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Heart valve regurgitation

MedGen UID:
538923
•Concept ID:
C0264879
•
Pathologic Function
Synonyms: Cardiac valve insufficiency; Valvular insufficiency
SNOMED CT: Heart valve regurgitation (40445007); Heart valve insufficiency (40445007); Heart valve incompetence (40445007)

Definition

Regurgitation of the blood of the heart valves owning to imperfect closing, insufficiency or incompetency of the valves. [from NCI]

Professional guidelines

PubMed

Cardiopulmonary sequelae after treatment for Hodgkin's disease: increased risk in females?
Lund MB, Kongerud J, Boe J, Nome O, Abrahamsen AF, Ihlen H, Forfang K
Ann Oncol 1996 Mar;7(3):257-64. doi: 10.1093/oxfordjournals.annonc.a010569. PMID: 8740789

Recent clinical studies

Etiology

Safety study of moxifloxacin in children with severe refractory Mycoplasma pneumoniae pneumonia.
He YS, Yang M, Liu G, Ji J, Qian SY
Pediatr Pulmonol 2023 Jul;58(7):2017-2024. Epub 2023 Apr 26 doi: 10.1002/ppul.26426. PMID: 37098833
Myocardial fibrosis in asymptomatic patients undergoing surgery for mitral and aortic valve regurgitation.
Fragasso G, Sanvito F, Monaca G, Ardizzone V, De Bonis M, Pappalardo F, Smart C, Montanaro C, Lapenna E, Calabrese MC, Castiglioni A, Benussi S, Maisano F, Zangrillo A, Ambrosi A, Doglioni C, Alfieri O, Margonato A
J Cardiovasc Med (Hagerstown) 2022 Aug 1;23(8):505-512. doi: 10.2459/JCM.0000000000001347. PMID: 35904996
Drug-induced aortic valve stenosis: An under recognized entity.
Ennezat PV, Bruneval P, Czitrom D, Gueffet JP, Piriou N, Trochu JN, Patra O, Blanchard-Lemoine B, du Fretay XH, Nazeyrollas P, Assoun B, Jobic Y, Brochet E, Bogino E, Roudaut R, Augier C, Greffe L, Petit-Eisenmann H, Dambrin C, Chavanon O, Guillou L, Grisoli D, Morera P, Banfi C, Remadi JP, Fabre O, Vincentelli A, Lantuejoul S, Ikoli JF, Copin MC, Malergue MC, Maréchaux S, Tribouilloy C
Int J Cardiol 2016 Oct 1;220:429-34. Epub 2016 Jun 23 doi: 10.1016/j.ijcard.2016.06.112. PMID: 27390966
Heart valve regurgitation, pergolide use, and parkinson disease: an observational study and meta-analysis.
Corvol JC, Anzouan-Kacou JB, Fauveau E, Bonnet AM, Lebrun-Vignes B, Girault C, Agid Y, Lechat P, Isnard R, Lacomblez L
Arch Neurol 2007 Dec;64(12):1721-6. doi: 10.1001/archneur.64.12.1721. PMID: 18071034
Association between selective serotonin-reuptake inhibitor therapy and heart valve regurgitation.
Mast ST, Gersing KR, Anstrom KJ, Krishnan KR, Califf RM, Jollis JG
Am J Cardiol 2001 Apr 15;87(8):989-93: A4. doi: 10.1016/s0002-9149(01)01435-7. PMID: 11305992

Diagnosis

Compressed sensing real-time cine imaging for assessment of ventricular function, volumes and mass in clinical practice.
Vermersch M, Longère B, Coisne A, Schmidt M, Forman C, Monnet A, Pagniez J, Silvestri V, Simeone A, Cheasty E, Montaigne D, Pontana F
Eur Radiol 2020 Jan;30(1):609-619. Epub 2019 Aug 1 doi: 10.1007/s00330-019-06341-2. PMID: 31372784
Drug-induced aortic valve stenosis: An under recognized entity.
Ennezat PV, Bruneval P, Czitrom D, Gueffet JP, Piriou N, Trochu JN, Patra O, Blanchard-Lemoine B, du Fretay XH, Nazeyrollas P, Assoun B, Jobic Y, Brochet E, Bogino E, Roudaut R, Augier C, Greffe L, Petit-Eisenmann H, Dambrin C, Chavanon O, Guillou L, Grisoli D, Morera P, Banfi C, Remadi JP, Fabre O, Vincentelli A, Lantuejoul S, Ikoli JF, Copin MC, Malergue MC, Maréchaux S, Tribouilloy C
Int J Cardiol 2016 Oct 1;220:429-34. Epub 2016 Jun 23 doi: 10.1016/j.ijcard.2016.06.112. PMID: 27390966
Heart valve disease: the role of calcidiol deficiency, elevated parathyroid hormone levels and oxidative stress in mitral and aortic valve insufficiency.
Eren E, Ellidag HY, Cekin Y, Ayoglu RU, Sekercioglu AO, Yılmaz N
Redox Rep 2014 Jan;19(1):34-9. Epub 2013 Nov 26 doi: 10.1179/1351000213Y.0000000069. PMID: 24192717Free PMC Article
Frequency of drug-induced valvular heart disease in patients previously exposd to benfluorex: a multicentre prospective study.
Tribouilloy C, Maréchaux S, Jobic Y, Jeu A, Ederhy S, Donal E, Réant P, Arnalsteen E, Boulanger J, Garban T, Ennezat PV, Andréjak M, Rusinaru D
Eur Heart J 2013 Dec;34(46):3580-7. Epub 2013 Sep 6 doi: 10.1093/eurheartj/eht266. PMID: 24014218
Increased risk of heart valve regurgitation after mediastinal radiation for Hodgkin's disease: an echocardiographic study.
Lund MB, Ihlen H, Voss BM, Abrahamsen AF, Nome O, Kongerud J, Stugaard M, Forfang K
Heart 1996 Jun;75(6):591-5. doi: 10.1136/hrt.75.6.591. PMID: 8697163Free PMC Article

Therapy

Safety study of moxifloxacin in children with severe refractory Mycoplasma pneumoniae pneumonia.
He YS, Yang M, Liu G, Ji J, Qian SY
Pediatr Pulmonol 2023 Jul;58(7):2017-2024. Epub 2023 Apr 26 doi: 10.1002/ppul.26426. PMID: 37098833
Drug-induced aortic valve stenosis: An under recognized entity.
Ennezat PV, Bruneval P, Czitrom D, Gueffet JP, Piriou N, Trochu JN, Patra O, Blanchard-Lemoine B, du Fretay XH, Nazeyrollas P, Assoun B, Jobic Y, Brochet E, Bogino E, Roudaut R, Augier C, Greffe L, Petit-Eisenmann H, Dambrin C, Chavanon O, Guillou L, Grisoli D, Morera P, Banfi C, Remadi JP, Fabre O, Vincentelli A, Lantuejoul S, Ikoli JF, Copin MC, Malergue MC, Maréchaux S, Tribouilloy C
Int J Cardiol 2016 Oct 1;220:429-34. Epub 2016 Jun 23 doi: 10.1016/j.ijcard.2016.06.112. PMID: 27390966
Long-term cabergoline therapy is not associated with valvular heart disease in patients with prolactinomas.
Vallette S, Serri K, Rivera J, Santagata P, Delorme S, Garfield N, Kahtani N, Beauregard H, Aris-Jilwan N, Houde G, Serri O
Pituitary 2009;12(3):153-7. doi: 10.1007/s11102-008-0134-2. PMID: 18594989
Heart valve regurgitation, pergolide use, and parkinson disease: an observational study and meta-analysis.
Corvol JC, Anzouan-Kacou JB, Fauveau E, Bonnet AM, Lebrun-Vignes B, Girault C, Agid Y, Lechat P, Isnard R, Lacomblez L
Arch Neurol 2007 Dec;64(12):1721-6. doi: 10.1001/archneur.64.12.1721. PMID: 18071034
Association between selective serotonin-reuptake inhibitor therapy and heart valve regurgitation.
Mast ST, Gersing KR, Anstrom KJ, Krishnan KR, Califf RM, Jollis JG
Am J Cardiol 2001 Apr 15;87(8):989-93: A4. doi: 10.1016/s0002-9149(01)01435-7. PMID: 11305992

Prognosis

Myocardial fibrosis in asymptomatic patients undergoing surgery for mitral and aortic valve regurgitation.
Fragasso G, Sanvito F, Monaca G, Ardizzone V, De Bonis M, Pappalardo F, Smart C, Montanaro C, Lapenna E, Calabrese MC, Castiglioni A, Benussi S, Maisano F, Zangrillo A, Ambrosi A, Doglioni C, Alfieri O, Margonato A
J Cardiovasc Med (Hagerstown) 2022 Aug 1;23(8):505-512. doi: 10.2459/JCM.0000000000001347. PMID: 35904996
Inverse problems in reduced order models of cardiovascular haemodynamics: aspects of data assimilation and heart rate variability.
Pant S, Corsini C, Baker C, Hsia TY, Pennati G, Vignon-Clementel IE
J R Soc Interface 2017 Jan;14(126) doi: 10.1098/rsif.2016.0513. PMID: 28077762Free PMC Article
Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study.
Tribouilloy C, Rusinaru D, Maréchaux S, Jeu A, Ederhy S, Donal E, Réant P, Arnalsteen E, Boulanger J, Ennezat PV, Garban T, Jobic Y
Circulation 2012 Dec 11;126(24):2852-8. Epub 2012 Nov 9 doi: 10.1161/CIRCULATIONAHA.112.111260. PMID: 23143159
Regression of cardiac valvulopathy related to ergot-derived dopamine agonists.
Zanettini R, Antonini A, Gatto G, Gentile R, Tesei S, Pezzoli G
Cardiovasc Ther 2011 Dec;29(6):404-10. Epub 2010 Jun 11 doi: 10.1111/j.1755-5922.2010.00169.x. PMID: 20553285
Dexfenfluramine and heart-valve regurgitation in Chinese patients with type 2 diabetes.
Ko GT, Chan HC, Chow CC
Hong Kong Med J 2003 Aug;9(4):243-6. PMID: 12904610

Clinical prediction guides

Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function.
Nagorska A, Zaucker A, Lambert F, Inman A, Toral-Perez S, Gorodkin J, Wan Y, Smutny M, Sampath K
Development 2023 Dec 1;150(23) Epub 2023 Nov 30 doi: 10.1242/dev.201657. PMID: 38032088Free PMC Article
Safety study of moxifloxacin in children with severe refractory Mycoplasma pneumoniae pneumonia.
He YS, Yang M, Liu G, Ji J, Qian SY
Pediatr Pulmonol 2023 Jul;58(7):2017-2024. Epub 2023 Apr 26 doi: 10.1002/ppul.26426. PMID: 37098833
Drug-induced aortic valve stenosis: An under recognized entity.
Ennezat PV, Bruneval P, Czitrom D, Gueffet JP, Piriou N, Trochu JN, Patra O, Blanchard-Lemoine B, du Fretay XH, Nazeyrollas P, Assoun B, Jobic Y, Brochet E, Bogino E, Roudaut R, Augier C, Greffe L, Petit-Eisenmann H, Dambrin C, Chavanon O, Guillou L, Grisoli D, Morera P, Banfi C, Remadi JP, Fabre O, Vincentelli A, Lantuejoul S, Ikoli JF, Copin MC, Malergue MC, Maréchaux S, Tribouilloy C
Int J Cardiol 2016 Oct 1;220:429-34. Epub 2016 Jun 23 doi: 10.1016/j.ijcard.2016.06.112. PMID: 27390966
Aortic regurgitation after transcatheter aortic valve implantation of the Edwards SAPIEN ™ valve.
Nielsen HH, Egeblad H, Andersen HR, Thuesen L, Poulsen SH, Klaaborg KE, Jakobsen CJ, Hjortdal VE
Scand Cardiovasc J Suppl 2013 Feb;47(1):36-41. Epub 2012 Oct 15 doi: 10.3109/14017431.2012.731519. PMID: 22989057
Heart valve regurgitation, pergolide use, and parkinson disease: an observational study and meta-analysis.
Corvol JC, Anzouan-Kacou JB, Fauveau E, Bonnet AM, Lebrun-Vignes B, Girault C, Agid Y, Lechat P, Isnard R, Lacomblez L
Arch Neurol 2007 Dec;64(12):1721-6. doi: 10.1001/archneur.64.12.1721. PMID: 18071034

Recent systematic reviews

Outcomes of mitral TEER in non-responders to cardiac resynchronization therapy: A systematic review and meta-analysis.
Rmilah AA, Abdelhafez M, Balla AK, Ahmad S, Jaber S, Latif O, Haq I, Alzu'Bi H, Al-Abdouh A, Assali M, Ghaly R, Prokop L, Guerrero ME
J Cardiol 2024 Nov;84(5):317-325. Epub 2024 May 16 doi: 10.1016/j.jjcc.2024.05.005. PMID: 38762190

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