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Sputum eosinophilia

MedGen UID:
537039
•Concept ID:
C0241234
•
Finding
Synonym: Sputum: eosinophilia
SNOMED CT: Sputum: eosinophilia (167997000)
 
HPO: HP:0032017

Definition

An increased proportion of eosinophils in sputum in the differentiated cell count. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSputum eosinophilia

Professional guidelines

PubMed

Biomarkers and asthma management: an update.
Bayes HK, Cowan DC
Curr Opin Allergy Clin Immunol 2016 Jun;16(3):210-7. doi: 10.1097/ACI.0000000000000263. PMID: 27057795
Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma.
Hilvering B, Xue L, Pavord ID
Ther Adv Respir Dis 2015 Aug;9(4):135-45. Epub 2015 Apr 21 doi: 10.1177/1753465815581279. PMID: 25900924
Eosinophilic bronchitis: clinical features, management and pathogenesis.
Birring SS, Berry M, Brightling CE, Pavord ID
Am J Respir Med 2003;2(2):169-73. doi: 10.1007/BF03256647. PMID: 14720015

Recent clinical studies

Etiology

Rheology predicts sputum eosinophilia in patients with muco-obstructive lung diseases.
Volpato M, Vialaret J, Hirtz C, Petit A, Suehs C, Patarin J, Matzner-Lober E, Vachier I, Molinari N, Bourdin A, Charriot J
Biochem Biophys Res Commun 2022 Sep 24;622:64-71. Epub 2022 Jul 11 doi: 10.1016/j.bbrc.2022.07.025. PMID: 35843096
Inflammatory Endotype-associated Airway Microbiome in Chronic Obstructive Pulmonary Disease Clinical Stability and Exacerbations: A Multicohort Longitudinal Analysis.
Wang Z, Locantore N, Haldar K, Ramsheh MY, Beech AS, Ma W, Brown JR, Tal-Singer R, Barer MR, Bafadhel M, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Miller BE, Brightling CE
Am J Respir Crit Care Med 2021 Jun 15;203(12):1488-1502. doi: 10.1164/rccm.202009-3448OC. PMID: 33332995Free PMC Article
Health surveillance for occupational asthma.
Fishwick D, Forman S
Curr Opin Allergy Clin Immunol 2018 Apr;18(2):80-86. doi: 10.1097/ACI.0000000000000424. PMID: 29461276
Improving the diagnosis of eosinophilic asthma.
Coumou H, Bel EH
Expert Rev Respir Med 2016 Oct;10(10):1093-103. Epub 2016 Sep 22 doi: 10.1080/17476348.2017.1236688. PMID: 27624868
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.
Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE
Am J Respir Crit Care Med 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC. PMID: 21680942

Diagnosis

Inflammatory Endotype-associated Airway Microbiome in Chronic Obstructive Pulmonary Disease Clinical Stability and Exacerbations: A Multicohort Longitudinal Analysis.
Wang Z, Locantore N, Haldar K, Ramsheh MY, Beech AS, Ma W, Brown JR, Tal-Singer R, Barer MR, Bafadhel M, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Miller BE, Brightling CE
Am J Respir Crit Care Med 2021 Jun 15;203(12):1488-1502. doi: 10.1164/rccm.202009-3448OC. PMID: 33332995Free PMC Article
Allergic bronchopulmonary aspergillosis.
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Adult asthma biomarkers.
Kim MA, Shin YS, Pham le D, Park HS
Curr Opin Allergy Clin Immunol 2014 Feb;14(1):49-54. doi: 10.1097/ACI.0000000000000028. PMID: 24300416
Asthma biomarkers in sputum.
Spahn JD
Immunol Allergy Clin North Am 2012 Aug;32(3):387-99. doi: 10.1016/j.iac.2012.06.004. PMID: 22877617
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.
Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE
Am J Respir Crit Care Med 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC. PMID: 21680942

Therapy

Rheology predicts sputum eosinophilia in patients with muco-obstructive lung diseases.
Volpato M, Vialaret J, Hirtz C, Petit A, Suehs C, Patarin J, Matzner-Lober E, Vachier I, Molinari N, Bourdin A, Charriot J
Biochem Biophys Res Commun 2022 Sep 24;622:64-71. Epub 2022 Jul 11 doi: 10.1016/j.bbrc.2022.07.025. PMID: 35843096
Lessons learned from clinical trials of asthma.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):410-413. doi: 10.2500/aap.2019.40.4259. PMID: 31690382
Triple inhaled therapy for chronic obstructive pulmonary disease.
Montuschi P, Malerba M, Macis G, Mores N, Santini G
Drug Discov Today 2016 Nov;21(11):1820-1827. Epub 2016 Jul 21 doi: 10.1016/j.drudis.2016.07.009. PMID: 27452453
Adult asthma biomarkers.
Kim MA, Shin YS, Pham le D, Park HS
Curr Opin Allergy Clin Immunol 2014 Feb;14(1):49-54. doi: 10.1097/ACI.0000000000000028. PMID: 24300416
Mepolizumab and eosinophil-mediated disease.
Walsh GM
Curr Med Chem 2009;16(36):4774-8. doi: 10.2174/092986709789909639. PMID: 19929788

Prognosis

Eosinophils in COPD-Current Concepts and Clinical Implications.
Mycroft K, Krenke R, Górska K
J Allergy Clin Immunol Pract 2020 Sep;8(8):2565-2574. Epub 2020 Apr 3 doi: 10.1016/j.jaip.2020.03.017. PMID: 32251737
Allergic bronchopulmonary aspergillosis.
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Lessons learned from clinical trials of asthma.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):410-413. doi: 10.2500/aap.2019.40.4259. PMID: 31690382
Eosinophil-derived IL-13 promotes emphysema.
Doyle AD, Mukherjee M, LeSuer WE, Bittner TB, Pasha SM, Frere JJ, Neely JL, Kloeber JA, Shim KP, Ochkur SI, Ho T, Svenningsen S, Wright BL, Rank MA, Lee JJ, Nair P, Jacobsen EA
Eur Respir J 2019 May;53(5) Epub 2019 May 30 doi: 10.1183/13993003.01291-2018. PMID: 30728205Free PMC Article
Biomarkers and asthma management: an update.
Bayes HK, Cowan DC
Curr Opin Allergy Clin Immunol 2016 Jun;16(3):210-7. doi: 10.1097/ACI.0000000000000263. PMID: 27057795

Clinical prediction guides

Eosinophils in COPD-Current Concepts and Clinical Implications.
Mycroft K, Krenke R, Górska K
J Allergy Clin Immunol Pract 2020 Sep;8(8):2565-2574. Epub 2020 Apr 3 doi: 10.1016/j.jaip.2020.03.017. PMID: 32251737
Lessons learned from clinical trials of asthma.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):410-413. doi: 10.2500/aap.2019.40.4259. PMID: 31690382
Eosinophil-derived IL-13 promotes emphysema.
Doyle AD, Mukherjee M, LeSuer WE, Bittner TB, Pasha SM, Frere JJ, Neely JL, Kloeber JA, Shim KP, Ochkur SI, Ho T, Svenningsen S, Wright BL, Rank MA, Lee JJ, Nair P, Jacobsen EA
Eur Respir J 2019 May;53(5) Epub 2019 May 30 doi: 10.1183/13993003.01291-2018. PMID: 30728205Free PMC Article
Biomarkers and asthma management: an update.
Bayes HK, Cowan DC
Curr Opin Allergy Clin Immunol 2016 Jun;16(3):210-7. doi: 10.1097/ACI.0000000000000263. PMID: 27057795
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.
Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE
Am J Respir Crit Care Med 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC. PMID: 21680942

Recent systematic reviews

Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults.
Petsky HL, Li A, Chang AB
Cochrane Database Syst Rev 2017 Aug 24;8(8):CD005603. doi: 10.1002/14651858.CD005603.pub3. PMID: 28837221Free PMC Article
Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults.
Petsky HL, Kynaston JA, Turner C, Li AM, Cates CJ, Lasserson TJ, Chang AB
Cochrane Database Syst Rev 2007 Apr 18;(2):CD005603. doi: 10.1002/14651858.CD005603.pub2. PMID: 17443604

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