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Sickle cell nephropathy

MedGen UID:
536792
•Concept ID:
C0238305
•
Disease or Syndrome
Synonym: Sickle Cell Nephropathy
SNOMED CT: Sickle cell nephropathy (13886001)

Definition

Nephropathy secondary to sickle cell disease, characterized by the presence of sickled erythrocytes in the renal medullary vessels, renal ischemia and microinfarctions, renal papillary necrosis, and renal tubular abnormalities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSickle cell nephropathy

Professional guidelines

PubMed

Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment.
Hariri E, Mansour A, El Alam A, Daaboul Y, Korjian S, Aoun Bahous S
Int Urol Nephrol 2018 Jun;50(6):1075-1083. Epub 2018 Jan 30 doi: 10.1007/s11255-018-1803-3. PMID: 29383580
New insights on pathophysiology, clinical manifestations, diagnosis, and treatment of sickle cell nephropathy.
da Silva GB Jr, Libório AB, Daher Ede F
Ann Hematol 2011 Dec;90(12):1371-9. Epub 2011 Sep 8 doi: 10.1007/s00277-011-1327-8. PMID: 21901339
Prevalence, prevention, and treatment of microalbuminuria and proteinuria in children with sickle cell disease.
McKie KT, Hanevold CD, Hernandez C, Waller JL, Ortiz L, McKie KM
J Pediatr Hematol Oncol 2007 Mar;29(3):140-4. doi: 10.1097/MPH.0b013e3180335081. PMID: 17356390

Recent clinical studies

Therapy

Sickle Cell Disease and Kidney.
Amarapurkar P, Roberts L, Navarrete J, El Rassi F
Adv Chronic Kidney Dis 2022 Mar;29(2):141-148.e1. doi: 10.1053/j.ackd.2022.03.004. PMID: 35817521
Sickle cell nephropathy. Clinical manifestations and new mechanisms involved in kidney injury.
Payán-Pernía S, Ruiz Llobet A, Remacha Sevilla ÁF, Egido J, Ballarín Castán JA, Moreno JA
Nefrologia (Engl Ed) 2021 Jul-Aug;41(4):373-382. Epub 2021 Oct 27 doi: 10.1016/j.nefroe.2021.10.001. PMID: 36165106
Sickle Cell Nephropathy in the Pediatric Population.
Olaniran KO, Eneanya ND, Nigwekar SU, Vela-Parada XF, Achebe MM, Sharma A, Thadhani RI
Blood Purif 2019;47(1-3):205-213. Epub 2018 Dec 5 doi: 10.1159/000494581. PMID: 30517931
Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment.
Hariri E, Mansour A, El Alam A, Daaboul Y, Korjian S, Aoun Bahous S
Int Urol Nephrol 2018 Jun;50(6):1075-1083. Epub 2018 Jan 30 doi: 10.1007/s11255-018-1803-3. PMID: 29383580
Sickle-cell nephropathy.
Buckalew VM Jr
Ann Intern Med 1970 Sep;73(3):488-9. doi: 10.7326/0003-4819-73-3-488. PMID: 5456001

Prognosis

Predictors associated with sickle cell nephropathy: a systematic review.
Maurício L, Ribeiro S, Santos L, Miranda DB
Rev Assoc Med Bras (1992) 2021 Feb;67(2):313-317. doi: 10.1590/1806-9282.67.02.20200676. PMID: 34406259
Sickle cell nephropathy.
Gargiulo R, Pandya M, Seba A, Haddad RY, Lerma EV
Dis Mon 2014 Oct;60(10):494-9. Epub 2014 Oct 3 doi: 10.1016/j.disamonth.2014.08.004. PMID: 25282510
An update on sickle cell nephropathy.
Alhwiesh A
Saudi J Kidney Dis Transpl 2014 Mar;25(2):249-65. doi: 10.4103/1319-2442.128495. PMID: 24625990
Sickle cell nephropathy - a practical approach.
Sharpe CC, Thein SL
Br J Haematol 2011 Nov;155(3):287-97. Epub 2011 Sep 9 doi: 10.1111/j.1365-2141.2011.08853.x. PMID: 21902687
Sickle cell disease and the kidney.
Scheinman JI
Nat Clin Pract Nephrol 2009 Feb;5(2):78-88. Epub 2008 Dec 2 doi: 10.1038/ncpneph1008. PMID: 19048000

Clinical prediction guides

Biomarkers of sickle cell nephropathy in Senegal.
Ndour EHM, Mnika K, Tall FG, Seck M, Ly ID, Nembaware V, Mazandu GK, Sagna Bassène HAT, Dione R, Ndongo AA, Diop JPD, Barry NOK, Djité M, Ndiaye Diallo R, Guèye PM, Diop S, Diagne I, Cissé A, Wonkam A, Lopez Sall P
PLoS One 2022;17(11):e0273745. Epub 2022 Nov 21 doi: 10.1371/journal.pone.0273745. PMID: 36409722Free PMC Article
Predictors associated with sickle cell nephropathy: a systematic review.
Maurício L, Ribeiro S, Santos L, Miranda DB
Rev Assoc Med Bras (1992) 2021 Feb;67(2):313-317. doi: 10.1590/1806-9282.67.02.20200676. PMID: 34406259
Sickle cell disease nephropathy: an update on risk factors and potential biomarkers in pediatric patients.
Belisário AR, da Silva AA, Silva CV, de Souza LM, Wakabayashi EA, Araújo SA, Simoes-E-Silva AC
Biomark Med 2019 Aug;13(11):967-987. Epub 2019 Aug 8 doi: 10.2217/bmm-2019-0105. PMID: 31390894
Renal Medullary Carcinoma.
Elliott A, Bruner E
Arch Pathol Lab Med 2019 Dec;143(12):1556-1561. Epub 2019 Mar 11 doi: 10.5858/arpa.2017-0492-RS. PMID: 30855171
Sickle cell disease and the kidney.
Scheinman JI
Nat Clin Pract Nephrol 2009 Feb;5(2):78-88. Epub 2008 Dec 2 doi: 10.1038/ncpneph1008. PMID: 19048000

Recent systematic reviews

Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease.
Labarque V, Okocha EC; International Hemoglobinopathy Research Network (INHERENT)
Int J Mol Sci 2024 May 16;25(10) doi: 10.3390/ijms25105427. PMID: 38791464Free PMC Article
Interventions for chronic kidney disease in people with sickle cell disease.
Roy NB, Carpenter A, Dale-Harris I, Dorée C, Estcourt LJ
Cochrane Database Syst Rev 2023 Aug 4;8(8):CD012380. doi: 10.1002/14651858.CD012380.pub3. PMID: 37539955Free PMC Article
Predictors associated with sickle cell nephropathy: a systematic review.
Maurício L, Ribeiro S, Santos L, Miranda DB
Rev Assoc Med Bras (1992) 2021 Feb;67(2):313-317. doi: 10.1590/1806-9282.67.02.20200676. PMID: 34406259
A Systematic Review for Variables to Be Collected in a Transplant Database for Improving Risk Prediction.
Almasri J, Tello M, Benkhadra R, Morrow AS, Hasan B, Farah W, Alvarez Villalobos N, Mohammed K, Allen JP, Prokop LJ, Wang Z, Kasiske BL, Israni AK, Murad MH
Transplantation 2019 Dec;103(12):2591-2601. doi: 10.1097/TP.0000000000002652. PMID: 30768569
Interventions for chronic kidney disease in people with sickle cell disease.
Roy NB, Fortin PM, Bull KR, Doree C, Trivella M, Hopewell S, Estcourt LJ
Cochrane Database Syst Rev 2017 Jul 3;7(7):CD012380. doi: 10.1002/14651858.CD012380.pub2. PMID: 28672087Free PMC Article

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