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Organizing pneumonia

MedGen UID:
538531
Concept ID:
C0264383
Disease or Syndrome
Synonym: Organized pneumonia
SNOMED CT: Organized pneumonia (68409003)
 
HPO: HP:0033670

Definition

Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities. [from HPO]

Term Hierarchy

Conditions with this feature

Hypoproteinemia, hypercatabolic
MedGen UID:
343422
Concept ID:
C1855796
Disease or Syndrome
Immunodeficiency-43 (IMD43) is an autosomal recessive immunologic disorder characterized by decreased or absent expression of MHC class I molecules on the cell surface. Most affected individuals develop recurrent bacterial respiratory tract infections in childhood or adulthood, which may progress to bronchiectasis, and about half develop ulcerating or necrotizing granulomatous inflammatory skin lesions. Laboratory studies show decreased numbers of B cells, hypogammaglobulinemia, hypoproteinemia, and decreased alpha-beta CD8+ T cells with increased gamma-delta CD8+ T cells. The severity is variable, and some individuals may be asymptomatic (summary by Ardeniz et al., 2015). For a discussion of genetic heterogeneity of MHC class I deficiency, see MHC1D1 (604571).

Professional guidelines

PubMed

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
Chest 2022 Nov;162(5):1188-1198. Epub 2022 Jun 1 doi: 10.1016/j.chest.2022.05.035. PMID: 35661746
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861

Recent clinical studies

Etiology

Jeong YJ, Wi YM, Park H, Lee JE, Kim SH, Lee KS
Radiology 2023 Feb;306(2):e222462. Epub 2023 Jan 10 doi: 10.1148/radiol.222462. PMID: 36625747Free PMC Article
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Samarelli AV, Tonelli R, Marchioni A, Bruzzi G, Gozzi F, Andrisani D, Castaniere I, Manicardi L, Moretti A, Tabbì L, Cerri S, Beghè B, Dominici M, Clini E
Int J Mol Sci 2021 Aug 19;22(16) doi: 10.3390/ijms22168952. PMID: 34445658Free PMC Article
Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

Diagnosis

Tonon CR, Tanni SE, Rocha J, Godoy I, Polegato BF, Pereira FWL, Martins D, Prudente RA, Franco ET, Brizola F, Baldi BG, Okoshi MP
Am J Med Sci 2023 Dec;366(6):458-463. Epub 2023 Sep 30 doi: 10.1016/j.amjms.2023.09.023. PMID: 37778722
Sumi T, Terai K, Suzuki K, Koshino Y, Ikeda T, Watanabe H, Yamada Y, Chiba H
Am J Respir Crit Care Med 2023 Dec 15;208(12):e47-e48. doi: 10.1164/rccm.202305-0885IM. PMID: 37703394
King TE Jr, Lee JS
N Engl J Med 2022 Mar 17;386(11):1058-1069. doi: 10.1056/NEJMra2116777. PMID: 35294814
Cherian SV, Patel D, Machnicki S, Naidich D, Stover D, Travis WD, Brown KK, Naidich JJ, Mahajan A, Esposito M, Mina B, Lakticova V, Cohen SL, Muller NL, Schulner J, Shah R, Raoof S
Chest 2022 Jul;162(1):156-178. Epub 2022 Jan 14 doi: 10.1016/j.chest.2021.12.659. PMID: 35038455Free PMC Article
Drakopanagiotakis F, Polychronopoulos V, Judson MA
Am J Med Sci 2008 Jan;335(1):34-9. doi: 10.1097/MAJ.0b013e31815d829d. PMID: 18195581

Therapy

Demortier J, Vautier M, Chosidow O, Gallay L, Bessis D, Berezne A, Cordel N, Schmidt J, Smail A, Duffau P, Jachiet M, Begon E, Gottlieb J, Chasset F, Graveleau J, Marque M, Cesbron E, Forestier A, Josse S, Kluger N, Beauchêne C, Le Corre Y, Pagis V, Rigolet A, Guillaume-Jugnot P, Authier FJ, Guilain N, Streichenberger N, Leonard-Louis S, Boussouar S, Landon-Cardinal O, Benveniste O, Allenbach Y
Rheumatology (Oxford) 2023 Dec 1;62(12):3932-3939. doi: 10.1093/rheumatology/kead154. PMID: 37010495
Ketchersid K
JAAPA 2023 Mar 1;36(3):16-19. doi: 10.1097/01.JAA.0000918776.59717.eb. PMID: 36749158
Trottier CA, Wong B, Kohli R, Boomsma C, Magro F, Kher S, Anderlind C, Golan Y
Clin Infect Dis 2023 Mar 4;76(5):923-925. doi: 10.1093/cid/ciac847. PMID: 36281907Free PMC Article
King TE Jr, Lee JS
N Engl J Med 2022 Mar 17;386(11):1058-1069. doi: 10.1056/NEJMra2116777. PMID: 35294814
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861

Prognosis

Arenas-Jiménez JJ, García-Garrigós E, Ureña Vacas A, Sirera Matilla M, Feliu Rey E
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:240-249. doi: 10.1016/j.rxeng.2022.08.002. PMID: 36737163
King TE Jr, Lee JS
N Engl J Med 2022 Mar 17;386(11):1058-1069. doi: 10.1056/NEJMra2116777. PMID: 35294814
Cherian SV, Patel D, Machnicki S, Naidich D, Stover D, Travis WD, Brown KK, Naidich JJ, Mahajan A, Esposito M, Mina B, Lakticova V, Cohen SL, Muller NL, Schulner J, Shah R, Raoof S
Chest 2022 Jul;162(1):156-178. Epub 2022 Jan 14 doi: 10.1016/j.chest.2021.12.659. PMID: 35038455Free PMC Article
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861
Morales AT, Cignarella AG, Jabeen IS, Barkin JS, Mirsaeidi M
Eur J Intern Med 2019 Aug;66:18-24. Epub 2019 Jun 19 doi: 10.1016/j.ejim.2019.06.010. PMID: 31227290

Clinical prediction guides

Demortier J, Vautier M, Chosidow O, Gallay L, Bessis D, Berezne A, Cordel N, Schmidt J, Smail A, Duffau P, Jachiet M, Begon E, Gottlieb J, Chasset F, Graveleau J, Marque M, Cesbron E, Forestier A, Josse S, Kluger N, Beauchêne C, Le Corre Y, Pagis V, Rigolet A, Guillaume-Jugnot P, Authier FJ, Guilain N, Streichenberger N, Leonard-Louis S, Boussouar S, Landon-Cardinal O, Benveniste O, Allenbach Y
Rheumatology (Oxford) 2023 Dec 1;62(12):3932-3939. doi: 10.1093/rheumatology/kead154. PMID: 37010495
Palmucci S, Di Mari A, Cancemi G, Pennisi I, Mauro LA, Sambataro G, Sambataro D, Galioto F, Fazio G, Ferlito A, Pino F, Basile A, Vancheri C
Medicina (Kaunas) 2022 Nov 30;58(12) doi: 10.3390/medicina58121757. PMID: 36556960Free PMC Article
Myall KJ, Mukherjee B, Castanheira AM, Lam JL, Benedetti G, Mak SM, Preston R, Thillai M, Dewar A, Molyneaux PL, West AG
Ann Am Thorac Soc 2021 May;18(5):799-806. doi: 10.1513/AnnalsATS.202008-1002OC. PMID: 33433263Free PMC Article
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

Recent systematic reviews

Lee JH, Yum HK, Jamous F, Santos C, Campisi A, Surani S, Lococo F, Goo JM, Yoon SH
Eur Radiol 2021 Oct;31(10):7283-7294. Epub 2021 Mar 31 doi: 10.1007/s00330-021-07868-z. PMID: 33791819
Epler GR, Kelly EM
Respir Care 2020 May;65(5):686-692. Epub 2019 Dec 31 doi: 10.4187/respcare.07150. PMID: 31892515
Lebargy F, Picard D, Hagenburg J, Toubas O, Perotin JM, Sandu S, Deslee G, Dury S
Medicine (Baltimore) 2017 Jan;96(3):e5788. doi: 10.1097/MD.0000000000005788. PMID: 28099335Free PMC Article
Epler GR, Kelly EM
Oncologist 2014 Dec;19(12):1216-26. Epub 2014 Oct 31 doi: 10.1634/theoncologist.2014-0041. PMID: 25361622Free PMC Article
Maturu VN, Agarwal R
Respir Care 2014 Sep;59(9):1440-9. Epub 2014 Apr 29 doi: 10.4187/respcare.03020. PMID: 24782557

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