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Sputum eosinophilia

MedGen UID:
537039
Concept ID:
C0241234
Finding
Synonym: Sputum: eosinophilia
SNOMED CT: Sputum: eosinophilia (167997000)
 
HPO: HP:0032017

Definition

An increased proportion of eosinophils in sputum in the differentiated cell count. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSputum eosinophilia

Professional guidelines

PubMed

Bayes HK, Cowan DC
Curr Opin Allergy Clin Immunol 2016 Jun;16(3):210-7. doi: 10.1097/ACI.0000000000000263. PMID: 27057795
Hilvering B, Xue L, Pavord ID
Ther Adv Respir Dis 2015 Aug;9(4):135-45. Epub 2015 Apr 21 doi: 10.1177/1753465815581279. PMID: 25900924
Birring SS, Berry M, Brightling CE, Pavord ID
Am J Respir Med 2003;2(2):169-73. doi: 10.1007/BF03256647. PMID: 14720015

Recent clinical studies

Etiology

Pasha MA, Hopp RJ, Habib N, Tang DD
J Asthma 2024 Nov;61(11):1376-1391. Epub 2024 Jun 13 doi: 10.1080/02770903.2024.2361783. PMID: 38805392
Gauthier M, Kale SL, Oriss TB, Gorry M, Ramonell RP, Dalton K, Ray P, Fahy JV, Seibold MA, Castro M, Jarjour N, Gaston B, Bleecker ER, Meyers DA, Moore W, Hastie AT, Israel E, Levy BD, Mauger D, Erzurum S, Comhair SA, Wenzel SE, Ray A
J Allergy Clin Immunol 2023 Jul;152(1):94-106.e12. Epub 2023 Mar 8 doi: 10.1016/j.jaci.2023.02.028. PMID: 36893862Free PMC Article
Wang Z, Locantore N, Haldar K, Ramsheh MY, Beech AS, Ma W, Brown JR, Tal-Singer R, Barer MR, Bafadhel M, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Miller BE, Brightling CE
Am J Respir Crit Care Med 2021 Jun 15;203(12):1488-1502. doi: 10.1164/rccm.202009-3448OC. PMID: 33332995Free PMC Article
Fishwick D, Forman S
Curr Opin Allergy Clin Immunol 2018 Apr;18(2):80-86. doi: 10.1097/ACI.0000000000000424. PMID: 29461276
Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE
Am J Respir Crit Care Med 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC. PMID: 21680942

Diagnosis

Wang Z, Locantore N, Haldar K, Ramsheh MY, Beech AS, Ma W, Brown JR, Tal-Singer R, Barer MR, Bafadhel M, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Miller BE, Brightling CE
Am J Respir Crit Care Med 2021 Jun 15;203(12):1488-1502. doi: 10.1164/rccm.202009-3448OC. PMID: 33332995Free PMC Article
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Kim MA, Shin YS, Pham le D, Park HS
Curr Opin Allergy Clin Immunol 2014 Feb;14(1):49-54. doi: 10.1097/ACI.0000000000000028. PMID: 24300416
Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE
Am J Respir Crit Care Med 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC. PMID: 21680942
Scott KA, Wardlaw AJ
Semin Respir Crit Care Med 2006 Apr;27(2):128-33. doi: 10.1055/s-2006-939515. PMID: 16612763

Therapy

Gauvreau GM, Sehmi R, FitzGerald JM, Leigh R, Cockcroft DW, Davis BE, Mayers I, Boulet LP, Al-Sajee D, Salter BM, Cusack RP, Ho T, Whetstone CE, Alsaji N, Satia I, Killian KJ, Mitchell PD, Magee IP, Bergeron C, Bhutani M, Werkström V, Durżyński T, Shoemaker K, Katial RK, Jison M, Newbold P, McCrae C, O'Byrne PM
Eur Respir J 2024 Sep;64(3) Epub 2024 Sep 12 doi: 10.1183/13993003.00512-2024. PMID: 39060015Free PMC Article
Pasha MA, Hopp RJ, Habib N, Tang DD
J Asthma 2024 Nov;61(11):1376-1391. Epub 2024 Jun 13 doi: 10.1080/02770903.2024.2361783. PMID: 38805392
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):410-413. doi: 10.2500/aap.2019.40.4259. PMID: 31690382
Kim MA, Shin YS, Pham le D, Park HS
Curr Opin Allergy Clin Immunol 2014 Feb;14(1):49-54. doi: 10.1097/ACI.0000000000000028. PMID: 24300416
Walsh GM
Curr Med Chem 2009;16(36):4774-8. doi: 10.2174/092986709789909639. PMID: 19929788

Prognosis

Covar R, Lazarus SC, Krishnan JA, Blake KV, Sorkness CA, Dyer AM, Lang JE, Lugogo NL, Mauger DT, Wechsler ME, Wenzel SE, Cardet JC, Castro M, Israel E, Phipatanakul W, King TS; National Heart, Lung, and Blood Institute AsthmaNet
J Allergy Clin Immunol Pract 2024 Apr;12(4):960-969.e6. Epub 2023 Dec 12 doi: 10.1016/j.jaip.2023.12.010. PMID: 38097180
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):410-413. doi: 10.2500/aap.2019.40.4259. PMID: 31690382
Doyle AD, Mukherjee M, LeSuer WE, Bittner TB, Pasha SM, Frere JJ, Neely JL, Kloeber JA, Shim KP, Ochkur SI, Ho T, Svenningsen S, Wright BL, Rank MA, Lee JJ, Nair P, Jacobsen EA
Eur Respir J 2019 May;53(5) Epub 2019 May 30 doi: 10.1183/13993003.01291-2018. PMID: 30728205Free PMC Article
Bayes HK, Cowan DC
Curr Opin Allergy Clin Immunol 2016 Jun;16(3):210-7. doi: 10.1097/ACI.0000000000000263. PMID: 27057795

Clinical prediction guides

Gauthier M, Kale SL, Oriss TB, Gorry M, Ramonell RP, Dalton K, Ray P, Fahy JV, Seibold MA, Castro M, Jarjour N, Gaston B, Bleecker ER, Meyers DA, Moore W, Hastie AT, Israel E, Levy BD, Mauger D, Erzurum S, Comhair SA, Wenzel SE, Ray A
J Allergy Clin Immunol 2023 Jul;152(1):94-106.e12. Epub 2023 Mar 8 doi: 10.1016/j.jaci.2023.02.028. PMID: 36893862Free PMC Article
Zhang RL, Pan CX, Tang CL, Cen LJ, Zhang XX, Huang Y, Lin ZH, Li HM, Zhang XF, Wang L, Guan WJ, Wang Y
Chest 2023 May;163(5):1038-1050. Epub 2022 Nov 24 doi: 10.1016/j.chest.2022.11.022. PMID: 36435264
Guan WJ, Oscullo G, He MZ, Xu DY, Gómez-Olivas JD, Martinez-Garcia MA
J Allergy Clin Immunol Pract 2023 Apr;11(4):1089-1099. Epub 2022 Oct 30 doi: 10.1016/j.jaip.2022.10.027. PMID: 36323380
Doyle AD, Mukherjee M, LeSuer WE, Bittner TB, Pasha SM, Frere JJ, Neely JL, Kloeber JA, Shim KP, Ochkur SI, Ho T, Svenningsen S, Wright BL, Rank MA, Lee JJ, Nair P, Jacobsen EA
Eur Respir J 2019 May;53(5) Epub 2019 May 30 doi: 10.1183/13993003.01291-2018. PMID: 30728205Free PMC Article
Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE
Am J Respir Crit Care Med 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC. PMID: 21680942

Recent systematic reviews

Petsky HL, Li A, Chang AB
Cochrane Database Syst Rev 2017 Aug 24;8(8):CD005603. doi: 10.1002/14651858.CD005603.pub3. PMID: 28837221Free PMC Article
Petsky HL, Kynaston JA, Turner C, Li AM, Cates CJ, Lasserson TJ, Chang AB
Cochrane Database Syst Rev 2007 Apr 18;(2):CD005603. doi: 10.1002/14651858.CD005603.pub2. PMID: 17443604

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