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Pseudomembrane

MedGen UID:
537011
•Concept ID:
C0240821
•
Pathologic Function
Synonym: Pseudomembrane Formation
SNOMED CT: Pseudomembrane (399016005)

Definition

Formation of membrane-like structures consisting of coagulated exudate that is loosely adherent to an inflamed tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudomembrane

Professional guidelines

PubMed

Current Diagnostic and Treatment Approach of Clostridioides difficile Infection.
Yunita B, Fauzi A
Acta Med Indones 2023 Apr;55(2):231-238. PMID: 37524596
Management of ocular involvement in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: french national audit of practices, literature review, and consensus agreement.
Thorel D, Ingen-Housz-Oro S, Royer G, Delcampe A, Bellon N, Bodemer C, Welfringer-Morin A, Bremond-Gignac D, Robert MP, Tauber M, Malecaze F, Dereure O, Daien V, Colin A, Bernier C, Couret C, Vabres B, Tetart F, Milpied B, Cornut T, Ben Said B, Burillon C, Cordel N, Beral L, de Prost N, Wolkenstein P, Muraine M, Gueudry J
Orphanet J Rare Dis 2020 Sep 22;15(1):259. doi: 10.1186/s13023-020-01538-x. PMID: 32962748Free PMC Article
Pathophysiology, diagnosis and treatment of Clostridium difficile infection.
Castagliuolo I, LaMont JT
Keio J Med 1999 Dec;48(4):169-74. doi: 10.2302/kjm.48.169. PMID: 10638139

Recent clinical studies

Etiology

Diphtheria.
Sharma NC, Efstratiou A, Mokrousov I, Mutreja A, Das B, Ramamurthy T
Nat Rev Dis Primers 2019 Dec 5;5(1):81. doi: 10.1038/s41572-019-0131-y. PMID: 31804499
Plasminogen deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID: 19141167
Pseudomembranous esophagitis.
Nayyar AK, Royston C, Slater DN, Bardhan KD
Gastrointest Endosc 2001 Dec;54(6):730-5. doi: 10.1067/mge.2001.119872. PMID: 11726849
Clostridium difficile infection.
Gröschel DH
Crit Rev Clin Lab Sci 1996;33(3):203-45. doi: 10.3109/10408369609083061. PMID: 8828001
Pseudomembranous croup.
Henry RL, Mellis CM, Benjamin B
Arch Dis Child 1983 Mar;58(3):180-3. doi: 10.1136/adc.58.3.180. PMID: 6838248Free PMC Article

Diagnosis

Recurrent aphthous stomatitis.
Conejero Del Mazo R, García Forcén L, Navarro Aguilar ME
Med Clin (Barc) 2023 Sep 29;161(6):251-259. Epub 2023 Jun 23 doi: 10.1016/j.medcli.2023.05.007. PMID: 37357066
Diphtheria.
Sharma NC, Efstratiou A, Mokrousov I, Mutreja A, Das B, Ramamurthy T
Nat Rev Dis Primers 2019 Dec 5;5(1):81. doi: 10.1038/s41572-019-0131-y. PMID: 31804499
Obstructive Fibrinous Tracheal Pseudomembrane.
Ammar Y, Vella-Boucaud J, Launois C, Vallerand H, Dury S, Lebargy F, Deslee G, Perotin JM
Anesth Analg 2017 Jul;125(1):172-175. doi: 10.1213/ANE.0000000000001408. PMID: 27258072
Obstructive Fibrinous Tracheal Pseudomembrane After Endotracheal Intubation.
Sehgal IS, Dhooria S, Bal A, Aggarwal AN, Behera D, Agarwal R
Respir Care 2016 Sep;61(9):1260-6. Epub 2016 May 31 doi: 10.4187/respcare.04662. PMID: 27247431
Clostridium difficile infection.
Gröschel DH
Crit Rev Clin Lab Sci 1996;33(3):203-45. doi: 10.3109/10408369609083061. PMID: 8828001

Therapy

Diphtheria.
Sharma NC, Efstratiou A, Mokrousov I, Mutreja A, Das B, Ramamurthy T
Nat Rev Dis Primers 2019 Dec 5;5(1):81. doi: 10.1038/s41572-019-0131-y. PMID: 31804499
Obstructive Fibrinous Tracheal Pseudomembrane.
Ammar Y, Vella-Boucaud J, Launois C, Vallerand H, Dury S, Lebargy F, Deslee G, Perotin JM
Anesth Analg 2017 Jul;125(1):172-175. doi: 10.1213/ANE.0000000000001408. PMID: 27258072
Plasminogen deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID: 19141167
Pseudomembranous esophagitis.
Nayyar AK, Royston C, Slater DN, Bardhan KD
Gastrointest Endosc 2001 Dec;54(6):730-5. doi: 10.1067/mge.2001.119872. PMID: 11726849
Clostridium difficile infection.
Gröschel DH
Crit Rev Clin Lab Sci 1996;33(3):203-45. doi: 10.3109/10408369609083061. PMID: 8828001

Prognosis

The Relationship between Clinical Findings and Viral Load in Adenoviral Keratoconjunctivitis.
Isik P, Harbiyeli II, Ozturk G, Erdem E, Yagmur M, Yarkin F
Jpn J Infect Dis 2022 Nov 22;75(6):592-596. Epub 2022 Jul 29 doi: 10.7883/yoken.JJID.2022.210. PMID: 35908877
Diphtheria: It is still prevalent!!!
Jain A, Samdani S, Meena V, Sharma MP
Int J Pediatr Otorhinolaryngol 2016 Jul;86:68-71. Epub 2016 Apr 21 doi: 10.1016/j.ijporl.2016.04.024. PMID: 27260583
Obstructive fibrinous tracheal pseudomembrane.
Yildirim BB, Karalezli A, Hasanoglu HC, Kandemir O
J Bronchology Interv Pulmonol 2012 Apr;19(2):129-31. doi: 10.1097/LBR.0b013e31824f525f. PMID: 23207356
Pseudomembranous esophagitis.
Nayyar AK, Royston C, Slater DN, Bardhan KD
Gastrointest Endosc 2001 Dec;54(6):730-5. doi: 10.1067/mge.2001.119872. PMID: 11726849
Epidemic keratoconjunctivitis.
Murrah WF
Ann Ophthalmol 1988 Jan;20(1):36-8. PMID: 2830832

Clinical prediction guides

The Relationship between Clinical Findings and Viral Load in Adenoviral Keratoconjunctivitis.
Isik P, Harbiyeli II, Ozturk G, Erdem E, Yagmur M, Yarkin F
Jpn J Infect Dis 2022 Nov 22;75(6):592-596. Epub 2022 Jul 29 doi: 10.7883/yoken.JJID.2022.210. PMID: 35908877
Obstructive Fibrinous Tracheal Pseudomembrane.
Ammar Y, Vella-Boucaud J, Launois C, Vallerand H, Dury S, Lebargy F, Deslee G, Perotin JM
Anesth Analg 2017 Jul;125(1):172-175. doi: 10.1213/ANE.0000000000001408. PMID: 27258072
Diphtheria: It is still prevalent!!!
Jain A, Samdani S, Meena V, Sharma MP
Int J Pediatr Otorhinolaryngol 2016 Jul;86:68-71. Epub 2016 Apr 21 doi: 10.1016/j.ijporl.2016.04.024. PMID: 27260583
Pseudomembranous esophagitis.
Nayyar AK, Royston C, Slater DN, Bardhan KD
Gastrointest Endosc 2001 Dec;54(6):730-5. doi: 10.1067/mge.2001.119872. PMID: 11726849
Clostridium difficile infection.
Gröschel DH
Crit Rev Clin Lab Sci 1996;33(3):203-45. doi: 10.3109/10408369609083061. PMID: 8828001

Recent systematic reviews

Obstructive Fibrinous Tracheal Pseudomembrane After Endotracheal Intubation.
Sehgal IS, Dhooria S, Bal A, Aggarwal AN, Behera D, Agarwal R
Respir Care 2016 Sep;61(9):1260-6. Epub 2016 May 31 doi: 10.4187/respcare.04662. PMID: 27247431

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