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Neonatal toxic erythema

MedGen UID:
537820
•Concept ID:
C0263324
•
Disease or Syndrome
Synonyms: Erythema neonatorum; Erythema Toxicum Neonatorum; Erythema toxicum neonatorum; Erythroderma neonatorum; ETN - erythema toxicum neonatorum; Neonatal erythema toxicum; Neonatal erythroderma; Toxic erythema of newborn
SNOMED CT: Erythroderma neonatorum (240302002); Neonatal toxic erythema (1162449005); Erythema toxicum neonatorum (1162449005); Erythema neonatorum (1162449005); ETN - erythema toxicum neonatorum (1162449005); Neonatal erythema toxicum (1162449005); Toxic erythema of newborn (1162449005); Neonatal erythroderma (240302002)

Definition

A benign, self-limited eruption of vesicles, pustules, papules and macules seen in newborns. An eosinophilic infiltrate can be isolated suggesting an immune-mediated reaction in the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal toxic erythema

Professional guidelines

PubMed

Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management.
Chang YS, Huang FC, Tseng SH, Hsu CK, Ho CL, Sheu HM
Cornea 2007 Feb;26(2):123-9. doi: 10.1097/ICO.0b013e31802eb264. PMID: 17251797
Ciprofloxacin treatment in newborns with multi-drug-resistant nosocomial Pseudomonas infections.
Belet N, Haciömeroğlu P, Küçüködük S
Biol Neonate 2004;85(4):263-8. Epub 2004 Jan 21 doi: 10.1159/000076364. PMID: 14739554
Scalded skin syndrome: Diagnosis, differential diagnosis, and management of 42 children.
Margileth AM
South Med J 1975 Apr;68(4):447-54. PMID: 123658

Recent clinical studies

Etiology

Algorithm to attenuate atopic dermatitis and for promoting a healthy skin barrier using skincare in newborns and infants.
Schachner LA, Blume-Peytavi U, Andriessen A, Izakovic J, Maruani A, Micali G, Murashkin N, Salavastru C, Torrelo A
Ital J Dermatol Venerol 2023 Jun;158(3):224-235. doi: 10.23736/S2784-8671.23.07336-X. PMID: 37278500
Infantile Stevens Johnson syndrome and toxic epidermal necrolysis: A systematic review of clinical features and outcomes in children ages 12 months and under.
Iriarte C, Karim SA, Nassim JS, Grenier PO, Massey KJ
Pediatr Dermatol 2022 Nov;39(6):876-882. Epub 2022 Jun 8 doi: 10.1111/pde.15047. PMID: 35676891
Toxic epidermal necrolysis.
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Bilirubin metabolism and kernicterus.
Gourley GR
Adv Pediatr 1997;44:173-229. PMID: 9265971
Coccidioidomycosis and pregnancy.
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516

Diagnosis

Neonatal Toxic Shock Syndrome-Like Exanthematous Disease in North America.
Freeman MC, Mitchell S, Ibrahim J, Williams JV
J Pediatric Infect Dis Soc 2021 Mar 26;10(2):205-206. doi: 10.1093/jpids/piz060. PMID: 31550351
Toxic epidermal necrolysis.
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Bilirubin metabolism and kernicterus.
Gourley GR
Adv Pediatr 1997;44:173-229. PMID: 9265971
Coccidioidomycosis and pregnancy.
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516
Neonatal skin disorders.
Mallory SB
Pediatr Clin North Am 1991 Aug;38(4):745-61. doi: 10.1016/s0031-3955(16)38152-4. PMID: 1870904

Therapy

Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Toxic epidermal necrolysis.
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Coccidioidomycosis and pregnancy.
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516
Vancomycin: an update.
Cheung RP, DiPiro JT
Pharmacotherapy 1986 Jul-Aug;6(4):153-69. doi: 10.1002/j.1875-9114.1986.tb03471.x. PMID: 3534799
Boric acid toxicity.
Siegel E, Wason S
Pediatr Clin North Am 1986 Apr;33(2):363-7. doi: 10.1016/s0031-3955(16)35006-4. PMID: 2870462

Prognosis

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Guide for Nurses.
Hanson LM, Bettencourt AP
AACN Adv Crit Care 2020 Sep 15;31(3):281-295. doi: 10.4037/aacnacc2020634. PMID: 32866260Free PMC Article
Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.
Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI
J Am Acad Dermatol 2017 May;76(5):811-817.e4. Epub 2017 Mar 9 doi: 10.1016/j.jaad.2016.12.024. PMID: 28285784Free PMC Article
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Neonatal necrotizing fasciitis: a report of three cases and review of the literature.
Hsieh WS, Yang PH, Chao HC, Lai JY
Pediatrics 1999 Apr;103(4):e53. doi: 10.1542/peds.103.4.e53. PMID: 10103345
Bilirubin metabolism and kernicterus.
Gourley GR
Adv Pediatr 1997;44:173-229. PMID: 9265971

Clinical prediction guides

Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.
Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI
J Am Acad Dermatol 2017 May;76(5):811-817.e4. Epub 2017 Mar 9 doi: 10.1016/j.jaad.2016.12.024. PMID: 28285784Free PMC Article
Nationwide Survey of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children in the United States.
Okubo Y, Nochioka K, Testa MA
Pediatr Dermatol 2017 Mar;34(2):206-208. Epub 2016 Dec 19 doi: 10.1111/pde.13050. PMID: 27990674
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Staphylococcal cutaneous infections: invasion, evasion and aggression.
Iwatsuki K, Yamasaki O, Morizane S, Oono T
J Dermatol Sci 2006 Jun;42(3):203-14. Epub 2006 May 6 doi: 10.1016/j.jdermsci.2006.03.011. PMID: 16679003
Bilirubin metabolism and kernicterus.
Gourley GR
Adv Pediatr 1997;44:173-229. PMID: 9265971

Recent systematic reviews

Algorithm to attenuate atopic dermatitis and for promoting a healthy skin barrier using skincare in newborns and infants.
Schachner LA, Blume-Peytavi U, Andriessen A, Izakovic J, Maruani A, Micali G, Murashkin N, Salavastru C, Torrelo A
Ital J Dermatol Venerol 2023 Jun;158(3):224-235. doi: 10.23736/S2784-8671.23.07336-X. PMID: 37278500
Infantile Stevens Johnson syndrome and toxic epidermal necrolysis: A systematic review of clinical features and outcomes in children ages 12 months and under.
Iriarte C, Karim SA, Nassim JS, Grenier PO, Massey KJ
Pediatr Dermatol 2022 Nov;39(6):876-882. Epub 2022 Jun 8 doi: 10.1111/pde.15047. PMID: 35676891
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article

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