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Xeroderma

MedGen UID:
53106
Concept ID:
C0043345
Disease or Syndrome
Synonym: Xerodermas
SNOMED CT: Dry skin (52475004); Anhydrotic skin (52475004); Xeroderma (52475004); Xerodermia (52475004)

Definition

A non-neoplastic disorder characterized by abnormally dry skin. Causes include vitamin A deficiency, sunlight exposure, medications, metabolic disorders, autoimmune disorders, and hereditary genetic disorders. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Lehmann AR, Fassihi H
DNA Repair (Amst) 2020 Sep;93:102907. doi: 10.1016/j.dnarep.2020.102907. PMID: 33087273
Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P
J Dtsch Dermatol Ges 2019 Nov;17 Suppl 7:3-33. doi: 10.1111/ddg.13906. PMID: 31738016
Moriwaki S, Kanda F, Hayashi M, Yamashita D, Sakai Y, Nishigori C; Xeroderma pigmentosum clinical practice guidelines revision committee
J Dermatol 2017 Oct;44(10):1087-1096. Epub 2017 Aug 3 doi: 10.1111/1346-8138.13907. PMID: 28771907

Recent clinical studies

Etiology

Theil AF, Häckes D, Lans H
DNA Repair (Amst) 2023 Dec;132:103568. Epub 2023 Sep 7 doi: 10.1016/j.dnarep.2023.103568. PMID: 37977600
Lehmann J, Seebode C, Martens MC, Emmert S
Anticancer Res 2018 Feb;38(2):1159-1164. doi: 10.21873/anticanres.12335. PMID: 29374753
Natale V, Raquer H
Orphanet J Rare Dis 2017 Apr 4;12(1):65. doi: 10.1186/s13023-017-0616-2. PMID: 28376890Free PMC Article
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Norgauer J, Idzko M, Panther E, Hellstern O, Herouy Y
Eur J Dermatol 2003 Jan-Feb;13(1):4-9. PMID: 12609773

Diagnosis

Martens MC, Emmert S, Boeckmann L
Genes (Basel) 2021 Jul 29;12(8) doi: 10.3390/genes12081173. PMID: 34440347Free PMC Article
Lehmann J, Seebode C, Martens MC, Emmert S
Anticancer Res 2018 Feb;38(2):1159-1164. doi: 10.21873/anticanres.12335. PMID: 29374753
Natale V, Raquer H
Orphanet J Rare Dis 2017 Apr 4;12(1):65. doi: 10.1186/s13023-017-0616-2. PMID: 28376890Free PMC Article
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Norgauer J, Idzko M, Panther E, Hellstern O, Herouy Y
Eur J Dermatol 2003 Jan-Feb;13(1):4-9. PMID: 12609773

Therapy

Galsky MD, Daneshmand S, Izadmehr S, Gonzalez-Kozlova E, Chan KG, Lewis S, Achkar BE, Dorff TB, Cetnar JP, Neil BO, D'Souza A, Mamtani R, Kyriakopoulos C, Jun T, Gogerly-Moragoda M, Brody R, Xie H, Nie K, Kelly G, Horowitz A, Kinoshita Y, Ellis E, Nose Y, Ioannou G, Cabal R, Del Valle DM, Haines GK, Wang L, Mouw KW, Samstein RM, Mehrazin R, Bhardwaj N, Yu M, Zhao Q, Kim-Schulze S, Sebra R, Zhu J, Gnjatic S, Sfakianos J, Pal SK
Nat Med 2023 Nov;29(11):2825-2834. Epub 2023 Oct 2 doi: 10.1038/s41591-023-02568-1. PMID: 37783966Free PMC Article
Yurchenko AA, Rajabi F, Braz-Petta T, Fassihi H, Lehmann A, Nishigori C, Wang J, Padioleau I, Gunbin K, Panunzi L, Morice-Picard F, Laplante P, Robert C, Kannouche PL, Menck CFM, Sarasin A, Nikolaev SI
Nat Commun 2023 May 4;14(1):2561. doi: 10.1038/s41467-023-38311-0. PMID: 37142601Free PMC Article
Weon JL, Glass DA 2nd
Br J Dermatol 2019 Aug;181(2):249-255. Epub 2018 Nov 25 doi: 10.1111/bjd.17253. PMID: 30265743
Lehmann J, Seebode C, Martens MC, Emmert S
Anticancer Res 2018 Feb;38(2):1159-1164. doi: 10.21873/anticanres.12335. PMID: 29374753
Urabe K, Hori Y
Semin Cutan Med Surg 1997 Mar;16(1):81-5. doi: 10.1016/s1085-5629(97)80039-9. PMID: 9125769

Prognosis

Zebian A, Shaito A, Mazurier F, Rezvani HR, Zibara K
Mutat Res Rev Mutat Res 2019 Oct-Dec;782:108286. Epub 2019 Jul 8 doi: 10.1016/j.mrrev.2019.108286. PMID: 31843141
Lehmann J, Seebode C, Martens MC, Emmert S
Anticancer Res 2018 Feb;38(2):1159-1164. doi: 10.21873/anticanres.12335. PMID: 29374753
Black JO
Head Neck Pathol 2016 Jun;10(2):139-44. Epub 2016 Mar 14 doi: 10.1007/s12105-016-0707-8. PMID: 26975629Free PMC Article
Lehmann AR, McGibbon D, Stefanini M
Orphanet J Rare Dis 2011 Nov 1;6:70. doi: 10.1186/1750-1172-6-70. PMID: 22044607Free PMC Article
Jen M, Murphy M, Grant-Kels JM
Clin Dermatol 2009 Nov-Dec;27(6):529-36. doi: 10.1016/j.clindermatol.2008.09.011. PMID: 19880040

Clinical prediction guides

Maguina M, Kang PB, Tsai AC, Pacak CA
Muscle Nerve 2023 Feb;67(2):101-110. Epub 2022 Oct 3 doi: 10.1002/mus.27721. PMID: 36190439Free PMC Article
Khatri ML
Int J Dermatol 2021 Mar;60(3):314-320. Epub 2021 Feb 4 doi: 10.1111/ijd.15395. PMID: 33538348
Borszéková Pulzová L, Ward TA, Chovanec M
Int J Mol Sci 2020 Mar 22;21(6) doi: 10.3390/ijms21062182. PMID: 32235701Free PMC Article
Jan SN, Khan FA, Khan BA
J Coll Physicians Surg Pak 2011 Feb;21(2):93-6. PMID: 21333240
Daya-Grosjean L
Adv Exp Med Biol 2008;637:19-27. doi: 10.1007/978-0-387-09599-8_3. PMID: 19181107

Recent systematic reviews

Hong DZ, Ong TCC, Timbadia DP, Tan HTA, Kwa ED, Chong WQ, Goh BC, Loh WS, Loh KS, Tan EC, Tay JK
Otolaryngol Head Neck Surg 2023 Jun;168(6):1324-1337. Epub 2023 Feb 17 doi: 10.1002/ohn.222. PMID: 36802061
Brambullo T, Colonna MR, Vindigni V, Piaserico S, Masciopinto G, Galeano M, Costa AL, Bassetto F
Biomed Res Int 2022;2022:8549532. Epub 2022 Jul 18 doi: 10.1155/2022/8549532. PMID: 35898688Free PMC Article
de Andrade FAG, Cavalcanti CEO, Isoldi FC, Ferreira LM
Indian J Dermatol Venereol Leprol 2021 Mar-Apr;87(2):176-189. doi: 10.25259/IJDVL_431_19. PMID: 33769755
Zhang W, Zhang Z
Oncotarget 2016 Dec 27;7(52):86621-86629. doi: 10.18632/oncotarget.13361. PMID: 27863412Free PMC Article
Green AC, McBride P
BMJ Clin Evid 2014 Aug 18;2014 PMID: 25137222Free PMC Article

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