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Neonatal toxic erythema

MedGen UID:
537820
Concept ID:
C0263324
Disease or Syndrome
Synonyms: Erythema neonatorum; Erythema Toxicum Neonatorum; Erythema toxicum neonatorum; Erythroderma neonatorum; ETN - erythema toxicum neonatorum; Neonatal erythema toxicum; Neonatal erythroderma; Toxic erythema of newborn
SNOMED CT: Erythroderma neonatorum (240302002); Neonatal toxic erythema (1162449005); Erythema toxicum neonatorum (1162449005); Erythema neonatorum (1162449005); ETN - erythema toxicum neonatorum (1162449005); Neonatal erythema toxicum (1162449005); Toxic erythema of newborn (1162449005); Neonatal erythroderma (240302002)

Definition

A benign, self-limited eruption of vesicles, pustules, papules and macules seen in newborns. An eosinophilic infiltrate can be isolated suggesting an immune-mediated reaction in the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal toxic erythema

Professional guidelines

PubMed

Teil J, Dupont D, Charpiat B, Corvaisier S, Vial T, Leboucher G, Wallon M, Peyron F
Pediatr Infect Dis J 2016 Jun;35(6):634-8. doi: 10.1097/INF.0000000000001120. PMID: 26906163
Chang YS, Huang FC, Tseng SH, Hsu CK, Ho CL, Sheu HM
Cornea 2007 Feb;26(2):123-9. doi: 10.1097/ICO.0b013e31802eb264. PMID: 17251797
Margileth AM
South Med J 1975 Apr;68(4):447-54. PMID: 123658

Recent clinical studies

Etiology

Arantes LB, Reis CS, Novaes AG, Carvalho MR, Göttems LBD, Novaes MRCG
An Bras Dermatol 2017 Sep-Oct;92(5):661-667. doi: 10.1590/abd1806-4841.20176610. PMID: 29166503Free PMC Article
Motola D, Donati M, Biagi C, Calamelli E, Cipriani F, Melis M, Monaco L, Vaccheri A, Ricci G
Pharmacoepidemiol Drug Saf 2017 Oct;26(10):1164-1171. Epub 2017 Jun 27 doi: 10.1002/pds.4246. PMID: 28653802
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Int J Toxicol 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. PMID: 17365137
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516

Diagnosis

Freeman MC, Mitchell S, Ibrahim J, Williams JV
J Pediatric Infect Dis Soc 2021 Mar 26;10(2):205-206. doi: 10.1093/jpids/piz060. PMID: 31550351
Arantes LB, Reis CS, Novaes AG, Carvalho MR, Göttems LBD, Novaes MRCG
An Bras Dermatol 2017 Sep-Oct;92(5):661-667. doi: 10.1590/abd1806-4841.20176610. PMID: 29166503Free PMC Article
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516
Mallory SB
Pediatr Clin North Am 1991 Aug;38(4):745-61. doi: 10.1016/s0031-3955(16)38152-4. PMID: 1870904

Therapy

Motola D, Donati M, Biagi C, Calamelli E, Cipriani F, Melis M, Monaco L, Vaccheri A, Ricci G
Pharmacoepidemiol Drug Saf 2017 Oct;26(10):1164-1171. Epub 2017 Jun 27 doi: 10.1002/pds.4246. PMID: 28653802
Hinc-Kasprzyk J, Polak-Krzemińska A, Ożóg-Zabolska I
Anaesthesiol Intensive Ther 2015;47(3):257-62. doi: 10.5603/AIT.2015.0037. PMID: 26165242
Int J Toxicol 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. PMID: 17365137
Peterson CM, Schuppert K, Kelly PC, Pappagianis D
Obstet Gynecol Surv 1993 Mar;48(3):149-56. doi: 10.1097/00006254-199303000-00002. PMID: 8441516
Cheung RP, DiPiro JT
Pharmacotherapy 1986 Jul-Aug;6(4):153-69. doi: 10.1002/j.1875-9114.1986.tb03471.x. PMID: 3534799

Prognosis

Hanson LM, Bettencourt AP
AACN Adv Crit Care 2020 Sep 15;31(3):281-295. doi: 10.4037/aacnacc2020634. PMID: 32866260Free PMC Article
Motola D, Donati M, Biagi C, Calamelli E, Cipriani F, Melis M, Monaco L, Vaccheri A, Ricci G
Pharmacoepidemiol Drug Saf 2017 Oct;26(10):1164-1171. Epub 2017 Jun 27 doi: 10.1002/pds.4246. PMID: 28653802
Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI
J Am Acad Dermatol 2017 May;76(5):811-817.e4. Epub 2017 Mar 9 doi: 10.1016/j.jaad.2016.12.024. PMID: 28285784Free PMC Article
Int J Toxicol 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. PMID: 17365137
Gourley GR
Adv Pediatr 1997;44:173-229. PMID: 9265971

Clinical prediction guides

Hsu DY, Brieva J, Silverberg NB, Paller AS, Silverberg JI
J Am Acad Dermatol 2017 May;76(5):811-817.e4. Epub 2017 Mar 9 doi: 10.1016/j.jaad.2016.12.024. PMID: 28285784Free PMC Article
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Int J Toxicol 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. PMID: 17365137
Iwatsuki K, Yamasaki O, Morizane S, Oono T
J Dermatol Sci 2006 Jun;42(3):203-14. Epub 2006 May 6 doi: 10.1016/j.jdermsci.2006.03.011. PMID: 16679003
Gourley GR
Adv Pediatr 1997;44:173-229. PMID: 9265971

Recent systematic reviews

Schachner LA, Blume-Peytavi U, Andriessen A, Izakovic J, Maruani A, Micali G, Murashkin N, Salavastru C, Torrelo A
Ital J Dermatol Venerol 2023 Jun;158(3):224-235. doi: 10.23736/S2784-8671.23.07336-X. PMID: 37278500
Iriarte C, Karim SA, Nassim JS, Grenier PO, Massey KJ
Pediatr Dermatol 2022 Nov;39(6):876-882. Epub 2022 Jun 8 doi: 10.1111/pde.15047. PMID: 35676891
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article

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