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Pseudomembrane

MedGen UID:
537011
•Concept ID:
C0240821
•
Pathologic Function
Synonym: Pseudomembrane Formation
SNOMED CT: Pseudomembrane (399016005)

Definition

Formation of membrane-like structures consisting of coagulated exudate that is loosely adherent to an inflamed tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudomembrane

Professional guidelines

PubMed

Current Diagnostic and Treatment Approach of Clostridioides difficile Infection.
Yunita B, Fauzi A
Acta Med Indones 2023 Apr;55(2):231-238. PMID: 37524596
Irradiation-induced nasopharyngeal necrosis (INN) in newly diagnosed nasopharyngeal carcinoma treated by intensity-modulated radiation therapy: clinical characteristics and the influence of treatment strategies.
Xu Y, Liu Y, Wang Z, Wang J, Zhang J, Chen X, Wu R, Liu Q, Qu Y, Wang K, Huang X, Luo J, Gao L, Xu G, Zhang Y, Yi J
Radiat Oncol 2022 Jan 21;17(1):13. doi: 10.1186/s13014-022-01980-0. PMID: 35062991Free PMC Article
Management of ocular involvement in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: french national audit of practices, literature review, and consensus agreement.
Thorel D, Ingen-Housz-Oro S, Royer G, Delcampe A, Bellon N, Bodemer C, Welfringer-Morin A, Bremond-Gignac D, Robert MP, Tauber M, Malecaze F, Dereure O, Daien V, Colin A, Bernier C, Couret C, Vabres B, Tetart F, Milpied B, Cornut T, Ben Said B, Burillon C, Cordel N, Beral L, de Prost N, Wolkenstein P, Muraine M, Gueudry J
Orphanet J Rare Dis 2020 Sep 22;15(1):259. doi: 10.1186/s13023-020-01538-x. PMID: 32962748Free PMC Article

Recent clinical studies

Etiology

Diphtheria.
Sharma NC, Efstratiou A, Mokrousov I, Mutreja A, Das B, Ramamurthy T
Nat Rev Dis Primers 2019 Dec 5;5(1):81. doi: 10.1038/s41572-019-0131-y. PMID: 31804499
Obstructive Fibrinous Tracheal Pseudomembrane.
Ammar Y, Vella-Boucaud J, Launois C, Vallerand H, Dury S, Lebargy F, Deslee G, Perotin JM
Anesth Analg 2017 Jul;125(1):172-175. doi: 10.1213/ANE.0000000000001408. PMID: 27258072
Plasminogen deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID: 19141167
Pseudomembranous esophagitis.
Nayyar AK, Royston C, Slater DN, Bardhan KD
Gastrointest Endosc 2001 Dec;54(6):730-5. doi: 10.1067/mge.2001.119872. PMID: 11726849
Clostridium difficile infection.
Gröschel DH
Crit Rev Clin Lab Sci 1996;33(3):203-45. doi: 10.3109/10408369609083061. PMID: 8828001

Diagnosis

Recurrent aphthous stomatitis.
Conejero Del Mazo R, García Forcén L, Navarro Aguilar ME
Med Clin (Barc) 2023 Sep 29;161(6):251-259. Epub 2023 Jun 23 doi: 10.1016/j.medcli.2023.05.007. PMID: 37357066
Diphtheria.
Sharma NC, Efstratiou A, Mokrousov I, Mutreja A, Das B, Ramamurthy T
Nat Rev Dis Primers 2019 Dec 5;5(1):81. doi: 10.1038/s41572-019-0131-y. PMID: 31804499
Obstructive Fibrinous Tracheal Pseudomembrane.
Ammar Y, Vella-Boucaud J, Launois C, Vallerand H, Dury S, Lebargy F, Deslee G, Perotin JM
Anesth Analg 2017 Jul;125(1):172-175. doi: 10.1213/ANE.0000000000001408. PMID: 27258072
Obstructive Fibrinous Tracheal Pseudomembrane After Endotracheal Intubation.
Sehgal IS, Dhooria S, Bal A, Aggarwal AN, Behera D, Agarwal R
Respir Care 2016 Sep;61(9):1260-6. Epub 2016 May 31 doi: 10.4187/respcare.04662. PMID: 27247431
Clostridium difficile infection.
Gröschel DH
Crit Rev Clin Lab Sci 1996;33(3):203-45. doi: 10.3109/10408369609083061. PMID: 8828001

Therapy

Diphtheria.
Sharma NC, Efstratiou A, Mokrousov I, Mutreja A, Das B, Ramamurthy T
Nat Rev Dis Primers 2019 Dec 5;5(1):81. doi: 10.1038/s41572-019-0131-y. PMID: 31804499
Obstructive Fibrinous Tracheal Pseudomembrane.
Ammar Y, Vella-Boucaud J, Launois C, Vallerand H, Dury S, Lebargy F, Deslee G, Perotin JM
Anesth Analg 2017 Jul;125(1):172-175. doi: 10.1213/ANE.0000000000001408. PMID: 27258072
Obstructive Fibrinous Tracheal Pseudomembrane After Endotracheal Intubation.
Sehgal IS, Dhooria S, Bal A, Aggarwal AN, Behera D, Agarwal R
Respir Care 2016 Sep;61(9):1260-6. Epub 2016 May 31 doi: 10.4187/respcare.04662. PMID: 27247431
Plasminogen deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID: 19141167
Clostridium difficile infection.
Gröschel DH
Crit Rev Clin Lab Sci 1996;33(3):203-45. doi: 10.3109/10408369609083061. PMID: 8828001

Prognosis

The Relationship between Clinical Findings and Viral Load in Adenoviral Keratoconjunctivitis.
Isik P, Harbiyeli II, Ozturk G, Erdem E, Yagmur M, Yarkin F
Jpn J Infect Dis 2022 Nov 22;75(6):592-596. Epub 2022 Jul 29 doi: 10.7883/yoken.JJID.2022.210. PMID: 35908877
Obstructive Tracheal Pseudomembrane.
Niusha S, Salehi F, Behgam Shadmehr M
Arch Iran Med 2017 Nov 1;20(11):714-715. PMID: 29480737
Diphtheria: It is still prevalent!!!
Jain A, Samdani S, Meena V, Sharma MP
Int J Pediatr Otorhinolaryngol 2016 Jul;86:68-71. Epub 2016 Apr 21 doi: 10.1016/j.ijporl.2016.04.024. PMID: 27260583
Obstructive fibrinous tracheal pseudomembrane.
Yildirim BB, Karalezli A, Hasanoglu HC, Kandemir O
J Bronchology Interv Pulmonol 2012 Apr;19(2):129-31. doi: 10.1097/LBR.0b013e31824f525f. PMID: 23207356
Pseudomembranous esophagitis.
Nayyar AK, Royston C, Slater DN, Bardhan KD
Gastrointest Endosc 2001 Dec;54(6):730-5. doi: 10.1067/mge.2001.119872. PMID: 11726849

Clinical prediction guides

The Relationship between Clinical Findings and Viral Load in Adenoviral Keratoconjunctivitis.
Isik P, Harbiyeli II, Ozturk G, Erdem E, Yagmur M, Yarkin F
Jpn J Infect Dis 2022 Nov 22;75(6):592-596. Epub 2022 Jul 29 doi: 10.7883/yoken.JJID.2022.210. PMID: 35908877
Obstructive Fibrinous Tracheal Pseudomembrane.
Ammar Y, Vella-Boucaud J, Launois C, Vallerand H, Dury S, Lebargy F, Deslee G, Perotin JM
Anesth Analg 2017 Jul;125(1):172-175. doi: 10.1213/ANE.0000000000001408. PMID: 27258072
Diphtheria: It is still prevalent!!!
Jain A, Samdani S, Meena V, Sharma MP
Int J Pediatr Otorhinolaryngol 2016 Jul;86:68-71. Epub 2016 Apr 21 doi: 10.1016/j.ijporl.2016.04.024. PMID: 27260583
Pseudomembranous esophagitis.
Nayyar AK, Royston C, Slater DN, Bardhan KD
Gastrointest Endosc 2001 Dec;54(6):730-5. doi: 10.1067/mge.2001.119872. PMID: 11726849
Clostridium difficile infection.
Gröschel DH
Crit Rev Clin Lab Sci 1996;33(3):203-45. doi: 10.3109/10408369609083061. PMID: 8828001

Recent systematic reviews

Obstructive Fibrinous Tracheal Pseudomembrane After Endotracheal Intubation.
Sehgal IS, Dhooria S, Bal A, Aggarwal AN, Behera D, Agarwal R
Respir Care 2016 Sep;61(9):1260-6. Epub 2016 May 31 doi: 10.4187/respcare.04662. PMID: 27247431

Supplemental Content

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