020 May 20 doi: 10.1111/den.13674. PMID: 32216134
Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip HC, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY
N Engl J Med 2020 Apr 2;382(14):1299-1308. doi: 10.1056/NEJMoa1912484. PMID: 32242355
Sung JJ, Chiu PW, Chan FKL, Lau JY, Goh KL, Ho LH, Jung HY, Sollano JD, Gotoda T, Reddy N, Singh R, Sugano K, Wu KC, Wu CY, Bjorkman DJ, Jensen DM, Kuipers EJ, Lanas A
Gut 2018 Oct;67(10):1757-1768. Epub 2018 Apr 24 doi: 10.1136/gutjnl-2018-316276. PMID: 29691276Free PMC Article

Recent systematic reviews

Kanno T, Yuan Y, Tse F, Howden CW, Moayyedi P, Leontiadis GI
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD005415. doi: 10.1002/14651858.CD005415.pub4. PMID: 34995368Free PMC Article
Lee PL, Yang KS, Tsai HW, Hou SK, Kang YN, Chang CC
Am J Emerg Med 2021 Jul;45:269-279. Epub 2020 Aug 29 doi: 10.1016/j.ajem.2020.08.062. PMID: 33041136
Stanley AJ, Laine L
BMJ 2019 Mar 25;364:l536. doi: 10.1136/bmj.l536. PMID: 30910853
Toews I, George AT, Peter JV, Kirubakaran R, Fontes LES, Ezekiel JPB, Meerpohl JJ
Cochrane Database Syst Rev 2018 Jun 4;6(6):CD008687. doi: 10.1002/14651858.CD008687.pub2. PMID: 29862492Free PMC Article
Odutayo A, Desborough MJ, Trivella M, Stanley AJ, Dorée C, Collins GS, Hopewell S, Brunskill SJ, Kahan BC, Logan RF, Barkun AN, Murphy MF, Jairath V
Lancet Gastroenterol Hepatol 2017 May;2(5):354-360. Epub 2017 Mar 23 doi: 10.1016/S2468-1253(17)30054-7. PMID: 28397699

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