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Endemic goiter(MNG1)

MedGen UID:
5357
•Concept ID:
C0018022
•
Disease or Syndrome
Synonym: MNG1
SNOMED CT: Simple goiter (267369002); Euthyroid goiter (267369002); Endemic goiter (56805008); Simple iodine deficiency goiter (56805008)
 
Monarch Initiative: MONDO:0006742

Definition

Thyroid gland enlargement caused by inadequate dietary iodine intake. It occurs in areas in which the soil lacks iodine compounds or there is low seafood consumption. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndemic goiter

Professional guidelines

PubMed

Toxicology review and risk assessment of resorcinol: thyroid effects.
Lynch BS, Delzell ES, Bechtel DH
Regul Toxicol Pharmacol 2002 Oct;36(2):198-210. doi: 10.1006/rtph.2002.1585. PMID: 12460754
Thyroxine treatment of benign goiter.
Gärtner R
Acta Med Austriaca 1994;21(2):44-7. PMID: 7998481
Management of goiter and thyroid nodules in an area of endemic goiter.
Röher HD, Goretzki PE
Surg Clin North Am 1987 Apr;67(2):233-49. doi: 10.1016/s0039-6109(16)44181-2. PMID: 3551146

Recent clinical studies

Etiology

Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma.
Yildirim Simsir I, Cetinkalp S, Kabalak T
Med Princ Pract 2020;29(1):1-5. Epub 2019 Sep 23 doi: 10.1159/000503575. PMID: 31542786Free PMC Article
Historical aspects of iodine deficiency control.
Vanderpas JB, Moreno-Reyes R
Minerva Med 2017 Apr;108(2):124-135. Epub 2017 Jan 12 doi: 10.23736/S0026-4806.17.04884-4. PMID: 28079353
Thyroid Disorders in Children and Adolescents: A Review.
Hanley P, Lord K, Bauer AJ
JAMA Pediatr 2016 Oct 1;170(10):1008-1019. doi: 10.1001/jamapediatrics.2016.0486. PMID: 27571216
Endemic goiter--individual risk factors necessitate individual treatment.
Schneider M, Welsch T, Kremer M, Büchler MW
Langenbecks Arch Surg 2011 Dec;396(8):1125-6. doi: 10.1007/s00423-011-0856-x. PMID: 22006052
Iodide-induced thyrotoxicosis.
Fradkin JE, Wolff J
Medicine (Baltimore) 1983 Jan;62(1):1-20. doi: 10.1097/00005792-198301000-00001. PMID: 6218369

Diagnosis

Thyroid Disorders in Children and Adolescents: A Review.
Hanley P, Lord K, Bauer AJ
JAMA Pediatr 2016 Oct 1;170(10):1008-1019. doi: 10.1001/jamapediatrics.2016.0486. PMID: 27571216
Endemic goiter--individual risk factors necessitate individual treatment.
Schneider M, Welsch T, Kremer M, Büchler MW
Langenbecks Arch Surg 2011 Dec;396(8):1125-6. doi: 10.1007/s00423-011-0856-x. PMID: 22006052
Diagnostic controversies in vascular proliferations of the thyroid gland.
Papotti M, Arrondini M, Tavaglione V, Veltri A, Volante M
Endocr Pathol 2008 Fall;19(3):175-83. doi: 10.1007/s12022-008-9039-x. PMID: 18766472
Autonomy in endemic goiter.
Corvilain B, Van Sande J, Dumont JE, Bourdoux P, Ermans AM
Thyroid 1998 Jan;8(1):107-13. doi: 10.1089/thy.1998.8.107. PMID: 9492160
Iodide-induced thyrotoxicosis.
Fradkin JE, Wolff J
Medicine (Baltimore) 1983 Jan;62(1):1-20. doi: 10.1097/00005792-198301000-00001. PMID: 6218369

Therapy

The Prevention of Iodine Deficiency: A History.
Pearce EN, Zimmermann MB
Thyroid 2023 Feb;33(2):143-149. doi: 10.1089/thy.2022.0454. PMID: 36795091
Historical aspects of iodine deficiency control.
Vanderpas JB, Moreno-Reyes R
Minerva Med 2017 Apr;108(2):124-135. Epub 2017 Jan 12 doi: 10.23736/S0026-4806.17.04884-4. PMID: 28079353
The way forward in Italy for iodine.
Olivieri A, DI Cosmo C, DE Angelis S, DA Cas R, Stacchini P, Pastorelli A, Vitti P; Regional Observatories for Goiter Prevention
Minerva Med 2017 Apr;108(2):159-168. Epub 2017 Jan 12 doi: 10.23736/S0026-4806.17.04877-7. PMID: 28079352
Role of iodine, selenium and other micronutrients in thyroid function and disorders.
Triggiani V, Tafaro E, Giagulli VA, Sabbà C, Resta F, Licchelli B, Guastamacchia E
Endocr Metab Immune Disord Drug Targets 2009 Sep;9(3):277-94. Epub 2009 Sep 1 doi: 10.2174/187153009789044392. PMID: 19594417
Iodine-supplementation trials.
Pharoah PO
Am J Clin Nutr 1993 Feb;57(2 Suppl):276S-279S. doi: 10.1093/ajcn/57.2.276S. PMID: 8427204

Prognosis

Spatial Association between Gastric Cancer Mortality and Goiter in Sardinia.
Pes GM, Fanciulli G, Delitala AP, Piana AF, Dore MP
Asian Pac J Cancer Prev 2021 Jan 1;22(1):105-110. doi: 10.31557/APJCP.2021.22.1.105. PMID: 33507686Free PMC Article
Historical aspects of iodine deficiency control.
Vanderpas JB, Moreno-Reyes R
Minerva Med 2017 Apr;108(2):124-135. Epub 2017 Jan 12 doi: 10.23736/S0026-4806.17.04884-4. PMID: 28079353
Endemic goiter and endemic thyroid disorders.
Gaitan E, Nelson NC, Poole GV
World J Surg 1991 Mar-Apr;15(2):205-15. doi: 10.1007/BF01659054. PMID: 2031356
Goitrogens in food and water.
Gaitan E
Annu Rev Nutr 1990;10:21-39. doi: 10.1146/annurev.nu.10.070190.000321. PMID: 1696490
Prophylaxis and treatment of endemic goiter with iodized oil in rural Ecuador and Peru.
Kevany J, Fierro-Benitez R, Pretell EA, Stanbury JB
Am J Clin Nutr 1969 Dec;22(12):1597-607. doi: 10.1093/ajcn/22.12.1597. PMID: 4312017

Clinical prediction guides

History of the Thyroid.
Connelly KJ, Park JJ, LaFranchi SH
Horm Res Paediatr 2022;95(6):546-556. Epub 2022 Nov 29 doi: 10.1159/000526621. PMID: 36446327
Making Endemic Goiter an American Disease, 1800-1820.
Naramore SE
J Hist Med Allied Sci 2021 Sep 6;76(3):239-263. doi: 10.1093/jhmas/jrab018. PMID: 34151940
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children.
Carvalho AC, Machado A, Embalo AR, Bordalo AA
Eur J Clin Nutr 2018 Nov;72(11):1576-1582. Epub 2017 Dec 28 doi: 10.1038/s41430-017-0055-0. PMID: 29284787
The way forward in Italy for iodine.
Olivieri A, DI Cosmo C, DE Angelis S, DA Cas R, Stacchini P, Pastorelli A, Vitti P; Regional Observatories for Goiter Prevention
Minerva Med 2017 Apr;108(2):159-168. Epub 2017 Jan 12 doi: 10.23736/S0026-4806.17.04877-7. PMID: 28079352
Thyroxine treatment of benign goiter.
Gärtner R
Acta Med Austriaca 1994;21(2):44-7. PMID: 7998481

Recent systematic reviews

Iodine nutritional status in Brazil: a meta-analysis of all studies performed in the country pinpoints to an insufficient evaluation and heterogeneity.
Campos Rde O, Barreto Idos S, Maia LR, Rebouças SC, Cerqueira TL, Oliveira CA, Santos CA, Mendes CM, Teixeira LS, Ramos HE
Arch Endocrinol Metab 2015 Feb;59(1):13-22. doi: 10.1590/2359-3997000000004. PMID: 25926109
EURRECA-Estimating iodine requirements for deriving dietary reference values.
Ristić-Medić D, Novaković R, Glibetić M, Gurinović M
Crit Rev Food Sci Nutr 2013;53(10):1051-63. doi: 10.1080/10408398.2012.742859. PMID: 23952087
Goiter and other iodine deficiency disorders: A systematic review of epidemiological studies to deconstruct the complex web.
Kotwal A, Priya R, Qadeer I
Arch Med Res 2007 Jan;38(1):1-14. doi: 10.1016/j.arcmed.2006.08.006. PMID: 17174717
Cost estimation of thyroid disorders in Germany.
Kahaly GJ, Dietlein M
Thyroid 2002 Oct;12(10):909-14. doi: 10.1089/105072502761016548. PMID: 12487774

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