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Acral erythema

MedGen UID:
536900
•Concept ID:
C0239343
•
Finding
Synonym: Acral Erythema
SNOMED CT: Acral erythema (238993006)

Definition

Reddening of the palmar and plantar regions of the body with occasional involvement of the distal extremities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcral erythema

Professional guidelines

PubMed

Hepatitis C virus and its cutaneous manifestations: treatment in the direct-acting antiviral era.
Wiznia LE, Laird ME, Franks AG Jr
J Eur Acad Dermatol Venereol 2017 Aug;31(8):1260-1270. Epub 2017 Mar 29 doi: 10.1111/jdv.14186. PMID: 28252812
The hand-foot-syndrome associated with medical tumor therapy - classification and management.
Degen A, Alter M, Schenck F, Satzger I, Völker B, Kapp A, Gutzmer R
J Dtsch Dermatol Ges 2010 Sep;8(9):652-61. Epub 2010 May 6 doi: 10.1111/j.1610-0387.2010.07449.x. PMID: 20482685
Management of cutaneous symptoms.
Gallagher J
Semin Oncol Nurs 1995 Nov;11(4):239-47. doi: 10.1016/s0749-2081(05)80004-x. PMID: 8578031

Recent clinical studies

Etiology

Hand-foot syndrome induced by chemotherapy drug: Case series study and literature review.
Zaiem A, Hammamia SB, Aouinti I, Charfi O, Ladhari W, Kastalli S, Aidli SE, Lakhoua G
Indian J Pharmacol 2022 May-Jun;54(3):208-215. doi: 10.4103/ijp.ijp_175_21. PMID: 35848692Free PMC Article
Hypersensitivity reaction to high-dose methotrexate and methotrexate-induced acral erythema in a child with acute lymphoblastic leukemia.
Akaihata M, Miyata K, Shimomura Y, Hori T, Okumura A
Int J Clin Pharmacol Ther 2022 Jun;60(6):264-268. doi: 10.5414/CP204143. PMID: 35343432
Acral manifestations of viral infections.
Adışen E, Önder M
Clin Dermatol 2017 Jan-Feb;35(1):40-49. Epub 2016 Sep 10 doi: 10.1016/j.clindermatol.2016.09.006. PMID: 27938811
Necrolytic acral erythema.
Patel U, Loyd A, Patel R, Meehan S, Kundu R
Dermatol Online J 2010 Nov 15;16(11):15. PMID: 21163166
Muco-cutaneous changes during long-term therapy with hydroxyurea in chronic myeloid leukaemia.
Vassallo C, Passamonti F, Merante S, Ardigò M, Nolli G, Mangiacavalli S, Borroni G
Clin Exp Dermatol 2001 Mar;26(2):141-8. doi: 10.1046/j.1365-2230.2001.00782.x. PMID: 11298103

Diagnosis

Dermatologic Adverse Events in Oncologic Therapies.
Čeović R, Kovačec L, Bukvić Mokos Z, Marinović B
Acta Dermatovenerol Croat 2022 Dec;30(4):237-249. PMID: 36919390
Top 10 acral skin manifestations associated with COVID-19: A scoping review.
Farajzadeh S, Khalili M, Dehghani S, Babaie S, Fattah M, Abtahi-Naeini B
Dermatol Ther 2021 Nov;34(6):e15157. Epub 2021 Oct 21 doi: 10.1111/dth.15157. PMID: 34628708Free PMC Article
Bullous acral erythema: an additional consideration in the differential diagnosis of pauci-inflammatory subepidermal bullae*.
Podjasek JO, Camilleri MJ
J Cutan Pathol 2012 Mar;39(3):382-90. doi: 10.1111/j.1600-0560.2012.01867.x. PMID: 22335596
Necrolytic acral erythema.
Patel U, Loyd A, Patel R, Meehan S, Kundu R
Dermatol Online J 2010 Nov 15;16(11):15. PMID: 21163166
Necrolytic acral erythema: a review of the literature.
Geria AN, Holcomb KZ, Scheinfeld NS
Cutis 2009 Jun;83(6):309-14. PMID: 19681342

Therapy

Paclitaxel-induced dorsal hand-foot syndrome.
Quan EY, Engel C, Rush PS, Eikenberg JD
Dermatol Online J 2023 Jun 15;29(3) doi: 10.5070/D329361434. PMID: 37591274
Dermatologic Adverse Events in Oncologic Therapies.
Čeović R, Kovačec L, Bukvić Mokos Z, Marinović B
Acta Dermatovenerol Croat 2022 Dec;30(4):237-249. PMID: 36919390
Necrolytic acral erythema.
Yost JM, Boyd KP, Patel RR, Ramachandran S, Franks AG Jr
Dermatol Online J 2013 Dec 16;19(12):20709. PMID: 24365000
Tec.
McCalmont TH
J Cutan Pathol 2013 Sep;40(9):785-7. doi: 10.1111/cup.12207. PMID: 23962116
Chemotherapy-induced acral erythema.
Baack BR, Burgdorf WH
J Am Acad Dermatol 1991 Mar;24(3):457-61. doi: 10.1016/0190-9622(91)70073-b. PMID: 2061446

Prognosis

Dermatologic Adverse Events in Oncologic Therapies.
Čeović R, Kovačec L, Bukvić Mokos Z, Marinović B
Acta Dermatovenerol Croat 2022 Dec;30(4):237-249. PMID: 36919390
Hand-foot syndrome induced by chemotherapy drug: Case series study and literature review.
Zaiem A, Hammamia SB, Aouinti I, Charfi O, Ladhari W, Kastalli S, Aidli SE, Lakhoua G
Indian J Pharmacol 2022 May-Jun;54(3):208-215. doi: 10.4103/ijp.ijp_175_21. PMID: 35848692Free PMC Article
Hypersensitivity reaction to high-dose methotrexate and methotrexate-induced acral erythema in a child with acute lymphoblastic leukemia.
Akaihata M, Miyata K, Shimomura Y, Hori T, Okumura A
Int J Clin Pharmacol Ther 2022 Jun;60(6):264-268. doi: 10.5414/CP204143. PMID: 35343432
Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): focus on sorafenib and sunitinib.
Lipworth AD, Robert C, Zhu AX
Oncology 2009;77(5):257-71. Epub 2009 Nov 16 doi: 10.1159/000258880. PMID: 19923864
Necrolytic acral erythema: a variant of necrolytic migratory erythema or a distinct entity?
Nofal AA, Nofal E, Attwa E, El-Assar O, Assaf M
Int J Dermatol 2005 Nov;44(11):916-21. doi: 10.1111/j.1365-4632.2004.02232.x. PMID: 16336523

Clinical prediction guides

Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies.
Papaetis GS, Syrigos KN
BioDrugs 2009;23(6):377-89. doi: 10.2165/11318860-000000000-00000. PMID: 19894779
Muco-cutaneous changes during long-term therapy with hydroxyurea in chronic myeloid leukaemia.
Vassallo C, Passamonti F, Merante S, Ardigò M, Nolli G, Mangiacavalli S, Borroni G
Clin Exp Dermatol 2001 Mar;26(2):141-8. doi: 10.1046/j.1365-2230.2001.00782.x. PMID: 11298103
Necrolytic acral erythema associated with hepatitis C: effective treatment with interferon alfa and zinc.
Khanna VJ, Shieh S, Benjamin J, Somach S, Zaim MT, Dorner W Jr, Shill M, Wood GS
Arch Dermatol 2000 Jun;136(6):755-7. doi: 10.1001/archderm.136.6.755. PMID: 10871939
Acral erythema: a clinical review.
Cohen PR
Cutis 1993 Mar;51(3):175-9. PMID: 8444048
Acral erythema and systemic toxicity related to CHA induction therapy in acute myeloid leukemia.
Oksenhendler E, Landais P, Cordonnier C, Kuentz M, Bagot M, Jais JP, Roujeau JC, Vernant JP
Eur J Cancer Clin Oncol 1989 Aug;25(8):1181-5. doi: 10.1016/0277-5379(89)90412-4. PMID: 2767107

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