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Cleft upper lip, upper jaw AND palate

MedGen UID:
539673
•Concept ID:
C0266090
•
Congenital Abnormality
Synonyms: Cheilognathopalatoschisis; Cheilognathouranoschisis
SNOMED CT: Cheilognathopalatoschisis (337471007); Cleft upper lip, upper jaw AND palate (337471007); Cheilognathouranoschisis (338486003)

Definition

A congenital abnormality consisting of a fissure in the midline of the lip, hard and/or soft palate and upper jaw. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCleft upper lip, upper jaw AND palate

Professional guidelines

PubMed

Norwegian Orthodontists' Experience and Challenges With Treatment of Patients With Cleft Lip and Palate.
Saele PK, Nordrehaug Aastrøm AK, Gjengedal H, Nasir EF, Mustafa M
Cleft Palate Craniofac J 2022 Jul;59(7):859-866. Epub 2021 Jul 20 doi: 10.1177/10556656211028509. PMID: 34282635Free PMC Article
Cleft Lip and Palate Midfacial Hypoplasia: Criteria to Choose the Treatment.
Fariña R, Lolas J, Moreno E, Alister JP, Uribe MF, Pantoja R, Valladares S, Arrué C
J Craniofac Surg 2022 Mar-Apr 01;33(2):496-501. doi: 10.1097/SCS.0000000000007973. PMID: 34261964
Management of the protuberant premaxilla: where does it fit in?
Morris L
Curr Opin Otolaryngol Head Neck Surg 2019 Aug;27(4):302-309. doi: 10.1097/MOO.0000000000000558. PMID: 31219831

Recent clinical studies

Etiology

Craniofacial and three-dimensional palatal analysis in cleft lip and palate patients treated in Spain.
Viñas MJ, Galiotto-Barba F, Cortez-Lede MG, Rodríguez-González MÁ, Moral I, Delso E, González-Meli B, Lobo F, López-Cedrún JL, Neagu D, Garatea J, Garatea A, Berenguer B, Lorca-García C, Delgado MD, Martí E, Gutiérrez JM, Hernández C, Murillo-González J, Martínez-Álvarez C, Martínez-Sanz E
Sci Rep 2022 Nov 6;12(1):18837. doi: 10.1038/s41598-022-23584-0. PMID: 36336749Free PMC Article
Cleft Lip and Palate Midfacial Hypoplasia: Criteria to Choose the Treatment.
Fariña R, Lolas J, Moreno E, Alister JP, Uribe MF, Pantoja R, Valladares S, Arrué C
J Craniofac Surg 2022 Mar-Apr 01;33(2):496-501. doi: 10.1097/SCS.0000000000007973. PMID: 34261964
Craniofacial Growth Analysis of Individuals With and Without Cleft Lip and Palate in Colombia.
Téllez-Conti C, Mora-Diaz II, Díaz-Báez D, Ocampo-Arias IJ, Jiménez-Luna NE, Niño-Paz JC, González-Carrera MC
Cleft Palate Craniofac J 2022 May;59(5):577-588. Epub 2021 May 18 doi: 10.1177/10556656211013690. PMID: 34000838
Orthognathic Surgery for Patients with Cleft Lip and Palate.
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Cleft lip and palate: current status from the literature and our experience.
Manna F, Pensiero S, Clarich G, Guarneri GF, Parodi PC
J Craniofac Surg 2009 Sep;20(5):1383-7. doi: 10.1097/SCS.0b013e3181b0daa3. PMID: 19816262

Diagnosis

Understanding the distinction between cleft lip and cleft palate: a critical step for successful prenatal detection.
Minor K, Chueh J
Curr Opin Obstet Gynecol 2023 Apr 1;35(2):113-126. Epub 2023 Jan 24 doi: 10.1097/GCO.0000000000000852. PMID: 36912278
Orofacial Cleft and Mandibular Prognathism-Human Genetics and Animal Models.
Jaruga A, Ksiazkiewicz J, Kuzniarz K, Tylzanowski P
Int J Mol Sci 2022 Jan 16;23(2) doi: 10.3390/ijms23020953. PMID: 35055138Free PMC Article
Selected Orthodontic Principles for Management of Cranio-Maxillofacial Deformities.
Tremont TJ, Posnick JC
Oral Maxillofac Surg Clin North Am 2020 May;32(2):321-338. Epub 2020 Mar 5 doi: 10.1016/j.coms.2020.01.006. PMID: 32146029
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938
Treatment outcome in cleft lip and palate: issues and perspectives.
Mølsted K
Crit Rev Oral Biol Med 1999;10(2):225-39. doi: 10.1177/10454411990100020801. PMID: 10759424

Therapy

Effectiveness of pre-surgical orthopedics on patients with cleft lip and palate: A systematic review and meta-analysis.
Dallaserra M, Pantoja T, Salazar J, Araya I, Yanine N, Villanueva J
J Stomatol Oral Maxillofac Surg 2022 Oct;123(5):e506-e520. Epub 2022 Feb 10 doi: 10.1016/j.jormas.2022.02.004. PMID: 35151895
Orthognathic Surgery for Patients with Cleft Lip and Palate.
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients.
Kloukos D, Fudalej P, Sequeira-Byron P, Katsaros C
Cochrane Database Syst Rev 2018 Aug 10;8(8):CD010403. doi: 10.1002/14651858.CD010403.pub3. PMID: 30095853Free PMC Article
Maxillofacial growth and speech outcome after one-stage or two-stage palatoplasty in unilateral cleft lip and palate. A systematic review.
Reddy RR, Gosla Reddy S, Vaidhyanathan A, Bergé SJ, Kuijpers-Jagtman AM
J Craniomaxillofac Surg 2017 Jun;45(6):995-1003. Epub 2017 Mar 22 doi: 10.1016/j.jcms.2017.03.006. PMID: 28427835
Treatment outcome in cleft lip and palate: issues and perspectives.
Mølsted K
Crit Rev Oral Biol Med 1999;10(2):225-39. doi: 10.1177/10454411990100020801. PMID: 10759424

Prognosis

Sella turcica dimensions and maxillary growth in patients with unilateral cleft lip and palate.
Antonarakis GS, Huanca Ghislanzoni L, Fisher DM
J Stomatol Oral Maxillofac Surg 2022 Nov;123(6):e916-e921. Epub 2022 Jun 10 doi: 10.1016/j.jormas.2022.06.008. PMID: 35697253
Is Cleft Lip or Palate a Risk Factor for Perioperative Complications in Orthognathic Surgery?
Lee CC, Peacock ZS
J Oral Maxillofac Surg 2022 Feb;80(2):276-284. Epub 2021 Sep 17 doi: 10.1016/j.joms.2021.09.008. PMID: 34648754
Cleft Lip and Palate: LeFort I Distraction with Halo and Hybrid Internal Maxillary Distractors.
Figueroa AA, Figueroa AD, Burton RG, Tragos C
Clin Plast Surg 2021 Jul;48(3):391-405. Epub 2021 May 8 doi: 10.1016/j.cps.2021.02.002. PMID: 34051893
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938
Craniofacial growth and development in unilateral cleft lip and palate: clinical implications (a review).
Smahel Z, Müllerová Z
Acta Chir Plast 1995;37(1):29-32. PMID: 7653173

Clinical prediction guides

Periodontal changes following distraction osteogenesis in patients with cleft lip and palate: a clinical trial.
Moussa H, Fahmy RA, Madi M, Khalil NM
Angle Orthod 2022 Nov 1;92(6):764-772. doi: 10.2319/020922-118.1. PMID: 36279255Free PMC Article
Is Cleft Lip or Palate a Risk Factor for Perioperative Complications in Orthognathic Surgery?
Lee CC, Peacock ZS
J Oral Maxillofac Surg 2022 Feb;80(2):276-284. Epub 2021 Sep 17 doi: 10.1016/j.joms.2021.09.008. PMID: 34648754
Cleft Lip and Palate: LeFort I Distraction with Halo and Hybrid Internal Maxillary Distractors.
Figueroa AA, Figueroa AD, Burton RG, Tragos C
Clin Plast Surg 2021 Jul;48(3):391-405. Epub 2021 May 8 doi: 10.1016/j.cps.2021.02.002. PMID: 34051893
Craniofacial growth and development in unilateral cleft lip and palate: clinical implications (a review).
Smahel Z, Müllerová Z
Acta Chir Plast 1995;37(1):29-32. PMID: 7653173
Clinical observations of cleft lip and palate.
Precious DS, Delaire J
Oral Surg Oral Med Oral Pathol 1993 Feb;75(2):141-51. doi: 10.1016/0030-4220(93)90084-h. PMID: 8426712

Recent systematic reviews

Sagittal Growth Restriction of the Midface Following Isolated Cleft Lip Repair: A Systematic Review and Meta-Analysis.
Celie KB, Wlodarczyk J, Naidu P, Tapia MF, Nagengast E, Yao C, Magee W 3rd
Cleft Palate Craniofac J 2024 Jan;61(1):20-32. Epub 2022 Jul 25 doi: 10.1177/10556656221116005. PMID: 35876322
Relapse-related factors of Le Fort I osteotomy in cleft lip and palate patients: A systematic review and meta-analysis.
Valls-Ontañón A, Fernandes-Ciaccia L, Haas-Junior OL, Hernández-Alfaro F
J Craniomaxillofac Surg 2021 Oct;49(10):879-890. Epub 2021 Sep 10 doi: 10.1016/j.jcms.2021.09.002. PMID: 34538538
What is the relapse after Le Fort I maxillary advancement in cleft lip and palate patients? A systematic review.
Velasques BD, Moura LB, Martins JR, Damian MF, Xavier CB
Oral Maxillofac Surg 2021 Jun;25(2):139-148. Epub 2020 Sep 17 doi: 10.1007/s10006-020-00906-y. PMID: 32940776
Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients.
Kloukos D, Fudalej P, Sequeira-Byron P, Katsaros C
Cochrane Database Syst Rev 2018 Aug 10;8(8):CD010403. doi: 10.1002/14651858.CD010403.pub3. PMID: 30095853Free PMC Article
Effects of labial adhesion on maxillary arch dimensions and nasolabial esthetics in cleft lip and palate: a systematic review.
Thierens L, Brusselaers N, De Roo N, De Pauw G
Oral Dis 2017 Oct;23(7):889-896. Epub 2017 Jan 24 doi: 10.1111/odi.12613. PMID: 27878905

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