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Piezogenic pedal papules

MedGen UID:
538035
Concept ID:
C0263654
Disease or Syndrome
Synonyms: Painful piezogenic pedal papule; Painful piezogenic pedal papules; Piezogenic pedal papule
SNOMED CT: Painful piezogenic pedal papule (50510006); Piezogenic pedal papule (50510006); Painful piezogenic pedal papules (50510006)
 
HPO: HP:0025509

Definition

Flesh-colored or yellowish papules, 2 mm or larger, that are responses to internal mechanical pressure and weakness in the connective tissue in the dermis, appear commonly over the medial aspect of the heel, but in some cases on the wrists. They are thought to represent herniations of adipose tissue through the plantar fascia retinaculum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPiezogenic pedal papules

Conditions with this feature

Ehlers-Danlos syndrome, classic-like, 3
MedGen UID:
1861383
Concept ID:
C5935631
Disease or Syndrome
Ehlers-Danlos syndrome classic-like-3 (EDSCLL3) is an autosomal dominant connective tissue disorder characterized by joint hypermobility and frequent joint dislocations, atrophic scarring, prolonged bleeding time, and age-related aortic dilatation and rupture (Hadar et al., 2024). For a discussion of genetic heterogeneity of classic-like Ehlers-Danlos syndrome, see 606408. For a discussion of the classificiation of Ehlers-Danlos syndrome, see EDSCL1 (130000).

Recent clinical studies

Etiology

Amarnani AA, Poladian KR, Marciano BE, Daub JR, Williams SG, Livinski AA, Hsu AP, Palmer CL, Kenney CM, Avila DN, Holland SM, Katz JD
Sci Rep 2020 May 20;10(1):8305. doi: 10.1038/s41598-020-64852-1. PMID: 32433473Free PMC Article
Kahana M, Feinstein A, Tabachnic E, Schewach-Millet M, Engelberg S
J Am Acad Dermatol 1987 Aug;17(2 Pt 1):205-9. doi: 10.1016/s0190-9622(87)70192-3. PMID: 3624559

Diagnosis

Amarnani AA, Poladian KR, Marciano BE, Daub JR, Williams SG, Livinski AA, Hsu AP, Palmer CL, Kenney CM, Avila DN, Holland SM, Katz JD
Sci Rep 2020 May 20;10(1):8305. doi: 10.1038/s41598-020-64852-1. PMID: 32433473Free PMC Article
Morais P, Ferreira O, Magina S, Silva C, Leão M, Maia A, Azevedo F
Acta Dermatovenerol Croat 2013;21(2):118-22. PMID: 24001420
Ma DL, Vano-Galvan S
CMAJ 2013 Dec 10;185(18):E847. Epub 2013 Jun 24 doi: 10.1503/cmaj.121963. PMID: 23798455Free PMC Article
Bender TW 3rd
Skinmed 2003 Jan-Feb;2(1):34-40. doi: 10.1111/j.1540-9740.2003.01968.x. PMID: 14673322
Kahana M, Feinstein A, Tabachnic E, Schewach-Millet M, Engelberg S
J Am Acad Dermatol 1987 Aug;17(2 Pt 1):205-9. doi: 10.1016/s0190-9622(87)70192-3. PMID: 3624559

Therapy

Liu C, Li MK, Alster TS
Dermatol Surg 2021 Nov 1;47(11):1466-1472. doi: 10.1097/DSS.0000000000003159. PMID: 34537786
Doukas DJ, Holmes J, Leonard JA
Cutis 2004 May;73(5):339-40, 346. PMID: 15186050
Bender TW 3rd
Skinmed 2003 Jan-Feb;2(1):34-40. doi: 10.1111/j.1540-9740.2003.01968.x. PMID: 14673322
Schlappner OL, Wood MG, Gerstein W, Gross PR
Arch Dermatol 1972 Nov;106(5):729-33. PMID: 4635806
Grant DJ, Gomez F
Arch Dermatol 1970 May;101(5):619-20. PMID: 5444090

Prognosis

Amarnani AA, Poladian KR, Marciano BE, Daub JR, Williams SG, Livinski AA, Hsu AP, Palmer CL, Kenney CM, Avila DN, Holland SM, Katz JD
Sci Rep 2020 May 20;10(1):8305. doi: 10.1038/s41598-020-64852-1. PMID: 32433473Free PMC Article
Woodrow SL, Brereton-Smith G, Handfield-Jones S
Br J Dermatol 1997 Apr;136(4):628-30. PMID: 9155975

Clinical prediction guides

Amarnani AA, Poladian KR, Marciano BE, Daub JR, Williams SG, Livinski AA, Hsu AP, Palmer CL, Kenney CM, Avila DN, Holland SM, Katz JD
Sci Rep 2020 May 20;10(1):8305. doi: 10.1038/s41598-020-64852-1. PMID: 32433473Free PMC Article
Kahana M, Feinstein A, Tabachnic E, Schewach-Millet M, Engelberg S
J Am Acad Dermatol 1987 Aug;17(2 Pt 1):205-9. doi: 10.1016/s0190-9622(87)70192-3. PMID: 3624559

Recent systematic reviews

Liu C, Li MK, Alster TS
Dermatol Surg 2021 Nov 1;47(11):1466-1472. doi: 10.1097/DSS.0000000000003159. PMID: 34537786

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