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Organizing pneumonia

MedGen UID:
538531
•Concept ID:
C0264383
•
Disease or Syndrome
Synonym: Organized pneumonia
SNOMED CT: Organized pneumonia (68409003); Organizing pneumonitis (68409003)
 
HPO: HP:0033670

Definition

Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrganizing pneumonia

Conditions with this feature

Hypoproteinemia, hypercatabolic
MedGen UID:
343422
•Concept ID:
C1855796
•
Disease or Syndrome
Immunodeficiency-43 (IMD43) is an autosomal recessive immunologic disorder characterized by decreased or absent expression of MHC class I molecules on the cell surface. Most affected individuals develop recurrent bacterial respiratory tract infections in childhood or adulthood, which may progress to bronchiectasis, and about half develop ulcerating or necrotizing granulomatous inflammatory skin lesions. Laboratory studies show decreased numbers of B cells, hypogammaglobulinemia, hypoproteinemia, and decreased alpha-beta CD8+ T cells with increased gamma-delta CD8+ T cells. The severity is variable, and some individuals may be asymptomatic (summary by Ardeniz et al., 2015). For a discussion of genetic heterogeneity of MHC class I deficiency, see MHC1D1 (604571).
See: Condition Record
Hypoproteinemia, hypercatabolic

Professional guidelines

PubMed

Trastuzumab Deruxtecan‒Related Interstitial Lung Disease/Pneumonitis: Computed Tomography Imaging Patterns to Guide Diagnosis and Management.
Nishino M, Kusumoto M, Bankier AA, Kurihara Y, Zhang L, Rasheed Z, Meinhardt G, Arunachalam M, Taitt C, Wang Q, Powell CA
JCO Precis Oncol 2023 Sep;7:e2300391. doi: 10.1200/PO.23.00391. PMID: 38061008
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Immune Checkpoint Inhibitor Therapy-related Pneumonitis: Patterns and Management.
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861

Recent clinical studies

Etiology

Current and Emerging Knowledge in COVID-19.
Jeong YJ, Wi YM, Park H, Lee JE, Kim SH, Lee KS
Radiology 2023 Feb;306(2):e222462. Epub 2023 Jan 10 doi: 10.1148/radiol.222462. PMID: 36625747Free PMC Article
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players.
Samarelli AV, Tonelli R, Marchioni A, Bruzzi G, Gozzi F, Andrisani D, Castaniere I, Manicardi L, Moretti A, Tabbì L, Cerri S, Beghè B, Dominici M, Clini E
Int J Mol Sci 2021 Aug 19;22(16) doi: 10.3390/ijms22168952. PMID: 34445658Free PMC Article
Mosaic Attenuation: Etiology, Methods of Differentiation, and Pitfalls.
Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445
Amiodarone: review of pulmonary effects and toxicity.
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

Diagnosis

Organizing pneumonia and COVID-19.
Tonon CR, Tanni SE, Rocha J, Godoy I, Polegato BF, Pereira FWL, Martins D, Prudente RA, Franco ET, Brizola F, Baldi BG, Okoshi MP
Am J Med Sci 2023 Dec;366(6):458-463. Epub 2023 Sep 30 doi: 10.1016/j.amjms.2023.09.023. PMID: 37778722
Organizing pneumonia.
Arenas-Jiménez JJ, García-Garrigós E, Ureña Vacas A, Sirera Matilla M, Feliu Rey E
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:240-249. doi: 10.1016/j.rxeng.2022.08.002. PMID: 36737163
Cryptogenic Organizing Pneumonia.
King TE Jr, Lee JS
N Engl J Med 2022 Mar 17;386(11):1058-1069. doi: 10.1056/NEJMra2116777. PMID: 35294814
Algorithmic Approach to the Diagnosis of Organizing Pneumonia: A Correlation of Clinical, Radiologic, and Pathologic Features.
Cherian SV, Patel D, Machnicki S, Naidich D, Stover D, Travis WD, Brown KK, Naidich JJ, Mahajan A, Esposito M, Mina B, Lakticova V, Cohen SL, Muller NL, Schulner J, Shah R, Raoof S
Chest 2022 Jul;162(1):156-178. Epub 2022 Jan 14 doi: 10.1016/j.chest.2021.12.659. PMID: 35038455Free PMC Article
Organizing pneumonia.
Drakopanagiotakis F, Polychronopoulos V, Judson MA
Am J Med Sci 2008 Jan;335(1):34-9. doi: 10.1097/MAJ.0b013e31815d829d. PMID: 18195581

Therapy

Anti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature.
Demortier J, Vautier M, Chosidow O, Gallay L, Bessis D, Berezne A, Cordel N, Schmidt J, Smail A, Duffau P, Jachiet M, Begon E, Gottlieb J, Chasset F, Graveleau J, Marque M, Cesbron E, Forestier A, Josse S, Kluger N, Beauchêne C, Le Corre Y, Pagis V, Rigolet A, Guillaume-Jugnot P, Authier FJ, Guilain N, Streichenberger N, Leonard-Louis S, Boussouar S, Landon-Cardinal O, Benveniste O, Allenbach Y
Rheumatology (Oxford) 2023 Dec 1;62(12):3932-3939. doi: 10.1093/rheumatology/kead154. PMID: 37010495
Dual Antiviral Therapy for Persistent Coronavirus Disease 2019 and Associated Organizing Pneumonia in an Immunocompromised Host.
Trottier CA, Wong B, Kohli R, Boomsma C, Magro F, Kher S, Anderlind C, Golan Y
Clin Infect Dis 2023 Mar 4;76(5):923-925. doi: 10.1093/cid/ciac847. PMID: 36281907Free PMC Article
Cryptogenic Organizing Pneumonia.
King TE Jr, Lee JS
N Engl J Med 2022 Mar 17;386(11):1058-1069. doi: 10.1056/NEJMra2116777. PMID: 35294814
Immune Checkpoint Inhibitor Therapy-related Pneumonitis: Patterns and Management.
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861
Organizing pneumonia.
Drakopanagiotakis F, Polychronopoulos V, Judson MA
Am J Med Sci 2008 Jan;335(1):34-9. doi: 10.1097/MAJ.0b013e31815d829d. PMID: 18195581

Prognosis

Organizing pneumonia.
Arenas-Jiménez JJ, García-Garrigós E, Ureña Vacas A, Sirera Matilla M, Feliu Rey E
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:240-249. doi: 10.1016/j.rxeng.2022.08.002. PMID: 36737163
Cryptogenic Organizing Pneumonia.
King TE Jr, Lee JS
N Engl J Med 2022 Mar 17;386(11):1058-1069. doi: 10.1056/NEJMra2116777. PMID: 35294814
Algorithmic Approach to the Diagnosis of Organizing Pneumonia: A Correlation of Clinical, Radiologic, and Pathologic Features.
Cherian SV, Patel D, Machnicki S, Naidich D, Stover D, Travis WD, Brown KK, Naidich JJ, Mahajan A, Esposito M, Mina B, Lakticova V, Cohen SL, Muller NL, Schulner J, Shah R, Raoof S
Chest 2022 Jul;162(1):156-178. Epub 2022 Jan 14 doi: 10.1016/j.chest.2021.12.659. PMID: 35038455Free PMC Article
Immune Checkpoint Inhibitor Therapy-related Pneumonitis: Patterns and Management.
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861
An update on IgG4-related lung disease.
Morales AT, Cignarella AG, Jabeen IS, Barkin JS, Mirsaeidi M
Eur J Intern Med 2019 Aug;66:18-24. Epub 2019 Jun 19 doi: 10.1016/j.ejim.2019.06.010. PMID: 31227290

Clinical prediction guides

Clinical and imaging features of interstitial lung disease in cancer patients treated with trastuzumab deruxtecan.
Baba T, Kusumoto M, Kato T, Kurihara Y, Sasaki S, Oikado K, Saito Y, Endo M, Fujiwara Y, Kenmotsu H, Sata M, Takano T, Kato K, Hirata K, Katagiri T, Saito H, Kuwano K
Int J Clin Oncol 2023 Dec;28(12):1585-1596. Epub 2023 Oct 3 doi: 10.1007/s10147-023-02414-x. PMID: 37787866Free PMC Article
Anti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature.
Demortier J, Vautier M, Chosidow O, Gallay L, Bessis D, Berezne A, Cordel N, Schmidt J, Smail A, Duffau P, Jachiet M, Begon E, Gottlieb J, Chasset F, Graveleau J, Marque M, Cesbron E, Forestier A, Josse S, Kluger N, Beauchêne C, Le Corre Y, Pagis V, Rigolet A, Guillaume-Jugnot P, Authier FJ, Guilain N, Streichenberger N, Leonard-Louis S, Boussouar S, Landon-Cardinal O, Benveniste O, Allenbach Y
Rheumatology (Oxford) 2023 Dec 1;62(12):3932-3939. doi: 10.1093/rheumatology/kead154. PMID: 37010495
Clinical and Radiological Features of Interstitial Lung Diseases Associated with Polymyositis and Dermatomyositis.
Palmucci S, Di Mari A, Cancemi G, Pennisi I, Mauro LA, Sambataro G, Sambataro D, Galioto F, Fazio G, Ferlito A, Pino F, Basile A, Vancheri C
Medicina (Kaunas) 2022 Nov 30;58(12) doi: 10.3390/medicina58121757. PMID: 36556960Free PMC Article
Immune Checkpoint Inhibitor Therapy-related Pneumonitis: Patterns and Management.
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861
Amiodarone: review of pulmonary effects and toxicity.
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

Recent systematic reviews

Diagnostic procedures and clinico-radiological findings of acute fibrinous and organizing pneumonia: a systematic review and pooled analysis.
Lee JH, Yum HK, Jamous F, Santos C, Campisi A, Surani S, Lococo F, Goo JM, Yoon SH
Eur Radiol 2021 Oct;31(10):7283-7294. Epub 2021 Mar 31 doi: 10.1007/s00330-021-07868-z. PMID: 33791819
Organizing pneumonia secondary to influenza infection: Two case reports and a literature review.
Nuñez-Conde A, Marquez-Algaba E, Falcó V, Almirante B, Burgos J
Enferm Infecc Microbiol Clin (Engl Ed) 2020 Mar;38(3):123-126. Epub 2019 May 22 doi: 10.1016/j.eimc.2019.04.006. PMID: 31126691
Micronodular pattern of organizing pneumonia: Case report and systematic literature review.
Lebargy F, Picard D, Hagenburg J, Toubas O, Perotin JM, Sandu S, Deslee G, Dury S
Medicine (Baltimore) 2017 Jan;96(3):e5788. doi: 10.1097/MD.0000000000005788. PMID: 28099335Free PMC Article
Systematic review of postradiotherapy bronchiolitis obliterans organizing pneumonia in women with breast cancer.
Epler GR, Kelly EM
Oncologist 2014 Dec;19(12):1216-26. Epub 2014 Oct 31 doi: 10.1634/theoncologist.2014-0041. PMID: 25361622Free PMC Article
Reversed halo sign: a systematic review.
Maturu VN, Agarwal R
Respir Care 2014 Sep;59(9):1440-9. Epub 2014 Apr 29 doi: 10.4187/respcare.03020. PMID: 24782557

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