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Late systolic murmur

MedGen UID:
534396
•Concept ID:
C0232261
•
Finding
Synonyms: Late Systolic Heart Murmur; Late Systolic Murmur
SNOMED CT: Late systolic murmur (65254001)
 
HPO: HP:0031666

Definition

A murmur that occurs in the latter phase of systole. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLate systolic murmur

Professional guidelines

PubMed

Current management of mitral valve prolapse.
Bouknight DP, O'Rourke RA
Am Fam Physician 2000 Jun 1;61(11):3343-50, 3353-4. PMID: 10865929
Recent developments in the diagnosis and management of mitral valve prolapse.
Devereux RB
Curr Opin Cardiol 1995 Mar;10(2):107-16. doi: 10.1097/00001573-199503000-00003. PMID: 7787275
The systolic click-murmur syndrome: clinical recognition and management.
O'rourke RA, Crawford MH
Curr Probl Cardiol 1976 Mar-Apr;1(1):1-60. doi: 10.1016/s0146-2806(76)80006-0. PMID: 1017208

Recent clinical studies

Etiology

Mitral valve prolapse with a late-systolic regurgitant murmur may be associated with significant hemodynamic consequences.
Ahmed MI, Sanagala T, Denney T, Inusah S, McGiffin D, Knowlan D, O'Rourke RA, Dell'Italia LJ
Am J Med Sci 2009 Aug;338(2):113-5. doi: 10.1097/MAJ.0b013e31819d5ec6. PMID: 19561453
Recent developments in the diagnosis and management of mitral valve prolapse.
Devereux RB
Curr Opin Cardiol 1995 Mar;10(2):107-16. doi: 10.1097/00001573-199503000-00003. PMID: 7787275
The cumulative risks of prolapsing mitral valve. 40 years of follow-up.
Chapman DW
Tex Heart Inst J 1994;21(4):267-71. PMID: 7888801Free PMC Article
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819
Mitral valve prolapse in childhood: the incidence and clinical presentations in different age groups.
Ohara N, Mikajima T, Takagi J, Kato H
Acta Paediatr Jpn 1991 Aug;33(4):467-75. doi: 10.1111/j.1442-200x.1991.tb02573.x. PMID: 1792905

Diagnosis

Recent developments in the diagnosis and management of mitral valve prolapse.
Devereux RB
Curr Opin Cardiol 1995 Mar;10(2):107-16. doi: 10.1097/00001573-199503000-00003. PMID: 7787275
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819
Mitral valve prolapse.
Cheng TO
Dis Mon 1987 Sep;33(9):481-534. doi: 10.1016/0011-5029(87)90005-8. PMID: 3308381
Mitral valve prolapse.
Wigle ED, Rakowski H, Ranganathan N, Silver MC
Annu Rev Med 1976;27:165-80. doi: 10.1146/annurev.me.27.020176.001121. PMID: 779595
Mitral valve prolapse.
Devereux RB, Perloff JK, Reichek N, Josephson ME
Circulation 1976 Jul;54(1):3-14. doi: 10.1161/01.cir.54.1.3. PMID: 776440

Therapy

Predisposing factors for severe mitral regurgitation in idiopathic mitral valve prolapse.
Fukuda N, Oki T, Iuchi A, Tabata T, Manabe K, Kageji Y, Sasaki M, Yamada H, Ito S
Am J Cardiol 1995 Sep 1;76(7):503-7. doi: 10.1016/s0002-9149(99)80139-8. PMID: 7653453
Mitral valve prolapse.
Gould L, Gopalaswamy C
Angiology 1984 May;35(5):290-9. doi: 10.1177/000331978403500505. PMID: 6144281
Mitral valve prolapse: etiology, diagnosis, and management.
de Leon AC Jr
Postgrad Med 1980 Jan;67(1):66-9, 72-7. doi: 10.1080/00325481.1980.11715338. PMID: 7350567
Infective endocarditis in the billowing mitral leaflet syndrome.
Lachman AS, Bramwell-Jones DM, Lakier JB, Pocock WA, Barlow JB
Br Heart J 1975 Mar;37(3):326-30. doi: 10.1136/hrt.37.3.326. PMID: 1138736Free PMC Article
The familial occurrence of the syndrome of mid-late systolic click and late systolic murmur.
Shell WE, Walton JA, Clifford ME, Willis PW 3rd
Circulation 1969 Mar;39(3):327-37. doi: 10.1161/01.cir.39.3.327. PMID: 5766802

Prognosis

Current management of mitral valve prolapse.
Bouknight DP, O'Rourke RA
Am Fam Physician 2000 Jun 1;61(11):3343-50, 3353-4. PMID: 10865929
The cumulative risks of prolapsing mitral valve. 40 years of follow-up.
Chapman DW
Tex Heart Inst J 1994;21(4):267-71. PMID: 7888801Free PMC Article
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819
Mitral valve prolapse.
Gould L, Gopalaswamy C
Angiology 1984 May;35(5):290-9. doi: 10.1177/000331978403500505. PMID: 6144281
The systolic click-murmur syndrome: clinical recognition and management.
O'rourke RA, Crawford MH
Curr Probl Cardiol 1976 Mar-Apr;1(1):1-60. doi: 10.1016/s0146-2806(76)80006-0. PMID: 1017208

Clinical prediction guides

Teaching cardiac auscultation: effectiveness of a patient-centered teaching conference on improving cardiac auscultatory skills.
March SK, Bedynek JL Jr, Chizner MA
Mayo Clin Proc 2005 Nov;80(11):1443-8. doi: 10.4065/80.11.1443. PMID: 16295024
Late outcome of unsupported annuloplasty for rheumatic mitral regurgitation.
Kalil RA, Lucchese FA, Prates PR, Sant'Anna JR, Faes FC, Pereira E, Nesralla IA
J Am Coll Cardiol 1993 Dec;22(7):1915-20. doi: 10.1016/0735-1097(93)90779-z. PMID: 8245349
Understanding mitral valve prolapse (MVP).
Schatz IJ
Herz 1988 Aug;13(4):235-42. PMID: 3049286
M mode and cross-sectional echocardiographic features of flail posterior mitral leaflets.
Child JS, Skorton DJ, Taylor RD, Krivokapich J, Abbasi AS, Wong M, Shah PD
Am J Cardiol 1979 Dec;44(7):1383-90. doi: 10.1016/0002-9149(79)90457-0. PMID: 506941
The determinants of onset of mitral valve prolapse in the systolic click-late systolic murmur syndrome.
Mathey DG, Decoodt PR, Allen HN, Swan HJ
Circulation 1976 May;53(5):872-8. doi: 10.1161/01.cir.53.5.872. PMID: 1260992

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