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Entoptic phenomenon

MedGen UID:
53032
•Concept ID:
C0042795
•
Disease or Syndrome
Synonyms: Entoptic Phenomena; Entoptic Phenomenon; Entoptic Vision; Phenomena, Entoptic; Phenomenon, Entoptic; Vision, Entoptic
SNOMED CT: Entoptic phenomenon (421809001)
 
HPO: HP:6001103

Definition

Visual sensations caused by changes within the eye itself, rather than by the normal light stimulation process. Entoptic phenomena are classified in the syndrome as floaters, blue field entoptic phenomenon, photopsia and self-light of the eye. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEntoptic phenomenon

Professional guidelines

PubMed

Visual snow syndrome: recent advances in understanding the pathophysiology and potential treatment approaches.
Aeschlimann SA, Klein A, Schankin CJ
Curr Opin Neurol 2024 Jun 1;37(3):283-288. Epub 2024 Mar 11 doi: 10.1097/WCO.0000000000001258. PMID: 38465699Free PMC Article
Insights into pathophysiology and treatment of visual snow syndrome: A systematic review.
Eren O, Schankin CJ
Prog Brain Res 2020;255:311-326. Epub 2020 Jun 15 doi: 10.1016/bs.pbr.2020.05.020. PMID: 33008511

Recent clinical studies

Etiology

Haidinger's brushes: Psychophysical analysis of an entoptic phenomenon.
Mottes J, Ortolan D, Ruffato G
Vision Res 2022 Oct;199:108076. Epub 2022 Jun 13 doi: 10.1016/j.visres.2022.108076. PMID: 35709591
Visual snow syndrome, the spectrum of perceptual disorders, and migraine as a common risk factor: A narrative review.
Klein A, Schankin CJ
Headache 2021 Oct;61(9):1306-1313. Epub 2021 Sep 27 doi: 10.1111/head.14213. PMID: 34570907Free PMC Article
The relation between migraine, typical migraine aura and "visual snow".
Schankin CJ, Maniyar FH, Sprenger T, Chou DE, Eller M, Goadsby PJ
Headache 2014 Jun;54(6):957-66. Epub 2014 May 9 doi: 10.1111/head.12378. PMID: 24816400
'Visual snow' - a disorder distinct from persistent migraine aura.
Schankin CJ, Maniyar FH, Digre KB, Goadsby PJ
Brain 2014 May;137(Pt 5):1419-28. Epub 2014 Mar 18 doi: 10.1093/brain/awu050. PMID: 24645145
The blue arc entoptic phenomenon in glaucoma (an American ophthalmological thesis).
Pasquale LR, Brusie S
Trans Am Ophthalmol Soc 2013 Sep;111:46-55. PMID: 24167324Free PMC Article

Diagnosis

Haidinger's brushes: Psychophysical analysis of an entoptic phenomenon.
Mottes J, Ortolan D, Ruffato G
Vision Res 2022 Oct;199:108076. Epub 2022 Jun 13 doi: 10.1016/j.visres.2022.108076. PMID: 35709591
Optical Scattering from Vitreous Floaters.
Harmer SW, Luff AJ, Gini G
Bioelectromagnetics 2022 Feb;43(2):90-105. Epub 2021 Dec 30 doi: 10.1002/bem.22386. PMID: 34969150Free PMC Article
Direct discrimination of structured light by humans.
Sarenac D, Kapahi C, Silva AE, Cory DG, Taminiau I, Thompson B, Pushin DA
Proc Natl Acad Sci U S A 2020 Jun 30;117(26):14682-14687. Epub 2020 Jun 16 doi: 10.1073/pnas.1920226117. PMID: 32546523Free PMC Article
Photopsias: A Key to Diagnosis.
Brown GC, Brown MM, Fischer DH
Ophthalmology 2015 Oct;122(10):2084-94. Epub 2015 Aug 3 doi: 10.1016/j.ophtha.2015.06.025. PMID: 26249730
Blue field entoptoscopy in diabetic retinopathy.
Mittl RN, Tiwari R, Wilkes E
Indian J Ophthalmol 1990 Jan-Mar;38(1):10-3. PMID: 2365429

Therapy

'Visual snow' - a disorder distinct from persistent migraine aura.
Schankin CJ, Maniyar FH, Digre KB, Goadsby PJ
Brain 2014 May;137(Pt 5):1419-28. Epub 2014 Mar 18 doi: 10.1093/brain/awu050. PMID: 24645145
Entoptic phenomenon following pars plana vitrectomy caused by retained preretinal gel.
Yavuz GA, Unver YB, Sinclair SH
Ophthalmic Surg Lasers Imaging 2009 Mar-Apr;40(2):188-91. doi: 10.3928/15428877-20090301-01. PMID: 19320311
The effect of pentoxifylline on retinal capillary blood flow velocity and whole blood viscosity.
Sonkin PL, Sinclair SH, Hatchell DL
Am J Ophthalmol 1993 Jun 15;115(6):775-80. doi: 10.1016/s0002-9394(14)73647-5. PMID: 8506913
Pentoxifylline increases retinal capillary blood flow velocity in patients with diabetes.
Sonkin PL, Kelly LW, Sinclair SH, Hatchell DL
Arch Ophthalmol 1993 Dec;111(12):1647-52. doi: 10.1001/archopht.1993.01090120069024. PMID: 8155035

Prognosis

Optical Scattering from Vitreous Floaters.
Harmer SW, Luff AJ, Gini G
Bioelectromagnetics 2022 Feb;43(2):90-105. Epub 2021 Dec 30 doi: 10.1002/bem.22386. PMID: 34969150Free PMC Article
Direct discrimination of structured light by humans.
Sarenac D, Kapahi C, Silva AE, Cory DG, Taminiau I, Thompson B, Pushin DA
Proc Natl Acad Sci U S A 2020 Jun 30;117(26):14682-14687. Epub 2020 Jun 16 doi: 10.1073/pnas.1920226117. PMID: 32546523Free PMC Article
Polarization perception in humans: on the origin of and relationship between Maxwell's spot and Haidinger's brushes.
Misson GP, Temple SE, Anderson SJ
Sci Rep 2020 Jan 10;10(1):108. doi: 10.1038/s41598-019-56916-8. PMID: 31924831Free PMC Article
The blue arc entoptic phenomenon in glaucoma (an American ophthalmological thesis).
Pasquale LR, Brusie S
Trans Am Ophthalmol Soc 2013 Sep;111:46-55. PMID: 24167324Free PMC Article
Visual consequences of the foveal pit.
Williams DR
Invest Ophthalmol Vis Sci 1980 Jun;19(6):653-67. PMID: 7380624

Clinical prediction guides

Optical Scattering from Vitreous Floaters.
Harmer SW, Luff AJ, Gini G
Bioelectromagnetics 2022 Feb;43(2):90-105. Epub 2021 Dec 30 doi: 10.1002/bem.22386. PMID: 34969150Free PMC Article
Direct discrimination of structured light by humans.
Sarenac D, Kapahi C, Silva AE, Cory DG, Taminiau I, Thompson B, Pushin DA
Proc Natl Acad Sci U S A 2020 Jun 30;117(26):14682-14687. Epub 2020 Jun 16 doi: 10.1073/pnas.1920226117. PMID: 32546523Free PMC Article
Polarization perception in humans: on the origin of and relationship between Maxwell's spot and Haidinger's brushes.
Misson GP, Temple SE, Anderson SJ
Sci Rep 2020 Jan 10;10(1):108. doi: 10.1038/s41598-019-56916-8. PMID: 31924831Free PMC Article
The blue arc entoptic phenomenon in glaucoma (an American ophthalmological thesis).
Pasquale LR, Brusie S
Trans Am Ophthalmol Soc 2013 Sep;111:46-55. PMID: 24167324Free PMC Article
Blue field entoptic phenomenon in amblyopia.
Grunwald JE, Sinclair SH, Crandall AS, Riva CE
Ophthalmology 1981 Oct;88(10):1054-7. doi: 10.1016/s0161-6420(81)80036-x. PMID: 7335309

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